DE19816550A1 - Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung - Google Patents
Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur AnalytbestimmungInfo
- Publication number
- DE19816550A1 DE19816550A1 DE19816550A DE19816550A DE19816550A1 DE 19816550 A1 DE19816550 A1 DE 19816550A1 DE 19816550 A DE19816550 A DE 19816550A DE 19816550 A DE19816550 A DE 19816550A DE 19816550 A1 DE19816550 A1 DE 19816550A1
- Authority
- DE
- Germany
- Prior art keywords
- partner
- specific binding
- binding pair
- analyte
- analysis element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012491 analyte Substances 0.000 title claims abstract description 87
- 238000004458 analytical method Methods 0.000 title claims description 67
- 230000009870 specific binding Effects 0.000 claims abstract description 137
- 238000001514 detection method Methods 0.000 claims abstract description 68
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 14
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 9
- 239000000523 sample Substances 0.000 claims description 58
- 239000000427 antigen Substances 0.000 claims description 40
- 108091007433 antigens Proteins 0.000 claims description 40
- 102000036639 antigens Human genes 0.000 claims description 40
- 150000007523 nucleic acids Chemical class 0.000 claims description 38
- 108020004707 nucleic acids Proteins 0.000 claims description 37
- 102000039446 nucleic acids Human genes 0.000 claims description 37
- 239000000126 substance Substances 0.000 claims description 26
- 230000027455 binding Effects 0.000 claims description 19
- 239000003480 eluent Substances 0.000 claims description 18
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 16
- 239000002773 nucleotide Substances 0.000 claims description 15
- 125000003729 nucleotide group Chemical group 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- 229960002685 biotin Drugs 0.000 claims description 10
- 239000011616 biotin Substances 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 9
- 108010090804 Streptavidin Proteins 0.000 claims description 8
- 235000020958 biotin Nutrition 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 108091034117 Oligonucleotide Chemical group 0.000 claims description 7
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 claims description 7
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 claims description 6
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims description 6
- 102000015636 Oligopeptides Human genes 0.000 claims description 6
- 108010038807 Oligopeptides Proteins 0.000 claims description 6
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 claims description 6
- 229960005156 digoxin Drugs 0.000 claims description 6
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims description 6
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims description 6
- 239000003446 ligand Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 108090001090 Lectins Proteins 0.000 claims description 5
- 102000004856 Lectins Human genes 0.000 claims description 5
- 230000003321 amplification Effects 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 5
- 239000002523 lectin Substances 0.000 claims description 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 5
- 210000003608 fece Anatomy 0.000 claims description 4
- 239000004816 latex Substances 0.000 claims description 4
- 229920000126 latex Polymers 0.000 claims description 4
- 108090001008 Avidin Proteins 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 239000002853 nucleic acid probe Substances 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 108050001427 Avidin/streptavidin Proteins 0.000 claims 1
- 239000000243 solution Substances 0.000 description 25
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 22
- 239000010931 gold Substances 0.000 description 22
- 229910052737 gold Inorganic materials 0.000 description 22
- 239000003153 chemical reaction reagent Substances 0.000 description 16
- 239000000835 fiber Substances 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 14
- 208000037797 influenza A Diseases 0.000 description 14
- 238000012360 testing method Methods 0.000 description 13
- 229920000728 polyester Polymers 0.000 description 12
