DE1618696B2 - - Google Patents
Info
- Publication number
- DE1618696B2 DE1618696B2 DE1618696A DE1618696A DE1618696B2 DE 1618696 B2 DE1618696 B2 DE 1618696B2 DE 1618696 A DE1618696 A DE 1618696A DE 1618696 A DE1618696 A DE 1618696A DE 1618696 B2 DE1618696 B2 DE 1618696B2
- Authority
- DE
- Germany
- Prior art keywords
- choline
- choline salicylate
- salicylate
- polygalacturonate
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UDKCHVLMFQVBAA-UHFFFAOYSA-M Choline salicylate Chemical compound C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O UDKCHVLMFQVBAA-UHFFFAOYSA-M 0.000 claims 16
- 229960002688 choline salicylate Drugs 0.000 claims 16
- 229960001231 choline Drugs 0.000 claims 12
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 12
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 6
- 229960004889 salicylic acid Drugs 0.000 claims 6
- 229920002230 Pectic acid Polymers 0.000 claims 5
- 239000010318 polygalacturonic acid Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000000843 powder Substances 0.000 claims 4
- 238000000354 decomposition reaction Methods 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 230000008018 melting Effects 0.000 claims 3
- 238000002844 melting Methods 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 238000003860 storage Methods 0.000 claims 3
- 238000000862 absorption spectrum Methods 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000000144 pharmacologic effect Effects 0.000 claims 2
- 229960001860 salicylate Drugs 0.000 claims 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 206010013654 Drug abuse Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000008297 liquid dosage form Substances 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 238000013112 stability test Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US550606A US3326760A (en) | 1966-05-17 | 1966-05-17 | Choline salicylate polygalacturonate therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1618696A1 DE1618696A1 (de) | 1971-07-01 |
| DE1618696B2 true DE1618696B2 (en:Method) | 1974-12-12 |
| DE1618696C3 DE1618696C3 (de) | 1975-08-07 |
Family
ID=24197867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1618696A Expired DE1618696C3 (de) | 1966-05-17 | 1967-05-16 | Cholinsalicylat-Polygalacturonat, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US3326760A (en:Method) |
| DE (1) | DE1618696C3 (en:Method) |
| FR (1) | FR6471M (en:Method) |
| GB (1) | GB1126153A (en:Method) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3947491A (en) * | 1972-03-24 | 1976-03-30 | The Purdue Frederick Company | Stabilized choline salicylate compounds |
| US4001311A (en) * | 1971-07-24 | 1977-01-04 | Synergistics, Inc. | Stabilized choline salicylate compounds |
| US4067974A (en) * | 1976-01-21 | 1978-01-10 | The Purdue Frederick Company | Stabilized solid form choline salicylate compositions |
| CA1070299A (en) * | 1976-01-21 | 1980-01-22 | Ernest J. Sasmor | Stabilized solid form choline salicylate compositions |
| US5043168A (en) * | 1990-04-26 | 1991-08-27 | Sidmak Laboratories, Inc. | Solid choline magnesium salicylate composition and method of preparing same |
| IT1264321B (it) * | 1992-01-13 | 1996-09-23 | Mini Ricerca Scient Tecnolog | Esteri di acidi pectici e pectinici, procedimento di preparazione e loro applicazioni farmaceutiche e biosanitarie |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3069321A (en) * | 1960-04-04 | 1962-12-18 | Lab For Pharmaceutical Dev Inc | Choline salicylate composition and methods of use |
-
1966
- 1966-05-17 US US550606A patent/US3326760A/en not_active Expired - Lifetime
-
1967
- 1967-05-11 GB GB21942/67A patent/GB1126153A/en not_active Expired
- 1967-05-16 DE DE1618696A patent/DE1618696C3/de not_active Expired
- 1967-05-17 FR FR106681A patent/FR6471M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1618696A1 (de) | 1971-07-01 |
| DE1618696C3 (de) | 1975-08-07 |
| GB1126153A (en) | 1968-09-05 |
| US3326760A (en) | 1967-06-20 |
| FR6471M (en:Method) | 1968-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| EHJ | Ceased/non-payment of the annual fee |