DE112005000128B4 - Probeninjektionssystem für die Flüssigkeitschromatographie - Google Patents

Probeninjektionssystem für die Flüssigkeitschromatographie Download PDF

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Publication number
DE112005000128B4
DE112005000128B4 DE112005000128.8T DE112005000128T DE112005000128B4 DE 112005000128 B4 DE112005000128 B4 DE 112005000128B4 DE 112005000128 T DE112005000128 T DE 112005000128T DE 112005000128 B4 DE112005000128 B4 DE 112005000128B4
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DE
Germany
Prior art keywords
fluid
chamber
valve means
output
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE112005000128.8T
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German (de)
English (en)
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DE112005000128T5 (de
Inventor
Geoff C. Gerhardt
James W. Jorgenson
Keith Fadgen
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Waters Technologies Corp
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Waters Technologies Corp
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Publication of DE112005000128T5 publication Critical patent/DE112005000128T5/de
Application granted granted Critical
Publication of DE112005000128B4 publication Critical patent/DE112005000128B4/de
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Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/20—Injection using a sampling valve
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N30/22—Injection in high pressure liquid systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/385—Flow patterns flow switching in a single column by switching valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

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  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Fluid Mechanics (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
DE112005000128.8T 2004-01-23 2005-01-18 Probeninjektionssystem für die Flüssigkeitschromatographie Expired - Lifetime DE112005000128B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53868304P 2004-01-23 2004-01-23
US60/538,683 2004-01-23
PCT/US2005/002401 WO2005071396A1 (en) 2004-01-23 2005-01-18 A sample injector system for liquid chromatography

Publications (2)

Publication Number Publication Date
DE112005000128T5 DE112005000128T5 (de) 2007-05-03
DE112005000128B4 true DE112005000128B4 (de) 2024-12-19

Family

ID=34807210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE112005000128.8T Expired - Lifetime DE112005000128B4 (de) 2004-01-23 2005-01-18 Probeninjektionssystem für die Flüssigkeitschromatographie

Country Status (5)

Country Link
US (1) US8173070B2 (enExample)
JP (1) JP4782701B2 (enExample)
DE (1) DE112005000128B4 (enExample)
GB (2) GB2426216B (enExample)
WO (1) WO2005071396A1 (enExample)

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Publication number Priority date Publication date Assignee Title
DE102008006266B4 (de) 2008-01-25 2011-06-09 Dionex Softron Gmbh Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie
US20100224543A1 (en) 2009-03-05 2010-09-09 Ellis Scott J Connection assembly for ultra high pressure liquid chromatography
US9151734B2 (en) * 2009-03-05 2015-10-06 Idex Health & Science Llc Connection assembly for ultra high pressure liquid chromatography
US9435773B2 (en) 2009-06-03 2016-09-06 Agilent Technologies, Inc. Sample injector with metering device balancing pressure differences in an intermediate valve state
EP2445602A4 (en) * 2009-06-26 2013-11-13 Waters Technologies Corp CHROMATOGRAPHY DEVICE WITH INTEGRATED CORE
US8541493B2 (en) * 2010-02-19 2013-09-24 Arch Chemicals, Inc. Synthesis of zinc acrylate copolymer from acid functional copolymer, zinc pyrithione, and copper compound
US9824876B2 (en) * 2010-02-26 2017-11-21 Perkinelmer Health Sciences, Inc. Fluid chromatography injectors and injector inserts
US8951471B2 (en) * 2010-02-26 2015-02-10 Perkinelmer Health Sciences, Inc. Jet assembly for use in detectors and other devices
US9056264B2 (en) 2010-07-16 2015-06-16 Idex Health & Science Llc Biocompatible tubing for liquid chromatography systems
US8569070B2 (en) 2010-07-16 2013-10-29 Idex Health & Science Llc Connection assembly for ultra high pressure liquid chromatography
US9188569B2 (en) 2011-03-01 2015-11-17 Idex Health & Science Llc High pressure fitting with self-releasing ferrule
US8931808B2 (en) 2011-03-01 2015-01-13 Idex Health & Science Llc High pressure fitting with self-releasing ferrule
EP2626697B1 (en) 2012-02-07 2018-10-31 King Saud University Liquid chromatography device
US9791080B2 (en) 2012-03-12 2017-10-17 Idex Health & Science Llc Microfluidic interconnect
US20140123819A1 (en) 2012-11-06 2014-05-08 Idex Health & Science Llc Torque Limiting Tool and Methods
TWI579553B (zh) 2013-11-24 2017-04-21 中央研究院 以紫外光－可見光檢測之高效能液相層析設備及方法
WO2015160840A1 (en) * 2014-04-16 2015-10-22 Idex Health & Science Llc High pressure fluidic connection assemblies
WO2015179430A1 (en) 2014-05-20 2015-11-26 Idex Health & Science Llc Frits for chromatography
EP3828455A1 (en) 2014-10-23 2021-06-02 Idex Health & Science LLC Face-sealing fluidic connection system
US10012620B1 (en) 2015-04-07 2018-07-03 Sielc Technologies Corporation Chromatography sample introduction device
US10371672B1 (en) 2015-04-15 2019-08-06 Yury Zelechonok Integrated chromatography column injector detector device
DE202016100451U1 (de) 2015-06-25 2016-02-16 Dionex Softron Gmbh Probengeber für die Flüssigkeitschromatographie, insbesondere für die Hochleistungsflüssigkeitschromatographie
US11054054B2 (en) 2016-12-09 2021-07-06 Idex Health & Science Llc High pressure valve with multi-piece stator assembly
US10520477B2 (en) 2016-12-09 2019-12-31 Idex Health & Science Llc High pressure valve with multi-piece stator assembly
US10384151B2 (en) 2016-12-09 2019-08-20 Idex Health & Science Llc High pressure valve with two-piece stator assembly
EP3561504B1 (en) 2018-04-25 2023-01-04 Idex Health & Science LLC High pressure valve with multi-piece stator assembly
US11085904B2 (en) 2018-09-28 2021-08-10 Idex Health And Science Llc Column having a compression-limited assembly

