DE19713793A1 - Öl-in-Wasser-Emulsionen zur Wiederherstellung der Lamellarität der Lipidstruktur geschädigter Haut - Google Patents
Öl-in-Wasser-Emulsionen zur Wiederherstellung der Lamellarität der Lipidstruktur geschädigter HautInfo
- Publication number
- DE19713793A1 DE19713793A1 DE19713793A DE19713793A DE19713793A1 DE 19713793 A1 DE19713793 A1 DE 19713793A1 DE 19713793 A DE19713793 A DE 19713793A DE 19713793 A DE19713793 A DE 19713793A DE 19713793 A1 DE19713793 A1 DE 19713793A1
- Authority
- DE
- Germany
- Prior art keywords
- oil
- emulsifier
- group
- lipophilic
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000839 emulsion Substances 0.000 title claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 17
- 125000003473 lipid group Chemical group 0.000 title 1
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 19
- 239000007957 coemulsifier Substances 0.000 claims abstract description 19
- 150000002632 lipids Chemical class 0.000 claims abstract description 19
- 239000002537 cosmetic Substances 0.000 claims abstract description 13
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 12
- 125000002252 acyl group Chemical group 0.000 claims abstract description 11
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 11
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001257 hydrogen Substances 0.000 claims abstract description 7
- 229960000735 docosanol Drugs 0.000 claims abstract description 5
- 239000012071 phase Substances 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 6
- 239000007764 o/w emulsion Substances 0.000 claims description 6
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 239000012875 nonionic emulsifier Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000004973 liquid crystal related substance Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 26
- 235000019198 oils Nutrition 0.000 description 26
- 235000014113 dietary fatty acids Nutrition 0.000 description 17
- 239000000194 fatty acid Substances 0.000 description 17
- 229930195729 fatty acid Natural products 0.000 description 17
- -1 fatty acid ester Chemical class 0.000 description 17
- 239000006071 cream Substances 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 11
- 239000003925 fat Substances 0.000 description 10
- 235000019197 fats Nutrition 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 6
- 239000004094 surface-active agent Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 150000003626 triacylglycerols Chemical class 0.000 description 4
- 239000001993 wax Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- BTFJIXJJCSYFAL-UHFFFAOYSA-N icosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 2
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000223 polyglycerol Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000007762 w/o emulsion Substances 0.000 description 2
- 239000002888 zwitterionic surfactant Substances 0.000 description 2
- CFOQKXQWGLAKSK-KTKRTIGZSA-N (13Z)-docosen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCCO CFOQKXQWGLAKSK-KTKRTIGZSA-N 0.000 description 1
- WFXHUBZUIFLWCV-UHFFFAOYSA-N (2,2-dimethyl-3-octanoyloxypropyl) octanoate Chemical compound CCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCC WFXHUBZUIFLWCV-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 1
