DE2058973C3 - Verfahren zum Bestimmen der Koagulationszeit von Flüssigkeitsproben - Google Patents
Verfahren zum Bestimmen der Koagulationszeit von FlüssigkeitsprobenInfo
- Publication number
- DE2058973C3 DE2058973C3 DE2058973A DE2058973A DE2058973C3 DE 2058973 C3 DE2058973 C3 DE 2058973C3 DE 2058973 A DE2058973 A DE 2058973A DE 2058973 A DE2058973 A DE 2058973A DE 2058973 C3 DE2058973 C3 DE 2058973C3
- Authority
- DE
- Germany
- Prior art keywords
- blood plasma
- reaction
- reagent
- coagulation
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015271 coagulation Effects 0.000 title claims description 29
- 238000005345 coagulation Methods 0.000 title claims description 29
- 238000000034 method Methods 0.000 title claims description 25
- 239000007788 liquid Substances 0.000 title claims description 20
- 238000006243 chemical reaction Methods 0.000 claims description 43
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 29
- 239000002245 particle Substances 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 23
- 230000005291 magnetic effect Effects 0.000 claims description 19
- 230000008859 change Effects 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 230000005294 ferromagnetic effect Effects 0.000 claims description 4
- 229910000428 cobalt oxide Inorganic materials 0.000 claims description 3
- 229910000480 nickel oxide Inorganic materials 0.000 claims description 3
- GNRSAWUEBMWBQH-UHFFFAOYSA-N oxonickel Chemical compound [Ni]=O GNRSAWUEBMWBQH-UHFFFAOYSA-N 0.000 claims description 3
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(ii) oxide Chemical compound [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 description 59
- 239000003153 chemical reaction reagent Substances 0.000 description 53
- 239000000523 sample Substances 0.000 description 53
- 108010094028 Prothrombin Proteins 0.000 description 16
- 102100027378 Prothrombin Human genes 0.000 description 16
- 229940039716 prothrombin Drugs 0.000 description 16
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 15
- 108010000499 Thromboplastin Proteins 0.000 description 15
- 102000002262 Thromboplastin Human genes 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 239000000835 fiber Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 102000009123 Fibrin Human genes 0.000 description 6
- 108010073385 Fibrin Proteins 0.000 description 6
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 6
- 229950003499 fibrin Drugs 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 108090000190 Thrombin Proteins 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 241001500396 Clangula hyemalis Species 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 238000005189 flocculation Methods 0.000 description 1
- 230000016615 flocculation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/110833—Utilizing a moving indicator strip or tape
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Ecology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88197169A | 1969-12-04 | 1969-12-04 | |
| US31493072A | 1972-12-14 | 1972-12-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2058973A1 DE2058973A1 (de) | 1971-06-16 |
| DE2058973B2 DE2058973B2 (de) | 1974-07-11 |
| DE2058973C3 true DE2058973C3 (de) | 1975-02-27 |
Family
ID=26979631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2058973A Expired DE2058973C3 (de) | 1969-12-04 | 1970-12-01 | Verfahren zum Bestimmen der Koagulationszeit von Flüssigkeitsproben |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US3650698A (enrdf_load_stackoverflow) |
| BE (1) | BE759811A (enrdf_load_stackoverflow) |
| CA (1) | CA959741A (enrdf_load_stackoverflow) |
| CH (1) | CH561422A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2058973C3 (enrdf_load_stackoverflow) |
| FR (1) | FR2072819A5 (enrdf_load_stackoverflow) |
| GB (2) | GB1340829A (enrdf_load_stackoverflow) |
| NL (1) | NL7016252A (enrdf_load_stackoverflow) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3861197A (en) * | 1973-06-29 | 1975-01-21 | Technicon Instr | Method and apparatus for determining the viscosity of a liquid sample |
| SE380100B (enrdf_load_stackoverflow) * | 1974-02-07 | 1975-10-27 | Monega Anstalt | |
| CH611420A5 (enrdf_load_stackoverflow) * | 1977-01-10 | 1979-05-31 | Battelle Memorial Institute | |
| US4201470A (en) * | 1977-02-24 | 1980-05-06 | Albrecht Ehrly | Method and apparatus for measurement and registration of the aggregation rate of particles suspended in a liquid |
| US4140401A (en) * | 1977-09-22 | 1979-02-20 | Paschal Richard C | Cleaning apparatus and method |
| US4282745A (en) | 1978-03-28 | 1981-08-11 | English Clays Lovering Pochin & Company Ltd. | Particle size determination |
| IT1105662B (it) * | 1978-09-07 | 1985-11-04 | Salus Istituto Diagnostico Di | Apparecchiatura per studiare e fenomeni della emocoagulazione e dell'aggregazione delle piastrine |
| US4477192A (en) * | 1982-06-25 | 1984-10-16 | Warner-Lambert Company | Magnetic stirring apparatus and method |
| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| FR2566126B1 (fr) | 1984-06-13 | 1988-05-06 | Cinqualbre Paul | Procede et appareil pour la determination, l'affichage et l'impression en automatique de la vitesse de sedimentation des particules en suspension dans un liquide biologique |
| US4676656A (en) * | 1985-01-25 | 1987-06-30 | Syntex (U.S.A.) Inc. | Fluid handling apparatus and method |
| US5069216A (en) * | 1986-07-03 | 1991-12-03 | Advanced Magnetics Inc. | Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract |
| US5219554A (en) * | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
| US4933088A (en) * | 1986-07-11 | 1990-06-12 | Kabushiki Kaisha Astec | Method of and apparatus for treating water utilizing proton-releasing substance and/or magnetic field |
| US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
| US4849340A (en) * | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| US4950908A (en) * | 1989-03-20 | 1990-08-21 | Consolidation Coal Company | Flocculant control system |
| GB2254423A (en) * | 1990-12-07 | 1992-10-07 | Alpha Dyffryn Cyfyngedig | Analytical apparatus with agitation of samples |
| US5174961A (en) * | 1991-01-18 | 1992-12-29 | Hemotec, Inc. | High sensitivity coagulation detection apparatus |
| ATE156263T1 (de) * | 1991-04-26 | 1997-08-15 | Monsanto Plc | Automatisierung von prüfeinrichtungen |
| DE4209871C2 (de) * | 1991-05-28 | 1997-04-30 | Dade Int Inc | Einrichtung zur automatischen Untersuchung von Blutproben |
| US5314826A (en) * | 1991-08-23 | 1994-05-24 | Medtronic Hemotec, Inc. | Platelet activation and function evaluation technique |
| WO1995006430A1 (en) * | 1993-08-31 | 1995-03-09 | Boehringer Mannheim Corporation | Analog heater control for medical instrument |
| US5841023A (en) * | 1993-08-31 | 1998-11-24 | Boehringer Mannheim Corporation | Magnet for medical instrument |
| US5522255A (en) | 1993-08-31 | 1996-06-04 | Boehringer Mannheim Corporation | Fluid dose, flow and coagulation sensor for medical instrument |
| US5526111A (en) * | 1993-08-31 | 1996-06-11 | Boehringer Mannheim Corporation | Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control |
| US5572997A (en) * | 1994-06-14 | 1996-11-12 | Ryder International Corporation | Coagulation timer |
| PT764046E (pt) | 1994-06-16 | 2000-12-29 | Dade Behring Marburg Gmbh | Metodo e dispositivo para misturar liquidos |
| US5629209A (en) * | 1995-10-19 | 1997-05-13 | Braun, Sr.; Walter J. | Method and apparatus for detecting viscosity changes in fluids |
| US5925319A (en) * | 1996-04-30 | 1999-07-20 | Medtronic, Inc. | Test cartridge for evaluating blood platelet functionality |
| US6458326B1 (en) | 1999-11-24 | 2002-10-01 | Home Diagnostics, Inc. | Protective test strip platform |
| RU2175763C1 (ru) * | 2000-06-02 | 2001-11-10 | Уфимский государственный авиационный технический университет | Измерительная головка для волоконно-оптического капельного анализатора |
| US6562625B2 (en) * | 2001-02-28 | 2003-05-13 | Home Diagnostics, Inc. | Distinguishing test types through spectral analysis |
| US6525330B2 (en) | 2001-02-28 | 2003-02-25 | Home Diagnostics, Inc. | Method of strip insertion detection |
