DE1902118C3 - Konservierung und Dispergierung lebender lyophilisierter Bakterien - Google Patents
Konservierung und Dispergierung lebender lyophilisierter BakterienInfo
- Publication number
- DE1902118C3 DE1902118C3 DE1902118A DE1902118A DE1902118C3 DE 1902118 C3 DE1902118 C3 DE 1902118C3 DE 1902118 A DE1902118 A DE 1902118A DE 1902118 A DE1902118 A DE 1902118A DE 1902118 C3 DE1902118 C3 DE 1902118C3
- Authority
- DE
- Germany
- Prior art keywords
- bacteria
- aerosol
- product
- well
- lyophilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000894006 Bacteria Species 0.000 title claims description 21
- 238000004321 preservation Methods 0.000 title claims 3
- 239000006185 dispersion Substances 0.000 title claims 2
- 239000000443 aerosol Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 229920001817 Agar Polymers 0.000 claims description 6
- 241000206672 Gelidium Species 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 235000010419 agar Nutrition 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 3
- 244000052616 bacterial pathogen Species 0.000 claims description 2
- 238000000855 fermentation Methods 0.000 claims description 2
- 230000004151 fermentation Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 241000238631 Hexapoda Species 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 230000001018 virulence Effects 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 239000007900 aqueous suspension Substances 0.000 claims 1
- 230000009172 bursting Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001143 conditioned effect Effects 0.000 claims 1
- 230000003750 conditioning effect Effects 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 claims 1
- 229940099364 dichlorofluoromethane Drugs 0.000 claims 1
- 238000009826 distribution Methods 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 230000002906 microbiologic effect Effects 0.000 claims 1
- 239000003595 mist Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000003456 pulmonary alveoli Anatomy 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 2
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000006872 mrs medium Substances 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR136857 | 1968-01-22 | ||
| FR148892A FR7414M (enrdf_load_stackoverflow) | 1968-04-22 | 1968-04-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1902118A1 DE1902118A1 (de) | 1969-10-30 |
| DE1902118B2 DE1902118B2 (de) | 1978-10-12 |
| DE1902118C3 true DE1902118C3 (de) | 1979-06-07 |
Family
ID=26181742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1902118A Expired DE1902118C3 (de) | 1968-01-22 | 1969-01-16 | Konservierung und Dispergierung lebender lyophilisierter Bakterien |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE726775A (enrdf_load_stackoverflow) |
| CA (1) | CA939261A (enrdf_load_stackoverflow) |
| CH (1) | CH502438A (enrdf_load_stackoverflow) |
| DE (1) | DE1902118C3 (enrdf_load_stackoverflow) |
| DK (1) | DK124339B (enrdf_load_stackoverflow) |
| GB (1) | GB1247219A (enrdf_load_stackoverflow) |
| IE (1) | IE32619B1 (enrdf_load_stackoverflow) |
| NL (1) | NL6901082A (enrdf_load_stackoverflow) |
| NO (1) | NO125685B (enrdf_load_stackoverflow) |
| OA (1) | OA03884A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9103905A (pt) * | 1991-09-11 | 1993-03-23 | Geratec S A Biotecnologia Apli | Processo de obtencao de inoculante em po-molhavel para a cultura de leguminosas |
| DE19512497C1 (de) * | 1995-04-04 | 1996-07-18 | Tuerk & Hillinger Gmbh | Elektrischer Durchlauferhitzer für flüssige Medien |
| JP2002306158A (ja) * | 2000-05-15 | 2002-10-22 | Makoto Kumazaki | 複合培養体、複合培養体の製造方法、前培養体、前培養体の製造方法及び微生物製剤の製造方法 |
-
1969
- 1969-01-10 BE BE726775D patent/BE726775A/xx unknown
- 1969-01-14 DK DK18669AA patent/DK124339B/da unknown
- 1969-01-15 IE IE57/69A patent/IE32619B1/xx unknown
- 1969-01-16 DE DE1902118A patent/DE1902118C3/de not_active Expired
- 1969-01-17 NO NO0191/69A patent/NO125685B/no unknown
- 1969-01-17 GB GB2779/69A patent/GB1247219A/en not_active Expired
- 1969-01-20 CH CH79769A patent/CH502438A/fr not_active IP Right Cessation
- 1969-01-20 CA CA40657A patent/CA939261A/en not_active Expired
- 1969-01-21 OA OA53481A patent/OA03884A/xx unknown
- 1969-01-22 NL NL6901082A patent/NL6901082A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE32619B1 (en) | 1973-10-03 |
| NL6901082A (enrdf_load_stackoverflow) | 1969-07-24 |
| GB1247219A (en) | 1971-09-22 |
| DE1902118A1 (de) | 1969-10-30 |
| OA03884A (fr) | 1975-08-14 |
| NO125685B (enrdf_load_stackoverflow) | 1972-10-16 |
| DK124339B (da) | 1972-10-09 |
| IE32619L (en) | 1969-07-22 |
| BE726775A (enrdf_load_stackoverflow) | 1969-07-10 |
| DE1902118B2 (de) | 1978-10-12 |
| CH502438A (fr) | 1971-01-31 |
| CA939261A (en) | 1974-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| EHJ | Ceased/non-payment of the annual fee |