ES2836899T3 - Sistema de filtro óptico y sistema de observación de fluorescencia - Google Patents
Sistema de filtro óptico y sistema de observación de fluorescencia Download PDFInfo
- Publication number
- ES2836899T3 ES2836899T3 ES15001596T ES15001596T ES2836899T3 ES 2836899 T3 ES2836899 T3 ES 2836899T3 ES 15001596 T ES15001596 T ES 15001596T ES 15001596 T ES15001596 T ES 15001596T ES 2836899 T3 ES2836899 T3 ES 2836899T3
- Authority
- ES
- Spain
- Prior art keywords
- light filter
- wavelength
- observation
- regions
- transmission
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003287 optical effect Effects 0.000 title claims abstract description 36
- 230000005540 biological transmission Effects 0.000 claims abstract description 171
- 238000005286 illumination Methods 0.000 claims abstract description 129
- 230000000903 blocking effect Effects 0.000 claims abstract description 92
- 238000002834 transmittance Methods 0.000 claims abstract description 49
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims description 11
- 229950003776 protoporphyrin Drugs 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 238000003384 imaging method Methods 0.000 claims description 7
- 230000006870 function Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 239000000835 fiber Substances 0.000 description 4
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 3
- 238000002189 fluorescence spectrum Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 238000012935 Averaging Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000000295 emission spectrum Methods 0.000 description 2
- 238000000695 excitation spectrum Methods 0.000 description 2
- 238000002073 fluorescence micrograph Methods 0.000 description 2
- 208000030173 low grade glioma Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010018338 Glioma Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000023077 detection of light stimulus Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000029824 high grade glioma Diseases 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 201000011614 malignant glioma Diseases 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0052—Optical details of the image generation
- G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/20—Filters
- G02B5/208—Filters for use with infrared or ultraviolet radiation, e.g. for separating visible light from infrared and/or ultraviolet radiation
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B5/00—Optical elements other than lenses
- G02B5/20—Filters
- G02B5/22—Absorbing filters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6471—Special filters, filter wheel
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Microscoopes, Condenser (AREA)
- Optical Filters (AREA)
- Endoscopes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102014008243.1A DE102014008243A1 (de) | 2014-05-27 | 2014-05-27 | Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2836899T3 true ES2836899T3 (es) | 2021-06-28 |
Family
ID=53489754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15001596T Active ES2836899T3 (es) | 2014-05-27 | 2015-05-27 | Sistema de filtro óptico y sistema de observación de fluorescencia |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9958392B2 (enExample) |
| EP (1) | EP2950129B1 (enExample) |
| JP (1) | JP6716201B2 (enExample) |
| CN (1) | CN105136753B (enExample) |
| DE (1) | DE102014008243A1 (enExample) |
| ES (1) | ES2836899T3 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102014016850B9 (de) | 2014-11-13 | 2017-07-27 | Carl Zeiss Meditec Ag | Optisches System zur Fluoreszenzbeobachtung |
| DE102015216570A1 (de) * | 2015-08-31 | 2016-11-03 | Carl Zeiss Meditec Ag | Mikroskopiesystem |
| DE102015011429B9 (de) * | 2015-09-01 | 2020-01-09 | Carl Zeiss Meditec Ag | Optisches Filtersystem und Fluoreszenzbeobachtungssystem |
| EP3205257B1 (en) * | 2016-02-15 | 2022-11-16 | Leica Instruments (Singapore) Pte Ltd | Illumination filter for an illumination filter system of a surgical multispectral fluorescence microscope having a spatial filter pattern |
| DE102017203448B9 (de) | 2017-03-02 | 2021-12-23 | Carl Zeiss Meditec Ag | Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz |
