GB1139411A - Preparation of 10-‡-methyl steroids - Google Patents

Preparation of 10-‡-methyl steroids

Info

Publication number
GB1139411A
GB1139411A GB291965A GB291965A GB1139411A GB 1139411 A GB1139411 A GB 1139411A GB 291965 A GB291965 A GB 291965A GB 291965 A GB291965 A GB 291965A GB 1139411 A GB1139411 A GB 1139411A
Authority
GB
United Kingdom
Prior art keywords
steroids
bisdehydro
preparation
hydrocarbonyloxy
keto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB291965A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB291965A priority Critical patent/GB1139411A/en
Priority to IL6523629A priority patent/IL23629A/en
Priority to CH1286667A priority patent/CH468986A/en
Priority to CH433668A priority patent/CH460755A/en
Priority to CH1286767A priority patent/CH468989A/en
Priority to DE19651518994 priority patent/DE1518994A1/en
Priority to FR20951A priority patent/FR4631M/fr
Priority to BR170589/65A priority patent/BR6570589D0/en
Priority to BE665762D priority patent/BE665762A/xx
Priority to DK319165AA priority patent/DK120337B/en
Priority to IL6523785A priority patent/IL23785A/en
Priority to CH876665A priority patent/CH464188A/en
Priority to GB26557/65A priority patent/GB1087920A/en
Priority to SE08369/65A priority patent/SE331277B/xx
Priority to FI1505/65A priority patent/FI41743B/fi
Priority to DE19651543274 priority patent/DE1543274A1/en
Priority to ES0314588A priority patent/ES314588A1/en
Priority to FR22045A priority patent/FR1446515A/en
Priority to AT573665A priority patent/AT261129B/en
Priority to US466818A priority patent/US3304314A/en
Priority to US466817A priority patent/US3423433A/en
Priority to DK324365AA priority patent/DK123352B/en
Priority to ES0314639A priority patent/ES314639A1/en
Priority to NL6508148A priority patent/NL6508148A/xx
Priority to NL6508179A priority patent/NL6508179A/xx
Priority to FR22465A priority patent/FR1439514A/en
Priority to BE666060A priority patent/BE666060A/xx
Publication of GB1139411A publication Critical patent/GB1139411A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

1,139,411. Preparation of 10α-methyl-steroids. T. D. THREADGOLD (Philips Gloeilampenfabrieken N.V.) 19 Jan., 1966 [22 Jan., 1965], No. 2919/65. Heading C2U. The invention comprises a process for preparing a 3-keto-4,6-bisdehydro-6-fluoro-, chloro- or bromo-9#,10α-steroid by oxidation of a corresponding 3 - hydrocarbonyloxy - 6 - halo - 3,5-bisdehydro-9#,10α-steroid by manganese dioxide under neutral or weakly acidic reaction conditions in the presence of a solvent. 3 - Hydrocarbonyloxy - 3,5 - bisdehydro 6 - halo- 9#,10α-steroids are prepared from the corresponding 6 - unsubstituted - 3 - keto - 4 - dehydro - 9#,10α-steroids by conversion to an enol ether, halogenation and re-conversion to an enol ether.
GB291965A 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids Expired GB1139411A (en)

Priority Applications (27)

Application Number Priority Date Filing Date Title
GB291965A GB1139411A (en) 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids
IL6523629A IL23629A (en) 1965-01-22 1965-05-30 9beta,10alpha-steroids and process for the manufacture thereof
CH1286667A CH468986A (en) 1965-01-22 1965-05-31 Process for making new 9B, 10a steroids
CH433668A CH460755A (en) 1965-01-22 1965-05-31 Process for making new 9B, 10a steroids
CH1286767A CH468989A (en) 1965-01-22 1965-05-31 Process for making new 9B, 10a steroids
DE19651518994 DE1518994A1 (en) 1965-01-22 1965-06-03 Process for making new beta, 10alpha steroids
FR20951A FR4631M (en) 1965-01-22 1965-06-16
BR170589/65A BR6570589D0 (en) 1965-01-22 1965-06-22 PROCESS FOR THE PREPARATION OF NEW 9B 10 D-STEROIDS
BE665762D BE665762A (en) 1965-01-22 1965-06-22
DK319165AA DK120337B (en) 1965-01-22 1965-06-23 Process for the preparation of therapeutically active 3-keto-6-halogen-9β10α-Δ <4,6> steroid dienes of the androstane or pregnane series.
IL6523785A IL23785A (en) 1965-01-22 1965-06-23 Method of producing 3-keto-4,6-bisdehydro-6-halogeno-9beta,10alpha-steroids of the androstane or preganane series
CH876665A CH464188A (en) 1965-01-22 1965-06-23 Process for the preparation of 3-keto-4,6-bisdehydro-6-halogen-9B, 10 -steroids
GB26557/65A GB1087920A (en) 1965-01-22 1965-06-23 Novel 10ª‡-methyl-9ª‰-steroids
SE08369/65A SE331277B (en) 1965-01-22 1965-06-23
FI1505/65A FI41743B (en) 1965-01-22 1965-06-23
DE19651543274 DE1543274A1 (en) 1965-01-22 1965-06-24 Process for the production of 4-keto-4,6-bisdehydro-6-halogen-9beta, 10alpha-steriods
ES0314588A ES314588A1 (en) 1965-01-22 1965-06-24 Preparation of 10- -methyl steroids
FR22045A FR1446515A (en) 1965-01-22 1965-06-24 Process for the preparation of new 9beta, 10alpha-steroids
AT573665A AT261129B (en) 1965-01-22 1965-06-24 Process for the preparation of 3 keto 4,6 bisdehydro 6 halogen 9β, 10α-steroids
US466818A US3304314A (en) 1965-01-22 1965-06-24 Novel 9beta, 10alpha-steroids and process for the manufacture thereof
US466817A US3423433A (en) 1965-01-22 1965-06-24 Method of producing 3-keto-4,6-bisdehydro-6-halogeno-9beta,10alpha-steroids
DK324365AA DK123352B (en) 1965-01-22 1965-06-25 Analogous process for the preparation of 6-halogen-substituted 9β, 10α-steroids of the androstane series.
ES0314639A ES314639A1 (en) 1965-01-22 1965-06-25 Procedure for the elaboration of new 9-beta, 10-alpha-steroids. (Machine-translation by Google Translate, not legally binding)
NL6508148A NL6508148A (en) 1965-01-22 1965-06-25
NL6508179A NL6508179A (en) 1965-01-22 1965-06-25
FR22465A FR1439514A (en) 1965-01-22 1965-06-26 Process for preparing 3-oxo-4.6-bis-dehydro-6-halogeno-9beta. 10alpha-steroids
BE666060A BE666060A (en) 1965-01-22 1965-06-28

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB291965A GB1139411A (en) 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids

Publications (1)

Publication Number Publication Date
GB1139411A true GB1139411A (en) 1969-01-08

Family

ID=9748548

Family Applications (1)

Application Number Title Priority Date Filing Date
GB291965A Expired GB1139411A (en) 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids

Country Status (2)

Country Link
ES (1) ES314588A1 (en)
GB (1) GB1139411A (en)

Also Published As

Publication number Publication date
ES314588A1 (en) 1966-03-01

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