DE10312763A1 - Verfahren zur Herstellung einer SLN-Dispersion - Google Patents

Info

Publication number

DE10312763A1

DE10312763A1 DE10312763A DE10312763A DE10312763A1 DE 10312763 A1 DE10312763 A1 DE 10312763A1 DE 10312763 A DE10312763 A DE 10312763A DE 10312763 A DE10312763 A DE 10312763A DE 10312763 A1 DE10312763 A1 DE 10312763A1

Authority

DE

Germany

Prior art keywords

phase

dispersion

active ingredient

aqueous

carrier

Prior art date

2003-03-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• DPMA
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• 238000000034 method Methods 0.000 title claims description 16
• 238000002360 preparation method Methods 0.000 title claims 2
• 239000012071 phase Substances 0.000 claims abstract description 49
• 150000002632 lipids Chemical class 0.000 claims abstract description 35
• 239000004480 active ingredient Substances 0.000 claims abstract description 29
• 239000002245 particle Substances 0.000 claims abstract description 25
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• 238000002156 mixing Methods 0.000 claims abstract description 17
• 239000008346 aqueous phase Substances 0.000 claims abstract description 13
• 239000007787 solid Substances 0.000 claims abstract description 11
• 238000003756 stirring Methods 0.000 claims abstract description 11
• 239000002537 cosmetic Substances 0.000 claims abstract description 10
• 238000000265 homogenisation Methods 0.000 claims abstract description 10
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• 238000002844 melting Methods 0.000 claims abstract description 9
• 230000008018 melting Effects 0.000 claims abstract description 9
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• 235000013305 food Nutrition 0.000 claims abstract description 6
• 230000015572 biosynthetic process Effects 0.000 claims abstract description 4
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• 239000000203 mixture Substances 0.000 claims description 12
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• 230000000694 effects Effects 0.000 claims description 8
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• 150000002191 fatty alcohols Chemical class 0.000 claims description 7
• 150000002170 ethers Chemical class 0.000 claims description 6
• 239000001993 wax Substances 0.000 claims description 5
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• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
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• MOILFCKRQFQVFS-UHFFFAOYSA-N 4,6,6-trimethylbicyclo[3.1.1]heptane-3,4-diol Chemical compound C1C2C(C)(C)C1CC(O)C2(O)C MOILFCKRQFQVFS-UHFFFAOYSA-N 0.000 description 2
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• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
• SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
• 239000005639 Lauric acid Substances 0.000 description 2
• YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
• 235000021355 Stearic acid Nutrition 0.000 description 2
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 2
• 229930003427 Vitamin E Natural products 0.000 description 2
• 229960004150 aciclovir Drugs 0.000 description 2
• MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 2
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• 125000000217 alkyl group Chemical group 0.000 description 2
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
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