DE19530816A1 - Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten - Google Patents
Verwendung von mutierter Subtilisin-Protease in kosmetischen ProduktenInfo
- Publication number
- DE19530816A1 DE19530816A1 DE19530816A DE19530816A DE19530816A1 DE 19530816 A1 DE19530816 A1 DE 19530816A1 DE 19530816 A DE19530816 A DE 19530816A DE 19530816 A DE19530816 A DE 19530816A DE 19530816 A1 DE19530816 A1 DE 19530816A1
- Authority
- DE
- Germany
- Prior art keywords
- protease
- amino acid
- blap
- mutant
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000746 purification Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 238000012807 shake-flask culturing Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229940074404 sodium succinate Drugs 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 241001478887 unidentified soil bacteria Species 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19530816A DE19530816A1 (de) | 1995-08-23 | 1995-08-23 | Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten |
| PCT/EP1996/003589 WO1997007770A1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
| ES96929256T ES2169258T3 (es) | 1995-08-23 | 1996-08-14 | Utilizacion de proteasa de subtilisina mutada en productos cosmeticos. |
| JP9509779A JPH11512092A (ja) | 1995-08-23 | 1996-08-14 | 化粧品生成物における突然変異型サブチリシンプロテアーゼの使用 |
| AT96929256T ATE209888T1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
| DE59608385T DE59608385D1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
| US09/011,889 US6509021B1 (en) | 1995-08-23 | 1996-08-14 | Use of mutated subtilisin protease in cosmetic products |
| DK96929256T DK0845972T3 (da) | 1995-08-23 | 1996-08-14 | Anvendelse af muteret subtilisinprotease i kosmetiske produkter |
| EP96929256A EP0845972B1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19530816A DE19530816A1 (de) | 1995-08-23 | 1995-08-23 | Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19530816A1 true DE19530816A1 (de) | 1997-02-27 |
Family
ID=7770073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19530816A Withdrawn DE19530816A1 (de) | 1995-08-23 | 1995-08-23 | Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten |
| DE59608385T Expired - Fee Related DE59608385D1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59608385T Expired - Fee Related DE59608385D1 (de) | 1995-08-23 | 1996-08-14 | Verwendung von mutierter subtilisin-protease in kosmetischen produkten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6509021B1 (enExample) |
| EP (1) | EP0845972B1 (enExample) |
| JP (1) | JPH11512092A (enExample) |
| AT (1) | ATE209888T1 (enExample) |
| DE (2) | DE19530816A1 (enExample) |
| DK (1) | DK0845972T3 (enExample) |
| ES (1) | ES2169258T3 (enExample) |
| WO (1) | WO1997007770A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999034774A1 (en) * | 1998-01-08 | 1999-07-15 | Dsm N.V. | Topical application of enzymes using a peelable film |
| DE19829789A1 (de) * | 1998-07-03 | 2000-01-05 | Beiersdorf Ag | Gegen Akne und entzündete Comedonen wirksame Zubereitungen enthaltend Serin-Proteasen und ein oder mehrere Calciumsalze |
| EP1553913A4 (en) * | 2002-06-14 | 2007-01-10 | Carol J Buck | COMPOSITIONS AND METHODS FOR ACQUIRING, THINNING AND REMOVING HYPERKERATOTIC TISSUE |
| DE102013219467A1 (de) * | 2013-09-26 | 2015-03-26 | Henkel Ag & Co. Kgaa | Stabilisierte Inhibitor-Proteasevarianten |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908757B1 (en) | 1998-03-26 | 2005-06-21 | The Procter & Gamble Company | Serine protease variants having amino acid deletions and substitutions |
| US6495136B1 (en) | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
| EP1082442A1 (en) | 1998-03-26 | 2001-03-14 | The Procter & Gamble Company | Serine protease variants having amino acid substitutions |
| DE19857543A1 (de) * | 1998-12-14 | 2000-06-15 | Henkel Kgaa | Verwendung von Protease in flüssigen bis gelförmigen Wasch- und Reinigungsmitteln |
| US6946128B1 (en) | 1999-07-22 | 2005-09-20 | The Procter & Gamble Company | Protease conjugates having sterically protected epitope regions |
| BR0012693A (pt) | 1999-07-22 | 2002-04-09 | Procter & Gamble | Variante, de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal |
| JP2003516116A (ja) | 1999-07-22 | 2003-05-13 | ザ、プロクター、エンド、ギャンブル、カンパニー | 立体的に保護されたクリップ部位を有するプロテアーゼ抱合体 |
