DE1283438B - Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Fuechsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose - Google Patents
Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Fuechsen gegen Staupe, Hepatitis contagiosa canis und LeptospiroseInfo
- Publication number
- DE1283438B DE1283438B DEB68006A DEB0068006A DE1283438B DE 1283438 B DE1283438 B DE 1283438B DE B68006 A DEB68006 A DE B68006A DE B0068006 A DEB0068006 A DE B0068006A DE 1283438 B DE1283438 B DE 1283438B
- Authority
- DE
- Germany
- Prior art keywords
- vaccine
- distemper
- virus
- vnd
- dogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title claims description 52
- 208000000655 Distemper Diseases 0.000 title claims description 47
- 241000282472 Canis lupus familiaris Species 0.000 title claims description 33
- 208000006454 hepatitis Diseases 0.000 title claims description 25
- 231100000283 hepatitis Toxicity 0.000 title claims description 24
- 241000282465 Canis Species 0.000 title claims description 23
- 206010024238 Leptospirosis Diseases 0.000 title claims description 18
- 230000003053 immunization Effects 0.000 title claims description 9
- 238000002649 immunization Methods 0.000 title claims description 9
- 241000282421 Canidae Species 0.000 title claims description 8
- 238000000034 method Methods 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 241000700605 Viruses Species 0.000 claims description 45
- 239000000725 suspension Substances 0.000 claims description 23
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 18
- 241000589902 Leptospira Species 0.000 claims description 15
- 238000007710 freezing Methods 0.000 claims description 9
- 230000008014 freezing Effects 0.000 claims description 9
- 241000724565 Chorella virus Species 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 208000028207 Weil disease Diseases 0.000 claims description 3
- 208000010772 Dog disease Diseases 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 238000012360 testing method Methods 0.000 description 26
- 238000002255 vaccination Methods 0.000 description 17
- 241001550390 Leptospira interrogans serovar Canicola Species 0.000 description 15
- 241000699673 Mesocricetus auratus Species 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 241000700198 Cavia Species 0.000 description 6
- 239000000910 agglutinin Substances 0.000 description 6
- 208000027744 congestion Diseases 0.000 description 6
- 230000003472 neutralizing effect Effects 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 4
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 4
- 230000010530 Virus Neutralization Effects 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 2
- 150000008043 acidic salts Chemical class 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 238000011888 autopsy Methods 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 229940001442 combination vaccine Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 241000712083 Canine morbillivirus Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000005084 renal tissue Anatomy 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/175—Canine distemper virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL295135D NL295135A (en:Method) | 1962-07-12 | ||
| DEB68006A DE1283438B (de) | 1962-07-12 | 1962-07-12 | Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Fuechsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose |
| LU43999D LU43999A1 (en:Method) | 1962-07-12 | 1963-07-03 | |
| NL295135A NL145902B (nl) | 1962-07-12 | 1963-07-10 | Werkwijze voor het bereiden van een combinatie-vaccin. |
| AT553063A AT243987B (de) | 1962-07-12 | 1963-07-10 | Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Füchsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose |
| CH858063A CH397957A (de) | 1958-07-31 | 1963-07-10 | Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Füchsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose (Stuttgarter Hundeseuche und Weil'sche Krankheit) |
| SE773363A SE308574B (en:Method) | 1962-07-12 | 1963-07-11 | |
| FI137763A FI40561B (en:Method) | 1962-07-12 | 1963-07-11 | |
| GB2760463A GB1008078A (en) | 1962-07-12 | 1963-07-11 | Composite vaccine for dogs or foxes, and a process for its manufacture |
| CA879884A CA937864A (en) | 1962-07-12 | 1963-07-11 | Polyvalent canine vaccine preparation |
| US647923A US3470294A (en) | 1961-06-21 | 1967-06-22 | Vaccine for immunization of dogs and foxes against distemper,hepatitis contagiosa and leptospirosis and process for preparing it |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB68006A DE1283438B (de) | 1962-07-12 | 1962-07-12 | Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Fuechsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1283438B true DE1283438B (de) | 1968-11-21 |
Family
ID=6975728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEB68006A Pending DE1283438B (de) | 1958-07-31 | 1962-07-12 | Verfahren zur Herstellung eines Impfstoffes zur gleichzeitigen Immunisierung von Hunden oder Fuechsen gegen Staupe, Hepatitis contagiosa canis und Leptospirose |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT243987B (en:Method) |
| CA (1) | CA937864A (en:Method) |
| DE (1) | DE1283438B (en:Method) |
| FI (1) | FI40561B (en:Method) |
| GB (1) | GB1008078A (en:Method) |
| LU (1) | LU43999A1 (en:Method) |
| NL (2) | NL145902B (en:Method) |
| SE (1) | SE308574B (en:Method) |
-
0
- NL NL295135D patent/NL295135A/xx unknown
-
1962
- 1962-07-12 DE DEB68006A patent/DE1283438B/de active Pending
-
1963
- 1963-07-03 LU LU43999D patent/LU43999A1/xx unknown
- 1963-07-10 NL NL295135A patent/NL145902B/xx not_active IP Right Cessation
- 1963-07-10 AT AT553063A patent/AT243987B/de active
- 1963-07-11 GB GB2760463A patent/GB1008078A/en not_active Expired
- 1963-07-11 SE SE773363A patent/SE308574B/xx unknown
- 1963-07-11 FI FI137763A patent/FI40561B/fi active
- 1963-07-11 CA CA879884A patent/CA937864A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA937864A (en) | 1973-12-04 |
| LU43999A1 (en:Method) | 1963-09-03 |
| NL295135A (en:Method) | |
| FI40561B (en:Method) | 1968-11-30 |
| GB1008078A (en) | 1965-10-27 |
| AT243987B (de) | 1965-12-10 |
| NL145902B (nl) | 1975-05-15 |
| SE308574B (en:Method) | 1969-02-17 |
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