DE1568025A1 - Verfahren zur Herstellung von Equilin - Google Patents
Verfahren zur Herstellung von EquilinInfo
- Publication number
- DE1568025A1 DE1568025A1 DE19661568025 DE1568025A DE1568025A1 DE 1568025 A1 DE1568025 A1 DE 1568025A1 DE 19661568025 DE19661568025 DE 19661568025 DE 1568025 A DE1568025 A DE 1568025A DE 1568025 A1 DE1568025 A1 DE 1568025A1
- Authority
- DE
- Germany
- Prior art keywords
- atcc
- nocardia
- equilin
- microorganisms
- estradiene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WKRLQDKEXYKHJB-UHFFFAOYSA-N Equilin Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3=CCC2=C1 WKRLQDKEXYKHJB-UHFFFAOYSA-N 0.000 title claims description 11
- WKRLQDKEXYKHJB-HFTRVMKXSA-N equilin Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 WKRLQDKEXYKHJB-HFTRVMKXSA-N 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 7
- 241000187654 Nocardia Species 0.000 claims description 10
- 244000005700 microbiome Species 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 241001509401 Gordonia rubripertincta Species 0.000 claims description 5
- OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims description 5
- 241000203720 Pimelobacter simplex Species 0.000 claims description 4
- 230000002906 microbiologic effect Effects 0.000 claims description 4
- 241000186359 Mycobacterium Species 0.000 claims description 3
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 241001021846 Nocardia canicruria Species 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/02—Dehydrogenating; Dehydroxylating
- C12P33/04—Forming an aryl ring from A ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US471415A US3386890A (en) | 1965-07-12 | 1965-07-12 | Process for preparing equilin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1568025A1 true DE1568025A1 (de) | 1970-02-12 |
Family
ID=23871547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19661568025 Pending DE1568025A1 (de) | 1965-07-12 | 1966-07-12 | Verfahren zur Herstellung von Equilin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3386890A (cg-RX-API-DMAC7.html) |
| CH (1) | CH459198A (cg-RX-API-DMAC7.html) |
| DE (1) | DE1568025A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1127295A (cg-RX-API-DMAC7.html) |
| IL (1) | IL26132A (cg-RX-API-DMAC7.html) |
| NL (1) | NL6609750A (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0496846B1 (de) * | 1990-08-18 | 1997-05-07 | Schering Aktiengesellschaft | Verfahren zur herstellung von 17-oxosteroiden |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549497A (en) * | 1967-12-05 | 1970-12-22 | Dieter Kluepfel | Microbiological process for estrogens |
| US4004978A (en) * | 1975-09-19 | 1977-01-25 | Imc Chemical Group, Inc. | Microbiological reduction of zearalenone and related compounds |
| US6458778B1 (en) | 1997-04-07 | 2002-10-01 | Wyeth | Estradienes |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2930805A (en) * | 1959-01-19 | 1960-03-29 | American Home Prod | Novel derivatives of estrane |
| US3067212A (en) * | 1958-04-24 | 1962-12-04 | Syntex Corp | Production of equilin and intermediates |
| US3272847A (en) * | 1964-01-15 | 1966-09-13 | American Home Prod | Process for preparing equilin and the intermediates produced therein |
-
1965
- 1965-07-12 US US471415A patent/US3386890A/en not_active Expired - Lifetime
-
1966
- 1966-07-12 NL NL6609750A patent/NL6609750A/xx unknown
- 1966-07-12 GB GB31305/66A patent/GB1127295A/en not_active Expired
- 1966-07-12 DE DE19661568025 patent/DE1568025A1/de active Pending
- 1966-07-12 IL IL26132A patent/IL26132A/xx unknown
- 1966-07-12 CH CH1010266A patent/CH459198A/fr unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0496846B1 (de) * | 1990-08-18 | 1997-05-07 | Schering Aktiengesellschaft | Verfahren zur herstellung von 17-oxosteroiden |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6609750A (cg-RX-API-DMAC7.html) | 1967-01-13 |
| CH459198A (fr) | 1968-07-15 |
| GB1127295A (en) | 1968-09-18 |
| IL26132A (en) | 1970-02-19 |
| US3386890A (en) | 1968-06-04 |
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