- 239000004372 Polyvinyl alcohol Substances 0.000 description 11
- 239000012528 membrane Substances 0.000 description 11
- 229920002451 polyvinyl alcohol Polymers 0.000 description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
- 239000000872 buffer Substances 0.000 description 9
- 208000037798 influenza B Diseases 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 102000011931 Nucleoproteins Human genes 0.000 description 8
- 108010061100 Nucleoproteins Proteins 0.000 description 8
- 229920002678 cellulose Polymers 0.000 description 8
- 239000001913 cellulose Substances 0.000 description 8
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 239000000020 Nitrocellulose Substances 0.000 description 6
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 description 6
- 239000003550 marker Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 229920001220 nitrocellulos Polymers 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 238000003752 polymerase chain reaction Methods 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 239000008279 sol Substances 0.000 description 6
- 239000002250 absorbent Substances 0.000 description 5
- 230000002745 absorbent Effects 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000012876 carrier material Substances 0.000 description 5
- 239000003365 glass fiber Substances 0.000 description 5
- 229920000136 polysorbate Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 208000031886 HIV Infections Diseases 0.000 description 4
- 208000037357 HIV infectious disease Diseases 0.000 description 4
- 241000712431 Influenza A virus Species 0.000 description 4
- 241000713196 Influenza B virus Species 0.000 description 4
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 239000012228 culture supernatant Substances 0.000 description 4
- -1 for example Substances 0.000 description 4
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- 229910000160 potassium phosphate Inorganic materials 0.000 description 4
- 235000011009 potassium phosphates Nutrition 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 241000606153 Chlamydia trachomatis Species 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 3
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960004308 acetylcysteine Drugs 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 229940098773 bovine serum albumin Drugs 0.000 description 3
- 229940038705 chlamydia trachomatis Drugs 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 229920002647 polyamide Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 238000002791 soaking Methods 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- AHCYMLUZIRLXAA-SHYZEUOFSA-N Deoxyuridine 5'-triphosphate Chemical compound O1[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C[C@@H]1N1C(=O)NC(=O)C=C1 AHCYMLUZIRLXAA-SHYZEUOFSA-N 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- 239000004831 Hot glue Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- 108010071390 Serum Albumin Proteins 0.000 description 2
- 102000007562 Serum Albumin Human genes 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000009918 complex formation Effects 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N dihydromaleimide Natural products O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000003365 immunocytochemistry Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 239000013612 plasmid Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960002317 succinimide Drugs 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- ZYECOAILUNWEAL-NUDFZHEQSA-N (4z)-4-[[2-methoxy-5-(phenylcarbamoyl)phenyl]hydrazinylidene]-n-(3-nitrophenyl)-3-oxonaphthalene-2-carboxamide Chemical compound COC1=CC=C(C(=O)NC=2C=CC=CC=2)C=C1N\N=C(C1=CC=CC=C1C=1)/C(=O)C=1C(=O)NC1=CC=CC([N+]([O-])=O)=C1 ZYECOAILUNWEAL-NUDFZHEQSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 229920003043 Cellulose fiber Polymers 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 1
- 102000002464 Galactosidases Human genes 0.000 description 1
- 108010093031 Galactosidases Proteins 0.000 description 1
- 238000012351 Integrated analysis Methods 0.000 description 1
