DE2130708A1 - gamma-Globulin-Antivenin - Google Patents
gamma-Globulin-AntiveninInfo
- Publication number
- DE2130708A1 DE2130708A1 DE19712130708 DE2130708A DE2130708A1 DE 2130708 A1 DE2130708 A1 DE 2130708A1 DE 19712130708 DE19712130708 DE 19712130708 DE 2130708 A DE2130708 A DE 2130708A DE 2130708 A1 DE2130708 A1 DE 2130708A1
- Authority
- DE
- Germany
- Prior art keywords
- fraction
- globulin
- antibody
- antivenin
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002303 anti-venom Effects 0.000 title claims description 14
- 108010074605 gamma-Globulins Proteins 0.000 title description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 40
- 108010044091 Globulins Proteins 0.000 claims description 25
- 102000006395 Globulins Human genes 0.000 claims description 25
- 210000002966 serum Anatomy 0.000 claims description 25
- 239000002244 precipitate Substances 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000270295 Serpentes Species 0.000 claims description 6
- 239000000644 isotonic solution Substances 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 4
- 239000002953 phosphate buffered saline Substances 0.000 claims description 4
- 239000003998 snake venom Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000012535 impurity Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 231100000614 poison Toxicity 0.000 description 9
- 239000002574 poison Substances 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000283707 Capra Species 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000004078 Snake Bites Diseases 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 230000001376 precipitating effect Effects 0.000 description 3
- 231100000611 venom Toxicity 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 241000272038 Micrurus Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 241000271026 Vipera ammodytes Species 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000172 allergic effect Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000000721 bacterilogical effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000000521 hyperimmunizing effect Effects 0.000 description 2
- 239000002198 insoluble material Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002435 venom Substances 0.000 description 2
- 210000001048 venom Anatomy 0.000 description 2
- 206010002199 Anaphylactic shock Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000639871 Piper dilatatum Species 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- -1 hydrochloric acid Chemical class 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000010414 supernatant solution Substances 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 230000014599 transmission of virus Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39575—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from other living beings excluding bacteria and viruses, e.g. protozoa, fungi, plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4846270A | 1970-06-22 | 1970-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2130708A1 true DE2130708A1 (de) | 1971-12-23 |
Family
ID=21954722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712130708 Pending DE2130708A1 (de) | 1970-06-22 | 1971-06-21 | gamma-Globulin-Antivenin |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2130708A1 (enExample) |
| FR (1) | FR2104761A1 (enExample) |
| GB (1) | GB1322671A (enExample) |
| ZA (1) | ZA713774B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024055A1 (en) * | 1997-11-06 | 1999-05-20 | National University Of Singapore | Therapeutic molecules |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113862227B (zh) * | 2021-09-30 | 2023-06-23 | 陕西师范大学 | 抗中介蝮GintexinA型PLA2毒素的杂交瘤细胞株、抗体及其应用 |
-
1971
- 1971-06-11 ZA ZA713774A patent/ZA713774B/xx unknown
- 1971-06-18 GB GB2880571A patent/GB1322671A/en not_active Expired
- 1971-06-21 FR FR7122503A patent/FR2104761A1/fr not_active Withdrawn
- 1971-06-21 DE DE19712130708 patent/DE2130708A1/de active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999024055A1 (en) * | 1997-11-06 | 1999-05-20 | National University Of Singapore | Therapeutic molecules |
| US6613745B1 (en) | 1997-11-06 | 2003-09-02 | National University Of Singapore | Therapeutic molecules derived from snake venom |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA713774B (en) | 1972-01-26 |
| FR2104761A1 (enExample) | 1972-04-21 |
| GB1322671A (en) | 1973-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2936047A1 (de) | Verfahren zur herstellung eines intravenoes verabreichbaren antikoerperhaeltigen immunglobulinpraeparates und danach hergestellte praeparate | |
| CH640140A5 (de) | Verfahren zur herstellung von intravenoes injizierbarem gamma-globulin. | |
| EP0122909A1 (de) | Immunglobulin-G-hältige Fraktion | |
| DE2459291A1 (de) | Verfahren zur gleichzeitigen herstellung von drei therapeutisch verwendbaren produkten aus einem ausgangsmaterial | |
| CH639854A5 (de) | Gefriergetrocknetes natives gammaglobulin-praeparat zur intravenoesen verabreichung und verfahren zu seiner herstellug. | |
| DE2433209C3 (de) | hitzestabilen Plasmaproteinpraparates | |
| DE2715832A1 (de) | Verfahren zur gewinnung von gereinigtem antihaemophilem globulin a (faktor viii) | |
| DE2837168A1 (de) | Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten immunglobulinloesung | |
| DE2639012C3 (de) | Inununtherapeutikum zur Prophylaxe und Therapie von Pseudomonas aeruginosa-Infektionen | |
| DE3236126A1 (de) | Verfahren zur herstellung von zur intravenoesen verabreichung geeignetem (gamma)-globulin | |
| DE2357800A1 (de) | Verfahren zur herstellung von gammaglobulin | |
| DE2505814C2 (de) | Verfahren zur Herstellung feinverteilter Mikropartikel von Tyrosin mit einem Gehalt eines darin dispergierten, mit Glutaraldehyd modifizierten Allergens und diese Mikropartikel als Wirkstoff enthaltende injizierbare Lösung | |
| DE2130708A1 (de) | gamma-Globulin-Antivenin | |
| DE2515666C3 (de) | Piasminreiche Gammaglobulinfraktion, Verfahren zu deren Herstellung und das Verfahrensprodukt enthaltendes Gammaglobulinpräparat | |
| DE2333884C3 (de) | Verfahren zum Herstellen von hochgereinigtem Humanalbumin | |
| CH575433A5 (en) | Treatment of post-traumatic arthritis - with orgotein | |
| DE1617344A1 (de) | Verfahren zur Herstellung einer Tetanus-Vaccine | |
| DE2404265A1 (de) | Verfahren zur gewinnung von immunglobulinen | |
| DE1818054C2 (de) | Verfahren zur Gewinnung von cytobiotischen Globulinen | |
| DE2733923C3 (de) | Verfahren zur Gewinnung von Humanalbumin | |
| DE951228C (de) | Verfahren zur Stabilisierung eines adrenocorticotropen Praeparates | |
| DE2856939A1 (de) | Verfahren zur gewinnung von intravenoes-vertraeglichen gammaglobulinen | |
| DE2015804A1 (de) | Verfahren zur Herstellung eines antigenen oder allergenen Extraktes | |
| DE4115910C2 (enExample) | ||
| DE1617344C3 (de) | Verfahren zur Herstellung eines Tetanus-Impfstoffes |