DE112005001781B4 - Verfahren und Vorrichtung zum Messen eines zeitveränderlichen, durch einen Ionenkanal fließenden Stroms mit einer kapazitiven Messelektrode - Google Patents

Verfahren und Vorrichtung zum Messen eines zeitveränderlichen, durch einen Ionenkanal fließenden Stroms mit einer kapazitiven Messelektrode Download PDF

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Publication number
DE112005001781B4
DE112005001781B4 DE112005001781.8T DE112005001781T DE112005001781B4 DE 112005001781 B4 DE112005001781 B4 DE 112005001781B4 DE 112005001781 T DE112005001781 T DE 112005001781T DE 112005001781 B4 DE112005001781 B4 DE 112005001781B4
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channel
membrane
voltage
electrode
measuring
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Expired - Lifetime
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DE112005001781.8T
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DE112005001781T5 (de
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Andrew D. Hibbs
Regina E. Dugan
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Electronic Biosciences Inc
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Electronic Biosciences Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R19/00—Arrangements for measuring currents or voltages or for indicating presence or sign thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R27/00—Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom
    • G01R27/02—Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
    • G01R27/26—Measuring inductance or capacitance; Measuring quality factor, e.g. by using the resonance method; Measuring loss factor; Measuring dielectric constants ; Measuring impedance or related variables
    • G01R27/2605—Measuring capacitance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DE112005001781.8T 2004-07-23 2005-07-22 Verfahren und Vorrichtung zum Messen eines zeitveränderlichen, durch einen Ionenkanal fließenden Stroms mit einer kapazitiven Messelektrode Expired - Lifetime DE112005001781B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59035104P 2004-07-23 2004-07-23
US60/590,351 2004-07-23
PCT/US2005/026181 WO2006012571A1 (en) 2004-07-23 2005-07-22 Method and apparatus for sensing a time varying current passing through an ion channel

Publications (2)

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DE112005001781T5 DE112005001781T5 (de) 2007-05-31
DE112005001781B4 true DE112005001781B4 (de) 2017-12-14

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DE112005001781.8T Expired - Lifetime DE112005001781B4 (de) 2004-07-23 2005-07-22 Verfahren und Vorrichtung zum Messen eines zeitveränderlichen, durch einen Ionenkanal fließenden Stroms mit einer kapazitiven Messelektrode

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US (1) US7622934B2 (https=)
JP (1) JP4897681B2 (https=)
DE (1) DE112005001781B4 (https=)
GB (1) GB2431013B (https=)
WO (1) WO2006012571A1 (https=)

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Also Published As

Publication number Publication date
US20080094076A1 (en) 2008-04-24
GB2431013B (en) 2008-05-21
JP4897681B2 (ja) 2012-03-14
JP2008507703A (ja) 2008-03-13
GB0700995D0 (en) 2007-02-28
WO2006012571A1 (en) 2006-02-02
GB2431013A (en) 2007-04-11
US7622934B2 (en) 2009-11-24
DE112005001781T5 (de) 2007-05-31

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