DE1795823C3 - Desacetylvincaleukoblastin und seine Salze mit Säuren - Google Patents

Desacetylvincaleukoblastin und seine Salze mit Säuren

Info

Publication number
DE1795823C3
DE1795823C3 DE1795823A DE1795823A DE1795823C3 DE 1795823 C3 DE1795823 C3 DE 1795823C3 DE 1795823 A DE1795823 A DE 1795823A DE 1795823 A DE1795823 A DE 1795823A DE 1795823 C3 DE1795823 C3 DE 1795823C3
Authority
DE
Germany
Prior art keywords
methylene dichloride
mixture
salts
residue
vlb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1795823A
Other languages
German (de)
English (en)
Other versions
DE1795823A1 (de
DE1795823B2 (de
Inventor
William Walter Indianapolis Ind. Hargrove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to DE1795823A priority Critical patent/DE1795823C3/de
Publication of DE1795823A1 publication Critical patent/DE1795823A1/de
Publication of DE1795823B2 publication Critical patent/DE1795823B2/de
Application granted granted Critical
Publication of DE1795823C3 publication Critical patent/DE1795823C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE1795823A 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren Expired DE1795823C3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE1795823A DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US350519A US3392173A (en) 1964-03-09 1964-03-09 Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
DE1795823A DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren

Publications (3)

Publication Number Publication Date
DE1795823A1 DE1795823A1 (de) 1976-02-05
DE1795823B2 DE1795823B2 (de) 1981-04-30
DE1795823C3 true DE1795823C3 (de) 1982-04-15

Family

ID=23377073

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1795823A Expired DE1795823C3 (de) 1964-03-09 1965-03-08 Desacetylvincaleukoblastin und seine Salze mit Säuren
DE1545760A Expired DE1545760C3 (de) 1964-03-09 1965-03-08 Vincaleukoblastinderivate
DE1795763A Expired DE1795763C3 (de) 1964-03-09 1965-03-08 Verfahren zur Herstellung von Vincaleukoblastin- und Leurocristinderivaten

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE1545760A Expired DE1545760C3 (de) 1964-03-09 1965-03-08 Vincaleukoblastinderivate
DE1795763A Expired DE1795763C3 (de) 1964-03-09 1965-03-08 Verfahren zur Herstellung von Vincaleukoblastin- und Leurocristinderivaten

Country Status (9)

Country Link
US (1) US3392173A (cg-RX-API-DMAC7.html)
BE (1) BE660843A (cg-RX-API-DMAC7.html)
CH (1) CH507970A (cg-RX-API-DMAC7.html)
DE (3) DE1795823C3 (cg-RX-API-DMAC7.html)
ES (1) ES310240A1 (cg-RX-API-DMAC7.html)
FR (2) FR1449628A (cg-RX-API-DMAC7.html)
GB (1) GB1095833A (cg-RX-API-DMAC7.html)
NL (1) NL6502977A (cg-RX-API-DMAC7.html)
SE (1) SE330700B (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU165986B (cg-RX-API-DMAC7.html) * 1973-02-16 1974-12-28
US4012390A (en) * 1974-10-16 1977-03-15 Eli Lilly And Company Vinblastinoic acid
US3954773A (en) * 1974-11-21 1976-05-04 Eli Lilly And Company 4-Desacetoxyvinblastine
US3944554A (en) * 1975-01-09 1976-03-16 Eli Lilly And Company 4-Desacetoxy-3-hydroxyvinblastine
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4209443A (en) * 1976-02-13 1980-06-24 Richter Gedeon Vegyeszeti Gyar Rt. Process for separating pharmaceutically active diindole alkaloids
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
US4195022A (en) * 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
FR2461714A1 (fr) 1979-07-17 1981-02-06 Anvar Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
ATE57187T1 (de) * 1983-03-30 1990-10-15 Lilly Industries Ltd Vincaleukoblastin-derivate.
US4522750A (en) * 1984-02-21 1985-06-11 Eli Lilly And Company Cytotoxic compositions of transferrin coupled to vinca alkaloids
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4801688A (en) * 1986-05-27 1989-01-31 Eli Lilly And Company Hydrazone immunoglobulin conjugates
HUT76925A (hu) * 1995-04-04 1998-01-28 MTA Enzimológiai Intézet Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények
US6326402B1 (en) 1998-08-12 2001-12-04 Octamer, Inc. Methods for treating viral infections using a compound capable of inhibiting microtubules
DE60231868D1 (de) * 2001-04-24 2009-05-20 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
JP4814520B2 (ja) * 2002-05-15 2011-11-16 エンドサイト，インコーポレイテッド ビタミン−マイトマイシン結合体
EP2529758A3 (en) 2003-01-27 2013-01-02 Endocyte, Inc. Vitamin receptor binding drug delivery conjugates
EP1789391B1 (en) 2004-07-23 2017-06-28 Endocyte, Inc. Bivalent linkers and conjugates thereof
CN101175757B (zh) * 2005-03-16 2012-11-14 恩多塞特公司 蝶酸及其缀合物的合成和纯化
WO2007022493A2 (en) 2005-08-19 2007-02-22 Endocyte, Inc. Ligand conjugates of vinca alkaloids, analogs, and derivatives
JP5475992B2 (ja) * 2005-08-19 2014-04-16 エンドサイト，インコーポレイテッド 多剤リガンド結合体
WO2008101231A2 (en) 2007-02-16 2008-08-21 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
CN101678124A (zh) * 2007-03-14 2010-03-24 恩多塞特公司 结合配体连接的微管溶素递药缀合物
EP3569251A1 (en) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN101909441B (zh) * 2007-10-25 2015-05-13 恩多塞特公司 微管蛋白抑制剂及其制备方法
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
KR20150070318A (ko) 2012-10-16 2015-06-24 엔도사이트, 인코포레이티드 비천연 아미노산을 함유하는 약물 전달 컨쥬게이트 및 사용 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3097137A (en) * 1960-05-19 1963-07-09 Canadian Patents Dev Vincaleukoblastine
US3169968A (en) * 1962-05-08 1965-02-16 Ciba Geigy Corp Esters of ajmaline and related compounds
US3225053A (en) * 1963-01-10 1965-12-21 Lilly Co Eli Quebrachidine and derivatives

