DE102014008243A1 - Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür - Google Patents

Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür Download PDF

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Publication number
DE102014008243A1
DE102014008243A1 DE102014008243.1A DE102014008243A DE102014008243A1 DE 102014008243 A1 DE102014008243 A1 DE 102014008243A1 DE 102014008243 A DE102014008243 A DE 102014008243A DE 102014008243 A1 DE102014008243 A1 DE 102014008243A1
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DE
Germany
Prior art keywords
filter
observation
wavelength
value
illumination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE102014008243.1A
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German (de)
English (en)
Inventor
Christoph Hauger
Roland Guckler
Marco Wilzbach
Helge Jess
Selamawit Getachew Kelemu
Holger Matz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss Meditec AG
Original Assignee
Carl Zeiss Meditec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Zeiss Meditec AG filed Critical Carl Zeiss Meditec AG
Priority to DE102014008243.1A priority Critical patent/DE102014008243A1/de
Priority to JP2015106256A priority patent/JP6716201B2/ja
Priority to CN201510403893.9A priority patent/CN105136753B/zh
Priority to EP15001596.4A priority patent/EP2950129B1/en
Priority to ES15001596T priority patent/ES2836899T3/es
Priority to US14/722,265 priority patent/US9958392B2/en
Publication of DE102014008243A1 publication Critical patent/DE102014008243A1/de
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/208—Filters for use with infrared or ultraviolet radiation, e.g. for separating visible light from infrared and/or ultraviolet radiation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/22—Absorbing filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Optical Filters (AREA)
  • Endoscopes (AREA)
DE102014008243.1A 2014-05-27 2014-05-27 Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür Ceased DE102014008243A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE102014008243.1A DE102014008243A1 (de) 2014-05-27 2014-05-27 Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür
JP2015106256A JP6716201B2 (ja) 2014-05-27 2015-05-26 光学フィルタシステム、蛍光観察システムおよび蛍光観察を実行する方法
CN201510403893.9A CN105136753B (zh) 2014-05-27 2015-05-27 滤光系统、荧光观测系统和执行荧光观测的方法
EP15001596.4A EP2950129B1 (en) 2014-05-27 2015-05-27 Optical filter system and fluorescence observation system
ES15001596T ES2836899T3 (es) 2014-05-27 2015-05-27 Sistema de filtro óptico y sistema de observación de fluorescencia
US14/722,265 US9958392B2 (en) 2014-05-27 2015-05-27 Optical filter system and fluorescence observation system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102014008243.1A DE102014008243A1 (de) 2014-05-27 2014-05-27 Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür

Publications (1)

Publication Number Publication Date
DE102014008243A1 true DE102014008243A1 (de) 2015-12-03

Family

ID=53489754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102014008243.1A Ceased DE102014008243A1 (de) 2014-05-27 2014-05-27 Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür

Country Status (6)

Country Link
US (1) US9958392B2 (enExample)
EP (1) EP2950129B1 (enExample)
JP (1) JP6716201B2 (enExample)
CN (1) CN105136753B (enExample)
DE (1) DE102014008243A1 (enExample)
ES (1) ES2836899T3 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015216570A1 (de) * 2015-08-31 2016-11-03 Carl Zeiss Meditec Ag Mikroskopiesystem
US10054775B2 (en) 2014-11-13 2018-08-21 Carl Zeiss Meditec Ag Optical system for fluorescence observation
DE102017203448A1 (de) 2017-03-02 2018-09-06 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz
DE102020131374A1 (de) 2020-11-26 2022-06-02 Dionex Softron Gmbh Fluoreszenzdetektion
EP3805838B1 (en) 2019-10-10 2023-12-06 Leica Instruments (Singapore) Pte. Ltd. Microscope and related apparatuses, methods and computer programs
DE102022125852A1 (de) * 2022-10-06 2024-04-11 Karl Storz Se & Co. Kg Medizinische Bildgebungsvorrichtung und Verfahren zur medizinischen Bildgebung

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015011429B9 (de) * 2015-09-01 2020-01-09 Carl Zeiss Meditec Ag Optisches Filtersystem und Fluoreszenzbeobachtungssystem
EP3205257B1 (en) 2016-02-15 2022-11-16 Leica Instruments (Singapore) Pte Ltd Illumination filter for an illumination filter system of a surgical multispectral fluorescence microscope having a spatial filter pattern
EP3422072B1 (en) * 2017-06-30 2020-01-08 Leica Instruments (Singapore) Pte. Ltd. Illumination system, microscope comprising an illumination system and microscope method
DE102018111958B4 (de) * 2018-05-17 2025-07-17 Carl Zeiss Meditec Ag Filtersatz, System und Verfahren zur Beobachtung von Protoporphyrin IX
DE102018114695B9 (de) * 2018-06-19 2020-05-28 Carl Zeiss Meditec Ag Filtersatz, System und Verfahren zur gleichzeitigen Anregung und Beobachtung von Protoporphyrin IX und Fluorescein