- 239000007987 MES buffer Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 108091093037 Peptide nucleic acid Proteins 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- XZTUSOXSLKTKJQ-UHFFFAOYSA-N Uzarigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C1=CC(=O)OC1 XZTUSOXSLKTKJQ-UHFFFAOYSA-N 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 150000001615 biotins Chemical class 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- XZTUSOXSLKTKJQ-CESUGQOBSA-N digitoxigenin Chemical compound C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC(=O)OC1 XZTUSOXSLKTKJQ-CESUGQOBSA-N 0.000 description 1
- 229960000648 digitoxin Drugs 0.000 description 1
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 229940127121 immunoconjugate Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- IZWSFJTYBVKZNK-UHFFFAOYSA-N lauryl sulfobetaine Chemical compound CCCCCCCCCCCC[N+](C)(C)CCCS([O-])(=O)=O IZWSFJTYBVKZNK-UHFFFAOYSA-N 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920006267 polyester film Polymers 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920005594 polymer fiber Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000008057 potassium phosphate buffer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000011895 specific detection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
- G01N33/54387—Immunochromatographic test strips
- G01N33/54388—Immunochromatographic test strips based on lateral flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19816550A DE19816550A1 (de) | 1997-12-24 | 1998-04-15 | Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung |
| CA002256943A CA2256943C (en) | 1997-12-24 | 1998-12-17 | General purpose structure of an analytical element and its application for analyte determination |
| US09/215,979 US6703196B1 (en) | 1997-12-24 | 1998-12-18 | General purpose structure of an analytical element and its application for analyte determination |
| SG1998005867A SG66919A1 (en) | 1997-12-24 | 1998-12-18 | General purpose structure of an analytical element and its application for analyte determination |
| KR1019980056247A KR19990063211A (ko) | 1997-12-24 | 1998-12-18 | 분석용 구성물의 다목적 구조 및 분석물질측정을 위한 이의 적용 |
| EP98124287A EP0926498B1 (de) | 1997-12-24 | 1998-12-21 | Verfahren zur Analytbestimmung unter Verwendung eines universellen Analysenelementes |
| ES98124287T ES2314985T3 (es) | 1997-12-24 | 1998-12-21 | Procedimiento para la determinacion de un analito mediante el empleo de un elemento de analisis universal. |
| EP08009295A EP2037273A1 (de) | 1997-12-24 | 1998-12-21 | Universell verwendbarer Aufbau eines Analysenelements und Kit enthaltend den universellen Aufbau |
| DE59814295T DE59814295D1 (de) | 1997-12-24 | 1998-12-21 | Verfahren zur Analytbestimmung unter Verwendung eines universellen Analysenelementes |
| AT98124287T ATE409862T1 (de) | 1997-12-24 | 1998-12-21 | Verfahren zur analytbestimmung unter verwendung eines universellen analysenelementes |
| CN98125504A CN1228538A (zh) | 1997-12-24 | 1998-12-24 | 分析元件的多种功能结构及其用于测定分析物的应用 |
| JP36817998A JPH11248708A (ja) | 1997-12-24 | 1998-12-24 | 分析要素の多目的構造体およびアナライト測定のためのその用途 |
| US10/748,560 US7118875B2 (en) | 1997-12-24 | 2003-12-30 | Analyte determination using a general purpose structure of an analytical element |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19757980 | 1997-12-24 | ||
| DE19816550A DE19816550A1 (de) | 1997-12-24 | 1998-04-15 | Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19816550A1 true DE19816550A1 (de) | 1999-06-24 |
Family
ID=26042854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19816550A Withdrawn DE19816550A1 (de) | 1997-12-24 | 1998-04-15 | Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung |
| DE59814295T Expired - Lifetime DE59814295D1 (de) | 1997-12-24 | 1998-12-21 | Verfahren zur Analytbestimmung unter Verwendung eines universellen Analysenelementes |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59814295T Expired - Lifetime DE59814295D1 (de) | 1997-12-24 | 1998-12-21 | Verfahren zur Analytbestimmung unter Verwendung eines universellen Analysenelementes |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6703196B1 (enExample) |
| EP (2) | EP0926498B1 (enExample) |
| JP (1) | JPH11248708A (enExample) |
| KR (1) | KR19990063211A (enExample) |