| US6541266B2 (en) | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
| US7300798B2 (en) * | 2001-10-18 | 2007-11-27 | Agilent Technologies, Inc. | Chemical arrays |
| US7235213B2 (en) * | 2002-03-25 | 2007-06-26 | Farallon Medical, Inc. | System for performing blood coagulation assays and measuring blood clotting times |
| GB0324641D0 (en) * | 2003-10-22 | 2003-11-26 | Unipath Ltd | Coagulation detection method |
| EP1544596B1 (de) * | 2003-12-17 | 2016-11-23 | Boehringer Ingelheim microParts GmbH | Verfahren und Vorrichtung zur Bestimmung der Viskosität |
| CA2567137A1 (en) * | 2004-05-17 | 2005-12-08 | Medtronic, Inc. | Point of care heparin determination system |
| EP1815785A1 (en) * | 2006-02-02 | 2007-08-08 | Bioception B.V.i.o. | Cassette-tape formed diagnostic device for fluid diagnostic |
| RU2336525C2 (ru) * | 2006-09-08 | 2008-10-20 | Государственное образовательное учреждение высшего профессионального образования Российский государственный медицинский университет Министерства здравоохранения Российской Федерации | Способ определения агрегации тромбоцитов в плазме крови и времени ее коагуляции |
| US8617899B2 (en) * | 2008-02-14 | 2013-12-31 | Palo Alto Research Center Incorporated | Enhanced drop mixing using magnetic actuation |
| DE102010038215B4 (de) * | 2010-10-15 | 2013-07-18 | Leica Biosystems Nussloch Gmbh | Verfahren und Vorrichtung zum sicherheitsgerechten Entleeren und Befüllen eines Reagenzienbehälters |
| US10823743B1 (en) | 2013-10-28 | 2020-11-03 | Ifirst Medical Technologies, Inc. | Methods of measuring coagulation of a biological sample |
| SE540132C2 (sv) * | 2014-05-22 | 2018-04-10 | Zafena Ab | Analysmetod för bestämning av antikoagulanter i blod eller blodplasma |
| CN106474997A (zh) * | 2016-12-20 | 2017-03-08 | 广西师范大学 | 一种新型磁力搅拌棒 |
| WO2021154995A1 (en) | 2020-01-29 | 2021-08-05 | Ifirst Medical Technologies, Inc. | Medical analyzer and diagnostic sample profiler |
| CN115839868B (zh) * | 2022-10-27 | 2024-01-12 | 山东冽泉环保工程咨询有限公司 | 一种与靶向取样装置配套的反清洗头 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2113063A (en) * | 1935-04-08 | 1938-04-05 | Albert R Stryker | Fluid testing apparatus |
| NL84420C (enrdf_load_stackoverflow) * | 1950-12-12 | |||
| US3146163A (en) * | 1962-01-23 | 1964-08-25 | John H Brewer | Apparatus for separating certain components from blood |
| US3395210A (en) * | 1964-02-07 | 1968-07-30 | Warner Lambert Pharmaceutical | Lyophilized diagnostic reagent for the determination of blood coagulation factors |
| US3470067A (en) * | 1967-09-19 | 1969-09-30 | Pfizer & Co C | Concentration and purification of viruses from particulate magnetic iron oxide-virus complexes |
| US3492096A (en) * | 1967-10-05 | 1970-01-27 | Paul G Hattersley | Apparatus for and method of detecting the coagulation of whole blood |
-
0
- BE BE759811D patent/BE759811A/xx unknown
-
1969
- 1969-12-04 US US881971A patent/US3650698A/en not_active Expired - Lifetime
-
1970
- 1970-10-19 CA CA095,902A patent/CA959741A/en not_active Expired
- 1970-11-06 NL NL7016252A patent/NL7016252A/xx not_active Application Discontinuation
- 1970-11-16 GB GB4040872A patent/GB1340829A/en not_active Expired
- 1970-11-16 GB GB5434770A patent/GB1325730A/en not_active Expired
- 1970-12-01 DE DE2058973A patent/DE2058973C3/de not_active Expired
- 1970-12-03 FR FR7043436A patent/FR2072819A5/fr not_active Expired
- 1970-12-03 CH CH1797970A patent/CH561422A5/xx not_active IP Right Cessation
-
1972
- 1972-12-14 US US27866D patent/USRE27866E/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2072819A5 (enrdf_load_stackoverflow) | 1971-09-24 |
| CH561422A5 (enrdf_load_stackoverflow) | 1975-04-30 |
| GB1325730A (en) | 1973-08-08 |
| CA959741A (en) | 1974-12-24 |
| BE759811A (fr) | 1971-06-03 |
| DE2058973B2 (de) | 1974-07-11 |
| GB1340829A (en) | 1973-12-19 |
| DE2058973A1 (de) | 1971-06-16 |
| NL7016252A (enrdf_load_stackoverflow) | 1971-06-08 |
| US3650698A (en) | 1972-03-21 |
| USRE27866E (en) | 1974-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| 8339 | Ceased/non-payment of the annual fee |