Citations (6)

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US328910A (en) 1885-10-20 Corn and cane harvester
DE4447333A1 (de) * 1994-12-31 1996-07-04 Bayer Ernst Prof Dr Gradienten - Injektions - Modul für Kapillar-HPLC, Kapillarelektrophorese und Elektrochromatographie
US5672810A (en) 1995-07-18 1997-09-30 Shimadzu Corporation Gas chromatograph apparatus for a liquid sample containing a solvent
US5795788A (en) * 1993-06-05 1998-08-18 Glaxo Group Limited Liquid flow management means
US6557575B1 (en) 2001-11-19 2003-05-06 Waters Investments Limited Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices
WO2004025153A2 (en) * 2002-09-16 2004-03-25 Waters Investments Limited Freeze-thaw valve limiting cryogenic usage

Family Cites Families (7)

* Cited by examiner, † Cited by third party
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US3186234A (en) * 1961-09-12 1965-06-01 Beckman Instruments Inc Sampling valve
US3621263A (en) * 1970-04-13 1971-11-16 Warren E Gilson Volumetric fraction supply apparatus
EP0327658B1 (en) * 1988-02-11 1991-10-23 Hewlett-Packard GmbH Sample injector for a liquid chromatograph
DE69832488T2 (de) * 1998-05-25 2006-06-01 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Probeninjektionsvorrichtung für ein Hochleistungs-Flüssigkeitschromatograph
US6387234B1 (en) * 1998-08-31 2002-05-14 Iowa State University Research Foundation, Inc. Integrated multiplexed capillary electrophoresis system
US6190550B1 (en) * 1999-09-30 2001-02-20 Cohesive Technologies, Inc. Monitoring high performance liquid chromatography
US6290909B1 (en) * 2000-04-13 2001-09-18 Sandia Corporation Sample injector for high pressure liquid chromatography

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US328910A (en) 1885-10-20 Corn and cane harvester
US5795788A (en) * 1993-06-05 1998-08-18 Glaxo Group Limited Liquid flow management means
US6159744A (en) * 1993-06-05 2000-12-12 Glaxo Group Limited Liquid flow management means
DE4447333A1 (de) * 1994-12-31 1996-07-04 Bayer Ernst Prof Dr Gradienten - Injektions - Modul für Kapillar-HPLC, Kapillarelektrophorese und Elektrochromatographie
US5672810A (en) 1995-07-18 1997-09-30 Shimadzu Corporation Gas chromatograph apparatus for a liquid sample containing a solvent
US6557575B1 (en) 2001-11-19 2003-05-06 Waters Investments Limited Fluid flow control freeze/thaw valve for narrow bore capillaries or microfluidic devices
WO2004025153A2 (en) * 2002-09-16 2004-03-25 Waters Investments Limited Freeze-thaw valve limiting cryogenic usage

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIDLINGMEYER, B. A. [et al.]: Improved chromatographic resolution from pres-sure-induced changes in liquid - solid distribution ratios. In: Separation Science, Vol. 4, 1969, No. 6, S. 439-446. - ISSN 0037-2366 *
BIDLINGMEYER, B. A. et al.: Improved chromatographic resolution from pressureinduced changes in liquid - solid distribution ratios. In: Separation Science, Vol. 4, 1969, No. 6, S. 439-446. - ISSN 0037-2366
MACNAIR, John E. ; LEWIS, Kenneth C. ; JORGENSON, James W.: Ultrahigh-pressure reversedphase liquid chromatography in packed capillary columns. In: Analytical Chemistry, Vol. 69, 1997, No. 6, S. 983-989. - ISSN 0003-2700 *
MACNAIR, John E. ; LEWIS, Kenneth C. ; JORGENSON, James W.: Ultrahighpressure reversedphase liquid chromatography in packed capillary columns. In: Analytical Chemistry, Vol. 69, 1997, No. 6, S. 983-989. - ISSN 0003-2700
WU, Naijun ; LIPPERT, J. Andreas ; LEE, Milton L.: Practical aspects of ultrahigh pressure capillary liquid chromatography. In: Journal of Chromatography A, Vol. 911, 2001, No. 1, S. 1-12. - ISSN 0021-9673 *
WU, Naijun ; LIPPERT, J. Andreas; LEE, Milton L.: Practical aspects of ultrahigh pressure capillary liquid chromatography. In: Journal of Chromatography A, Vol. 911, 2001, No. 1, S. 1-12. - ISSN 0021-9673

Also Published As

Publication number Publication date
US20070283746A1 (en) 2007-12-13
GB2426216A (en) 2006-11-22
WO2005071396A1 (en) 2005-08-04
GB2426216B (en) 2010-05-26
JP2007519007A (ja) 2007-07-12
DE112005000128T5 (de) 2007-05-03
GB0615960D0 (en) 2006-09-27
US8173070B2 (en) 2012-05-08
GB0615976D0 (en) 2006-09-20
JP4782701B2 (ja) 2011-09-28

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