| CN (1) | CN1228538A (enExample) |
| AT (1) | ATE409862T1 (enExample) |
| CA (1) | CA2256943C (enExample) |
| DE (2) | DE19816550A1 (enExample) |
| ES (1) | ES2314985T3 (enExample) |
| SG (1) | SG66919A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281004B1 (en) * | 1999-04-14 | 2001-08-28 | Cytologix Corporation | Quality control for cytochemical assays |
| US7011940B1 (en) | 1999-04-14 | 2006-03-14 | Medical Discovery Partners Llc | Quality control for cytochemical assays |
| DE19927783A1 (de) * | 1999-06-18 | 2000-12-21 | Roche Diagnostics Gmbh | Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts |
| DE19956820A1 (de) | 1999-11-25 | 2001-05-31 | Roche Diagnostics Gmbh | Spezies-spezifischer Nachweis von Nukleinsäuren mittels eines Analyseelementes |
| SE0103072D0 (sv) * | 2001-09-17 | 2001-09-17 | Pharmacia Diagnostics Ab | Multi-analyte assay device with multi-spot detection zone |
| WO2003044534A1 (fr) * | 2001-11-22 | 2003-05-30 | Wakunaga Pharmaceutical Co.,Ltd. | Bande d'essai immunochromatographique permettant de mesurer en quantite de trace un objet d'analyse dans un specimen |
| AU2003291250A1 (en) * | 2002-11-05 | 2004-06-07 | Therasense, Inc. | Assay device, system and method |
| ES2332523T3 (es) | 2004-02-09 | 2010-02-08 | Rapid Pathogen Screening Inc. | Metodo para el diagnostico rapido de blancos en fluidos corporales humanos. |
| WO2005121794A1 (ja) * | 2004-06-07 | 2005-12-22 | Denka Seiken Co., Ltd. | クロマトグラフィー式検出装置、検査法及びこれを応用したキット |
| US20060046310A1 (en) * | 2004-08-25 | 2006-03-02 | Zong-Li Xia | Amplification method for solid phase immunoassays |
| JP4547272B2 (ja) * | 2005-01-12 | 2010-09-22 | シスメックス株式会社 | イムノクロマトグラフィー用試験具 |
| US8445293B2 (en) | 2005-02-09 | 2013-05-21 | Rapid Pathogen Screening, Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
| US8669052B2 (en) | 2008-06-10 | 2014-03-11 | Rapid Pathogen Screening, Inc. | Lateral flow nucleic acid detector |
| US7189522B2 (en) * | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| WO2006098804A2 (en) * | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| EP3095467B1 (en) * | 2005-11-23 | 2020-05-06 | Ventana Medical Systems, Inc. | Antibody-enzyme conjugate |
| KR100762825B1 (ko) | 2006-01-03 | 2007-10-04 | 대한민국(관리부서 : 농림부 국립수의과학검역원) | 신속 면역크로마토그라피법에 의한 ｈ5형 고병원성 및 일반조류인플루엔자 바이러스 항원 진단 스트립 및 그 제조방법 |
| GB0604973D0 (en) * | 2006-03-11 | 2006-04-19 | Central Science Lab Csl Of San | Purification method and kit |
| AU2007235649A1 (en) * | 2006-04-10 | 2007-10-18 | 3M Innovative Properties Company | Nucleic acid detection using lateral flow methods |
| WO2009039239A2 (en) * | 2007-09-18 | 2009-03-26 | Idexx Laboratories, Inc. | Lateral flow assay using centrifugal force |
| US8163474B2 (en) * | 2008-03-15 | 2012-04-24 | Arbor Vita Corporation | NS1-NP diagnostics of influenza virus infection |
| JP2009236685A (ja) * | 2008-03-27 | 2009-10-15 | Sysmex Corp | クロマトグラフィー用試験具 |
| US20130196310A1 (en) | 2008-05-20 | 2013-08-01 | Rapid Pathogen Screening, Inc. | Method and Device for Combined Detection of Viral and Bacterial Infections |
| US9068981B2 (en) | 2009-12-04 | 2015-06-30 | Rapid Pathogen Screening, Inc. | Lateral flow assays with time delayed components |
| US8962260B2 (en) | 2008-05-20 | 2015-02-24 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| US8609433B2 (en) | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| US8815609B2 (en) | 2008-05-20 | 2014-08-26 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with diverting zone |
| US20110086359A1 (en) * | 2008-06-10 | 2011-04-14 | Rapid Pathogen Screening, Inc. | Lateral flow assays |
| JP2012503170A (ja) * | 2008-07-15 | 2012-02-02 | ラピッド パトゲン スクリーニング，インク． | 側方流動イムノアッセイにおけるインサイツでの細胞の溶解 |
| US20100022916A1 (en) | 2008-07-24 | 2010-01-28 | Javanbakhsh Esfandiari | Method and Apparatus for Collecting and Preparing Biological Samples for Testing |
| EP2507632B1 (en) * | 2009-12-04 | 2014-08-20 | Rapid Pathogen Screening Inc. | Multiplanar lateral flow assay with sample compressor |
| US8603835B2 (en) | 2011-02-10 | 2013-12-10 | Chembio Diagnostic Systems, Inc. | Reduced step dual path immunoassay device and method |
| CN102323422B (zh) * | 2011-05-30 | 2014-03-12 | 中国科学院上海微系统与信息技术研究所 | 半定量同时检测cTnI和Myo的免疫层析试纸条及其制备 |
| USD694425S1 (en) * | 2011-12-12 | 2013-11-26 | Charm Sciences, Inc. | Recognition test strip |
| WO2013105090A1 (en) * | 2012-01-11 | 2013-07-18 | Aptateck Bio Ltd. | A versatile lateral flow strip device |
| BR112016022829B1 (pt) | 2014-04-02 | 2022-03-03 | Chembio Diagnostic Systems, Inc | Dispositivo de teste para determinar a presença de um primeiro ligante em uma amostra líquida, e método para testar uma amostra quanto à presença de um primeiro ligante |
| CN104101706B (zh) * | 2014-07-28 | 2016-05-18 | 国家纳米科学中心 | 一种检测甲流抗原的胶体金免疫层析试纸条及检测甲流抗原的方法 |
| US20160116466A1 (en) | 2014-10-27 | 2016-04-28 | Chembio Diagnostic Systems, Inc. | Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses |
| US11040892B2 (en) | 2015-02-09 | 2021-06-22 | Digital Concepts Of Missouri, Inc. | Spa/pool water treatment system and method |
| US9990560B2 (en) | 2015-02-09 | 2018-06-05 | Digital Concepts Of Missouri, Inc. | Test strip mobile APP system and method |
| US10808287B2 (en) | 2015-10-23 | 2020-10-20 | Rapid Pathogen Screening, Inc. | Methods and devices for accurate diagnosis of infections |
| USD878624S1 (en) * | 2018-06-05 | 2020-03-17 | Digital Concepts Of Missouri, Inc. | Test strip |
| CN110592201A (zh) * | 2019-10-30 | 2019-12-20 | 上海千履基因科技有限公司 | 一管式高特异性核酸产物的pcr扩增方法、核酸快速检测方法和核酸检测试纸条 |
| KR102352617B1 (ko) * | 2019-12-26 | 2022-01-19 | 프리시젼바이오 주식회사 | 다중 면역 분석용 검사 스트립 제조 방법 및 이를 이용하여 제조된 검사 스트립 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| US4816224A (en) | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
| DE3044385A1 (de) | 1980-11-25 | 1982-06-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur durchfuehrung analytischer bestimmungen und hierfuer geeignetes rotoreinsatzelement |
| US4791056A (en) * | 1984-03-27 | 1988-12-13 | Syntex (U.S.A.) Inc. | Calibration device for heterogeneous immunoassay |
| DE3445816C1 (de) * | 1984-12-15 | 1986-06-12 | Behringwerke Ag, 3550 Marburg | Flaechenfoermiges diagnostisches Mittel |
| US4806311A (en) * | 1985-08-28 | 1989-02-21 | Miles Inc. | Multizone analytical element having labeled reagent concentration zone |
| CA1303983C (en) | 1987-03-27 | 1992-06-23 | Robert W. Rosenstein | Solid phase assay |
| ES2150428T3 (es) | 1987-04-27 | 2000-12-01 | Unilever Nv | Ensayos de union especifica. |
| DE3802366A1 (de) | 1988-01-27 | 1989-08-10 | Boehringer Mannheim Gmbh | Traegervlies fuer abloesbar impraegnierte reagenzien |
| EP0328106A3 (en) * | 1988-02-09 | 1990-12-19 | Konica Corporation | Method of assaying substance and immunoassay element |
| US5141850A (en) | 1990-02-07 | 1992-08-25 | Hygeia Sciences, Inc. | Porous strip form assay device method |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| DE4217732A1 (de) | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Vliesschicht enthaltender Testträger |
| US5354692A (en) * | 1992-09-08 | 1994-10-11 | Pacific Biotech, Inc. | Analyte detection device including a hydrophobic barrier for improved fluid flow |
| EP0630974A3 (en) * | 1993-06-25 | 1995-11-15 | Clinical Diagnostic Syst | Method and test kit for the detection of inorganic orthophosphate in the amplification of target nucleic acids. |
| EP0699906B1 (de) * | 1994-07-25 | 2002-04-24 | Roche Diagnostics GmbH | Verfahren zum Nachweis der Kontamination einer Oberfläche mit einem Analyten |
| ES2171190T3 (es) | 1994-07-25 | 2002-09-01 | Roche Diagnostics Gmbh | Peptidos marcados con haptenos. |
| US5719034A (en) * | 1995-03-27 | 1998-02-17 | Lifescan, Inc. | Chemical timer for a visual test strip |
| AU6720096A (en) | 1995-08-09 | 1997-03-05 | Quidel Corporation | Test strip and method for one step lateral flow assay |
| DE19609838A1 (de) | 1996-03-13 | 1997-09-18 | Boehringer Mannheim Gmbh | Verfahren und Teststreifen zur Bestimmung eines Analyten |
| US5667653A (en) | 1996-03-15 | 1997-09-16 | Mine Safety Appliances Company | Electrochemical sensor |
| US5795783A (en) * | 1996-03-19 | 1998-08-18 | International Remote Imaging Systems, Inc. | Control solutions and a method of use therefor |
-
1998
- 1998-04-15 DE DE19816550A patent/DE19816550A1/de not_active Withdrawn
- 1998-12-17 CA CA002256943A patent/CA2256943C/en not_active Expired - Fee Related
