EP1605923A2 - Mssn-dispersion und verfahren zu ihrer herstellung - Google Patents

Mssn-dispersion und verfahren zu ihrer herstellung

Info

Publication number
EP1605923A2
EP1605923A2 EP04712492A EP04712492A EP1605923A2 EP 1605923 A2 EP1605923 A2 EP 1605923A2 EP 04712492 A EP04712492 A EP 04712492A EP 04712492 A EP04712492 A EP 04712492A EP 1605923 A2 EP1605923 A2 EP 1605923A2
Authority
EP
European Patent Office
Prior art keywords
phase
nanoparticles
dispersion
active substance
active ingredient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04712492A
Other languages
German (de)
English (en)
French (fr)
Inventor
Gerd Dahms
Holger Seidel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kemira Oyj
Original Assignee
IFAC GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IFAC GmbH and Co KG filed Critical IFAC GmbH and Co KG
Publication of EP1605923A2 publication Critical patent/EP1605923A2/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • EP-B 0 605 497 describes drug carriers made of solid lipid particles (solid lipid nanospheres (SLN)).
  • the production is carried out by high pressure homogenization or high pressure dispersion at pressures from 500 to 1550 bar.
  • a gap homogenizer or a high-speed homogenizer, for example, are used as the high-pressure linearizer.
  • Predispersion is usually carried out using a rotor-stator disperser.
  • the MSSN can be loaded with a wide variety of active ingredients, as explained in more detail below.
  • the maximum achievable degree of loading depends, among other things. from the melting point of the loading substance (active substance). If the active substance has a high solubility in the active substance carrier, high degrees of loading can be achieved.
  • organic dyes are used as active substances or instead of active substances.
  • the invention also relates to a method for producing a multiple dispersion by mixing a dispersion which has been prepared as described above with a further polyol or oil phase.
  • the invention also relates to a correspondingly produced multiple dispersion. Multiple emulsions are described, for example, in DE-A-43 41 113.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP04712492A 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung Withdrawn EP1605923A2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10312763A DE10312763A1 (de) 2003-03-21 2003-03-21 Verfahren zur Herstellung einer SLN-Dispersion
DE10312763 2003-03-21
PCT/EP2004/001589 WO2004082666A2 (de) 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
EP1605923A2 true EP1605923A2 (de) 2005-12-21

Family

ID=32921086

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04712492A Withdrawn EP1605923A2 (de) 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US20060257334A1 (cg-RX-API-DMAC7.html)
EP (1) EP1605923A2 (cg-RX-API-DMAC7.html)
JP (1) JP2006520750A (cg-RX-API-DMAC7.html)
KR (1) KR20050114255A (cg-RX-API-DMAC7.html)
AU (1) AU2004222631B2 (cg-RX-API-DMAC7.html)
CA (1) CA2519697C (cg-RX-API-DMAC7.html)
DE (1) DE10312763A1 (cg-RX-API-DMAC7.html)
WO (1) WO2004082666A2 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
EP3428257B1 (en) 2003-09-29 2023-06-14 Deb IP Limited High alcohol content gel-like and foaming compositions
JP2007516259A (ja) 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
DE102004062775A1 (de) 2004-12-21 2006-06-29 Stockhausen Gmbh Alkoholischer Pumpschaum
CN103417388A (zh) 2005-03-07 2013-12-04 戴博全球保健有限公司 含有有机硅表面活性剂的高醇含量发泡组合物
US8580860B2 (en) * 2007-02-23 2013-11-12 Gojo Industries, Inc. Foamable alcoholic composition
DE102007063133A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Wachs in Wasser Dispersionen aus selbstemulgierenden Gelkonzentraten
DE102007063134A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Öl in Wasser Emulsionen aus selbstemulgierenden Gelkonzentraten
EP2123606A1 (en) * 2008-05-19 2009-11-25 Kemira Pigments Oy Ultrafine titanium dioxide nanoparticles and dispersions thereof
AR080551A1 (es) * 2009-10-05 2012-04-18 Marrone Bio Innovations Derivados que contienen antraquinona como productos agricolas bioquimicos
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
CN102711743A (zh) * 2009-10-22 2012-10-03 Api起源有限责任公司 含有黄酮类的组合物的制备和使用方法
WO2011133996A2 (en) 2010-04-30 2011-11-03 Kemira Oyj Aqueous dispersions for sizing paper
US20110275738A1 (en) * 2010-05-05 2011-11-10 Basf Se Process for producing finely divided suspensions by melt emulsification
EP2823811A1 (en) * 2013-07-09 2015-01-14 OTC GmbH Targeted active release system comprising solid lipid nano-particles
WO2021033482A1 (ja) * 2019-08-19 2021-02-25 Jsr株式会社 分散組成物、分散剤、異方性膜及びその製造方法、並びに異方性膜形成装置
AU2021226149A1 (en) * 2020-02-26 2022-10-06 Capcium Inc. Nanostructure lipid carrier delivery system, composition, and methods

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Publication number Priority date Publication date Assignee Title
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
DE4131562A1 (de) 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5747012A (en) * 1993-06-11 1998-05-05 Tioxide Specialties Limited Compositions containing sunscreens
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
DE4341113B4 (de) * 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stabile multiple X/O/Y-Emulsion
EP0766992B1 (en) * 1995-10-06 2003-07-30 ENITECNOLOGIE S.p.a. Nitrogen oxides reduction catalyst and process for reducing nitrogen oxides in exhaust gas
JP2001019609A (ja) * 1999-07-08 2001-01-23 Pola Chem Ind Inc 多相乳化剤形の皮膚外用剤
JP2002292270A (ja) * 2001-03-30 2002-10-08 Sunstar Inc 多相エマルジョン
JP4182195B2 (ja) * 2001-09-03 2008-11-19 独立行政法人農業・食品産業技術総合研究機構 単分散複合型エマルションの製造装置
EP1628626B2 (de) * 2003-05-07 2013-12-04 OTC GmbH Zusammensetzungen zur gezielten freisetzung von duftstoffen und aromen

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Title
See references of WO2004082666A2 *

Also Published As

Publication number Publication date
WO2004082666A3 (de) 2005-05-12
JP2006520750A (ja) 2006-09-14
US20060257334A1 (en) 2006-11-16
DE10312763A1 (de) 2004-09-30
AU2004222631B2 (en) 2009-02-26
AU2004222631A1 (en) 2004-09-30
CA2519697C (en) 2011-01-18
CA2519697A1 (en) 2004-09-30
WO2004082666A2 (de) 2004-09-30
KR20050114255A (ko) 2005-12-05

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