Also Published As

Publication number Publication date
CH507970A (de) 1971-05-31
ES310240A1 (es) 1965-10-16
DE1795823A1 (de) 1976-02-05
DE1545760C3 (de) 1978-10-05
DE1545760A1 (de) 1969-11-27
GB1095833A (en) 1967-12-20
SE330700B (cg-RX-API-DMAC7.html) 1970-11-30
US3392173A (en) 1968-07-09
BE660843A (cg-RX-API-DMAC7.html) 1965-09-09
DE1795763A1 (de) 1974-11-21
DE1545760B2 (de) 1978-02-09
DE1795823B2 (de) 1981-04-30
DE1795763C3 (de) 1978-06-29
FR1449628A (fr) 1966-08-19
DE1795763B2 (de) 1977-11-10
NL6502977A (cg-RX-API-DMAC7.html) 1965-09-10
FR6668M (cg-RX-API-DMAC7.html) 1969-02-03

Similar Documents

Publication Publication Date Title
DE1795823C3 (de) Desacetylvincaleukoblastin und seine Salze mit Säuren
DE1183508B (de) Verfahren zur Herstellung von N-Allyl-14-hydroxydihydronormorphinon und seinen Salzen
DE1921676C2 (de) 2-Cyano-3-morpholinoacrylsäure-Derivate und Verfahren zu ihrer Herstellung
DE2229223C3 (de) 2-Nitro-S-imidazol-Derivate und Verfahren zu deren Herstellung
DE1958514C3 (de) Apovincaminsaureamid
DE2005959A1 (de) 7-Nitro-8-hydroxychinolinester, ihre Verwendung und Verfahren zur Herstellung derselben
DE2520131C3 (de) 1,1,-Disubstituierte Octahydro-indolo[2,3-a]chinolizine und verfahren zu deren Herstellung
DE2831555C2 (cg-RX-API-DMAC7.html)
DE2221123C2 (de) Reserpsäurederivate, Verfahren zu deren Herstellung und Arzneimittel
DE2543821A1 (de) Cyclische aminosaeuren
DE1795539A1 (de) Verfahren zur Herstellung von neuen Pyrrolderivaten und ihren Salzen
DE1111163B (de) Verfahren zur Herstellung von Gemischen aus ª‡, ª‡, ª†- und ª‡, ª†, ª†-Trimethyladipinsaeure
DE1795125C (de) Chinolinderivate, ein Verfahren zu ihrer Herstellung und Arzneimittel
DE2264638C2 (de) 5'-Acetyl-2,2'-cyclocytidin-Derivate
AT243990B (de) Verfahren zur Herstellung von neuen, am Indolstickstoff substituierten Amiden der Lysergsäure und der Dihydrolysergsäure
AT358171B (de) Verfahren zur herstellung von neuen rifamycin- -verbindungen
DE2602340B2 (de) 5-benzylpikolinsaeurederivate
DE2160673C3 (de) Verfahren zur Herstellung von 4-Cyanoimidazol-5-carboxyamid bzw. S-Cyanoimidazol-4-carboxyamid
DE2024805C3 (de) Verfahren zur Herstellung von 2-Amino-3-chlorpyrazin
AT226380B (de) Verfahren zur Herstellung von Lysergsäurehydraziden
AT212980B (de) Verfahren zur Herstellung der Deserpidinsäure
DE1695580C (de) Quaternare Verbindungen des Benzil saure beta piperidino athylesters und ein Verfahren zu ihrer Herstellung
DE1296650B (de) N, N-disubstituierte Thienyl-(2)- bzw. Thienyl-(3)-propionsaeure- und -acrylsaeureamidine sowie Verfahren zu ihrer Herstellung
DE1076138B (de) Verfahren zur Herstellung eines neuen kristallisierten Pantothensaeureesters
DE2427377A1 (de) 3-phenoxymethylpyrido eckige klammer auf 3,4-e eckige klammer zu -as-triazine und verfahren zu deren herstellung

Legal Events

Date Code Title Description
AC Divided out of

Ref country code: DE

Ref document number: 1545760

Format of ref document f/p: P

C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee