DE2146174A1 - Direkt gepresste Tablette und Verfahren zu ihrer Herstellung - Google Patents

Direkt gepresste Tablette und Verfahren zu ihrer Herstellung

Info

Publication number
DE2146174A1
DE2146174A1 DE19712146174 DE2146174A DE2146174A1 DE 2146174 A1 DE2146174 A1 DE 2146174A1 DE 19712146174 DE19712146174 DE 19712146174 DE 2146174 A DE2146174 A DE 2146174A DE 2146174 A1 DE2146174 A1 DE 2146174A1
Authority
DE
Germany
Prior art keywords
tablets
particles
agent
microcapsules
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712146174
Other languages
German (de)
English (en)
Inventor
Lewis David Princeton Hammes Paul Aloysius Westfield; NJ. Morse (V.StA.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2146174A1 publication Critical patent/DE2146174A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
DE19712146174 1970-09-16 1971-09-15 Direkt gepresste Tablette und Verfahren zu ihrer Herstellung Pending DE2146174A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7285670A 1970-09-16 1970-09-16

Publications (1)

Publication Number Publication Date
DE2146174A1 true DE2146174A1 (de) 1972-03-30

Family

ID=22110165

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712146174 Pending DE2146174A1 (de) 1970-09-16 1971-09-15 Direkt gepresste Tablette und Verfahren zu ihrer Herstellung

Country Status (4)

Country Link
AU (1) AU3317871A (cs)
DE (1) DE2146174A1 (cs)
FR (1) FR2106566A1 (cs)
NL (1) NL7112083A (cs)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173626A (en) 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
EP0057184A4 (en) * 1980-04-21 1983-06-09 Nicholas Pty Ltd ENCAPSULATION PROCESS.
DE4119306A1 (de) * 1991-06-12 1992-12-17 Wheli Inter Ag Organische rohstoffe, zwischen- und endprodukte fuer die ernaehrung und zur verwendung fuer technische zwecke, die vitalstoffe enthalten
WO1995027482A1 (en) * 1994-04-06 1995-10-19 Elan Corporation, Plc Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1403584A (en) * 1972-05-19 1975-08-28 Beecham Group Ltd Control medicaments
DE2347713C3 (de) * 1972-09-25 1980-03-06 Warner-Lambert Co., Morris Plains, N.J. (V.St.A.) Acetylsalicylsäurekautablette
IL43853A0 (en) * 1973-02-16 1974-03-14 Sparamedica Ag Pharmaceutical compositions and their manufacture
GB1479655A (en) * 1974-03-08 1977-07-13 Beecham Group Ltd Antibiotic preparations
GB1598458A (en) * 1977-04-01 1981-09-23 Hoechst Uk Ltd Tableting of microcapsules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5788M (cs) * 1965-11-18 1968-03-18
US3488418A (en) * 1965-11-18 1970-01-06 Sterling Drug Inc Sustained relief analgesic composition
US3557279A (en) * 1969-06-12 1971-01-19 Merck & Co Inc Microencapsulation form of an anti-inflammatory drug

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173626A (en) 1978-12-11 1979-11-06 Merck & Co., Inc. Sustained release indomethacin
EP0057184A4 (en) * 1980-04-21 1983-06-09 Nicholas Pty Ltd ENCAPSULATION PROCESS.
US4442051A (en) * 1980-04-21 1984-04-10 Nicholas Proprietary Limited Encapsulation of indomethacin
DE4119306A1 (de) * 1991-06-12 1992-12-17 Wheli Inter Ag Organische rohstoffe, zwischen- und endprodukte fuer die ernaehrung und zur verwendung fuer technische zwecke, die vitalstoffe enthalten
WO1995027482A1 (en) * 1994-04-06 1995-10-19 Elan Corporation, Plc Effervescent pharmaceutical formulations containing controlled release biodegradable microcapsules

Also Published As

Publication number Publication date
AU3317871A (en) 1973-03-15
FR2106566B1 (cs) 1975-04-18
FR2106566A1 (en) 1972-05-05
NL7112083A (cs) 1972-03-20

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DE2146174A1 (de) Direkt gepresste Tablette und Verfahren zu ihrer Herstellung