ES314588A1 - Preparation of 10- -methyl steroids - Google Patents

Preparation of 10- -methyl steroids

Info

Publication number
ES314588A1
ES314588A1 ES0314588A ES314588A ES314588A1 ES 314588 A1 ES314588 A1 ES 314588A1 ES 0314588 A ES0314588 A ES 0314588A ES 314588 A ES314588 A ES 314588A ES 314588 A1 ES314588 A1 ES 314588A1
Authority
ES
Spain
Prior art keywords
alpha
bisdehydro
steroids
preparation
hydrocarbonyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0314588A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NV filed Critical Philips Gloeilampenfabrieken NV
Publication of ES314588A1 publication Critical patent/ES314588A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises a process for preparing a 3-keto-4,6-bisdehydro-6-fluoro-, chloro- or bromo-9#,10[alpha]-steroid by oxidation of a corresponding 3 - hydrocarbonyloxy - 6 - halo - 3,5-bisdehydro-9#,10[alpha]-steroid by manganese dioxide under neutral or weakly acidic reaction conditions in the presence of a solvent. 3 - Hydrocarbonyloxy - 3,5 - bisdehydro 6 - halo- 9#,10[alpha]-steroids are prepared from the corresponding 6 - unsubstituted - 3 - keto - 4 - dehydro - 9#,10[alpha]-steroids by conversion to an enol ether, halogenation and re-conversion to an enol ether.
ES0314588A 1965-01-22 1965-06-24 Preparation of 10- -methyl steroids Expired ES314588A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB291965A GB1139411A (en) 1965-01-22 1965-01-22 Preparation of 10-‡-methyl steroids

Publications (1)

Publication Number Publication Date
ES314588A1 true ES314588A1 (en) 1966-03-01

Family

ID=9748548

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0314588A Expired ES314588A1 (en) 1965-01-22 1965-06-24 Preparation of 10- -methyl steroids

Country Status (2)

Country Link
ES (1) ES314588A1 (en)
GB (1) GB1139411A (en)

Also Published As

Publication number Publication date
GB1139411A (en) 1969-01-08

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