| EP1210415A2 (en) | 1999-07-22 | 2002-06-05 | The Procter & Gamble Company | Subtilisin protease variants having amino acid substitutions in defined epitope regions |
| DE10121463A1 (de) * | 2001-05-02 | 2003-02-27 | Henkel Kgaa | Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten |
| DE10153792A1 (de) * | 2001-10-31 | 2003-05-22 | Henkel Kgaa | Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten |
| DE10162728A1 (de) | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| DE10162727A1 (de) * | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| DE10163884A1 (de) | 2001-12-22 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| DE10163883A1 (de) * | 2001-12-22 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus sp. (DSM 14390) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| CN1906303B (zh) | 2003-11-19 | 2013-06-05 | 金克克国际有限公司 | 丝氨酸蛋白酶、编码丝氨酸酶的核酸以及包含它们的载体和宿主细胞 |
| US7985569B2 (en) | 2003-11-19 | 2011-07-26 | Danisco Us Inc. | Cellulomonas 69B4 serine protease variants |
| DE10360805A1 (de) * | 2003-12-23 | 2005-07-28 | Henkel Kgaa | Neue Alkalische Protease und Wasch- und Reinigungsmittel, enthaltend diese neue Alkalische Protease |
| DE102004019751A1 (de) * | 2004-04-23 | 2005-11-17 | Henkel Kgaa | Neue Alkalische Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Alkalischen Proteasen |
| KR100558751B1 (ko) | 2004-10-18 | 2006-03-14 | 주식회사 태평양 | 피부보습용 화장료 조성물 |
| FR2884710A1 (fr) * | 2005-04-26 | 2006-10-27 | Clarins Soc Par Actions Simpli | Composition cosmetique preparant la peau au rasage |
| FR2884711A1 (fr) * | 2005-04-26 | 2006-10-27 | Clarins Soc Par Actions Simpli | Composition cosmetique preparant la peau au rasage |
| EP2032698B1 (en) | 2006-06-23 | 2012-06-27 | Danisco US Inc. | Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties |
| JP2010507001A (ja) * | 2006-10-16 | 2010-03-04 | ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン | 非リン酸系食器洗浄剤 |
| DE102007003143A1 (de) * | 2007-01-16 | 2008-07-17 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| DE102007032111B4 (de) | 2007-07-09 | 2017-07-20 | Henkel Ag & Co. Kgaa | Neue Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen |
| DE102007036756A1 (de) | 2007-08-03 | 2009-02-05 | Henkel Ag & Co. Kgaa | Neue Proteasen und Wasch- und Reinigungsmittel, enthaltend diese neuen Proteasen |
| DE102007049830A1 (de) | 2007-10-16 | 2009-04-23 | Henkel Ag & Co. Kgaa | Neue Proteinvarianten durch zirkulare Permutation |
| DE102007051092A1 (de) | 2007-10-24 | 2009-04-30 | Henkel Ag & Co. Kgaa | Subtilisin aus Becillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin |
| US7618801B2 (en) | 2007-10-30 | 2009-11-17 | Danison US Inc. | Streptomyces protease |
| MX2010013121A (es) | 2008-06-06 | 2011-01-21 | Danisco Inc | Composiciones y metodos que comprenden proteasas microbianas variantes. |
| BR122013014156A2 (pt) | 2008-11-11 | 2015-07-14 | Danisco Us Inc | Composição de limpeza compreendendo variantes de subtilisina, bem como processo de limpeza |
| JP2012508031A (ja) | 2008-11-11 | 2012-04-05 | ダニスコ・ユーエス・インク | １以上の組み合わせ変異を含むプロテアーゼ |
| DE102009029513A1 (de) * | 2009-09-16 | 2011-03-24 | Henkel Ag & Co. Kgaa | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Proteasen |
| JP6018044B2 (ja) | 2010-04-15 | 2016-11-02 | ダニスコ・ユーエス・インク | プロテアーゼ変異体を含む組成物及び方法 |
| PL3095861T3 (pl) | 2010-05-06 | 2020-04-30 | The Procter & Gamble Company | Produkty konsumenckie z odmianami proteaz |
| MX357386B (es) | 2011-05-05 | 2018-07-06 | Procter & Gamble | Composiciones y metodos que comprenden variantes de proteasa serina. |
| EP4230735A1 (en) | 2011-05-05 | 2023-08-23 | Danisco US Inc. | Compositions and methods comprising serine protease variants |
| DE102012201522A1 (de) * | 2012-02-02 | 2013-08-08 | Basf Se | Lagerstabiles flüssiges Geschirrspülmittel enthaltend Protease und Amylase |
| JP2019510036A (ja) | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティクス／プレバイオティクス有効成分を含む清浄剤組成物 |
| WO2017173240A1 (en) | 2016-03-31 | 2017-10-05 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| EP3544575A1 (en) | 2016-11-23 | 2019-10-02 | GOJO Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| BR112019023254A2 (pt) * | 2017-05-07 | 2020-05-19 | Locus Ip Company, Llc | composições cosméticas para saúde da pele e métodos de usar as mesmas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ208612A (en) | 1983-06-24 | 1991-09-25 | Genentech Inc | Method of producing "procaryotic carbonyl hydrolases" containing predetermined, site specific mutations |