- CFOQKXQWGLAKSK-UHFFFAOYSA-N 13-docosen-1-ol Natural products CCCCCCCCC=CCCCCCCCCCCCCO CFOQKXQWGLAKSK-UHFFFAOYSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- DHGISFWHDBPFBJ-UHFFFAOYSA-N 2-(11-methyldodecanoyloxy)ethyl 11-methyldodecanoate Chemical compound CC(C)CCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCC(C)C DHGISFWHDBPFBJ-UHFFFAOYSA-N 0.000 description 1
- RYKSMKFLIHUEBL-UHFFFAOYSA-N 2-(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(C)OC(=O)C(CC)CCCC RYKSMKFLIHUEBL-UHFFFAOYSA-N 0.000 description 1
- NDHKAEBPGBKCIO-UHFFFAOYSA-N 2-(hexadecylamino)propanoic acid Chemical compound CCCCCCCCCCCCCCCCNC(C)C(O)=O NDHKAEBPGBKCIO-UHFFFAOYSA-N 0.000 description 1
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-Hydroxyoctadecanoic acid Natural products CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- QVRMIJZFODZFNE-UHFFFAOYSA-N 2-[dimethyl-[3-(octadecanoylamino)propyl]azaniumyl]acetate Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O QVRMIJZFODZFNE-UHFFFAOYSA-N 0.000 description 1
- DHVLDKHFGIVEIP-UHFFFAOYSA-N 2-bromo-2-(bromomethyl)pentanedinitrile Chemical compound BrCC(Br)(C#N)CCC#N DHVLDKHFGIVEIP-UHFFFAOYSA-N 0.000 description 1
- LWLRMRFJCCMNML-UHFFFAOYSA-N 2-ethylhexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CC)CCCC LWLRMRFJCCMNML-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- MWKPHOIHTLQZIY-UHFFFAOYSA-N 2-hexyldecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(CCCCCC)CCCCCCCC MWKPHOIHTLQZIY-UHFFFAOYSA-N 0.000 description 1
- RUDXBXPTJPNTSO-UHFFFAOYSA-N 2-octyldodecyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CCCCCCCC)CCCCCCCCCC RUDXBXPTJPNTSO-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- SJIDAAGFCNIAJP-UHFFFAOYSA-N 6-methylheptyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCC(C)C SJIDAAGFCNIAJP-UHFFFAOYSA-N 0.000 description 1
- UBGYURICIGUKHC-UHFFFAOYSA-N 7-methyloctyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCCCCCCC(C)C UBGYURICIGUKHC-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
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- BPFSYMVTOQQAQU-KTKRTIGZSA-N CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCC(CO)(CO)CO Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(=O)OCC(CO)(CO)CO BPFSYMVTOQQAQU-KTKRTIGZSA-N 0.000 description 1
- 244000001582 Canarium odontophyllum Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 description 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 description 1
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- 239000000337 buffer salt Substances 0.000 description 1
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- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001281 polyalkylene Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- PZQSQRCNMZGWFT-QXMHVHEDSA-N propan-2-yl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC(C)C PZQSQRCNMZGWFT-QXMHVHEDSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003470 sulfuric acid monoesters Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0295—Liquid crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
- Medicinal Preparation (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19713793A DE19713793A1 (de) | 1997-04-03 | 1997-04-03 | Öl-in-Wasser-Emulsionen zur Wiederherstellung der Lamellarität der Lipidstruktur geschädigter Haut |
| PCT/EP1997/006639 WO1998044896A1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
| EP97953710A EP0973484B1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
| JP54228598A JP2001518886A (ja) | 1997-04-03 | 1997-11-28 | 損傷した皮膚の脂質構造のラメラ性を再構成するための水中油型エマルジョン |
| AT97953710T ATE270537T1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
| CA002285216A CA2285216A1 (en) | 1997-04-03 | 1997-11-28 | Oil-in-water emulsions for reconstituting lamellarity of the lipid structure of damaged skin |
| US09/402,301 US6379681B1 (en) | 1997-04-03 | 1997-11-28 | Oil-in-water emulsions for reconstituting lamellarity of the lipid structure of damaged skin |
| PL97335902A PL335902A1 (en) | 1997-04-03 | 1997-11-28 | Oil-in-water type emulsion for restoring lamellarity of lipide structure in injured skin |
| CN97182084A CN1248904A (zh) | 1997-04-03 | 1997-11-28 | 用于修复受损皮肤脂质结构的层状性的水包油乳液 |
| ES97953710T ES2226010T3 (es) | 1997-04-03 | 1997-11-28 | Emulsiones de aceite-en agua para el restablecimiento de la lamelaridad de la estructura lipida de la piel dañada. |
| DE59711769T DE59711769D1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
| HU0000501A HUP0000501A3 (en) | 1997-04-03 | 1997-11-28 | Oil-in-water emulsions for reconstituting lamellarity of the lipid structure of damaged skin |
| SK1337-99A SK133799A3 (en) | 1997-04-03 | 1997-11-28 | Oil-in-water emulsions for reconstituting lamellarity of the lipid structure of damaged skin |
| NO994786A NO994786L (no) | 1997-04-03 | 1999-10-01 | Olje-i-vann-emulsjoner for rekonstituering av lamellaeriteten i lipidstrukturen i skadet hud |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19713793A DE19713793A1 (de) | 1997-04-03 | 1997-04-03 | Öl-in-Wasser-Emulsionen zur Wiederherstellung der Lamellarität der Lipidstruktur geschädigter Haut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19713793A1 true DE19713793A1 (de) | 1998-10-08 |
Family
ID=7825359
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19713793A Withdrawn DE19713793A1 (de) | 1997-04-03 | 1997-04-03 | Öl-in-Wasser-Emulsionen zur Wiederherstellung der Lamellarität der Lipidstruktur geschädigter Haut |
| DE59711769T Expired - Lifetime DE59711769D1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59711769T Expired - Lifetime DE59711769D1 (de) | 1997-04-03 | 1997-11-28 | Öl-in-wasser-emulsionen zur wiederherstellung der lamellarität der lipidstruktur geschädigter haut |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6379681B1 (enExample) |
| EP (1) | EP0973484B1 (enExample) |
| JP (1) | JP2001518886A (enExample) |
| CN (1) | CN1248904A (enExample) |
| AT (1) | ATE270537T1 (enExample) |
| CA (1) | CA2285216A1 (enExample) |
| DE (2) | DE19713793A1 (enExample) |
| ES (1) | ES2226010T3 (enExample) |
| HU (1) | HUP0000501A3 (enExample) |
| NO (1) | NO994786L (enExample) |
| PL (1) | PL335902A1 (enExample) |
| SK (1) | SK133799A3 (enExample) |
| WO (1) | WO1998044896A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007112712A1 (de) * | 2006-03-31 | 2007-10-11 | Kuhs Gmbh | Topisch zu applizierende zusammensetzung |
| WO2012052097A1 (de) * | 2010-09-29 | 2012-04-26 | Sanderstrothmann Gmbh | Verfahren zur herstellung eines kosmetischen mittels |
| WO2020242787A1 (en) * | 2019-05-31 | 2020-12-03 | Li Dongcui | Compositions and methods for treating keratinous substrates |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19857349A1 (de) * | 1998-12-11 | 2000-06-15 | Wolfgang Schnizer | Hautpflege-System |
| FR2816852B1 (fr) * | 2000-11-21 | 2005-08-26 | Nuxe Lab | Association stabilisee d'un colorant et d'un emulsionnant, composition cosmetique et/ou dermatologique la contenant et procede de preparation |
| JP2002265347A (ja) * | 2001-03-13 | 2002-09-18 | Shiseido Co Ltd | コーニファイドエンベロープの成熟を促す化粧料 |
| US6608011B2 (en) * | 2001-06-11 | 2003-08-19 | Colgate-Palmolive Company | Shampoos with behenyl-alcohol |
| US7758636B2 (en) * | 2002-09-20 | 2010-07-20 | Innovational Holdings Llc | Expandable medical device with openings for delivery of multiple beneficial agents |
| CN100455193C (zh) * | 2003-03-11 | 2009-01-28 | 科宁公司 | 用作农用化学品佐剂的微乳液 |
| JP4592347B2 (ja) * | 2003-07-14 | 2010-12-01 | 株式会社ヤクルト本社 | 外用剤組成物 |
| CN1874752A (zh) * | 2003-11-04 | 2006-12-06 | 宝洁公司 | 个人清洁组合物 |
| WO2005044206A1 (en) | 2003-11-04 | 2005-05-19 | The Procter & Gamble Company | Fragrances comprising residual accords |
| GB0403879D0 (en) * | 2004-02-21 | 2004-03-24 | Unilever Plc | Hair conditioning compositions and methods of manufacture |
| JP4854194B2 (ja) * | 2004-07-05 | 2012-01-18 | 株式会社ファンケル | ラメラ構造再生剤及び皮膚外用剤 |
| WO2006018149A1 (de) * | 2004-08-13 | 2006-02-23 | Henkel Kommanditgesellschaft Auf Aktien | Kosmetische zusammensetzungen zur behandlung gestresster haut enthaltend taurin und langkettige fettalkohole |
| DE102005063178A1 (de) * | 2005-12-30 | 2007-07-05 | Henkel Kgaa | Kosmetische Lichtschutzzusammensetzungen auf der Basis lamellarer Emulsionen |
| GB0714817D0 (en) * | 2007-07-31 | 2007-09-12 | Croda Int Plc | Polyglycerol derivatives |
| FR2991171B1 (fr) * | 2012-06-01 | 2014-05-23 | Galderma Res & Dev | Procede de preparation d'une composition dermatologique comprenant des oleosomes |
| DE102013217316A1 (de) * | 2013-08-30 | 2015-03-05 | Henkel Ag & Co. Kgaa | Hautpflegeöl |
| MX375852B (es) | 2016-04-21 | 2025-03-07 | Unilever Ip Holdings B V | Nanoemulsiones novedosas que comprenden acido graso y sales de derivados n-acilo de aminoacidos |
| US11026869B2 (en) | 2016-04-21 | 2021-06-08 | Conopco, Inc. | Process for producing small droplet emulsions at low pressure |
| US20200009027A1 (en) * | 2016-12-13 | 2020-01-09 | Basf Se | Textured compositions |
| CN113476346A (zh) * | 2021-06-16 | 2021-10-08 | 西安德诺海思医疗科技有限公司 | 一种皮肤屏障修复组合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4400295A (en) * | 1979-03-24 | 1983-08-23 | Loire Cosmetics Co., Ltd. | Emulsifier composition |
| JPS61158909A (ja) * | 1984-12-29 | 1986-07-18 | Pola Chem Ind Inc | パツク料 |
| US4767625A (en) | 1985-09-02 | 1988-08-30 | Kao Corporation | Lamella type single phase liquid crystal composition and oil-base cosmetic compositions using the same |
| GB8724254D0 (en) | 1987-10-15 | 1987-11-18 | Unilever Plc | Hair treatment product |
| GB9302492D0 (en) | 1993-02-09 | 1993-03-24 | Procter & Gamble | Cosmetic compositions |
| JP3250877B2 (ja) * | 1993-07-08 | 2002-01-28 | 株式会社資生堂 | 撥水性水中油型乳化組成物 |
| JP2855057B2 (ja) * | 1993-07-09 | 1999-02-10 | 株式会社資生堂 | 増粘ゲル化剤及び増粘ゲル状組成物 |
| FR2709666B1 (fr) | 1993-09-07 | 1995-10-13 | Oreal | Composition cosmétique ou dermatologique constituée d'une émulsion huile dans eau à base de globules huileux pourvus d'un enrobage cristal liquide lamellaire. |
| DE4337041A1 (de) | 1993-10-29 | 1995-05-04 | Henkel Kgaa | Verfahren zur Herstellung in Öl-in-Wasser-Emulsionen |
| FR2714382B1 (fr) * | 1993-12-27 | 1996-02-02 | Roussel Uclaf | Phospholipides vecteur de molécule active, leur préparation et leur utilisation dans des compositions cosmétiques ou dermatologiques. |
| GB9408259D0 (en) | 1994-04-26 | 1994-06-15 | Procter & Gamble | Cosmetic compositions |
| GB9414572D0 (en) * | 1994-07-19 | 1994-09-07 | Unilever Plc | Soap composition |
| JPH08268877A (ja) * | 1995-03-31 | 1996-10-15 | Shiseido Co Ltd | 撥水撥油性水中油型乳化組成物 |
| JPH08337513A (ja) * | 1995-06-13 | 1996-12-24 | Shiseido Co Ltd | 撥水性水中油型乳化組成物 |
| US5948416A (en) * | 1995-06-29 | 1999-09-07 | The Procter & Gamble Company | Stable topical compositions |
| JP3549336B2 (ja) * | 1995-10-12 | 2004-08-04 | 株式会社資生堂 | 水中油型乳化組成物 |
| US5738856A (en) * | 1995-11-03 | 1998-04-14 | Ocular Research Of Boston, Inc. | Skin care preparation and method |
| JPH09301847A (ja) * | 1996-03-15 | 1997-11-25 | Shiseido Co Ltd | 低粘度水中油型乳化組成物及びこれを用いた皮膚外用剤 |
| AU728163B2 (en) * | 1996-08-21 | 2001-01-04 | Children's Hospital Medical Center | Skin lightening compositions |
-
1997
- 1997-04-03 DE DE19713793A patent/DE19713793A1/de not_active Withdrawn
- 1997-11-28 WO PCT/EP1997/006639 patent/WO1998044896A1/de not_active Ceased
- 1997-11-28 JP JP54228598A patent/JP2001518886A/ja not_active Ceased
- 1997-11-28 HU HU0000501A patent/HUP0000501A3/hu unknown
- 1997-11-28 ES ES97953710T patent/ES2226010T3/es not_active Expired - Lifetime
- 1997-11-28 SK SK1337-99A patent/SK133799A3/sk unknown
- 1997-11-28 AT AT97953710T patent/ATE270537T1/de not_active IP Right Cessation
- 1997-11-28 DE DE59711769T patent/DE59711769D1/de not_active Expired - Lifetime
- 1997-11-28 CA CA002285216A patent/CA2285216A1/en not_active Abandoned
- 1997-11-28 PL PL97335902A patent/PL335902A1/xx unknown
- 1997-11-28 EP EP97953710A patent/EP0973484B1/de not_active Revoked
- 1997-11-28 CN CN97182084A patent/CN1248904A/zh active Pending
- 1997-11-28 US US09/402,301 patent/US6379681B1/en not_active Expired - Lifetime
-
1999
- 1999-10-01 NO NO994786A patent/NO994786L/no not_active Application Discontinuation
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007112712A1 (de) * | 2006-03-31 | 2007-10-11 | Kuhs Gmbh | Topisch zu applizierende zusammensetzung |
| WO2012052097A1 (de) * | 2010-09-29 | 2012-04-26 | Sanderstrothmann Gmbh | Verfahren zur herstellung eines kosmetischen mittels |
| WO2020242787A1 (en) * | 2019-05-31 | 2020-12-03 | Li Dongcui | Compositions and methods for treating keratinous substrates |
| US12343411B2 (en) | 2019-05-31 | 2025-07-01 | L'oreal | Compositions and methods for treating keratinous substrates |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0973484A1 (de) | 2000-01-26 |
| US6379681B1 (en) | 2002-04-30 |
| CA2285216A1 (en) | 1998-10-15 |
| ATE270537T1 (de) | 2004-07-15 |
| CN1248904A (zh) | 2000-03-29 |
| HUP0000501A3 (en) | 2001-11-28 |
| NO994786D0 (no) | 1999-10-01 |
| DE59711769D1 (de) | 2004-08-12 |
| EP0973484B1 (de) | 2004-07-07 |
| HUP0000501A2 (en) | 2000-07-28 |
| WO1998044896A1 (de) | 1998-10-15 |
| NO994786L (no) | 1999-10-01 |
| SK133799A3 (en) | 2000-02-14 |
| PL335902A1 (en) | 2000-05-22 |
| ES2226010T3 (es) | 2005-03-16 |
| JP2001518886A (ja) | 2001-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |