DE2117573C3 - Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel - Google Patents

Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel

Info

Publication number
DE2117573C3
DE2117573C3 DE19712117573 DE2117573A DE2117573C3 DE 2117573 C3 DE2117573 C3 DE 2117573C3 DE 19712117573 DE19712117573 DE 19712117573 DE 2117573 A DE2117573 A DE 2117573A DE 2117573 C3 DE2117573 C3 DE 2117573C3
Authority
DE
Germany
Prior art keywords
ester
acid
dihydropyridine
ethanol
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19712117573
Other languages
German (de)
English (en)
Other versions
DE2117573A1 (de
DE2117573B2 (de
Inventor
Friedrich Dr. Bossert
Horst Dr. Meyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19712117573 priority Critical patent/DE2117573C3/de
Priority to CH346072A priority patent/CH571492A5/xx
Priority to SU1768161A priority patent/SU421193A3/ru
Priority to BG020166A priority patent/BG20105A3/xx
Priority to FI94872A priority patent/FI55188C/fi
Priority to DD16215572A priority patent/DD104520A5/xx
Priority to NO119272A priority patent/NO133712C/no
Priority to LU65130D priority patent/LU65130A1/xx
Priority to NL7204695A priority patent/NL170535C/xx
Priority to DK172472A priority patent/DK134600C/da
Priority to JP3450872A priority patent/JPS5529990B1/ja
Priority to AT301872A priority patent/AT315178B/de
Priority to ES401616A priority patent/ES401616A1/es
Priority to PL15462572A priority patent/PL83824B1/pl
Priority to YU95672A priority patent/YU34992B/xx
Priority to CS237972A priority patent/CS178407B2/cs
Priority to HUBA002727 priority patent/HU163996B/hu
Priority to CA139293A priority patent/CA934758A/en
Priority to RO7048872A priority patent/RO61069A/ro
Priority to YU96072A priority patent/YU34993B/xx
Priority to SE460872A priority patent/SE371441B/xx
Publication of DE2117573A1 publication Critical patent/DE2117573A1/de
Publication of DE2117573B2 publication Critical patent/DE2117573B2/de
Application granted granted Critical
Publication of DE2117573C3 publication Critical patent/DE2117573C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19712117573 1971-04-10 1971-04-10 Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel Expired DE2117573C3 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19712117573 DE2117573C3 (de) 1971-04-10 1971-04-10 Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
CH346072A CH571492A5 (xx) 1971-04-10 1972-03-09
SU1768161A SU421193A3 (ru) 1971-04-10 1972-04-05 Способ получения несимметричных эфиров 1,4-дигидропиридиндикарбоновых кислот
FI94872A FI55188C (fi) 1971-04-10 1972-04-06 Foerfarande foer framstaellning av nya osymmetriska 1 4-dihydropyridindikarboxylsyraestrar
BG020166A BG20105A3 (bg) 1971-04-10 1972-04-06 Метод за получаване на естери на несиметрични 1,4-дихидропиридин- дикарбонови киселини
JP3450872A JPS5529990B1 (xx) 1971-04-10 1972-04-07
NO119272A NO133712C (xx) 1971-04-10 1972-04-07
LU65130D LU65130A1 (xx) 1971-04-10 1972-04-07
NL7204695A NL170535C (nl) 1971-04-10 1972-04-07 Werkwijze voor het bereiden van asymmetrische 1.4-dihydropyridine 3.5-dicarbonzuuresters, alsmede voor het bereiden van farmaceutische preparaten en de onder toepassing daarvan verkregen gevormde voortbrengselen.
DK172472A DK134600C (da) 1971-04-10 1972-04-07 Fremgangsmade til fremstilling af usymmetriske 1,4-dihydropyridindicarboxylsyreestere
DD16215572A DD104520A5 (xx) 1971-04-10 1972-04-07
AT301872A AT315178B (de) 1971-04-10 1972-04-07 Verfahren zur Herstellung von neuen unsymmetrischen 1,4-Dihydropyridindicarbonsäureestern
PL15462572A PL83824B1 (xx) 1971-04-10 1972-04-08
ES401616A ES401616A1 (es) 1971-04-10 1972-04-08 Procedimiento para la obtencion de 1,4-dihidropiridin - di-carboxilatos asimetricos.
CS237972A CS178407B2 (xx) 1971-04-10 1972-04-10
HUBA002727 HU163996B (xx) 1971-04-10 1972-04-10
CA139293A CA934758A (en) 1971-04-10 1972-04-10 Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates
RO7048872A RO61069A (xx) 1971-04-10 1972-04-10
YU96072A YU34993B (en) 1971-04-10 1972-04-10 Process for preparing novel non-symmetric 1,4-dihydropyridines
SE460872A SE371441B (xx) 1971-04-10 1972-04-10
YU95672A YU34992B (en) 1971-04-10 1972-04-10 Process for preparing non-symmetric 1,4-dihydrpyridines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712117573 DE2117573C3 (de) 1971-04-10 1971-04-10 Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel

Publications (3)

Publication Number Publication Date
DE2117573A1 DE2117573A1 (de) 1972-10-19
DE2117573B2 DE2117573B2 (de) 1977-12-01
DE2117573C3 true DE2117573C3 (de) 1978-07-27

Family

ID=5804435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712117573 Expired DE2117573C3 (de) 1971-04-10 1971-04-10 Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel

Country Status (19)

Country Link
JP (1) JPS5529990B1 (xx)
AT (1) AT315178B (xx)
BG (1) BG20105A3 (xx)
CA (1) CA934758A (xx)
CH (1) CH571492A5 (xx)
CS (1) CS178407B2 (xx)
DD (1) DD104520A5 (xx)
DE (1) DE2117573C3 (xx)
DK (1) DK134600C (xx)
ES (1) ES401616A1 (xx)
FI (1) FI55188C (xx)
HU (1) HU163996B (xx)
LU (1) LU65130A1 (xx)
NL (1) NL170535C (xx)
NO (1) NO133712C (xx)
PL (1) PL83824B1 (xx)
RO (1) RO61069A (xx)
SE (1) SE371441B (xx)
SU (1) SU421193A3 (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58159490A (ja) * 1982-02-23 1983-09-21 Nikken Kagaku Kk １，４−ジヒドロピリジン化合物
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58185562A (ja) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4529733A (en) * 1983-04-06 1985-07-16 Merrell Dow Pharmaceuticals Inc. Antihypertensive 3-furoyl-1,4-dihydropyridines
US4607041A (en) * 1983-04-27 1986-08-19 Fisons Plc Antihypertensive 2-phenyl Hantzsch dihydropyridines
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
EP0311053A3 (en) * 1987-10-06 1991-05-08 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
DE3741540A1 (de) * 1987-12-08 1989-06-22 Bayer Ag Verfahren zur herstellung von unsymmetrischen dihydropyridinen
DE59410255D1 (de) * 1993-12-10 2003-04-17 Bayer Ag Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
EP1108710A4 (en) * 1998-07-23 2001-11-21 Chen Ing Jun GUAIACOXYPROPANOLAMINE WITH ALPHA / BETA ADRENERGIC INHIBIT ACTIVITY

Also Published As

Publication number Publication date
NL7204695A (xx) 1972-10-12
NO133712B (xx) 1976-03-08
NO133712C (xx) 1976-06-16
SE371441B (xx) 1974-11-18
DE2117573A1 (de) 1972-10-19
DK134600C (da) 1977-05-16
DE2117573B2 (de) 1977-12-01
HU163996B (xx) 1973-12-28
CS178407B2 (xx) 1977-09-15
FI55188B (fi) 1979-02-28
AT315178B (de) 1974-05-10
NL170535B (nl) 1982-06-16
PL83824B1 (xx) 1976-02-28
CA934758A (en) 1973-10-02
CH571492A5 (xx) 1976-01-15
DD104520A5 (xx) 1974-03-12
NL170535C (nl) 1982-11-16
RO61069A (xx) 1976-11-15
SU421193A3 (ru) 1974-03-25
BG20105A3 (bg) 1975-10-30
FI55188C (fi) 1979-06-11
JPS5529990B1 (xx) 1980-08-07
LU65130A1 (xx) 1972-07-12
ES401616A1 (es) 1975-02-16
DK134600B (da) 1976-12-06

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)