| US4760025A (en) | 1984-05-29 | 1988-07-26 | Genencor, Inc. | Modified enzymes and methods for making same |
| US5801038A (en) * | 1984-05-29 | 1998-09-01 | Genencor International Inc. | Modified subtilisins having amino acid alterations |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| PT89702B (pt) * | 1988-02-11 | 1994-04-29 | Gist Brocades Nv | Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem |
| DK316989D0 (da) | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
| ES2144990T3 (es) | 1989-08-25 | 2000-07-01 | Henkel Of America Inc | Enzima proteolitica alcalina y metodo de produccion. |
| US5230891A (en) * | 1990-08-20 | 1993-07-27 | Kanebo Limited | Modified protease, method of producing the same and cosmetic products containing the modified protease |
| DK0563169T3 (da) | 1990-12-21 | 1998-05-18 | Novo Nordisk As | Enzymmutanter med lille variation i molekylær ladning i et pH område |
| US5340735A (en) * | 1991-05-29 | 1994-08-23 | Cognis, Inc. | Bacillus lentus alkaline protease variants with increased stability |
| AU671625B2 (en) | 1991-06-19 | 1996-09-05 | Exxon Chemical Patents Inc. | Method of suppressing mist formation from oil-containing functional fluids |
| ATE376061T1 (de) * | 1992-07-17 | 2007-11-15 | Genencor Int | Hochalkalische serinproteasen |
| DE69434962T2 (de) | 1993-10-14 | 2008-01-17 | The Procter & Gamble Company, Cincinnati | Proteasehaltige reinigungsmittel |
| MA23346A1 (fr) * | 1993-10-14 | 1995-04-01 | Genencor Int | Variantes de la subtilisine |
| US5691295A (en) * | 1995-01-17 | 1997-11-25 | Cognis Gesellschaft Fuer Biotechnologie Mbh | Detergent compositions |
| ES2364776T3 (es) * | 1994-02-24 | 2011-09-14 | HENKEL AG & CO. KGAA | Enzimas mejoradas y detergentes que las contienen. |
| DK1921147T3 (da) | 1994-02-24 | 2011-09-19 | Henkel Ag & Co Kgaa | Forbedrede enzymer og detergenter indeholdende disse |
| US6599730B1 (en) * | 1994-05-02 | 2003-07-29 | Procter & Gamble Company | Subtilisin 309 variants having decreased adsorption and increased hydrolysis |
| FR2737116B1 (fr) * | 1995-07-25 | 1997-08-22 | Oreal | Composition stable contenant un actif cosmetique et/ou dermatologique sensible a l'eau |
| FR2737119B1 (fr) * | 1995-07-25 | 1997-09-12 | Oreal | Composition siliconee contenant un actif sensible a l'eau |
-
1995
- 1995-08-23 DE DE19530816A patent/DE19530816A1/de not_active Withdrawn
-
1996
- 1996-08-14 DE DE59608385T patent/DE59608385D1/de not_active Expired - Fee Related
- 1996-08-14 WO PCT/EP1996/003589 patent/WO1997007770A1/de not_active Ceased
- 1996-08-14 AT AT96929256T patent/ATE209888T1/de not_active IP Right Cessation
- 1996-08-14 ES ES96929256T patent/ES2169258T3/es not_active Expired - Lifetime
- 1996-08-14 JP JP9509779A patent/JPH11512092A/ja active Pending
- 1996-08-14 US US09/011,889 patent/US6509021B1/en not_active Expired - Fee Related
- 1996-08-14 EP EP96929256A patent/EP0845972B1/de not_active Revoked
- 1996-08-14 DK DK96929256T patent/DK0845972T3/da active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999034774A1 (en) * | 1998-01-08 | 1999-07-15 | Dsm N.V. | Topical application of enzymes using a peelable film |
| DE19829789A1 (de) * | 1998-07-03 | 2000-01-05 | Beiersdorf Ag | Gegen Akne und entzündete Comedonen wirksame Zubereitungen enthaltend Serin-Proteasen und ein oder mehrere Calciumsalze |
| EP1553913A4 (en) * | 2002-06-14 | 2007-01-10 | Carol J Buck | COMPOSITIONS AND METHODS FOR ACQUIRING, THINNING AND REMOVING HYPERKERATOTIC TISSUE |
| DE102013219467A1 (de) * | 2013-09-26 | 2015-03-26 | Henkel Ag & Co. Kgaa | Stabilisierte Inhibitor-Proteasevarianten |
| DE102013219467A9 (de) * | 2013-09-26 | 2015-05-13 | Henkel Ag & Co. Kgaa | Stabilisierte Inhibitor-Proteasevarianten |
| WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Also Published As
| Publication number | Publication date |
|---|---|
| US6509021B1 (en) | 2003-01-21 |
| DE59608385D1 (de) | 2002-01-17 |
| ES2169258T3 (es) | 2002-07-01 |
| EP0845972A1 (de) | 1998-06-10 |
| EP0845972B1 (de) | 2001-12-05 |
| JPH11512092A (ja) | 1999-10-19 |
| DK0845972T3 (da) | 2002-04-02 |
| ATE209888T1 (de) | 2001-12-15 |
| WO1997007770A1 (de) | 1997-03-06 |
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