DE10235624A1 - Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben - Google Patents

Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben Download PDF

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Publication number
DE10235624A1
DE10235624A1 DE10235624A DE10235624A DE10235624A1 DE 10235624 A1 DE10235624 A1 DE 10235624A1 DE 10235624 A DE10235624 A DE 10235624A DE 10235624 A DE10235624 A DE 10235624A DE 10235624 A1 DE10235624 A1 DE 10235624A1
Authority
DE
Germany
Prior art keywords
compound
formula
alkyl
alkenyl
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10235624A
Other languages
German (de)
English (en)
Inventor
Claudia Dr. Eder
Herbert Dr. Kogler
Sabine Dr. Haag-Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE10235624A priority Critical patent/DE10235624A1/de
Priority to EP03784025A priority patent/EP1529040B1/de
Priority to BR0313199-8A priority patent/BR0313199A/pt
Priority to AU2003250099A priority patent/AU2003250099B2/en
Priority to ES03784025T priority patent/ES2254980T3/es
Priority to MXPA05000387A priority patent/MXPA05000387A/es
Priority to AT03784025T priority patent/ATE314359T1/de
Priority to PCT/EP2003/007821 priority patent/WO2004014888A1/de
Priority to CA2493483A priority patent/CA2493483C/en
Priority to DE50302084T priority patent/DE50302084D1/de
Priority to DK03784025T priority patent/DK1529040T3/da
Priority to JP2004526742A priority patent/JP4598523B2/ja
Priority to US10/627,850 priority patent/US7019028B2/en
Publication of DE10235624A1 publication Critical patent/DE10235624A1/de
Priority to IL166439A priority patent/IL166439A/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE10235624A 2002-08-02 2002-08-02 Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben Withdrawn DE10235624A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE10235624A DE10235624A1 (de) 2002-08-02 2002-08-02 Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
PCT/EP2003/007821 WO2004014888A1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma
CA2493483A CA2493483C (en) 2002-08-02 2003-07-18 Endiandric acid h as c-maf inhibitors derivatives for use against asthma
AU2003250099A AU2003250099B2 (en) 2002-08-02 2003-07-18 Endiandric acid H derivatives as c-maf inhibitors for using against asthma
ES03784025T ES2254980T3 (es) 2002-08-02 2003-07-18 Derivados de acido endiandrico h como inhibidores de c-maf para uso contra el asma.
MXPA05000387A MXPA05000387A (es) 2002-08-02 2003-07-18 El acido endiandrico h como derivados inhibidores de c-maf para su uso contra el asma.
AT03784025T ATE314359T1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma
EP03784025A EP1529040B1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma
BR0313199-8A BR0313199A (pt) 2002-08-02 2003-07-18 Derivados h de ácido endiândrico como inibidores de c-maf para o emprego contra asma
DE50302084T DE50302084D1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma
DK03784025T DK1529040T3 (da) 2002-08-02 2003-07-18 Endiandric acid H-derivater som c-maf-inhibitorer til anvendelse mod astma
JP2004526742A JP4598523B2 (ja) 2002-08-02 2003-07-18 喘息に使用するｃ−ｍａｆ阻害剤としてのエンジアンドリック酸ｈ誘導体
US10/627,850 US7019028B2 (en) 2002-08-02 2003-07-25 Endiandric acid H and its derivatives, process for their preparation and use thereof
IL166439A IL166439A (en) 2002-08-02 2005-01-23 Endiandric acid h derivatives as c-maf inhibitors for using against asthma, their preparation and pharmaceutical compositions comprising them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10235624A DE10235624A1 (de) 2002-08-02 2002-08-02 Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben

Publications (1)

Publication Number Publication Date
DE10235624A1 true DE10235624A1 (de) 2004-02-19

Family

ID=30469404

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10235624A Withdrawn DE10235624A1 (de) 2002-08-02 2002-08-02 Endiandric acid H und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
DE50302084T Expired - Lifetime DE50302084D1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50302084T Expired - Lifetime DE50302084D1 (de) 2002-08-02 2003-07-18 Endiandric acid h derivate als c-maf inhibitoren zur verwendung gegen asthma

Country Status (13)

