DE1518994A1 - Verfahren zur Herstellung von neuen Beta,10Alpha-Steroiden - Google Patents

Verfahren zur Herstellung von neuen Beta,10Alpha-Steroiden

Info

Publication number
DE1518994A1
DE1518994A1 DE19651518994 DE1518994A DE1518994A1 DE 1518994 A1 DE1518994 A1 DE 1518994A1 DE 19651518994 DE19651518994 DE 19651518994 DE 1518994 A DE1518994 A DE 1518994A DE 1518994 A1 DE1518994 A1 DE 1518994A1
Authority
DE
Germany
Prior art keywords
androsta
general formula
acetoxy
keto
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19651518994
Other languages
German (de)
English (en)
Inventor
Reerink Engbert Harmen
Schoeler Hendrik Frederi Louis
Pieter Westerhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB291965A external-priority patent/GB1139411A/en
Priority claimed from CH846564A external-priority patent/CH454842A/de
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE1518994A1 publication Critical patent/DE1518994A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19651518994 1965-01-22 1965-06-03 Verfahren zur Herstellung von neuen Beta,10Alpha-Steroiden Pending DE1518994A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB291965A GB1139411A (en) 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids
CH846564A CH454842A (de) 1965-05-31 1965-05-31 Verfahren zur Herstellung von neuen 9B,10a-Steroiden

Publications (1)

Publication Number Publication Date
DE1518994A1 true DE1518994A1 (de) 1969-09-25

Family

ID=25703347

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19651518994 Pending DE1518994A1 (de) 1965-01-22 1965-06-03 Verfahren zur Herstellung von neuen Beta,10Alpha-Steroiden
DE19651543274 Pending DE1543274A1 (de) 1965-01-22 1965-06-24 Verfahren zur Herstellung von 4-Keto-4,6-bisdehydro-6-halogen-9beta,10alpha-sterioden

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19651543274 Pending DE1543274A1 (de) 1965-01-22 1965-06-24 Verfahren zur Herstellung von 4-Keto-4,6-bisdehydro-6-halogen-9beta,10alpha-sterioden

Country Status (14)

Country Link
US (2) US3423433A (https=)
AT (1) AT261129B (https=)
BE (2) BE665762A (https=)
BR (1) BR6570589D0 (https=)
CH (1) CH464188A (https=)
DE (2) DE1518994A1 (https=)
DK (2) DK120337B (https=)
ES (1) ES314639A1 (https=)
FI (1) FI41743B (https=)
FR (3) FR4631M (https=)
GB (1) GB1087920A (https=)
IL (2) IL23629A (https=)
NL (2) NL6508148A (https=)
SE (1) SE331277B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE667121A (https=) * 1964-10-28
IL23629A (en) * 1965-01-22 1969-01-29 Hoffmann La Roche 9beta,10alpha-steroids and process for the manufacture thereof
GB1228801A (https=) * 1967-07-11 1971-04-21
US3937700A (en) * 1970-03-04 1976-02-10 U.S. Philips Corporation Novel 1,2-methylene-17α-acyloxy (or improved hydroxy)-9β, 10α-steroid compounds of the pregnane series, pharmaceutic preparations on the basis of the novel compounds and methods of producing said compounds and preparations
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
US20070082876A1 (en) * 2005-09-30 2007-04-12 Solvay Pharmaceuticals Gmbh Novel C18 modified retrosteroids as progesterone receptor modulator compounds
US20070212751A1 (en) * 2006-01-18 2007-09-13 Solvay Pharmaceuticals Gmbh Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL252417A (https=) * 1959-06-08
US3258473A (en) * 1963-10-04 1966-06-28 Syntex Corp 17-dihaloacetate esters of 17alpha-hydroxy-21-desoxypregnane derivatives
IL23629A (en) * 1965-01-22 1969-01-29 Hoffmann La Roche 9beta,10alpha-steroids and process for the manufacture thereof

Also Published As

Publication number Publication date
GB1087920A (en) 1967-10-18
IL23629A (en) 1969-01-29
DE1543274A1 (de) 1969-07-24
BE665762A (https=) 1965-12-22
CH464188A (de) 1968-10-31
AT261129B (de) 1968-04-10
US3304314A (en) 1967-02-14
SE331277B (https=) 1970-12-21
FI41743B (https=) 1969-10-31
NL6508148A (https=) 1966-06-27
DK123352B (da) 1972-06-12
FR4631M (https=) 1966-11-28
IL23785A (en) 1969-09-25
US3423433A (en) 1969-01-21
FR1446515A (fr) 1966-07-22
BR6570589D0 (pt) 1973-08-02
DK120337B (da) 1971-05-17
FR1439514A (fr) 1966-05-20
ES314639A1 (es) 1966-02-16
NL6508179A (https=) 1965-12-27
BE666060A (https=) 1965-12-28

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