- 1998-12-18 KR KR1019980056247A patent/KR19990063211A/ko not_active Withdrawn
- 1998-12-18 SG SG1998005867A patent/SG66919A1/en unknown
- 1998-12-18 US US09/215,979 patent/US6703196B1/en not_active Expired - Lifetime
- 1998-12-21 AT AT98124287T patent/ATE409862T1/de not_active IP Right Cessation
- 1998-12-21 DE DE59814295T patent/DE59814295D1/de not_active Expired - Lifetime
- 1998-12-21 EP EP98124287A patent/EP0926498B1/de not_active Expired - Lifetime
- 1998-12-21 ES ES98124287T patent/ES2314985T3/es not_active Expired - Lifetime
- 1998-12-21 EP EP08009295A patent/EP2037273A1/de not_active Withdrawn
- 1998-12-24 CN CN98125504A patent/CN1228538A/zh active Pending
- 1998-12-24 JP JP36817998A patent/JPH11248708A/ja active Pending
-
2003
- 2003-12-30 US US10/748,560 patent/US7118875B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| SG66919A1 (en) | 2000-08-22 |
| EP0926498A1 (de) | 1999-06-30 |
| KR19990063211A (ko) | 1999-07-26 |
| ATE409862T1 (de) | 2008-10-15 |
| CA2256943A1 (en) | 1999-06-24 |
| ES2314985T3 (es) | 2009-03-16 |
| EP2037273A1 (de) | 2009-03-18 |
| US20040152142A1 (en) | 2004-08-05 |
| EP0926498B1 (de) | 2008-10-01 |
| US7118875B2 (en) | 2006-10-10 |
| DE59814295D1 (de) | 2008-11-13 |
| CN1228538A (zh) | 1999-09-15 |
| JPH11248708A (ja) | 1999-09-17 |
| US6703196B1 (en) | 2004-03-09 |
| CA2256943C (en) | 2009-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0926498B1 (de) | Verfahren zur Analytbestimmung unter Verwendung eines universellen Analysenelementes | |
| DE3781180T2 (de) | Pruefung unter verwendung von bindungspaargliedern auf teilchen und auf einem filter oder einer membran. | |
| DE68920140T2 (de) | Gerät und verfahren zur schnellen qualitativen und quantitativen bestimmung der anwesenheit eines reaktiven liganden in einer flüssigkeit. | |
| DE69132967T2 (de) | Mikrotest auf einer karte | |
| DE69122832T2 (de) | Vorrichtung zur Durchführung einer raschen einfachen Handprüfung | |
| DE69230884T2 (de) | Auf drehbare stromrichtung beruhender chromatographischer bindungsassay | |
| DE3689973T2 (de) | Verfahren zur Bindung einer Verbindung bei absorbierendem Werkstoff. | |
| DE3856421T2 (de) | Spezifische Bindungstestverfahren | |
| DE69033569T2 (de) | Festphasen-analytische Vorrichtung | |
| DE69330067T2 (de) | Analytische testvorrichtung einschliesslich negativ- und positivkontrolle | |
| DE69128618T3 (de) | Vorrichtung und verfahren zur ausführung von immunoassays | |
| DE69434285T2 (de) | Lyophilisierte ligand-rezeptor komplexe zum nachweis und als sensoren | |
| DE69027020T2 (de) | Immunoassay-Verfahren einschliesslich Deaktivierung von endogener alkalischer Phosphatase | |
| DE69131933T2 (de) | Testvorrictung für Liganden-Rezeptor- Verfahren | |
| DE69116236T2 (de) | Bestimmung von Analyten, die Bindungsstellen für mindestens zwei Bindungsgruppen haben | |
| DE10009503A1 (de) | Verfahren zur Immobilisierung von Konjugaten in diagnostischen Tests | |
| EP1061369B1 (de) | Element, Verfahren und Kit zur Bestimmung eines Analyts in einer Flüssigkeit | |
| DE69932161T2 (de) | Verfahren zur bestimmung des beta-lactam nukleus enthaltenden antibiotikums | |
| DE69032383T2 (de) | Heterogene Bindungstests | |
| EP2194381B1 (de) | Testelement mit kombinierter Kontroll- und Kalibrationszone | |
| DE68925112T2 (de) | Haptenderivatisierte aufnahmemembran und diagnostische tests, die eine solche membran verwenden | |
| EP2823309B1 (de) | Verfahren und vorrichtung zum nachweis von analyten | |
| DE69327059T2 (de) | Verfahren zur herstellung von testelementen | |
| DE60318435T2 (de) | Universeller biosensor und verfahren zur verwendung | |
| WO2014064046A1 (de) | Verfahren und vorrichtung zum nachweis von illegalen drogen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8181 | Inventor (new situation) |
Free format text: KLEPP, JUERGEN, DIPL.-CHEM. DR., 76131 KARLSRUHE, DE HILLER, GERHARD, DIPL.-BIO.-CHEM. DR., 68305 MANNHEIM, DE NICHTL, ALFONS, DIPL.-BIOL. DR., 82383 HOHENPEISSENBERG, DE FISCHER, THOMAS, 69231 RAUENBERG, DE HOESCH, MARTINA, 68163 MANNHEIM, DE |
|
| 8110 | Request for examination paragraph 44 | ||
| R120 | Application withdrawn or ip right abandoned |
Effective date: 20111026 |