DE1467999A1 - Mittel zur Behandlung der Tuberkulose und Verfahren zu seiner Herstellung - Google Patents
Mittel zur Behandlung der Tuberkulose und Verfahren zu seiner HerstellungInfo
- Publication number
- DE1467999A1 DE1467999A1 DE1965L0050767 DEL0050767A DE1467999A1 DE 1467999 A1 DE1467999 A1 DE 1467999A1 DE 1965L0050767 DE1965L0050767 DE 1965L0050767 DE L0050767 A DEL0050767 A DE L0050767A DE 1467999 A1 DE1467999 A1 DE 1467999A1
- Authority
- DE
- Germany
- Prior art keywords
- solution
- polyvinylpyrrolidone
- tuberculosis
- treatment
- aminosalicylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 9
- 201000008827 tuberculosis Diseases 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000000243 solution Substances 0.000 claims description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 19
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
- AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 claims description 15
- 229960002001 ethionamide Drugs 0.000 claims description 14
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims description 10
- 229960004909 aminosalicylic acid Drugs 0.000 claims description 10
- 150000001408 amides Chemical class 0.000 claims description 7
- 229920002521 macromolecule Polymers 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000000205 acacia gum Substances 0.000 claims description 3
- 235000010489 acacia gum Nutrition 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 229960000633 dextran sulfate Drugs 0.000 claims description 3
- 239000008273 gelatin Substances 0.000 claims description 3
- 229920000159 gelatin Polymers 0.000 claims description 3
- 235000019322 gelatine Nutrition 0.000 claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000001814 pectin Substances 0.000 claims description 3
- 235000010987 pectin Nutrition 0.000 claims description 3
- 229920001277 pectin Polymers 0.000 claims description 3
- 210000002381 plasma Anatomy 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 241000978776 Senegalia senegal Species 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 244000171897 Acacia nilotica subsp nilotica Species 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- -1 polygalactoside Polymers 0.000 claims 1
- 238000002360 preparation method Methods 0.000 description 11
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 8
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 4
- 229960005322 streptomycin Drugs 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000011287 therapeutic dose Methods 0.000 description 2
- KGKSTPKEAQNJJD-UHFFFAOYSA-N 1-bromo-3-methylpent-1-yn-3-ol Chemical group CCC(C)(O)C#CBr KGKSTPKEAQNJJD-UHFFFAOYSA-N 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229960003350 isoniazid Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- SSOLNOMRVKKSON-UHFFFAOYSA-N proguanil Chemical compound CC(C)\N=C(/N)N=C(N)NC1=CC=C(Cl)C=C1 SSOLNOMRVKKSON-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000001549 tubercolostatic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR983536A FR3719M (fr) | 1964-07-29 | 1964-07-29 | Médicament anti-tuberculeux perfusable. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1467999A1 true DE1467999A1 (de) | 1969-03-13 |
Family
ID=8835712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE1965L0050767 Pending DE1467999A1 (de) | 1964-07-29 | 1965-05-20 | Mittel zur Behandlung der Tuberkulose und Verfahren zu seiner Herstellung |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE663688A (enrdf_load_stackoverflow) |
| DE (1) | DE1467999A1 (enrdf_load_stackoverflow) |
| FR (1) | FR3719M (enrdf_load_stackoverflow) |
| GB (1) | GB1050804A (enrdf_load_stackoverflow) |
-
0
- GB GB1050804D patent/GB1050804A/en active Active
-
1964
- 1964-07-29 FR FR983536A patent/FR3719M/fr not_active Expired
-
1965
- 1965-05-10 BE BE663688A patent/BE663688A/xx unknown
- 1965-05-20 DE DE1965L0050767 patent/DE1467999A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BE663688A (enrdf_load_stackoverflow) | 1965-11-10 |
| FR3719M (fr) | 1965-11-29 |
| GB1050804A (enrdf_load_stackoverflow) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69223624T2 (de) | Taxan-derivate enthaltende arzneimittel | |
| DE69109021T2 (de) | Augentropfenarzneimittel. | |
| DE3119051A1 (de) | Mittel zur behandlung der augen | |
| DE3886075T2 (de) | Verwendung von Metformin zur Herstellung von Arzneimitteln. | |
| DE3316510A1 (de) | Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen | |
| DE602005002495T2 (de) | Injizierbare Formulierung mit Natriumdiclofenac, Beta-Cyclodextrin und einem Polysorbat | |
| DE2515001C2 (de) | Prostaglandin enthaltende gefriergetrocknete Pulver | |
| DE68915269T2 (de) | Polyvalentes entzündungshemmendes mittel. | |
| DE3014223C2 (enrdf_load_stackoverflow) | ||
| DE2504615C3 (de) | Verfahren zur Herstellung eines Geles mit einem Gehalt an ß-Methason- 17-benzoat bzw. Fluocinolonacetonid und Neomycin | |
| DE3619426A1 (de) | Mittel zur erhoehung der widerstandskraft gegen erkaeltungskrankheiten bei patienten mit eingeschraenkter lungenfunktion | |
| DE3119510A1 (de) | "antitumormittel und verfahren zu deren herstellung" | |
| DE2243776A1 (de) | Komplexe von tetracyclinen mit tris(hydroxymethyl)-aminomethan | |
| EP0132595B1 (de) | Tokolytisches Mittel | |
| DE69635775T2 (de) | Medikament gegen pulmonale herzprobleme | |
| DE2335729A1 (de) | Vincanolsalze, verfahren zu deren herstellung und diese verbindungen als wirkstoffe enthaltende pharmazeutische zubereitungen | |
| DE1467999A1 (de) | Mittel zur Behandlung der Tuberkulose und Verfahren zu seiner Herstellung | |
| DE2163054A1 (de) | Lokalanaesthetisches mittel | |
| DE2314387C3 (de) | Arzneimittel zur Behandlung bösartiger Neubildungen | |
| DE1792448C3 (de) | Verfahren zur Herstellung von zur parenteralen Verabreichung geeigneten stabilen Lösungen von therapeutisch anwendbaren Benzodiazepinderivaten | |
| DE2556001C3 (de) | Spritzfertige injizierbare Lösungen mit einem Gehalt an Alkalicanrenoat | |
| DE2145359A1 (de) | Neue Phthalazindenvate | |
| DD291924A5 (de) | Verfahren zur herstellung einer waessrigen loesung eines pentamidinsalzes | |
| DE69228235T2 (de) | Verwendung eines Mittels zur Herstellung eines Arzneimittels zur Behandlung von Lebererkrankung | |
| DE69914937T2 (de) | Betablocker und carbopol enthaltende ophtalmische zusammensetzung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SH | Request for examination between 03.10.1968 and 22.04.1971 |