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69131176T2 (de) * 1990-08-10 1999-12-30 Univ Minnesota Konfokales Mikroskopsystem für Mehrfarbenfluoreszenz
US20010046673A1 (en) * 1999-03-16 2001-11-29 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
DE10339784A1 (de) * 2002-08-28 2004-03-25 Carl Zeiss Mikroskopiesystem und Mikroskopieverfahren
US6899675B2 (en) * 2002-01-15 2005-05-31 Xillix Technologies Corp. Fluorescence endoscopy video systems with no moving parts in the camera
DE102005005253A1 (de) * 2004-02-11 2005-11-17 Carl Zeiss Ag Untersuchungssystem und Untersuchungsverfahren
DE102006015272A1 (de) * 2006-04-01 2007-10-04 Carl Zeiss Microimaging Gmbh Spektralfilter-Set für LED-basierte Mikroskopbeleuchtungen
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
DE102009058663A1 (de) * 2009-12-16 2011-06-22 Karl Storz GmbH & Co. KG, 78532 Verfahren zum Prüfen einer optischen Vorrichtung
DE102010044503A1 (de) * 2010-09-06 2012-03-08 Leica Microsystems (Schweiz) Ag Fluoreszenz-Operations-Stereomikroskop

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6212425B1 (en) 1995-09-26 2001-04-03 Karl Storz Gmbh & Co., Kg Apparatus for photodynamic diagnosis
DE19548913A1 (de) 1995-12-31 1997-07-03 Storz Karl Gmbh & Co Vorrichtung zur photodynamischen Diagnose
JP2006509573A (ja) 2002-12-13 2006-03-23 イエトメド リミテッド 手術中に腫瘍と正常組織とを実時間で区別するのに特に有用な光学的検査方法および装置
DE102005008925A1 (de) * 2005-02-24 2006-09-07 Leica Microsystems Cms Gmbh Laser-Mikrodissektionsgerät
DE102005048006A1 (de) * 2005-10-06 2007-04-12 Carl Zeiss Surgical Gmbh Mikroskopiesystem und Aufnahmeverfahren zur Sichtbarmachung einer Fluoreszenz
JP2009122203A (ja) * 2007-11-12 2009-06-04 Shimadzu Corp 光学フィルタ、蛍光分析用フィルタセット及びその光学フィルタを用いた蛍光測定装置
DE102010033825B9 (de) * 2010-08-09 2024-04-18 Carl Zeiss Meditec Ag Fluoreszenzbeobachtungssystem und Filtersatz
DE102011002990B4 (de) * 2011-01-21 2014-02-27 Carl Zeiss Meditec Ag Visualisieren von Gewebe in einem Operationsbereich
JP2014036759A (ja) * 2012-08-17 2014-02-27 Hoya Corp 電子内視鏡システムおよび内視鏡用光源装置
CN103529506A (zh) * 2013-09-27 2014-01-22 华侨大学 一种紫外荧光滤光片及其制备方法
CN103735249B (zh) * 2013-12-27 2015-04-22 中国科学院苏州生物医学工程技术研究所 荧光检测仪

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69131176T2 (de) * 1990-08-10 1999-12-30 Univ Minnesota Konfokales Mikroskopsystem für Mehrfarbenfluoreszenz
US20010046673A1 (en) * 1999-03-16 2001-11-29 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6899675B2 (en) * 2002-01-15 2005-05-31 Xillix Technologies Corp. Fluorescence endoscopy video systems with no moving parts in the camera
DE10339784A1 (de) * 2002-08-28 2004-03-25 Carl Zeiss Mikroskopiesystem und Mikroskopieverfahren
DE102005005253A1 (de) * 2004-02-11 2005-11-17 Carl Zeiss Ag Untersuchungssystem und Untersuchungsverfahren
DE102006015272A1 (de) * 2006-04-01 2007-10-04 Carl Zeiss Microimaging Gmbh Spektralfilter-Set für LED-basierte Mikroskopbeleuchtungen
DE102008034008A1 (de) * 2008-07-21 2010-01-28 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
DE102009058663A1 (de) * 2009-12-16 2011-06-22 Karl Storz GmbH & Co. KG, 78532 Verfahren zum Prüfen einer optischen Vorrichtung
DE102010044503A1 (de) * 2010-09-06 2012-03-08 Leica Microsystems (Schweiz) Ag Fluoreszenz-Operations-Stereomikroskop

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10054775B2 (en) 2014-11-13 2018-08-21 Carl Zeiss Meditec Ag Optical system for fluorescence observation
DE102015216570A1 (de) * 2015-08-31 2016-11-03 Carl Zeiss Meditec Ag Mikroskopiesystem
DE102017203448A1 (de) 2017-03-02 2018-09-06 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz
US11079587B2 (en) 2017-03-02 2021-08-03 Carl Zeiss Meditec Ag Microscopy system and microscopy method for quantifying a fluorescence
DE102017203448B4 (de) 2017-03-02 2021-08-19 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz
DE102017203448B9 (de) 2017-03-02 2021-12-23 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz
EP3805838B1 (en) 2019-10-10 2023-12-06 Leica Instruments (Singapore) Pte. Ltd. Microscope and related apparatuses, methods and computer programs
DE102020131374A1 (de) 2020-11-26 2022-06-02 Dionex Softron Gmbh Fluoreszenzdetektion
DE102020131374B4 (de) * 2020-11-26 2024-02-08 Dionex Softron Gmbh Fluoreszenzdetektion
DE102022125852A1 (de) * 2022-10-06 2024-04-11 Karl Storz Se & Co. Kg Medizinische Bildgebungsvorrichtung und Verfahren zur medizinischen Bildgebung

Also Published As

Publication number Publication date
JP6716201B2 (ja) 2020-07-01
JP2015225344A (ja) 2015-12-14
CN105136753B (zh) 2019-04-12
US9958392B2 (en) 2018-05-01
EP2950129A1 (en) 2015-12-02
EP2950129B1 (en) 2020-10-28
US20150346098A1 (en) 2015-12-03
ES2836899T3 (es) 2021-06-28
CN105136753A (zh) 2015-12-09

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