DE19613976C1 - Thalidomid-Prodrugs mit immunmodulatorischer Wirkung - Google Patents

Thalidomid-Prodrugs mit immunmodulatorischer Wirkung

Info

Publication number
DE19613976C1
DE19613976C1 DE19613976A DE19613976A DE19613976C1 DE 19613976 C1 DE19613976 C1 DE 19613976C1 DE 19613976 A DE19613976 A DE 19613976A DE 19613976 A DE19613976 A DE 19613976A DE 19613976 C1 DE19613976 C1 DE 19613976C1
Authority
DE
Germany
Prior art keywords
thalidomide
prodrugs
amino
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19613976A
Other languages
German (de)
English (en)
Inventor
Johannes Dr Schneider
Werner Prof Dipl Chem D Winter
Stephan Wnendt
Kai Dr Zwingenberger
Kurt Prof Dr Eger
Michaela Akermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grünenthal GmbH
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19613976A priority Critical patent/DE19613976C1/de
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Priority to PT97916380T priority patent/PT892794E/pt
Priority to HK99102396.8A priority patent/HK1017350B/xx
Priority to AT97916380T priority patent/ATE212989T1/de
Priority to DK97916380T priority patent/DK0892794T3/da
Priority to ES97916380T priority patent/ES2171923T3/es
Priority to JP9535786A priority patent/JP2000508298A/ja
Priority to PCT/EP1997/001475 priority patent/WO1997037988A1/de
Priority to EP97916380A priority patent/EP0892794B1/de
Priority to CN97193682A priority patent/CN1102931C/zh
Priority to CA002251060A priority patent/CA2251060C/en
Priority to SI9730242T priority patent/SI0892794T1/xx
Priority to HU9902181A priority patent/HUP9902181A3/hu
Priority to AU25052/97A priority patent/AU707144B2/en
Priority to DE59706313T priority patent/DE59706313D1/de
Priority to US09/155,896 priority patent/US6417197B1/en
Application granted granted Critical
Publication of DE19613976C1 publication Critical patent/DE19613976C1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
DE19613976A 1996-04-09 1996-04-09 Thalidomid-Prodrugs mit immunmodulatorischer Wirkung Expired - Fee Related DE19613976C1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19613976A DE19613976C1 (de) 1996-04-09 1996-04-09 Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
CA002251060A CA2251060C (en) 1996-04-09 1997-03-22 Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
AT97916380T ATE212989T1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
DK97916380T DK0892794T3 (da) 1996-04-09 1997-03-22 Acylerede N-hydroxymethyl thalidomid-promedikamenter med immunmodulatorisk virkning
ES97916380T ES2171923T3 (es) 1996-04-09 1997-03-22 Profarmacos de la talidomida, su procedimiento de preparacion y su utilizacion como principios activos en medicamentos.
JP9535786A JP2000508298A (ja) 1996-04-09 1997-03-22 免疫調節作用を有するアシル化ｎ―ヒドロキシメチルサリドマイドプロドラッグ
PCT/EP1997/001475 WO1997037988A1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
EP97916380A EP0892794B1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
PT97916380T PT892794E (pt) 1996-04-09 1997-03-22 Prodrogas de n-hidroximetil-talidomida aciladas de efeito imunomodulador
HK99102396.8A HK1017350B (en) 1996-04-09 1997-03-22 Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
SI9730242T SI0892794T1 (en) 1996-04-09 1997-03-22 Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
HU9902181A HUP9902181A3 (en) 1996-04-09 1997-03-22 Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
AU25052/97A AU707144B2 (en) 1996-04-09 1997-03-22 Acylated N-hydroxymethyl thalidomide prodrugs having an immunomodulatory effect
DE59706313T DE59706313D1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung
US09/155,896 US6417197B1 (en) 1996-04-09 1997-03-22 Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
CN97193682A CN1102931C (zh) 1996-04-09 1997-03-22 具有免疫调解剂作用的酰化n－羟甲基酞胺哌啶酮－前药

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19613976A DE19613976C1 (de) 1996-04-09 1996-04-09 Thalidomid-Prodrugs mit immunmodulatorischer Wirkung

Publications (1)

Publication Number Publication Date
DE19613976C1 true DE19613976C1 (de) 1997-11-20

Family

ID=7790778

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19613976A Expired - Fee Related DE19613976C1 (de) 1996-04-09 1996-04-09 Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
DE59706313T Expired - Fee Related DE59706313D1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59706313T Expired - Fee Related DE59706313D1 (de) 1996-04-09 1997-03-22 Acylierte n-hydroxymethyl thalidomid-prodrugs mit immunomodulatorischer wirkung

Country Status (12)

