CA934758A - Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates - Google Patents

Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates

Info

Publication number
CA934758A
CA934758A CA139293A CA139293A CA934758A CA 934758 A CA934758 A CA 934758A CA 139293 A CA139293 A CA 139293A CA 139293 A CA139293 A CA 139293A CA 934758 A CA934758 A CA 934758A
Authority
CA
Canada
Prior art keywords
dicarboxylates
unsymmetrical
dihydropyridine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA139293A
Other languages
English (en)
Other versions
CA139293S (en
Inventor
Meyer Horst
Bossert Friedrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of CA934758A publication Critical patent/CA934758A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA139293A 1971-04-10 1972-04-10 Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates Expired CA934758A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712117573 DE2117573C3 (de) 1971-04-10 1971-04-10 Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
CA934758A true CA934758A (en) 1973-10-02

Family

ID=5804435

Family Applications (1)

Application Number Title Priority Date Filing Date
CA139293A Expired CA934758A (en) 1971-04-10 1972-04-10 Process for the preparation of unsymmetrical 1,4-dihydropyridine 3,5-dicarboxylates

Country Status (19)

Country Link
JP (1) JPS5529990B1 (xx)
AT (1) AT315178B (xx)
BG (1) BG20105A3 (xx)
CA (1) CA934758A (xx)
CH (1) CH571492A5 (xx)
CS (1) CS178407B2 (xx)
DD (1) DD104520A5 (xx)
DE (1) DE2117573C3 (xx)
DK (1) DK134600C (xx)
ES (1) ES401616A1 (xx)
FI (1) FI55188C (xx)
HU (1) HU163996B (xx)
LU (1) LU65130A1 (xx)
NL (1) NL170535C (xx)
NO (1) NO133712C (xx)
PL (1) PL83824B1 (xx)
RO (1) RO61069A (xx)
SE (1) SE371441B (xx)
SU (1) SU421193A3 (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622332A (en) * 1982-03-10 1986-11-11 Bayer Aktiengesellschaft Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2320750A1 (fr) * 1975-08-12 1977-03-11 Hexachimie Dihydro-1,4 pyridines et leur application therapeutique
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
SE429652B (sv) * 1978-06-30 1983-09-19 Haessle Ab 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58159490A (ja) * 1982-02-23 1983-09-21 Nikken Kagaku Kk １，４−ジヒドロピリジン化合物
JPS58185562A (ja) * 1982-04-22 1983-10-29 Taisho Pharmaceut Co Ltd １，４−ジヒドロピリジン誘導体
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
US4529733A (en) * 1983-04-06 1985-07-16 Merrell Dow Pharmaceuticals Inc. Antihypertensive 3-furoyl-1,4-dihydropyridines
US4607041A (en) * 1983-04-27 1986-08-19 Fisons Plc Antihypertensive 2-phenyl Hantzsch dihydropyridines
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
EP0311053A3 (en) * 1987-10-06 1991-05-08 Banyu Pharmaceutical Co., Ltd. Ameliorant of cerebral circulation and optical isomer of nb-818, processes for its production and its use
DE3741540A1 (de) * 1987-12-08 1989-06-22 Bayer Ag Verfahren zur herstellung von unsymmetrischen dihydropyridinen
DE59410255D1 (de) * 1993-12-10 2003-04-17 Bayer Ag Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
EP1108710A4 (en) * 1998-07-23 2001-11-21 Chen Ing Jun GUAIACOXYPROPANOLAMINE WITH ALPHA / BETA ADRENERGIC INHIBIT ACTIVITY

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4622332A (en) * 1982-03-10 1986-11-11 Bayer Aktiengesellschaft Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity

Also Published As

Publication number Publication date
NL7204695A (xx) 1972-10-12
NO133712B (xx) 1976-03-08
NO133712C (xx) 1976-06-16
SE371441B (xx) 1974-11-18
DE2117573A1 (de) 1972-10-19
DK134600C (da) 1977-05-16
DE2117573B2 (de) 1977-12-01
HU163996B (xx) 1973-12-28
CS178407B2 (xx) 1977-09-15
FI55188B (fi) 1979-02-28
AT315178B (de) 1974-05-10
NL170535B (nl) 1982-06-16
PL83824B1 (xx) 1976-02-28
CH571492A5 (xx) 1976-01-15
DD104520A5 (xx) 1974-03-12
NL170535C (nl) 1982-11-16
RO61069A (xx) 1976-11-15
SU421193A3 (ru) 1974-03-25
BG20105A3 (bg) 1975-10-30
FI55188C (fi) 1979-06-11
JPS5529990B1 (xx) 1980-08-07
LU65130A1 (xx) 1972-07-12
DE2117573C3 (de) 1978-07-27
ES401616A1 (es) 1975-02-16
DK134600B (da) 1976-12-06

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