| EP3422072B1 (en) | 2017-06-30 | 2020-01-08 | Leica Instruments (Singapore) Pte. Ltd. | Illumination system, microscope comprising an illumination system and microscope method |
| DE102018111958B4 (de) * | 2018-05-17 | 2025-07-17 | Carl Zeiss Meditec Ag | Filtersatz, System und Verfahren zur Beobachtung von Protoporphyrin IX |
| DE102018114695B9 (de) * | 2018-06-19 | 2020-05-28 | Carl Zeiss Meditec Ag | Filtersatz, System und Verfahren zur gleichzeitigen Anregung und Beobachtung von Protoporphyrin IX und Fluorescein |
| EP3805838B1 (en) | 2019-10-10 | 2023-12-06 | Leica Instruments (Singapore) Pte. Ltd. | Microscope and related apparatuses, methods and computer programs |
| DE102020131374B4 (de) | 2020-11-26 | 2024-02-08 | Dionex Softron Gmbh | Fluoreszenzdetektion |
| DE102022125852A1 (de) * | 2022-10-06 | 2024-04-11 | Karl Storz Se & Co. Kg | Medizinische Bildgebungsvorrichtung und Verfahren zur medizinischen Bildgebung |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5127730A (en) | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
| JP3621704B2 (ja) | 1995-09-26 | 2005-02-16 | カール．ストルツ．ゲゼルシャフト．ミット．ベシュレンクテル．ハフツング．ウント．カンパニー | 光力学的診断用装置 |
| DE19548913A1 (de) | 1995-12-31 | 1997-07-03 | Storz Karl Gmbh & Co | Vorrichtung zur photodynamischen Diagnose |
| US20010046673A1 (en) * | 1999-03-16 | 2001-11-29 | Ljl Biosystems, Inc. | Methods and apparatus for detecting nucleic acid polymorphisms |
| US6899675B2 (en) * | 2002-01-15 | 2005-05-31 | Xillix Technologies Corp. | Fluorescence endoscopy video systems with no moving parts in the camera |
| US7580185B2 (en) | 2002-08-28 | 2009-08-25 | Carl Zeiss Surgical Gmbh | Microscopy system, microscopy method and a method of treating an aneurysm |
| JP2006509573A (ja) | 2002-12-13 | 2006-03-23 | イエトメド リミテッド | 手術中に腫瘍と正常組織とを実時間で区別するのに特に有用な光学的検査方法および装置 |
| DE102005005253B4 (de) * | 2004-02-11 | 2018-06-28 | Carl Zeiss Ag | Fluoreszenzbeobachtungssystem und Fluoreszenzbeobachtungsverfahren |
| DE102005008925A1 (de) * | 2005-02-24 | 2006-09-07 | Leica Microsystems Cms Gmbh | Laser-Mikrodissektionsgerät |
| DE102005048006A1 (de) * | 2005-10-06 | 2007-04-12 | Carl Zeiss Surgical Gmbh | Mikroskopiesystem und Aufnahmeverfahren zur Sichtbarmachung einer Fluoreszenz |
| DE102006015272A1 (de) * | 2006-04-01 | 2007-10-04 | Carl Zeiss Microimaging Gmbh | Spektralfilter-Set für LED-basierte Mikroskopbeleuchtungen |
| JP2009122203A (ja) * | 2007-11-12 | 2009-06-04 | Shimadzu Corp | 光学フィルタ、蛍光分析用フィルタセット及びその光学フィルタを用いた蛍光測定装置 |
| DE102008034008B4 (de) * | 2008-07-21 | 2010-07-01 | Carl Zeiss Surgical Gmbh | Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe |
| DE102009058663B4 (de) | 2009-12-16 | 2024-07-25 | Karl Storz Se & Co. Kg | Verfahren zum Prüfen einer optischen Vorrichtung |
| DE102010033825B9 (de) * | 2010-08-09 | 2024-04-18 | Carl Zeiss Meditec Ag | Fluoreszenzbeobachtungssystem und Filtersatz |
| DE102010044503B4 (de) * | 2010-09-06 | 2017-11-02 | Leica Microsystems (Schweiz) Ag | Fluoreszenz-Operations-Stereomikroskop |
| DE102011002990B4 (de) * | 2011-01-21 | 2014-02-27 | Carl Zeiss Meditec Ag | Visualisieren von Gewebe in einem Operationsbereich |
| JP2014036759A (ja) * | 2012-08-17 | 2014-02-27 | Hoya Corp | 電子内視鏡システムおよび内視鏡用光源装置 |
| CN103529506A (zh) * | 2013-09-27 | 2014-01-22 | 华侨大学 | 一种紫外荧光滤光片及其制备方法 |
| CN103735249B (zh) * | 2013-12-27 | 2015-04-22 | 中国科学院苏州生物医学工程技术研究所 | 荧光检测仪 |
-
2014
- 2014-05-27 DE DE102014008243.1A patent/DE102014008243A1/de not_active Ceased
-
2015
- 2015-05-26 JP JP2015106256A patent/JP6716201B2/ja active Active
- 2015-05-27 EP EP15001596.4A patent/EP2950129B1/en active Active
- 2015-05-27 CN CN201510403893.9A patent/CN105136753B/zh active Active
- 2015-05-27 US US14/722,265 patent/US9958392B2/en active Active
- 2015-05-27 ES ES15001596T patent/ES2836899T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2950129A1 (en) | 2015-12-02 |
| CN105136753A (zh) | 2015-12-09 |
| EP2950129B1 (en) | 2020-10-28 |
| US20150346098A1 (en) | 2015-12-03 |
| JP2015225344A (ja) | 2015-12-14 |
| JP6716201B2 (ja) | 2020-07-01 |
| DE102014008243A1 (de) | 2015-12-03 |
| US9958392B2 (en) | 2018-05-01 |
| CN105136753B (zh) | 2019-04-12 |
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