Country Link
US (1) US7019028B2 (https=)
EP (1) EP1529040B1 (https=)
JP (1) JP4598523B2 (https=)
AT (1) ATE314359T1 (https=)
AU (1) AU2003250099B2 (https=)
BR (1) BR0313199A (https=)
CA (1) CA2493483C (https=)
DE (2) DE10235624A1 (https=)
DK (1) DK1529040T3 (https=)
ES (1) ES2254980T3 (https=)
IL (1) IL166439A (https=)
MX (1) MXPA05000387A (https=)
WO (1) WO2004014888A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1944361A1 (en) 2007-01-11 2008-07-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for expanding monocytes
CN108192972B (zh) 2010-10-06 2022-09-09 生物医学研究机构基金会 用于乳腺癌转移的诊断、预后和治疗的方法
EP2650682A1 (en) 2012-04-09 2013-10-16 Fundació Privada Institut de Recerca Biomèdica Method for the prognosis and treatment of cancer metastasis
BR112014030750A2 (pt) 2012-06-06 2017-08-22 Inst Catalana Recerca Estudis Avancats Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar
US10119171B2 (en) 2012-10-12 2018-11-06 Inbiomotion S.L. Method for the diagnosis, prognosis and treatment of prostate cancer metastasis
ES2906586T3 (es) 2012-10-12 2022-04-19 Inbiomotion Sl Método para el diagnóstico, pronóstico y tratamiento de metástasis de cáncer de próstata
WO2015019125A1 (en) * 2013-08-05 2015-02-12 Societe De Developpement Et De Recherche Industrielle Molecular targets for the treatment of wounds, in particular chronic wounds
US11596642B2 (en) 2016-05-25 2023-03-07 Inbiomotion S.L. Therapeutic treatment of breast cancer based on c-MAF status
KR20200104298A (ko) 2017-11-22 2020-09-03 인바이오모션 에스.엘. c-MAF 상태에 기반한 유방암의 요법 치료

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BANDARANAYAKE,Wickramasinge,M.,et.al.:Endiandric Acid, a Novel Carboxylic Acid from Endiandra introsorsa (Lauraceae):X-Ray Structure Determination. In:J.C.S. Chem. Comm.,1980,4,S.162-163 *
BANDARANAYAKE,Wickramasinge,M.,et.al.:Endiandric Acid, a Novel Carboxylic Acid from Endiandra introsorsa (Lauraceae):X-Ray Structure Determination. In:J.C.S. Chem. Comm.,1980,4,S.162-163;
BANFIELD,J.E.,et.al.:Constituents of Some Species of Beilschmiedia and Endiandra (Lauraceae):New Endiandric Acid and Benzopyran Derivatives Isolated from B. oligandra. In:Aust. J. Chem.1994,47,S.587-607 *
BANFIELD,J.E.,et.al.:Constituents of Some Species of Beilschmiedia and Endiandra (Lauraceae):New Endiandric Acid and Benzopyran Derivatives Isolated from B. oligandra. In:Aust. J. Chem.1994,47,S.587-607;
Constituents of Endiandra Species.IV Isolation of 2- (8C-((E,E)-5"-Phenylpenta-2",4"-dien1"-yl)bicyclo (4,2,0)octa-2C,4C-dien-7C-yl)acetic Acid, a Biogenetically Predicted Metabolite of Endiandra introrsa (Lauraceae)and its Structure Determination by Means of 1D and 2D N.M.R. Spectroscopy.In:Aust.J.Chem.,1982,35,S.2247-56 *
Constituents of Endiandra Species.IV Isolation of 2- (8Č-((E,E)-5"-Phenylpenta-2",4"-dien1"-yl)bicyclo (4,2,0)octa-2Č,4Č-dien-7Č-yl)acetic Acid, a Biogenetically Predicted Metabolite of Endiandra introrsa (Lauraceae)and its Structure Determination by Means of 1D and 2D N.M.R. Spectroscopy.In:Aust.J.Chem.,1982,35,S.2247-56;

Also Published As

Publication number Publication date
BR0313199A (pt) 2005-06-21
IL166439A (en) 2009-12-24
MXPA05000387A (es) 2005-03-23
IL166439A0 (en) 2006-01-15
US7019028B2 (en) 2006-03-28
DE50302084D1 (de) 2006-02-02
EP1529040B1 (de) 2005-12-28
AU2003250099B2 (en) 2008-12-18
JP2006503006A (ja) 2006-01-26
ES2254980T3 (es) 2006-06-16
ATE314359T1 (de) 2006-01-15
DK1529040T3 (da) 2006-05-08
CA2493483A1 (en) 2004-02-19
US20040138313A1 (en) 2004-07-15
AU2003250099A1 (en) 2004-02-25
CA2493483C (en) 2011-09-20
JP4598523B2 (ja) 2010-12-15
EP1529040A1 (de) 2005-05-11
WO2004014888A1 (de) 2004-02-19

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Legal Events

Date Code Title Description
OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8127 New person/name/address of the applicant

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

8130 Withdrawal