DE1620047A1 - Pyrimidin-Nucleoside und Verfahren zu deren Herstellung - Google Patents

Pyrimidin-Nucleoside und Verfahren zu deren Herstellung

Info

Publication number
DE1620047A1
DE1620047A1 DE19661620047 DE1620047A DE1620047A1 DE 1620047 A1 DE1620047 A1 DE 1620047A1 DE 19661620047 DE19661620047 DE 19661620047 DE 1620047 A DE1620047 A DE 1620047A DE 1620047 A1 DE1620047 A1 DE 1620047A1
Authority
DE
Germany
Prior art keywords
deoxy
methanol
fluoro
solution
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19661620047
Other languages
German (de)
English (en)
Inventor
Boxer George Ernst
Nutt Ruth Foelsche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1620047A1 publication Critical patent/DE1620047A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05B—PHOSPHATIC FERTILISERS
    • C05B11/00—Fertilisers produced by wet-treating or leaching raw materials either with acids in such amounts and concentrations as to yield solutions followed by neutralisation, or with alkaline lyes
    • C05B11/04—Fertilisers produced by wet-treating or leaching raw materials either with acids in such amounts and concentrations as to yield solutions followed by neutralisation, or with alkaline lyes using mineral acid
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05B—PHOSPHATIC FERTILISERS
    • C05B11/00—Fertilisers produced by wet-treating or leaching raw materials either with acids in such amounts and concentrations as to yield solutions followed by neutralisation, or with alkaline lyes
    • C05B11/04—Fertilisers produced by wet-treating or leaching raw materials either with acids in such amounts and concentrations as to yield solutions followed by neutralisation, or with alkaline lyes using mineral acid
    • C05B11/06—Fertilisers produced by wet-treating or leaching raw materials either with acids in such amounts and concentrations as to yield solutions followed by neutralisation, or with alkaline lyes using mineral acid using nitric acid (nitrophosphates)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE19661620047 1965-10-24 1966-10-21 Pyrimidin-Nucleoside und Verfahren zu deren Herstellung Pending DE1620047A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US505029A US3346561A (en) 1965-10-24 1965-10-24 Pyrimidine 3-deoxynucleosides

Publications (1)

Publication Number Publication Date
DE1620047A1 true DE1620047A1 (de) 1970-03-19

Family

ID=24008711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19661620047 Pending DE1620047A1 (de) 1965-10-24 1966-10-21 Pyrimidin-Nucleoside und Verfahren zu deren Herstellung

Country Status (6)

Country Link
US (1) US3346561A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR6683657D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE1620047A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR1502956A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1117039A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL6614805A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311694A4 (en) * 1987-04-23 1991-05-08 Rikagaku Kenkyusho Nucleoside derivatives and process for their preparation
EP0501511A3 (en) * 1991-03-01 1993-04-21 Bristol-Myers Squibb Company Processes for preparation of nucleoside derivatives
EP0805683A4 (en) * 1995-01-27 1999-09-01 Univ Emory 5-CARBOXAMIDO OR 5-FLUORO (-2 ', 3'-UNSATURATED OR 3'-MODIFIED) PYRIMIDINE NUCLEOSIDE
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US7115584B2 (en) 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3457255A (en) * 1967-05-17 1969-07-22 Syntex Corp Novel ribo and lyxo nucleoside derivatives and a process for their preparation
GB1270445A (en) * 1968-06-04 1972-04-12 Asahi Chemical Ind Stabilized polymer compositions
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
DE2122991C2 (de) * 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden
US5588298A (en) 1995-10-20 1996-12-31 Exergy, Inc. Supplying heat to an externally fired power system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277077A (en) * 1964-06-03 1966-10-04 Merck & Co Inc 3-deoxy ribofuranosyl halides

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311694A4 (en) * 1987-04-23 1991-05-08 Rikagaku Kenkyusho Nucleoside derivatives and process for their preparation
US5144018A (en) * 1987-04-23 1992-09-01 Rikagaku Kenkyusho 2',3'-dideoxy-adenosine derivatives
EP0501511A3 (en) * 1991-03-01 1993-04-21 Bristol-Myers Squibb Company Processes for preparation of nucleoside derivatives
EP0805683A4 (en) * 1995-01-27 1999-09-01 Univ Emory 5-CARBOXAMIDO OR 5-FLUORO (-2 ', 3'-UNSATURATED OR 3'-MODIFIED) PYRIMIDINE NUCLEOSIDE
US6232300B1 (en) 1995-01-27 2001-05-15 Emory University Treatment of HIV by administration of β-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC)
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US6680303B2 (en) 1995-01-27 2004-01-20 Emory University 3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith
EP1361227A3 (en) * 1995-01-27 2004-03-03 Emory University [5-carboxamide or 5-fluoro]-[2', 3'-unsaturated or 3'-modifield]-pyrimidine nucleosides
US7419966B2 (en) 1995-01-27 2008-09-02 Emory University [5-carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US7115584B2 (en) 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine

Also Published As

Publication number Publication date
NL6614805A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1967-04-25
BR6683657D0 (pt) 1973-12-04
US3346561A (en) 1967-10-10
FR1502956A (fr) 1967-11-24
GB1117039A (en) 1968-06-12

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