DE19820151A1 - Transdermales therapeutisches System zur Anwendung von Candesartan - Google Patents
Transdermales therapeutisches System zur Anwendung von CandesartanInfo
- Publication number
- DE19820151A1 DE19820151A1 DE19820151A DE19820151A DE19820151A1 DE 19820151 A1 DE19820151 A1 DE 19820151A1 DE 19820151 A DE19820151 A DE 19820151A DE 19820151 A DE19820151 A DE 19820151A DE 19820151 A1 DE19820151 A1 DE 19820151A1
- Authority
- DE
- Germany
- Prior art keywords
- transdermal therapeutic
- therapeutic system
- candesartan
- layer
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002053 C09CA06 - Candesartan Substances 0.000 title claims abstract description 32
- 229960000932 candesartan Drugs 0.000 title claims abstract description 32
- 230000001225 therapeutic effect Effects 0.000 title claims description 28
- SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract description 22
- 150000002148 esters Chemical class 0.000 claims abstract description 20
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 239000010410 layer Substances 0.000 claims description 23
- -1 polypropylene Polymers 0.000 claims description 17
- 239000011159 matrix material Substances 0.000 claims description 16
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 14
- 239000012528 membrane Substances 0.000 claims description 12
- 229920001296 polysiloxane Polymers 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000011241 protective layer Substances 0.000 claims description 10
- 229960004349 candesartan cilexetil Drugs 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 229920001155 polypropylene Polymers 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- 229920006395 saturated elastomer Polymers 0.000 claims description 6
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 5
- 229920002367 Polyisobutene Polymers 0.000 claims description 5
- 229960002003 hydrochlorothiazide Drugs 0.000 claims description 5
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims description 5
- 229920000058 polyacrylate Polymers 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- 239000004698 Polyethylene Substances 0.000 claims description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 4
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000853 adhesive Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229920000573 polyethylene Polymers 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000005557 antagonist Substances 0.000 claims description 3
- 239000002934 diuretic Substances 0.000 claims description 3
- 229940030606 diuretics Drugs 0.000 claims description 3
- 239000005038 ethylene vinyl acetate Substances 0.000 claims description 3
- 239000002207 metabolite Substances 0.000 claims description 3
- 239000011505 plaster Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 2
- 235000004866 D-panthenol Nutrition 0.000 claims description 2
- 239000011703 D-panthenol Substances 0.000 claims description 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 claims description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 claims description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Natural products CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 150000001447 alkali salts Chemical class 0.000 claims description 2
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims description 2
- 229920005549 butyl rubber Polymers 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 150000003997 cyclic ketones Chemical class 0.000 claims description 2
- 229960003949 dexpanthenol Drugs 0.000 claims description 2
- 229920001971 elastomer Polymers 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 150000002191 fatty alcohols Chemical class 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 2
- 239000011118 polyvinyl acetate Substances 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 235000003441 saturated fatty acids Nutrition 0.000 claims description 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 2
- 229920003048 styrene butadiene rubber Polymers 0.000 claims description 2
- 229940111630 tea tree oil Drugs 0.000 claims description 2
- 239000010677 tea tree oil Substances 0.000 claims description 2
- 150000003505 terpenes Chemical class 0.000 claims description 2
- 235000007586 terpenes Nutrition 0.000 claims description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 150000003712 vitamin E derivatives Chemical class 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 abstract description 3
- HTQMVQVXFRQIKW-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 HTQMVQVXFRQIKW-UHFFFAOYSA-N 0.000 description 24
