DE19937394A1 - Fluorenderivate - Google Patents

Fluorenderivate

Info

Publication number
DE19937394A1
DE19937394A1 DE19937394A DE19937394A DE19937394A1 DE 19937394 A1 DE19937394 A1 DE 19937394A1 DE 19937394 A DE19937394 A DE 19937394A DE 19937394 A DE19937394 A DE 19937394A DE 19937394 A1 DE19937394 A1 DE 19937394A1
Authority
DE
Germany
Prior art keywords
formula
compounds
atoms
acid
solvates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19937394A
Other languages
German (de)
English (en)
Inventor
Wolfgang Staehle
Simon Goodman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19937394A priority Critical patent/DE19937394A1/de
Priority to MXPA02001297A priority patent/MXPA02001297A/es
Priority to PL00353054A priority patent/PL353054A1/xx
Priority to CZ2002298A priority patent/CZ2002298A3/cs
Priority to CA002380981A priority patent/CA2380981A1/en
Priority to JP2001515308A priority patent/JP2003506439A/ja
Priority to BR0013083-4A priority patent/BR0013083A/pt
Priority to SK140-2002A priority patent/SK1402002A3/sk
Priority to EP00956284A priority patent/EP1208088A2/de
Priority to AU68286/00A priority patent/AU6828600A/en
Priority to CN00811476A priority patent/CN1368962A/zh
Priority to KR1020027000660A priority patent/KR20020012631A/ko
Priority to PCT/EP2000/007153 priority patent/WO2001010841A2/de
Priority to HU0202464A priority patent/HUP0202464A3/hu
Priority to ARP000104035A priority patent/AR025042A1/es
Publication of DE19937394A1 publication Critical patent/DE19937394A1/de
Priority to NO20020592A priority patent/NO20020592L/no
Priority to ZA200201873A priority patent/ZA200201873B/xx
Priority to HK03101305.5A priority patent/HK1049006A1/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19937394A 1999-08-07 1999-08-07 Fluorenderivate Withdrawn DE19937394A1 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE19937394A DE19937394A1 (de) 1999-08-07 1999-08-07 Fluorenderivate
AU68286/00A AU6828600A (en) 1999-08-07 2000-07-26 Fluorene derivatives
CN00811476A CN1368962A (zh) 1999-08-07 2000-07-26 芴衍生物
CZ2002298A CZ2002298A3 (cs) 1999-08-07 2000-07-26 Derivát fluorenu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje
CA002380981A CA2380981A1 (en) 1999-08-07 2000-07-26 Fluorene derivatives
JP2001515308A JP2003506439A (ja) 1999-08-07 2000-07-26 フルオレン誘導体
BR0013083-4A BR0013083A (pt) 1999-08-07 2000-07-26 Derivados de fluorano
SK140-2002A SK1402002A3 (en) 1999-08-07 2000-07-26 Fluorene derivative, process for the preparation thereof and pharmaceutical composition comprising same
EP00956284A EP1208088A2 (de) 1999-08-07 2000-07-26 Fluorenderivate als integrininhibitoren
MXPA02001297A MXPA02001297A (es) 1999-08-07 2000-07-26 Derivados del fluoreno.
PL00353054A PL353054A1 (en) 1999-08-07 2000-07-26 Fluorene derivatives as integrin inhibitors
KR1020027000660A KR20020012631A (ko) 1999-08-07 2000-07-26 플루오렌 유도체
PCT/EP2000/007153 WO2001010841A2 (de) 1999-08-07 2000-07-26 Fluorenderivate als integrin inhibitoren
HU0202464A HUP0202464A3 (en) 1999-08-07 2000-07-26 Imidazolyl aminoalkyl fluorene derivatives, process for their preparation, pharmaceutical compositions containing them and their use
ARP000104035A AR025042A1 (es) 1999-08-07 2000-08-04 Derivados del fluoreno, sus enantiomeros y diastereomeros, un procedimiento para su preparacion, un medicamento a base de estos derivados, laspreparaciones farmaceuticas que los contienen y el empleo de los mismos para preparar un medicamento
NO20020592A NO20020592L (no) 1999-08-07 2002-02-06 Fluorenderivater som integrininhibitorer
ZA200201873A ZA200201873B (en) 1999-08-07 2002-03-06 Fluorene derivatives.
HK03101305.5A HK1049006A1 (zh) 1999-08-07 2003-02-20 芴衍生物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19937394A DE19937394A1 (de) 1999-08-07 1999-08-07 Fluorenderivate

Publications (1)

Publication Number Publication Date
DE19937394A1 true DE19937394A1 (de) 2001-02-08

Family

ID=7917613

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19937394A Withdrawn DE19937394A1 (de) 1999-08-07 1999-08-07 Fluorenderivate

Country Status (18)

Country Link
EP (1) EP1208088A2 (no)
JP (1) JP2003506439A (no)
KR (1) KR20020012631A (no)
CN (1) CN1368962A (no)
AR (1) AR025042A1 (no)
AU (1) AU6828600A (no)
BR (1) BR0013083A (no)
CA (1) CA2380981A1 (no)
CZ (1) CZ2002298A3 (no)
DE (1) DE19937394A1 (no)
HK (1) HK1049006A1 (no)
HU (1) HUP0202464A3 (no)
MX (1) MXPA02001297A (no)
NO (1) NO20020592L (no)
PL (1) PL353054A1 (no)
SK (1) SK1402002A3 (no)
WO (1) WO2001010841A2 (no)
ZA (1) ZA200201873B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101102808B1 (ko) * 2010-04-13 2012-01-05 윤태삼 라이저 인장 장치
US8574899B2 (en) 2010-12-22 2013-11-05 Vladimir B Serikov Methods for augmentation collection of placental hematopoietic stem cells and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04506350A (ja) * 1989-06-22 1992-11-05 ノバ　ファーマスーティカル　コーポレイション 炎症の処置用の医薬組成物及び炎症の処置方法
IL113196A0 (en) * 1994-03-31 1995-06-29 Bristol Myers Squibb Co Imidazole derivatives and pharmaceutical compositions containing the same
ATE204857T1 (de) * 1996-03-29 2001-09-15 Searle & Co Meta-substituierte phenylenderivate und ihre verwendung als alphavbeta3 intergrin-antagonisten oder inhibitoren
DE19654483A1 (de) * 1996-06-28 1998-01-02 Merck Patent Gmbh Phenylalanin-Derivate
CA2214931A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Tetrahydrobenzo-a-fluorene compounds and method of use

Also Published As

Publication number Publication date
AR025042A1 (es) 2002-11-06
BR0013083A (pt) 2002-04-23
HK1049006A1 (zh) 2003-04-25
NO20020592D0 (no) 2002-02-06
HUP0202464A2 (hu) 2002-12-28
CN1368962A (zh) 2002-09-11
NO20020592L (no) 2002-04-04
HUP0202464A3 (en) 2003-02-28
EP1208088A2 (de) 2002-05-29
WO2001010841A3 (de) 2001-09-07
AU6828600A (en) 2001-03-05
ZA200201873B (en) 2003-08-27
WO2001010841A2 (de) 2001-02-15
CZ2002298A3 (cs) 2002-04-17
MXPA02001297A (es) 2004-07-16
PL353054A1 (en) 2003-10-06
SK1402002A3 (en) 2002-06-04
JP2003506439A (ja) 2003-02-18
KR20020012631A (ko) 2002-02-16
CA2380981A1 (en) 2001-02-15

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee