GB1325730A - Method and apparatus for determining the coagulation time of a fluid - Google Patents

Method and apparatus for determining the coagulation time of a fluid

Info

Publication number
GB1325730A
GB1325730A GB5434770A GB5434770A GB1325730A GB 1325730 A GB1325730 A GB 1325730A GB 5434770 A GB5434770 A GB 5434770A GB 5434770 A GB5434770 A GB 5434770A GB 1325730 A GB1325730 A GB 1325730A
Authority
GB
United Kingdom
Prior art keywords
coagulation
arrangement
particles
determining
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5434770A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Publication of GB1325730A publication Critical patent/GB1325730A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Ecology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1325730 Photo-electric coagulation time determining TECHNICON INSTRUMENTS CORP 16 Nov 1970 [4 Dec 1969] 54347/70 Heading G1A In an arrangement for determining the coagulation time of a fluid, a sample is mixed with a coagulating agent and opaque magnetic particles and the mixture is subjected to a moving magnetic field, changes in the turbidity being optically detected at the point of coagulation. Iron oxide particles in a slurry of polyvinyl, pyrollidome and glycerine are deposited by drying on discrete regularly spaced areas of a film or web 66 moved across a temperature controlled testing station in programme controlled steps and a sample and a measure of a coagulant are added at points A and B to each area before stepping to point C where the re-suspended particles are influenced by the rotating field of a rotating magnet 100, a marked change in turbidity which occurs at coagulation is detected by a photo-electric head 92 and mirror arrangement 78 to apply a signal to a timer recorder 95. The arrangement includes a table 12 carrying a number of samples 14 which are applied to the discrete areas by a peristaltic pump arrangement the samples being air spaced and including also between a pair of air spaces a washing fluid. Provision is made for returning any surplus coagulating agent to a supply container 48. The blood sample supply conduit 54 includes a heater coil 58. The process of coagulation around the moving iron particles is described.
GB5434770A 1969-12-04 1970-11-16 Method and apparatus for determining the coagulation time of a fluid Expired GB1325730A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88197169A 1969-12-04 1969-12-04
US31493072A 1972-12-14 1972-12-14

Publications (1)

Publication Number Publication Date
GB1325730A true GB1325730A (en) 1973-08-08

Family

ID=26979631

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4040872A Expired GB1340829A (en) 1969-12-04 1970-11-16 Flexible strip for use in apparatus for determination of the coagulation time of fluid samples
GB5434770A Expired GB1325730A (en) 1969-12-04 1970-11-16 Method and apparatus for determining the coagulation time of a fluid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB4040872A Expired GB1340829A (en) 1969-12-04 1970-11-16 Flexible strip for use in apparatus for determination of the coagulation time of fluid samples

Country Status (8)

Country Link
US (2) US3650698A (en)
BE (1) BE759811A (en)
CA (1) CA959741A (en)
CH (1) CH561422A5 (en)
DE (1) DE2058973C3 (en)
FR (1) FR2072819A5 (en)
GB (2) GB1340829A (en)
NL (1) NL7016252A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115839868A (en) * 2022-10-27 2023-03-24 山东冽泉环保工程咨询有限公司 Anti-cleaning head matched with targeted sampling device

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US3861197A (en) * 1973-06-29 1975-01-21 Technicon Instr Method and apparatus for determining the viscosity of a liquid sample
SE380100B (en) * 1974-02-07 1975-10-27 Monega Anstalt
CH611420A5 (en) * 1977-01-10 1979-05-31 Battelle Memorial Institute
GB1601222A (en) * 1977-02-24 1981-10-28 Schmitt H J Method and apparatus for measurement of the aggregation rate of red blood corpuscles suspended in blood
US4140401A (en) * 1977-09-22 1979-02-20 Paschal Richard C Cleaning apparatus and method
IT1105662B (en) * 1978-09-07 1985-11-04 Salus Istituto Diagnostico Di EQUIPMENT FOR STUDYING AND PHENOMENA OF HEMOCOAGULATION AND PLATE AGGREGATION
US4477192A (en) * 1982-06-25 1984-10-16 Warner-Lambert Company Magnetic stirring apparatus and method
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4676656A (en) * 1985-01-25 1987-06-30 Syntex (U.S.A.) Inc. Fluid handling apparatus and method
US5069216A (en) * 1986-07-03 1991-12-03 Advanced Magnetics Inc. Silanized biodegradable super paramagnetic metal oxides as contrast agents for imaging the gastrointestinal tract
US5219554A (en) * 1986-07-03 1993-06-15 Advanced Magnetics, Inc. Hydrated biodegradable superparamagnetic metal oxides
EP0274539A4 (en) * 1986-07-11 1989-02-23 Astec Kk Method of treating water by making use of proton releasing material and/or magnetic field and apparatus for use in said method.
US4935346A (en) * 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
US4950908A (en) * 1989-03-20 1990-08-21 Consolidation Coal Company Flocculant control system
GB2254423A (en) * 1990-12-07 1992-10-07 Alpha Dyffryn Cyfyngedig Analytical apparatus with agitation of samples
US5174961A (en) * 1991-01-18 1992-12-29 Hemotec, Inc. High sensitivity coagulation detection apparatus
ATE156263T1 (en) * 1991-04-26 1997-08-15 Monsanto Plc AUTOMATION OF TESTING FACILITIES
DE4209871C2 (en) * 1991-05-28 1997-04-30 Dade Int Inc Device for the automatic analysis of blood samples
US5314826A (en) * 1991-08-23 1994-05-24 Medtronic Hemotec, Inc. Platelet activation and function evaluation technique
US5522255A (en) * 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
WO1995006430A1 (en) * 1993-08-31 1995-03-09 Boehringer Mannheim Corporation Analog heater control for medical instrument
US5841023A (en) * 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
US5572997A (en) * 1994-06-14 1996-11-12 Ryder International Corporation Coagulation timer
EP0764046B1 (en) 1994-06-16 2000-08-09 Dade Behring Marburg GmbH Method and device for mixing liquids
US5629209A (en) * 1995-10-19 1997-05-13 Braun, Sr.; Walter J. Method and apparatus for detecting viscosity changes in fluids
US5925319A (en) * 1996-04-30 1999-07-20 Medtronic, Inc. Test cartridge for evaluating blood platelet functionality
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US7300798B2 (en) * 2001-10-18 2007-11-27 Agilent Technologies, Inc. Chemical arrays
AU2003226027A1 (en) * 2002-03-25 2003-10-13 Vector Ii, Inc. System for performing blood coagulation assays and measuring blood clotting times
GB0324641D0 (en) * 2003-10-22 2003-11-26 Unipath Ltd Coagulation detection method
EP1544596B1 (en) * 2003-12-17 2016-11-23 Boehringer Ingelheim microParts GmbH Method and device for determining viscosity
CA2567137A1 (en) * 2004-05-17 2005-12-08 Medtronic, Inc. Point of care heparin determination system
EP1815785A1 (en) * 2006-02-02 2007-08-08 Bioception B.V.i.o. Cassette-tape formed diagnostic device for fluid diagnostic
US8617899B2 (en) * 2008-02-14 2013-12-31 Palo Alto Research Center Incorporated Enhanced drop mixing using magnetic actuation
DE102010038215B4 (en) * 2010-10-15 2013-07-18 Leica Biosystems Nussloch Gmbh Method and device for safely emptying and filling a reagent container
US10823743B1 (en) * 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
SE540132C2 (en) * 2014-05-22 2018-04-10 Zafena Ab Method of analysis for the determination of anticoagulants in blood or blood plasma
CN106474997A (en) * 2016-12-20 2017-03-08 广西师范大学 A kind of novel magnetic stirring rod

Family Cites Families (6)

* Cited by examiner, † Cited by third party
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US2113063A (en) * 1935-04-08 1938-04-05 Albert R Stryker Fluid testing apparatus
NL84420C (en) * 1950-12-12
US3146163A (en) * 1962-01-23 1964-08-25 John H Brewer Apparatus for separating certain components from blood
US3395210A (en) * 1964-02-07 1968-07-30 Warner Lambert Pharmaceutical Lyophilized diagnostic reagent for the determination of blood coagulation factors
US3470067A (en) * 1967-09-19 1969-09-30 Pfizer & Co C Concentration and purification of viruses from particulate magnetic iron oxide-virus complexes
US3492096A (en) * 1967-10-05 1970-01-27 Paul G Hattersley Apparatus for and method of detecting the coagulation of whole blood

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115839868A (en) * 2022-10-27 2023-03-24 山东冽泉环保工程咨询有限公司 Anti-cleaning head matched with targeted sampling device
CN115839868B (en) * 2022-10-27 2024-01-12 山东冽泉环保工程咨询有限公司 Back-cleaning head matched with target sampling device

Also Published As

Publication number Publication date
DE2058973C3 (en) 1975-02-27
GB1340829A (en) 1973-12-19
US3650698A (en) 1972-03-21
DE2058973A1 (en) 1971-06-16
CH561422A5 (en) 1975-04-30
NL7016252A (en) 1971-06-08
FR2072819A5 (en) 1971-09-24
USRE27866E (en) 1974-01-01
BE759811A (en) 1971-06-03
CA959741A (en) 1974-12-24
DE2058973B2 (en) 1974-07-11

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee