WO2004082666A3 - Mssn-dispersion und verfahren zu ihrer herstellung - Google Patents

Mssn-dispersion und verfahren zu ihrer herstellung Download PDF

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Publication number
WO2004082666A3
WO2004082666A3 PCT/EP2004/001589 EP2004001589W WO2004082666A3 WO 2004082666 A3 WO2004082666 A3 WO 2004082666A3 EP 2004001589 W EP2004001589 W EP 2004001589W WO 2004082666 A3 WO2004082666 A3 WO 2004082666A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substance
phase
dispersion
substance carrier
emulsifier
Prior art date
Application number
PCT/EP2004/001589
Other languages
English (en)
French (fr)
Other versions
WO2004082666A2 (de
Inventor
Gerd Dahms
Holger Seidel
Original Assignee
Ifac Gmbh & Co Kg
Gerd Dahms
Holger Seidel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ifac Gmbh & Co Kg, Gerd Dahms, Holger Seidel filed Critical Ifac Gmbh & Co Kg
Priority to JP2006500036A priority Critical patent/JP2006520750A/ja
Priority to AU2004222631A priority patent/AU2004222631B2/en
Priority to CA2519697A priority patent/CA2519697C/en
Priority to US10/550,193 priority patent/US20060257334A1/en
Priority to EP04712492A priority patent/EP1605923A2/de
Publication of WO2004082666A2 publication Critical patent/WO2004082666A2/de
Publication of WO2004082666A3 publication Critical patent/WO2004082666A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Membran-strukturierte Solid-Nanoparticles mit einem mittleren Teilchendurchmesser im Bereich von 10 bis 10.000 nm, die bei 25 °C fest sind und eine Kombination aus Wirk­stoffträgerteilchen und Emulgatoren derart aufweisen, dass Membranen gebildet werden, die die gesamten Nanoparticles durchdringen, so dass im Inneren und an der Oberfläche der Nanoparticles Emulgatoren vorliegen, werden beschrieben. Die Herstellung einer wässrigen Stoffträger-Dispersion, in der feste Wirkstoffträgerteil­chen auf Wachs-, Polymer- oder Lipidbasis mit einem mittleren Durchmesser im Bereich von 10 bis 10000 nm vorliegen, die mindestens einen pharmazeutischen, kosmetischen und/oder lebensmitteltechnologischen Wirkstoff enthalten, erfolgt durch a)Vermischen des Wirkstoffs mit dem Wirkstoffträger auf Wachs-, Polymer­- oder Lipidbasis und mindestens einem Emulgator, der in Stufe b) zur Aus­bildung einer lyotropen flüssigkristallinen Mischphase führt, bei einer Tem­peratur oberhalb des Schmelz- oder Erweichungspunktes des Wirkstoffträ­gers, zur Ausbildung einer Phase B; b) mechanisches Vermischen der Phase B mit einer wässrigen Phase A, die ei­nen Emulgator enthalten kann, bei einer Temperatur oberhalb des Schmelz- ­oder Erweichungspunktes des Wirkstoffträgers, wobei das Gewichtsverhält­nis von Phase B zu Phase A 1 : 5 bis 5 : 1 beträgt, ohne Hochdruckhomoge­nisierung, zur Ausbildung einer lyotropen flüssigkristallinen Mischphase; c) Verdünnen der Mischphase mit einer wässrigen Phase, die einen Emulgator enthalten kann, bei einer Temperatur der wässrigen Phase, die unter dem Schmelz- oder Erweichungspunkt des Wirkstoffträgers liegt, unter Rühren und ohne Hochdruckhomogenisierung, auf eine gewünschte Endkonzentra­tion der Dispersion.
PCT/EP2004/001589 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung WO2004082666A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2006500036A JP2006520750A (ja) 2003-03-21 2004-02-19 Ｍｓｓｎ分散およびその作製方法
AU2004222631A AU2004222631B2 (en) 2003-03-21 2004-02-19 MSSN dispersion and method for producing the same
CA2519697A CA2519697C (en) 2003-03-21 2004-02-19 Mssn dispersion and method for producing the same
US10/550,193 US20060257334A1 (en) 2003-03-21 2004-02-19 Mssn dispersion and method for producing the same
EP04712492A EP1605923A2 (de) 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10312763.1 2003-03-21
DE10312763A DE10312763A1 (de) 2003-03-21 2003-03-21 Verfahren zur Herstellung einer SLN-Dispersion

Publications (2)

Publication Number Publication Date
WO2004082666A2 WO2004082666A2 (de) 2004-09-30
WO2004082666A3 true WO2004082666A3 (de) 2005-05-12

Family

ID=32921086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001589 WO2004082666A2 (de) 2003-03-21 2004-02-19 Mssn-dispersion und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (1) US20060257334A1 (de)
EP (1) EP1605923A2 (de)
JP (1) JP2006520750A (de)
KR (1) KR20050114255A (de)
AU (1) AU2004222631B2 (de)
CA (1) CA2519697C (de)
DE (1) DE10312763A1 (de)
WO (1) WO2004082666A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200600666A1 (ru) 2003-09-29 2006-10-27 Этена Хелткеа Инк. Гелеобразные и пенистые композиции с высоким содержанием спирта
JP2007516259A (ja) * 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
DE102004062775A1 (de) 2004-12-21 2006-06-29 Stockhausen Gmbh Alkoholischer Pumpschaum
EP3292757A1 (de) 2005-03-07 2018-03-14 Deb IP Limited Schäumungszusammensetzungen mit hohem alkoholgehalt mit silikonbasierten tensiden
US8580860B2 (en) * 2007-02-23 2013-11-12 Gojo Industries, Inc. Foamable alcoholic composition
DE102007063134A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Öl in Wasser Emulsionen aus selbstemulgierenden Gelkonzentraten
DE102007063133A1 (de) * 2007-12-24 2009-06-25 Sasol Germany Gmbh Verfahren zur Herstellung von Wachs in Wasser Dispersionen aus selbstemulgierenden Gelkonzentraten
EP2123606A1 (de) * 2008-05-19 2009-11-25 Kemira Pigments Oy Ultrafeine Titaniumdioxid-Nanopartikel und Dispersionen davon
AR080551A1 (es) * 2009-10-05 2012-04-18 Marrone Bio Innovations Derivados que contienen antraquinona como productos agricolas bioquimicos
US8637569B2 (en) 2009-10-22 2014-01-28 Api Genesis, Llc Methods of increasing solubility of poorly soluble compounds and methods of making and using formulations of such compounds
BR112012011336A2 (pt) 2009-10-22 2018-10-16 Api Genesis Llc Composições compreendendo flavonoides, seu método de preparação, adesivo para aplicação de flavonoide, métodos de produção de flavonoide hidratado,métodos de preparação de formulação tópica, e uso de flavonoide
WO2011133996A2 (en) 2010-04-30 2011-11-03 Kemira Oyj Aqueous dispersions for sizing paper
US20110275738A1 (en) * 2010-05-05 2011-11-10 Basf Se Process for producing finely divided suspensions by melt emulsification
EP2823811A1 (de) * 2013-07-09 2015-01-14 OTC GmbH Gerichtetes aktives Freisetzungssystem mit festen Lipidnanopartikeln
JPWO2021033482A1 (de) * 2019-08-19 2021-02-25
AU2021226149A1 (en) * 2020-02-26 2022-10-06 Capcium Inc. Nanostructure lipid carrier delivery system, composition, and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880634A (en) * 1984-06-08 1989-11-14 Dr. Rentschler Arzneimittel Gmbh & Co. Lipid nano-pellets as excipient system for perorally administered drugs
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
DE4131562A1 (de) 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
CA2091152C (en) * 1993-03-05 2005-05-03 Kirsten Westesen Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
US5747012A (en) * 1993-06-11 1998-05-05 Tioxide Specialties Limited Compositions containing sunscreens
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
DE4341113B4 (de) * 1993-12-02 2006-04-13 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Stabile multiple X/O/Y-Emulsion
ATE246032T1 (de) * 1995-10-06 2003-08-15 Enitecnologie Spa Katalysator und verfahren zur entfernung von stickstoffoxiden in abgas
JP2001019609A (ja) * 1999-07-08 2001-01-23 Pola Chem Ind Inc 多相乳化剤形の皮膚外用剤
JP2002292270A (ja) * 2001-03-30 2002-10-08 Sunstar Inc 多相エマルジョン
JP4182195B2 (ja) * 2001-09-03 2008-11-19 独立行政法人農業・食品産業技術総合研究機構 単分散複合型エマルションの製造装置
CA2524589A1 (en) * 2003-05-07 2004-11-18 Ifac Gmbh & Co. Kg Compositions for the targetted release of fragrances and aromas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880634A (en) * 1984-06-08 1989-11-14 Dr. Rentschler Arzneimittel Gmbh & Co. Lipid nano-pellets as excipient system for perorally administered drugs
US5188837A (en) * 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances

Also Published As

Publication number Publication date
CA2519697C (en) 2011-01-18
EP1605923A2 (de) 2005-12-21
AU2004222631A1 (en) 2004-09-30
US20060257334A1 (en) 2006-11-16
JP2006520750A (ja) 2006-09-14
AU2004222631B2 (en) 2009-02-26
KR20050114255A (ko) 2005-12-05
DE10312763A1 (de) 2004-09-30
WO2004082666A2 (de) 2004-09-30
CA2519697A1 (en) 2004-09-30

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