DE1518051A1 - Derivate der 3,5-Diamino-2,4,6-trijodbenzoesaeure und Verfahren zu ihrer Herstellung - Google Patents
Derivate der 3,5-Diamino-2,4,6-trijodbenzoesaeure und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE1518051A1 DE1518051A1 DE19601518051 DE1518051A DE1518051A1 DE 1518051 A1 DE1518051 A1 DE 1518051A1 DE 19601518051 DE19601518051 DE 19601518051 DE 1518051 A DE1518051 A DE 1518051A DE 1518051 A1 DE1518051 A1 DE 1518051A1
- Authority
- DE
- Germany
- Prior art keywords
- der
- diamino
- derivatives
- preparation
- triiodobenzoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title description 2
- GOQCZMZLABPEME-UHFFFAOYSA-N 3,5-diamino-2,4,6-triiodobenzoic acid Chemical class NC1=C(I)C(N)=C(I)C(C(O)=O)=C1I GOQCZMZLABPEME-UHFFFAOYSA-N 0.000 title 1
- 241000711981 Sais Species 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- ZINJLDJMHCUBIP-UHFFFAOYSA-N ethametsulfuron-methyl Chemical compound CCOC1=NC(NC)=NC(NC(=O)NS(=O)(=O)C=2C(=CC=CC=2)C(=O)OC)=N1 ZINJLDJMHCUBIP-UHFFFAOYSA-N 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102100033070 Histone acetyltransferase KAT6B Human genes 0.000 description 1
- 101100019690 Homo sapiens KAT6B gene Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- ZZIZZTHXZRDOFM-XFULWGLBSA-N tamsulosin hydrochloride Chemical compound [H+].[Cl-].CCOC1=CC=CC=C1OCCN[C@H](C)CC1=CC=C(OC)C(S(N)(=O)=O)=C1 ZZIZZTHXZRDOFM-XFULWGLBSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO13407559 | 1959-12-08 | ||
| NO13804460 | 1960-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1518051A1 true DE1518051A1 (de) | 1969-01-16 |
Family
ID=26649132
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19601518051 Pending DE1518051A1 (de) | 1959-12-08 | 1960-12-07 | Derivate der 3,5-Diamino-2,4,6-trijodbenzoesaeure und Verfahren zu ihrer Herstellung |
| DEN19296A Pending DE1192369B (de) | 1959-12-08 | 1960-12-07 | Roentgenkontrastmittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEN19296A Pending DE1192369B (de) | 1959-12-08 | 1960-12-07 | Roentgenkontrastmittel |
Country Status (9)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
| US4018783A (en) | 1970-09-09 | 1977-04-19 | Beecham Group Limited | Esters of metrizoic acid |
| DE2050217A1 (de) * | 1970-10-02 | 1972-04-06 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Monomethylamino Verbindungen |
| DE2235935C3 (de) * | 1972-07-21 | 1979-07-26 | Lentia Gmbh | Neue Derivate von trijodierten Aminobenzolcarbonsäuren, ein Verfahren zu deren Herstellung und diese Verbindungen enthaltende Röntgenkontrastmittel |
| US4314055A (en) * | 1975-09-29 | 1982-02-02 | Mallinckrodt, Inc. | 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids |
| FR2512014A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Composes bromes utilisables dans des produits opacifiants |
| FR2511871A1 (fr) * | 1981-08-28 | 1983-03-04 | Guerbet Sa | Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus |
| US4567034A (en) * | 1984-09-07 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Esters of diatrizoic acid as X-ray contrast agents |
| US5141739A (en) * | 1986-07-03 | 1992-08-25 | Advanced Magnetics, Inc. | Delivery of x-ray contrast agents using receptor mediated endocytosis |
| US5463080A (en) * | 1992-08-27 | 1995-10-31 | Bracco International B.V. | 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents |
| US6051210A (en) * | 1997-05-15 | 2000-04-18 | Bracco Research Usa | N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging |
| WO2006074809A2 (en) | 2005-01-13 | 2006-07-20 | Cinvention Ag | Composite materials containing carbon nanoparticles |
| EP1937753A1 (en) * | 2005-10-18 | 2008-07-02 | Cinvention Ag | Thermoset particles and methods for production thereof |
| AU2008206953A1 (en) * | 2007-01-19 | 2008-07-24 | Cinvention Ag | Porous, non-degradable implant made by powder molding |
| EP2126040A1 (en) * | 2007-02-28 | 2009-12-02 | Cinvention Ag | High surface cultivation system |
| WO2008104599A1 (en) * | 2007-02-28 | 2008-09-04 | Cinvention Ag | High surface cultivation system bag |
| CN114478295B (zh) * | 2022-01-24 | 2023-12-15 | 浙江海洲制药有限公司 | 一种泛影酸的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE970133C (de) * | 1953-02-06 | 1958-08-21 | Schering Ag | Verfahren zur Herstellung von N-Acylderivaten der 3, 5-Diamino-2, 4, 6-trijod-benzoesaeure |
| NL93842C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1953-03-27 | 1960-04-19 | ||
| GB779500A (en) * | 1953-12-17 | 1957-07-24 | Sterling Drug Inc | Improvements in or relating to esters of acylated 3,5-diaminotriiodobenzoic acid |
| CH332648A (de) * | 1954-02-06 | 1958-09-15 | Schering Ag | Verfahren zur Herstellung von Röntgenphotogrammen |
| US3076024A (en) * | 1954-02-19 | 1963-01-29 | Sterling Drug Inc | Acylated 3, 5-diaminopolyhalobenzoic acids |
| BE555768A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1956-03-13 |
-
1960
- 1960-11-30 BR BR124559/60A patent/BR6024559D0/pt unknown
- 1960-12-05 GB GB41782/60A patent/GB973881A/en not_active Expired
- 1960-12-06 FR FR846003A patent/FR820M/fr active Active
- 1960-12-07 DE DE19601518051 patent/DE1518051A1/de active Pending
- 1960-12-07 DE DEN19296A patent/DE1192369B/de active Pending
- 1960-12-08 US US74485A patent/US3476802A/en not_active Expired - Lifetime
-
1961
- 1961-01-31 CH CH113461A patent/CH398887A/fr unknown
- 1961-03-04 FR FR1548251D patent/FR1548251A/fr not_active Expired
-
1963
- 1963-05-16 DK DK235263AA patent/DK125282B/da unknown
-
1964
- 1964-01-17 FI FI0098/64A patent/FI40563B/fi active
-
1968
- 1968-03-06 NL NL6803180A patent/NL6803180A/xx unknown
-
1969
- 1969-07-18 US US843179A patent/US3637824A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR1548251A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-12-06 |
| US3476802A (en) | 1969-11-04 |
| FI40563B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-11-30 |
| DE1192369B (de) | 1965-05-06 |
| NL6803180A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-05-27 |
| FR820M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1961-09-25 |
| GB973881A (en) | 1964-10-28 |
| DK125282B (da) | 1973-01-29 |
| BR6024559D0 (pt) | 1973-05-31 |
| CH398887A (fr) | 1966-03-15 |
| US3637824A (en) | 1972-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E77 | Valid patent as to the heymanns-index 1977 |