- 210000004185 liver Anatomy 0.000 description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- 229940087168 alpha tocopherol Drugs 0.000 description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
- 229960000984 tocofersolan Drugs 0.000 description 3
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 3
- 239000002076 α-tocopherol Substances 0.000 description 3
- 235000004835 α-tocopherol Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 description 2
- 229960000528 amlodipine Drugs 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- ZXUJWPHOPHHZLR-UHFFFAOYSA-N 1,1,1-trichloro-2-fluoroethane Chemical compound FCC(Cl)(Cl)Cl ZXUJWPHOPHHZLR-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 125000005233 alkylalcohol group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 description 1
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 230000037058 blood plasma level Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000013267 controlled drug release Methods 0.000 description 1
- FNTHQRXVZDCWSP-UHFFFAOYSA-N cyclohexane-1,1,2-triol Chemical compound OC1CCCCC1(O)O FNTHQRXVZDCWSP-UHFFFAOYSA-N 0.000 description 1
- PDXRQENMIVHKPI-UHFFFAOYSA-N cyclohexane-1,1-diol Chemical compound OC1(O)CCCCC1 PDXRQENMIVHKPI-UHFFFAOYSA-N 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- UKAWBCGIASBYFE-UHFFFAOYSA-N cyclohexyl 1-hydroxyethyl carbonate Chemical compound CC(O)OC(=O)OC1CCCCC1 UKAWBCGIASBYFE-UHFFFAOYSA-N 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 238000010931 ester hydrolysis Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19820151A DE19820151A1 (de) | 1998-05-06 | 1998-05-06 | Transdermales therapeutisches System zur Anwendung von Candesartan |
| AT99922167T ATE280575T1 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
| BR9910201-3A BR9910201A (pt) | 1998-05-06 | 1999-05-04 | Sistema terapêutico transdérmico para emprego de candesartan |
| EP99922167A EP1085858B1 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
| JP2000546761A JP4659982B2 (ja) | 1998-05-06 | 1999-05-04 | カンデサルタン投与用経皮治療システム |
| CA002331414A CA2331414C (en) | 1998-05-06 | 1999-05-04 | Transdermal therapeutic system for the administration of candesartan |
| AU39311/99A AU760550B2 (en) | 1998-05-06 | 1999-05-04 | Transdermal therapeutic system for the administration of candesartan |
| PCT/EP1999/003029 WO1999056734A2 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
| DE59910944T DE59910944D1 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19820151A DE19820151A1 (de) | 1998-05-06 | 1998-05-06 | Transdermales therapeutisches System zur Anwendung von Candesartan |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19820151A1 true DE19820151A1 (de) | 1999-11-11 |
Family
ID=7866803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19820151A Withdrawn DE19820151A1 (de) | 1998-05-06 | 1998-05-06 | Transdermales therapeutisches System zur Anwendung von Candesartan |
| DE59910944T Expired - Lifetime DE59910944D1 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59910944T Expired - Lifetime DE59910944D1 (de) | 1998-05-06 | 1999-05-04 | Transdermales therapeutisches system zur anwendung von candesartan |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1085858B1 (enExample) |
| JP (1) | JP4659982B2 (enExample) |
| AT (1) | ATE280575T1 (enExample) |
| AU (1) | AU760550B2 (enExample) |
| BR (1) | BR9910201A (enExample) |
| CA (1) | CA2331414C (enExample) |
| DE (2) | DE19820151A1 (enExample) |
| WO (1) | WO1999056734A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097045A1 (en) * | 2002-05-17 | 2003-11-27 | Novartis Ag | Combination of organic compounds |
| WO2005070462A3 (en) * | 2004-01-12 | 2006-03-16 | Sepracor Inc | Compositions comprising (s)-amlodipine and an angiotensin receptor blocker and methods of their use |
| EP1997479A1 (en) * | 2007-05-31 | 2008-12-03 | Helm AG | Stabilized amorphous candesartan cilexetil compositions for oral administration |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60045211D1 (de) | 1999-02-19 | 2010-12-23 | Takeda Pharmaceutical | Präparationen zur perkutanen aufnahme von zusammnesetzungen die einen angiotensin-ii-rezeptorantagonismus aufweisen |
| EP1711168A2 (en) * | 2004-01-23 | 2006-10-18 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of candesartan cilexetil |
| JP5308788B2 (ja) * | 2008-11-27 | 2013-10-09 | 興和株式会社 | 貼付剤 |
| CA2766120C (en) * | 2009-07-07 | 2018-08-14 | Convatec Technologies Inc. | Amphiphilic silicone copolymers for pressure sensitive adhesive applications |