Country Link
US (1) US6417197B1 (enExample)
EP (1) EP0892794B1 (enExample)
JP (1) JP2000508298A (enExample)
CN (1) CN1102931C (enExample)
AT (1) ATE212989T1 (enExample)
AU (1) AU707144B2 (enExample)
DE (2) DE19613976C1 (enExample)
DK (1) DK0892794T3 (enExample)
ES (1) ES2171923T3 (enExample)
HU (1) HUP9902181A3 (enExample)
PT (1) PT892794E (enExample)
WO (1) WO1997037988A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041755A3 (en) * 1999-12-02 2002-02-21 Univ Michigan Topical compositions comprising thalidomide for the treatment of inflammatory diseases

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung
WO1997045117A1 (en) * 1996-05-29 1997-12-04 Prototek, Inc. Prodrugs of thalidomide and methods for using same as modulators of t-cell function
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
DE19743968C2 (de) * 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenöse Applikationsform von Thalidomid zur Therapie immunologischer Erkrankungen
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
AU752958B2 (en) * 1997-11-18 2002-10-03 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and their use to reduce TNFalpha levels
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
JP4361273B2 (ja) * 2001-02-27 2009-11-11 アメリカ合衆国 潜在的な血管形成阻害剤としてのサリドマイド類似体
CN100488959C (zh) * 2003-03-27 2009-05-20 天津和美生物技术有限公司 水溶性的酞胺哌啶酮衍生物
WO2005016326A2 (en) * 2003-07-11 2005-02-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
CN100398534C (zh) * 2003-09-15 2008-07-02 天津和美生物技术有限公司 合成酞胺哌啶酮及其衍生物的方法
CA2808646C (en) 2003-09-17 2016-08-23 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Thalidomide analogs as tnf-alpha modulators
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
EP1682126B1 (en) * 2003-10-16 2009-07-01 Novartis Vaccines and Diagnostics, Inc. Substituted benzazoles and use thereof as inhibitors of raf kinase
ITMI20041113A1 (it) * 2004-06-01 2004-09-01 Antibioticos Spa Processo per la sintesi della talidomide
US20070155791A1 (en) * 2005-12-29 2007-07-05 Zeldis Jerome B Methods for treating cutaneous lupus using aminoisoindoline compounds
EP2004614B1 (en) 2006-04-13 2016-10-19 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
CA2957226C (en) * 2008-10-29 2018-08-14 Celgene Corporation Isoindoline compounds for use in the treatment of cancer
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
TWI782395B (zh) * 2016-01-08 2022-11-01 美商西建公司 抗增生化合物，及其醫藥組合物及用途
US20200199097A1 (en) * 2017-08-21 2020-06-25 Nanjing Noratech Pharmaceuticals Co., Ltd Pomalidomide derivative and preparation method therefor
CN111499610A (zh) * 2019-01-31 2020-08-07 南京诺瑞特医药科技有限公司 泊马度胺前体药物盐的多晶型物
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4211812C2 (de) * 1991-04-17 1994-05-05 Gruenenthal Gmbh Thalidomidderivate, ein Verfahren zu deren Herstellung sowie die Verwendung derselben in Arzneimitteln

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1531492A (en) * 1991-02-14 1992-09-15 Rockefeller University, The Method for controlling abnormal concentration tnf alpha in human tissues
DE19613976C1 (de) * 1996-04-09 1997-11-20 Gruenenthal Gmbh Thalidomid-Prodrugs mit immunmodulatorischer Wirkung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4211812C2 (de) * 1991-04-17 1994-05-05 Gruenenthal Gmbh Thalidomidderivate, ein Verfahren zu deren Herstellung sowie die Verwendung derselben in Arzneimitteln

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001041755A3 (en) * 1999-12-02 2002-02-21 Univ Michigan Topical compositions comprising thalidomide for the treatment of inflammatory diseases

Also Published As

Publication number Publication date
AU707144B2 (en) 1999-07-01
CN1102931C (zh) 2003-03-12
JP2000508298A (ja) 2000-07-04
EP0892794B1 (de) 2002-02-06
DK0892794T3 (da) 2002-04-15
WO1997037988A1 (de) 1997-10-16
HUP9902181A2 (hu) 2000-04-28
HK1017350A1 (en) 1999-11-19
ATE212989T1 (de) 2002-02-15
PT892794E (pt) 2002-07-31
CN1215397A (zh) 1999-04-28
EP0892794A1 (de) 1999-01-27
AU2505297A (en) 1997-10-29
HUP9902181A3 (en) 2002-11-28
ES2171923T3 (es) 2002-09-16
US6417197B1 (en) 2002-07-09
DE59706313D1 (de) 2002-03-21

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Legal Events

Date Code Title Description
8100 Publication of the examined application without publication of unexamined application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee