DE19637237A1 - Piperazin-Derivate - Google Patents

Piperazin-Derivate

Info

Publication number
DE19637237A1
DE19637237A1 DE19637237A DE19637237A DE19637237A1 DE 19637237 A1 DE19637237 A1 DE 19637237A1 DE 19637237 A DE19637237 A DE 19637237A DE 19637237 A DE19637237 A DE 19637237A DE 19637237 A1 DE19637237 A1 DE 19637237A1
Authority
DE
Germany
Prior art keywords
piperazine
formula
methyl
compound
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19637237A
Other languages
German (de)
English (en)
Inventor
Michael Dr Arlt
Henning Dr Boettcher
Gerd Bartoszyk
Christoph Dr Seyfried
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19637237A priority Critical patent/DE19637237A1/de
Priority to UA99041976A priority patent/UA57749C2/uk
Priority to SK303-99A priority patent/SK282708B6/sk
Priority to BR9712037A priority patent/BR9712037A/pt
Priority to PL97332081A priority patent/PL332081A1/xx
Priority to DE59707613T priority patent/DE59707613D1/de
Priority to EP97944823A priority patent/EP0931067B1/de
Priority to CN97197883A priority patent/CN1114594C/zh
Priority to RU99106804/04A priority patent/RU2180660C2/ru
Priority to SI9730393T priority patent/SI0931067T1/xx
Priority to CZ1999824A priority patent/CZ292210B6/cs
Priority to AU46203/97A priority patent/AU724374B2/en
Priority to CA002266050A priority patent/CA2266050C/en
Priority to KR1019997002097A priority patent/KR20000036085A/ko
Priority to DK97944823T priority patent/DK0931067T3/da
Priority to PT97944823T priority patent/PT931067E/pt
Priority to ES97944823T priority patent/ES2178011T3/es
Priority to JP10513215A priority patent/JP2001500142A/ja
Priority to AT97944823T priority patent/ATE219768T1/de
Priority to HU9904521A priority patent/HUP9904521A3/hu
Priority to PCT/EP1997/004789 priority patent/WO1998011068A1/de
Priority to US09/254,489 priority patent/US6258813B1/en
Priority to ZA978194A priority patent/ZA978194B/xx
Priority to ARP970104189A priority patent/AR009770A1/es
Publication of DE19637237A1 publication Critical patent/DE19637237A1/de
Priority to NO19991236A priority patent/NO312589B1/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
DE19637237A 1996-09-13 1996-09-13 Piperazin-Derivate Withdrawn DE19637237A1 (de)

Priority Applications (25)

Application Number Priority Date Filing Date Title
DE19637237A DE19637237A1 (de) 1996-09-13 1996-09-13 Piperazin-Derivate
UA99041976A UA57749C2 (uk) 1996-09-13 1997-03-09 Похідні піперазину, спосіб їх одержання, фармацевтична композиція та спосіб її одержання
KR1019997002097A KR20000036085A (ko) 1996-09-13 1997-09-03 Ｄ4 수용체 선택성 피페라진 유도체
PT97944823T PT931067E (pt) 1996-09-13 1997-09-03 Derivados de piperazina com uma selectividade para o receptor d-4
PL97332081A PL332081A1 (en) 1996-09-13 1997-09-03 Piperazine derivatives being selective in respect to d-4 receptor
DE59707613T DE59707613D1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor
EP97944823A EP0931067B1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor
CN97197883A CN1114594C (zh) 1996-09-13 1997-09-03 具有d4受体选择性的哌嗪衍生物
RU99106804/04A RU2180660C2 (ru) 1996-09-13 1997-09-03 Производные пиперазина, способ их получения и фармацевтическая композиция
SI9730393T SI0931067T1 (en) 1996-09-13 1997-09-03 D4 receptor selectivity piperazine derivatives
CZ1999824A CZ292210B6 (cs) 1996-09-13 1997-09-03 Derivát piperazinu se selektivitou pro D-4 receptor, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje
AU46203/97A AU724374B2 (en) 1996-09-13 1997-09-03 Piperazine derivatives
CA002266050A CA2266050C (en) 1996-09-13 1997-09-03 Piperazine derivatives
SK303-99A SK282708B6 (sk) 1996-09-13 1997-09-03 Derivát piperazínu so selektivitou pre D-4 receptor, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje
DK97944823T DK0931067T3 (da) 1996-09-13 1997-09-03 Piperazinderivater med en selektivitet for D4-receptoren
BR9712037A BR9712037A (pt) 1996-09-13 1997-09-03 Derivados de piperazina
ES97944823T ES2178011T3 (es) 1996-09-13 1997-09-03 Derivados de piperazina con una selectividad para el receptor d-4.
JP10513215A JP2001500142A (ja) 1996-09-13 1997-09-03 Ｄ４受容体選択性を有するピペラジン誘導体
AT97944823T ATE219768T1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor
HU9904521A HUP9904521A3 (en) 1996-09-13 1997-09-03 Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
PCT/EP1997/004789 WO1998011068A1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor
US09/254,489 US6258813B1 (en) 1996-09-13 1997-09-03 D4 receptor selectivity piperazine derivatives
ZA978194A ZA978194B (en) 1996-09-13 1997-09-11 Piperazine derivatives
ARP970104189A AR009770A1 (es) 1996-09-13 1997-09-12 Derivados de piperazina, un procedimiento para prepararlos, el empleo de estos compuestos para preparar un medicamento, las preparaciones farmaceuticasque los contienen y un procedimiento para obtener estas preparaciones farmaceuticas
NO19991236A NO312589B1 (no) 1996-09-13 1999-03-12 Piperazinderivater med en selektivitet for D-4-reseptoren, fremgangsmåte for fremstilling derav, farmasöytiske preparater,fremgangsmåte for fremstilling derav, samt anvendelse avforbindelsene til fremstilling av legemidler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19637237A DE19637237A1 (de) 1996-09-13 1996-09-13 Piperazin-Derivate

Publications (1)

Publication Number Publication Date
DE19637237A1 true DE19637237A1 (de) 1998-03-19

Family

ID=7805470

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19637237A Withdrawn DE19637237A1 (de) 1996-09-13 1996-09-13 Piperazin-Derivate
DE59707613T Expired - Fee Related DE59707613D1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59707613T Expired - Fee Related DE59707613D1 (de) 1996-09-13 1997-09-03 Piperazin-derivate mit einer selektivität für den d-4 rezeptor

Country Status (23)

Country Link
US (1) US6258813B1 (OSRAM)
EP (1) EP0931067B1 (OSRAM)
JP (1) JP2001500142A (OSRAM)
KR (1) KR20000036085A (OSRAM)
CN (1) CN1114594C (OSRAM)
AR (1) AR009770A1 (OSRAM)
AT (1) ATE219768T1 (OSRAM)
AU (1) AU724374B2 (OSRAM)
BR (1) BR9712037A (OSRAM)
CA (1) CA2266050C (OSRAM)
CZ (1) CZ292210B6 (OSRAM)
DE (2) DE19637237A1 (OSRAM)
DK (1) DK0931067T3 (OSRAM)
ES (1) ES2178011T3 (OSRAM)
HU (1) HUP9904521A3 (OSRAM)
NO (1) NO312589B1 (OSRAM)
PL (1) PL332081A1 (OSRAM)
PT (1) PT931067E (OSRAM)
RU (1) RU2180660C2 (OSRAM)
SK (1) SK282708B6 (OSRAM)
UA (1) UA57749C2 (OSRAM)
WO (1) WO1998011068A1 (OSRAM)
ZA (1) ZA978194B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090812A (en) * 1997-09-24 2000-07-18 Duphar International Research B.V. Piperazine and piperidine compounds