| CN104356116A (zh) * | 2014-10-17 | 2015-02-18 | 北京理工大学 | 坎地沙坦有机胺盐及氨盐的制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898732A (en) * | 1988-05-04 | 1990-02-06 | The Clinipad Corporation | Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system |
| DE4341444A1 (de) * | 1993-12-04 | 1995-06-08 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster |
| US5464628A (en) * | 1991-05-31 | 1995-11-07 | Orion-Yhtyma Oy | Pharmaceutical compositions containing 4-substituted imidazoles to be administered transdermally |
| EP0459136B1 (en) * | 1990-04-27 | 1996-12-27 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
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|---|---|---|---|---|
| CH674618A5 (enExample) * | 1987-04-02 | 1990-06-29 | Ciba Geigy Ag | |
| DE58906975D1 (de) * | 1988-08-02 | 1994-03-24 | Ciba Geigy | Mehrschichtiges Pflaster. |
| ATE107517T1 (de) * | 1989-05-25 | 1994-07-15 | Takeda Chemical Industries Ltd | Transdermales therapeutisches mittel. |
| CA2115985A1 (en) * | 1993-02-25 | 1994-08-26 | Kohei Nishikawa | Vascular hypertrophy suppressor |
| DE19512181C2 (de) * | 1995-03-31 | 2003-11-06 | Hexal Pharma Gmbh | Transdermales System mit Ramipril und/oder Trandolapril als ACE-Hemmer |
| JPH08310946A (ja) * | 1995-05-19 | 1996-11-26 | Yuutoku Yakuhin Kogyo Kk | 経皮吸収製剤 |
| FR2735365B1 (fr) * | 1995-06-14 | 1997-09-05 | Sanofi Sa | Utilisation d'un antagoniste de l'angiotensine ii et d'un derive du benzofurane pour la preparation d'un medicament utile dans le traitement des affections cardiovasculaires |
| FR2746013B1 (fr) * | 1996-03-18 | 1998-05-29 | Sanofi Sa | Utilisation de composes antiarythmiques dans la prevention de la mortalite post infarctus |
| JP4346696B2 (ja) * | 1996-05-28 | 2009-10-21 | 久光製薬株式会社 | 経皮治療用装置 |
| DE19626621A1 (de) * | 1996-07-02 | 1998-01-08 | Hexal Ag | Pflaster zur transdermalen Anwendung von Pergolid |
| JPH11315034A (ja) * | 1998-03-04 | 1999-11-16 | Takeda Chem Ind Ltd | アンギオテンシンｉｉ拮抗作用を有する化合物の徐放性製剤、その製造法および用途 |
-
1998
- 1998-05-06 DE DE19820151A patent/DE19820151A1/de not_active Withdrawn
-
1999
- 1999-05-04 EP EP99922167A patent/EP1085858B1/de not_active Expired - Lifetime
- 1999-05-04 AT AT99922167T patent/ATE280575T1/de active
- 1999-05-04 AU AU39311/99A patent/AU760550B2/en not_active Ceased
- 1999-05-04 WO PCT/EP1999/003029 patent/WO1999056734A2/de not_active Ceased
- 1999-05-04 CA CA002331414A patent/CA2331414C/en not_active Expired - Fee Related
- 1999-05-04 DE DE59910944T patent/DE59910944D1/de not_active Expired - Lifetime
- 1999-05-04 JP JP2000546761A patent/JP4659982B2/ja not_active Expired - Fee Related
- 1999-05-04 BR BR9910201-3A patent/BR9910201A/pt not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4898732A (en) * | 1988-05-04 | 1990-02-06 | The Clinipad Corporation | Inhibiting of tumor growth with an antagonist of the renin-angioten-sin system |
| EP0459136B1 (en) * | 1990-04-27 | 1996-12-27 | Takeda Chemical Industries, Ltd. | Benzimidazole derivatives, their production and use |
| US5464628A (en) * | 1991-05-31 | 1995-11-07 | Orion-Yhtyma Oy | Pharmaceutical compositions containing 4-substituted imidazoles to be administered transdermally |
| DE4341444A1 (de) * | 1993-12-04 | 1995-06-08 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003097045A1 (en) * | 2002-05-17 | 2003-11-27 | Novartis Ag | Combination of organic compounds |
| US8101599B2 (en) | 2002-05-17 | 2012-01-24 | Novartis Ag | Pharmaceutical composition containing anti-hypertensive agents |
| WO2005070462A3 (en) * | 2004-01-12 | 2006-03-16 | Sepracor Inc | Compositions comprising (s)-amlodipine and an angiotensin receptor blocker and methods of their use |
| WO2005070463A3 (en) * | 2004-01-12 | 2006-03-16 | Sepracor Inc | Compositions comprising (s)-amlodipine malate and an angiotensin receptor blocker and methods of their use |
| EP1997479A1 (en) * | 2007-05-31 | 2008-12-03 | Helm AG | Stabilized amorphous candesartan cilexetil compositions for oral administration |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1085858B1 (de) | 2004-10-27 |
| WO1999056734A3 (de) | 2000-01-27 |
| WO1999056734A2 (de) | 1999-11-11 |
| EP1085858A2 (de) | 2001-03-28 |
| DE59910944D1 (de) | 2004-12-02 |
| CA2331414C (en) | 2008-09-16 |
| JP4659982B2 (ja) | 2011-03-30 |
| JP2002513753A (ja) | 2002-05-14 |
| AU3931199A (en) | 1999-11-23 |
| AU760550B2 (en) | 2003-05-15 |
| ATE280575T1 (de) | 2004-11-15 |
| BR9910201A (pt) | 2001-01-09 |
| CA2331414A1 (en) | 1999-11-11 |
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| Date | Code | Title | Description |
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| OM8 | Search report available as to paragraph 43 lit. 1 sentence 1 patent law | ||
| 8141 | Disposal/no request for examination |