DE2112715A1 - Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone - Google Patents

Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone

Info

Publication number
DE2112715A1
DE2112715A1 DE19712112715 DE2112715A DE2112715A1 DE 2112715 A1 DE2112715 A1 DE 2112715A1 DE 19712112715 DE19712112715 DE 19712112715 DE 2112715 A DE2112715 A DE 2112715A DE 2112715 A1 DE2112715 A1 DE 2112715A1
Authority
DE
Germany
Prior art keywords
general formula
biphenylyl
acid
hydroxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712112715
Other languages
German (de)
English (en)
Inventor
Wolfhard Dipl-Chem Dr Engel
Josef Dipl-Chem Dr Nickl
Ernst Dipl-Chem Dr Seeger
Helmut Dipl-Chem Dr Teufel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE19712112715 priority Critical patent/DE2112715A1/de
Priority to CH1083775A priority patent/CH586178A5/xx
Priority to CH1083875A priority patent/CH585173A5/xx
Priority to CH371572A priority patent/CH583679A5/xx
Priority to NL7203400A priority patent/NL7203400A/xx
Priority to ES400790A priority patent/ES400790A1/es
Priority to AT222172A priority patent/AT317188B/de
Priority to DK124272A priority patent/DK132943C/da
Priority to AT00014/73A priority patent/AT319219B/de
Priority to IL38999A priority patent/IL38999A/xx
Priority to AT00022/73A priority patent/AT318585B/de
Priority to AT00017/73A priority patent/AT319220B/de
Priority to AT00021/73A priority patent/AT319221B/de
Priority to IE338/72A priority patent/IE36174B1/xx
Priority to BE780821A priority patent/BE780821A/xx
Priority to AT00016/73A priority patent/AT317876B/de
Priority to AT2373A priority patent/AT318586B/de
Priority to AT1873A priority patent/AT317877B/de
Priority to AT00025/73A priority patent/AT320622B/de
Priority to GB1241672A priority patent/GB1390091A/en
Priority to AT00019/73A priority patent/AT320620B/de
Priority to AT2073A priority patent/AT317878B/de
Priority to FR7209420A priority patent/FR2130390A1/fr
Priority to AU40115/72A priority patent/AU472025B2/en
Priority to ES405645A priority patent/ES405645A1/es
Priority to ES405650A priority patent/ES405650A1/es
Priority to ES405643A priority patent/ES405643A1/es
Priority to ES405646A priority patent/ES405646A1/es
Priority to ES405644A priority patent/ES405644A1/es
Priority to ES405648A priority patent/ES405648A1/es
Priority to ES405651A priority patent/ES405651A1/es
Priority to ES405647A priority patent/ES405647A1/es
Priority to ES405649A priority patent/ES405649A1/es
Publication of DE2112715A1 publication Critical patent/DE2112715A1/de
Priority to AT1573A priority patent/AT317875B/de
Priority to AT00024/73A priority patent/AT320621B/de
Priority to US05/406,196 priority patent/US4021479A/en
Priority to FR7442065A priority patent/FR2279385A1/fr
Priority to US05/543,266 priority patent/US3997589A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/88—Unsaturated compounds containing keto groups containing halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
DE19712112715 1971-03-17 1971-03-17 Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone Pending DE2112715A1 (de)

Priority Applications (38)

Application Number Priority Date Filing Date Title
DE19712112715 DE2112715A1 (de) 1971-03-17 1971-03-17 Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone
CH1083775A CH586178A5 (es) 1971-03-17 1972-03-14
CH1083875A CH585173A5 (es) 1971-03-17 1972-03-14
CH371572A CH583679A5 (es) 1971-03-17 1972-03-14
NL7203400A NL7203400A (es) 1971-03-17 1972-03-15
ES400790A ES400790A1 (es) 1971-03-17 1972-03-15 Procedimiento para la preparacion de nuevos acidos 4-(4-bi-fenilil) - 4 - hidroxibutiricos, sus esteres o lactonas.
GB1241672A GB1390091A (en) 1971-03-17 1972-03-16 4-4-biphenylyl-butyric acid derivatives
DK124272A DK132943C (da) 1971-03-17 1972-03-16 Analogifremgangsmade til fremstilling af 4-(4-biphenylyl)-4-hydroxy-smorsyrer eller estere eller lactoner eller salte heraf
AT00014/73A AT319219B (de) 1971-03-17 1972-03-16 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
IL38999A IL38999A (en) 1971-03-17 1972-03-16 4-(4-biphenyl)-butyric acids and derivatives thereof and the preparation of such compounds
AT00022/73A AT318585B (de) 1971-03-17 1972-03-16 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT00017/73A AT319220B (de) 1971-03-17 1972-03-16 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT00021/73A AT319221B (de) 1971-03-17 1972-03-16 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
IE338/72A IE36174B1 (en) 1971-03-17 1972-03-16 4-(4-biphenylyl)-butyric acid derivatives
BE780821A BE780821A (fr) 1971-03-17 1972-03-16 Nouveaux derives de l'acide 4-(4-biphenylyl) butyrique
AT00016/73A AT317876B (de) 1971-03-17 1972-03-16 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT2373A AT318586B (de) 1971-03-17 1972-03-16 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT1873A AT317877B (de) 1971-03-17 1972-03-16 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT00025/73A AT320622B (de) 1971-03-17 1972-03-16 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern oder lactonen
AT222172A AT317188B (de) 1971-03-17 1972-03-16 Verfahren zur Herstellung von neuen 4-(4-Biphenylyl)-4-hydroxy-buttersäuren, ihren Salzen, Estern und Lactonen
AT00019/73A AT320620B (de) 1971-03-17 1972-03-16 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern oder lactonen
AT2073A AT317878B (de) 1971-03-17 1972-03-16 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AU40115/72A AU472025B2 (en) 1971-03-17 1972-03-17 4-(4-biphenylyl)-butyric acids and derivatives thereof
FR7209420A FR2130390A1 (es) 1971-03-17 1972-03-17
ES405647A ES405647A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405651A ES405651A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405643A ES405643A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405646A ES405646A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405649A ES405649A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405648A ES405648A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405650A ES405650A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405645A ES405645A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
ES405644A ES405644A1 (es) 1971-03-17 1972-08-08 Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
AT1573A AT317875B (de) 1971-03-17 1973-01-02 Verfahren zur herstellung von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern und lactonen
AT00024/73A AT320621B (de) 1971-03-17 1973-01-02 Vzh von neuen 4-(4-biphenylyl)-4-hydroxybuttersaeuren,ihren salzen,estern oder lactonen
US05/406,196 US4021479A (en) 1971-03-17 1973-10-15 Derivatives of 4-(4-biphenylyl)-butyric acid
FR7442065A FR2279385A1 (fr) 1971-03-17 1974-12-19 Nouveaux derives de l'acide 4-(4-biphenylyl)-4-hydroxybutyrique
US05/543,266 US3997589A (en) 1971-03-17 1975-01-23 4-(2'-Fluoro-4-biphenylylr-4-oxo-butyric acid and esters and salts thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712112715 DE2112715A1 (de) 1971-03-17 1971-03-17 Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone

Publications (1)

Publication Number Publication Date
DE2112715A1 true DE2112715A1 (de) 1972-10-05

Family

ID=5801759

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712112715 Pending DE2112715A1 (de) 1971-03-17 1971-03-17 Neue 4-(4-Biphenylyl)-4-hydroxybuttersaeuren,ihre Salze,Ester und Lactone

Country Status (6)

Country Link
AT (13) AT319219B (es)
CH (3) CH585173A5 (es)
DE (1) DE2112715A1 (es)
DK (1) DK132943C (es)
ES (10) ES400790A1 (es)
FR (1) FR2279385A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295050A1 (en) * 1987-06-11 1988-12-14 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US7091228B2 (en) 2003-05-09 2006-08-15 Bayer Pharmaceuticals Corporation Preparation and use of aryl alkyl acid derivatives for the treatment of obesity

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5973579A (ja) * 1982-10-19 1984-04-25 Kotobuki Seiyaku Kk ベンゾフラン又はベンゾチオフェン誘導体，この化合物を有効成分とする尿酸排泄剤及びその製造方法
AT401513B (de) * 1994-12-22 1996-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-hydroxy-4-phenylbuttersäure
FR2817256B1 (fr) 2000-11-27 2005-07-15 Univ Pasteur Derives de l'acides 4-hydroxybutanoique et de son homologue superieur comme ligands des recepteurs du gamma- hydroxybutyrate (ghb), compositions pharmaceutiques les contenant et utilisations pharmaceutiques

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295050A1 (en) * 1987-06-11 1988-12-14 Pfizer Inc. Process for preparing a 4,4-diphenylbutanoic acid derivative
US7091228B2 (en) 2003-05-09 2006-08-15 Bayer Pharmaceuticals Corporation Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
US7423156B2 (en) 2003-05-09 2008-09-09 Bayer Pharmaceuticals Corporation Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
US7968576B2 (en) 2003-05-09 2011-06-28 Smith Roger A Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
US8013166B2 (en) 2003-05-09 2011-09-06 Bayer Healthcare Llc Preparation and use of aryl alkyl acid derivatives for the treatment of obesity

Also Published As

Publication number Publication date
AT318585B (de) 1974-10-25
AT319221B (de) 1974-12-10
ES405648A1 (es) 1975-07-16
CH586178A5 (es) 1977-03-31
AT320620B (de) 1975-02-25
ES400790A1 (es) 1975-01-16
CH583679A5 (es) 1977-01-14
ES405643A1 (es) 1975-07-16
AT317877B (de) 1974-09-25
CH585173A5 (es) 1977-02-28
AT317878B (de) 1974-09-25
AT317876B (de) 1974-09-25
AT317188B (de) 1974-08-12
ES405650A1 (es) 1975-07-16
DK132943C (da) 1976-08-02
ES405649A1 (es) 1975-07-16
AT319219B (de) 1974-12-10
AT320621B (de) 1975-02-25
AT317875B (de) 1974-09-25
ES405647A1 (es) 1975-07-16
ES405651A1 (es) 1975-07-16
AT318586B (de) 1974-10-25
ES405645A1 (es) 1975-07-16
ES405644A1 (es) 1975-07-16
FR2279385A1 (fr) 1976-02-20
ES405646A1 (es) 1975-07-16
AT319220B (de) 1974-12-10
AT320622B (de) 1975-02-25
DK132943B (da) 1976-03-01

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