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5011067A1 (es) * 1997-11-03 2001-02-28 Novartis Ag Derivados de bifenilo como productos farmaceuticos, su pre- paracion y composiciones farmaceuticas que los contienen
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904724D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
SE9904723D0 (sv) * 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
DE60131675T2 (de) * 2000-11-14 2008-11-20 Merck Patent Gmbh Neue verwendung von substanzen mit kombinierten 5-ht1a agonistischen und serotonin reuptake inhibitor-aktivitäten
KR100394083B1 (ko) * 2000-12-04 2003-08-06 학교법인 성신학원 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규4,5-디히드로이소옥사졸릴알킬피페라진 유도체와, 이의제조방법
KR100394086B1 (ko) * 2000-12-04 2003-08-06 한국과학기술연구원 도파민 ｄ3 및 ｄ4 수용체의 선택적 활성을 지닌 신규이소옥사졸릴알킬피페라진 유도체와, 이의 제조방법
EP1935885A3 (en) * 2001-05-22 2008-10-15 Neurogen Corporation Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues.
US6953801B2 (en) 2001-05-22 2005-10-11 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
US6552188B2 (en) * 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
US6509329B1 (en) * 2001-06-29 2003-01-21 Kowa Co., Ltd. Cyclic diamine compound with 6-membered ring groups
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
BRPI0408136A (pt) * 2003-03-07 2006-03-01 Astellas Pharma Inc derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda
JP4596792B2 (ja) * 2004-02-24 2010-12-15 あすか製薬株式会社 ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
KR101245075B1 (ko) 2004-06-08 2013-03-18 엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 도파민 신경전달의 모듈레이터로서 신 2기치환된페닐피페리딘/피페라진
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
ATE449070T1 (de) 2004-06-08 2009-12-15 Nsab Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission
HUE029790T2 (hu) 2004-10-13 2017-04-28 Teva Pharmaceuticals Int Gmbh Eljárás 4-(3-metánszulfonil-fenil)-l-N-propil-piperidin elõállítására
EP1695971A1 (en) * 2004-12-30 2006-08-30 Laboratorios Del Dr. Esteve, S.A. Substituted phenyl-piperazine compounds, their preparation and use in medicaments
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
WO2008047839A1 (en) * 2006-10-19 2008-04-24 Dainippon Sumitomo Pharma Co., Ltd. 5-ht1a receptor agonist
JO2857B1 (en) * 2008-06-16 2015-03-15 سانوفي أفينتس Vinyl pipers with modified activity of tumor-resistant TNF
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012027495A1 (en) 2010-08-27 2012-03-01 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
US9073882B2 (en) 2010-10-27 2015-07-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9056859B2 (en) 2010-10-29 2015-06-16 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
RU2448962C1 (ru) * 2011-02-08 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения 1,4-бис(2-амино-4-(трифторметил)фенил)пиперазина
CA2844310A1 (en) 2011-08-19 2013-02-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TW201317213A (zh) 2011-09-16 2013-05-01 Merck Sharp & Dohme 腎外髓質鉀通道抑制劑
WO2013062900A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013062892A1 (en) 2011-10-25 2013-05-02 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066714A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
WO2013066718A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013086425A1 (en) 2011-12-08 2013-06-13 IVAX International GmbH The hydrobromide salt of pridopidine
WO2013090271A1 (en) 2011-12-16 2013-06-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US20130267552A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy
KR20150003382A (ko) 2012-04-27 2015-01-08 요시노 셋고 가부시키가이샤 석고계 주조용 매몰재 조성물
JP6125500B2 (ja) 2012-06-18 2017-05-10 吉野石膏株式会社 鋳造用埋没材組成物およびこれを用いた鋳物の鋳造方法
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
EP2925322B1 (en) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
RU2505536C1 (ru) * 2012-12-29 2014-01-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" 4-(1-гидрокси-1-метил-2-морфолиноэтил)бензойная и 4-(1-гидрокси-2-морфолиноциклогексил)бензойная кислоты, их фармацевтически приемлемые соли, сложные эфиры, обладающие анксиолитической активностью, и способ их получения
US8883796B2 (en) * 2013-02-08 2014-11-11 Korea Institute Of Science And Technology Biphenyl derivatives, pharmaceutical composition comprising the same, and preparation method thereof
WO2014126944A2 (en) 2013-02-18 2014-08-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9765074B2 (en) 2013-03-15 2017-09-19 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel
WO2018089493A1 (en) * 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. PYRROLE mTORC INHIBITORS AND USES THEREOF

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959368A (en) * 1986-02-24 1990-09-25 Mitsui Petrochemical Industries Ltd. Therapeutic agent for neurological diseases
US5681956A (en) 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
GEP20001939B (en) * 1992-01-17 2000-02-05 Angelini Ricerca S P A Soc Consortile Alkyl Derivatives of Trazodone with CNS Activity
CZ224195A3 (en) * 1993-03-01 1996-03-13 Merck Sharp & Dohme The use of pyrrolopyridine derivatives for preparing pharmaceutical preparations
GB9305623D0 (en) 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
US5538965A (en) 1993-12-23 1996-07-23 Allelix Biopharmaceuticals Inc. Dopamine receptor ligands
EP0793653A1 (en) 1994-11-23 1997-09-10 Neurogen Corporation Certain 4-aminomethyl-2-substituted imidazole derivatives and 2-aminomethyl-4-substituted imidazole derivatives; new classes of dopamine receptor subtype specific ligands
US5594141A (en) * 1994-11-23 1997-01-14 Neurogen Corporation Certain aminomethyl biphenyl, aminomethyl phenyl pyridine and aminomethyl phenyl pyrimidine derivatives; novel dopamine receptor subtype selective ligands
FR2734819B1 (fr) 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090812A (en) * 1997-09-24 2000-07-18 Duphar International Research B.V. Piperazine and piperidine compounds
USRE41425E1 (en) 1997-09-24 2010-07-06 Duphar International Research B.V. Piperazine and piperidine compounds

Also Published As

Publication number Publication date
NO312589B1 (no) 2002-06-03
CA2266050C (en) 2007-05-22
SK282708B6 (sk) 2002-11-06
HUP9904521A2 (hu) 2000-05-28
AU724374B2 (en) 2000-09-21
CZ292210B6 (cs) 2003-08-13
BR9712037A (pt) 1999-08-24
DK0931067T3 (da) 2002-09-30
JP2001500142A (ja) 2001-01-09
PT931067E (pt) 2002-11-29
SK30399A3 (en) 2000-05-16
ATE219768T1 (de) 2002-07-15
HUP9904521A3 (en) 2001-07-30
AU4620397A (en) 1998-04-02
RU2180660C2 (ru) 2002-03-20
NO991236D0 (no) 1999-03-12
US6258813B1 (en) 2001-07-10
ES2178011T3 (es) 2002-12-16
PL332081A1 (en) 1999-08-30
CZ82499A3 (cs) 1999-06-16
DE59707613D1 (de) 2002-08-01
CN1230180A (zh) 1999-09-29
EP0931067A1 (de) 1999-07-28
ZA978194B (en) 1999-03-03
CA2266050A1 (en) 1998-03-19
NO991236L (no) 1999-03-12
AR009770A1 (es) 2000-05-03
WO1998011068A1 (de) 1998-03-19
UA57749C2 (uk) 2003-07-15
KR20000036085A (ko) 2000-06-26
EP0931067B1 (de) 2002-06-26
CN1114594C (zh) 2003-07-16

Similar Documents

Publication Publication Date Title
EP0931067B1 (de) Piperazin-derivate mit einer selektivität für den d-4 rezeptor
EP0648767B1 (de) Piperidine und Piperazine, die Wirkungen auf das z.n.s. Zeigen
AU2011249167B2 (en) Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same
EP0529462A1 (de) Benzodioxanderivate
EP0683166B1 (de) 3-Indolylpiperidine
DE19730989A1 (de) Piperazin-Derivate
EP1802578B1 (de) 3,6-substituierte 5-arylamino-1h-pyidin-2-on derivative und verwandte verbindungen als poly(adp-ribose)polymerase (parp) inhibitoren zur behandlung von durch nekose oder apoptose verursachten gewebeschäden oder erkankungen
DE4101686A1 (de) Indolderivate
US20030022887A1 (en) Unsymmetrical cyclic diamine compound
EP0407844B1 (de) Indolderivate
JP2007503444A (ja) 肥満症および関連障害の処置のための、選択的メラニン凝集ホルモンレセプターアンタゴニストとしての２置換ベンズイミダゾール誘導体。
EP0586866A2 (de) 1,4-Benzodioxanderivate mit pharmakologischen Eigenschaften
EP2269988B1 (en) Anthranilic acid amides and pharmaceutical use thereof
WO2001098293A1 (de) Heterocyclische aminoalkylpyridinderivate als psychopharmaka
KR20050119192A (ko) 치환된 피라졸 화합물
DE19648384A1 (de) Fluorene, Dibenzofurane und Dibenzothiophene
AU2023384037A1 (en) Substituted macrocyclic amine modulators of orexin receptor 2
MXPA00002601A (en) 3-substituted tetrahydropyridopyrimidinone derivatives, method for producing the same, and their use

Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee