GB1389092A - Mixing apparatus - Google Patents

Mixing apparatus

Info

Publication number
GB1389092A
GB1389092A GB4872472A GB4872472A GB1389092A GB 1389092 A GB1389092 A GB 1389092A GB 4872472 A GB4872472 A GB 4872472A GB 4872472 A GB4872472 A GB 4872472A GB 1389092 A GB1389092 A GB 1389092A
Authority
GB
United Kingdom
Prior art keywords
particles
magnet
station
magnetic
plasma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4872472A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Publication of GB1389092A publication Critical patent/GB1389092A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/451—Magnetic mixers; Mixers with magnetically driven stirrers wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation

Abstract

1389092 Mixing apparatus TECHNICON INSTRUMENTS CORP 23 Oct 1972 [13 Dec 1971] 48724/72 Heading B1C Mixing apparatus is provided to mix a volume of combined liquids by activation of magnetic particles in suspension in the liquid volume 22, a first magnet 10 is rotated to rotate in turn the magnetic particles about their own axes, to oppose the centrifugal forces acting on the particles a second magnet 48 is provided so that the magnetic field gradient it generates overlaps that of the first magnet. thus substantial uniformity of distribution of the particles in the liquid is maintained. In the embodiment shown the apparatus is used to measure the Prothrombin Time of a blood plasma sample. A tape 28 has wells 30 thereon and is movable over a support 20 consisting of a non-magnetic strip 24 heated by a coil 23. A mirror 26 is set in the strip 36 denotes a lamp and 38 a photo-cell. Magnet 48 is vertically movable and magnet 10 is rotated by a motor 18. Both magnets are permanent magnets. Each of the wells have an iron oxide material dried therein. In operation blood plasma is dispersed by a probe 32 at a first station whereby the iron particles are suspend in the plasma. The rotating magnetic field promotes mixing of the particles in the plasma rendering it substantially turpid or opaque. After a predetermined time the well is moved to a second station where a probe dispenses a thromboplastic reagent to commence a coagulation reaction. The rotating particles promote mixing of the sample and the reagent. The well is moved to a third station over mirror 26 and the photocell and a timer are activated. As the end point of the coagulation reaction is reached the opaque sample undergoes a sharp and dramatic change due to the collection of the iron oxide particles by one or more fibrin strands formed generally centrally of the mixture; this renders the mixture substantially transparent for detection by photocell 38.
GB4872472A 1971-12-13 1972-10-23 Mixing apparatus Expired GB1389092A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20719671A 1971-12-13 1971-12-13

Publications (1)

Publication Number Publication Date
GB1389092A true GB1389092A (en) 1975-04-03

Family

ID=22769570

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4872472A Expired GB1389092A (en) 1971-12-13 1972-10-23 Mixing apparatus

Country Status (11)

Country Link
US (1) US3752443A (en)
JP (1) JPS4866895A (en)
AU (1) AU460038B2 (en)
BE (1) BE792113A (en)
CA (1) CA956303A (en)
CH (1) CH546094A (en)
DE (1) DE2260153C3 (en)
FR (1) FR2163483B1 (en)
GB (1) GB1389092A (en)
IT (1) IT969622B (en)
NL (1) NL7214185A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452313A1 (en) * 1979-03-29 1980-10-24 Toyo Engineering Corp AGITATION METHOD USING THE MOVEMENT OF MAGNETIC PARTICLES
CN111293827A (en) * 2020-03-11 2020-06-16 湖州天启家居科技有限公司 Polymer water based paint agitating unit based on magnetism generates electricity

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3861197A (en) * 1973-06-29 1975-01-21 Technicon Instr Method and apparatus for determining the viscosity of a liquid sample
US3966333A (en) 1975-02-03 1976-06-29 Baxter Laboratories, Inc. Magnetic stirrer noise cancellation system
CH611420A5 (en) * 1977-01-10 1979-05-31 Battelle Memorial Institute
FR2383444A1 (en) * 1977-03-11 1978-10-06 Laborgeraete Analysensyst Gmbh MEASURING BLOOD COAGULATION TIME
US4140401A (en) * 1977-09-22 1979-02-20 Paschal Richard C Cleaning apparatus and method
WO1979000622A1 (en) * 1978-02-14 1979-09-06 R Brown Improvements in or relating to methods and apparatus for separating mixtures of particulate solids
FR2580407B1 (en) * 1985-04-11 1987-06-26 Vieillard Didier METHOD AND APPARATUS FOR MEASURING COAGULATION OF BLOOD PLASMA
SE8601528D0 (en) * 1986-04-07 1986-04-07 Leo Ab MIXING APPARATUS AND METHOD
US4849340A (en) * 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
TW221493B (en) * 1990-07-10 1994-03-01 Cardiovascular Diagnostics Inc
US5670329A (en) * 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
US5841023A (en) * 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
US5526111A (en) * 1993-08-31 1996-06-11 Boehringer Mannheim Corporation Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
US5522255A (en) * 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
WO1995034374A2 (en) 1994-06-16 1995-12-21 Behringwerke Aktiengesellschaft Method and device for mixing liquids
EP1712921A2 (en) * 1997-09-29 2006-10-18 F.Hoffmann-La Roche Ag Apparatus for separating magnetic particles
DE69839294T2 (en) 1997-09-29 2009-04-09 F. Hoffmann-La Roche Ag Apparatus for depositing magnetic particles
DE19836109A1 (en) * 1998-08-10 2000-03-02 Biotul Bio Instr Gmbh Device and method for the near-surface mixing of samples in biosensor systems
US20100213136A1 (en) * 2005-06-23 2010-08-26 Koninklijke Philips Electronics, N.V. Apparatus for moving magnetic particles
WO2006137334A1 (en) * 2005-06-23 2006-12-28 Arkray, Inc. Analytical implement
US20070207272A1 (en) * 2006-03-03 2007-09-06 Puri Ishwar K Method and apparatus for magnetic mixing in micron size droplets
US8617899B2 (en) * 2008-02-14 2013-12-31 Palo Alto Research Center Incorporated Enhanced drop mixing using magnetic actuation
US20100282099A1 (en) * 2009-05-08 2010-11-11 Lahav Gil Magnetic Homogenizer Apparatus
CN108839282B (en) * 2018-05-29 2020-10-27 安徽航睿电子科技有限公司 Photocatalysis plastic biodegradation system
CN113083107B (en) * 2021-04-15 2022-09-23 东北电力大学 Enhanced passive micro mixer based on random rotating particles and manufacturing method thereof
CN114306790B (en) * 2021-12-16 2022-09-30 江苏恰瑞生物科技有限公司 Immobilized uricase perfusion apparatus and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3219318A (en) * 1961-08-22 1965-11-23 Hershler Abe Fluid treating method and apparatus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452313A1 (en) * 1979-03-29 1980-10-24 Toyo Engineering Corp AGITATION METHOD USING THE MOVEMENT OF MAGNETIC PARTICLES
CN111293827A (en) * 2020-03-11 2020-06-16 湖州天启家居科技有限公司 Polymer water based paint agitating unit based on magnetism generates electricity

Also Published As

Publication number Publication date
DE2260153A1 (en) 1973-07-05
FR2163483A1 (en) 1973-07-27
CA956303A (en) 1974-10-15
JPS4866895A (en) 1973-09-13
DE2260153C3 (en) 1974-08-01
IT969622B (en) 1974-04-10
DE2260153B2 (en) 1974-01-03
AU460038B2 (en) 1975-04-10
US3752443A (en) 1973-08-14
AU4798172A (en) 1974-04-26
NL7214185A (en) 1973-06-15
FR2163483B1 (en) 1977-12-30
CH546094A (en) 1974-02-28
BE792113A (en) 1973-05-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees