JP6716201B2 - 光学フィルタシステム、蛍光観察システムおよび蛍光観察を実行する方法 - Google Patents

光学フィルタシステム、蛍光観察システムおよび蛍光観察を実行する方法 Download PDF

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JP6716201B2
JP6716201B2 JP2015106256A JP2015106256A JP6716201B2 JP 6716201 B2 JP6716201 B2 JP 6716201B2 JP 2015106256 A JP2015106256 A JP 2015106256A JP 2015106256 A JP2015106256 A JP 2015106256A JP 6716201 B2 JP6716201 B2 JP 6716201B2
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light
optical filter
light filter
observation
filter
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JP2015225344A (ja
JP2015225344A5 (enExample
Inventor
クリストフ・ホーガー
ローランド・グックラー
マルコ・ビルツバッハ
ヘルゲ・イエス
セラマビット・ゲタチュー・ケレミュ
ホルガー・マッツ
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カール ツアイス メディテック アクチエンゲゼルシャフト
カール ツアイス メディテック アクチエンゲゼルシャフト
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/208—Filters for use with infrared or ultraviolet radiation, e.g. for separating visible light from infrared and/or ultraviolet radiation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses
    • G02B5/20—Filters
    • G02B5/22—Absorbing filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Optical Filters (AREA)
  • Endoscopes (AREA)
JP2015106256A 2014-05-27 2015-05-26 光学フィルタシステム、蛍光観察システムおよび蛍光観察を実行する方法 Active JP6716201B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102014008243.1A DE102014008243A1 (de) 2014-05-27 2014-05-27 Fluoreszenbeobachtungssystem und optisches Filtersystem hierfür
DE102014008243.1 2014-05-27

Publications (3)

Publication Number Publication Date
JP2015225344A JP2015225344A (ja) 2015-12-14
JP2015225344A5 JP2015225344A5 (enExample) 2018-06-21
JP6716201B2 true JP6716201B2 (ja) 2020-07-01

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JP2015106256A Active JP6716201B2 (ja) 2014-05-27 2015-05-26 光学フィルタシステム、蛍光観察システムおよび蛍光観察を実行する方法

Country Status (6)

Country Link
US (1) US9958392B2 (enExample)
EP (1) EP2950129B1 (enExample)
JP (1) JP6716201B2 (enExample)
CN (1) CN105136753B (enExample)
DE (1) DE102014008243A1 (enExample)
ES (1) ES2836899T3 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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DE102014016850B9 (de) 2014-11-13 2017-07-27 Carl Zeiss Meditec Ag Optisches System zur Fluoreszenzbeobachtung
DE102015216570A1 (de) * 2015-08-31 2016-11-03 Carl Zeiss Meditec Ag Mikroskopiesystem
DE102015011429B9 (de) * 2015-09-01 2020-01-09 Carl Zeiss Meditec Ag Optisches Filtersystem und Fluoreszenzbeobachtungssystem
EP3205257B1 (en) * 2016-02-15 2022-11-16 Leica Instruments (Singapore) Pte Ltd Illumination filter for an illumination filter system of a surgical multispectral fluorescence microscope having a spatial filter pattern
DE102017203448B9 (de) 2017-03-02 2021-12-23 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren zum Quantifizieren einer Fluoreszenz
EP3422072B1 (en) 2017-06-30 2020-01-08 Leica Instruments (Singapore) Pte. Ltd. Illumination system, microscope comprising an illumination system and microscope method
DE102018111958B4 (de) * 2018-05-17 2025-07-17 Carl Zeiss Meditec Ag Filtersatz, System und Verfahren zur Beobachtung von Protoporphyrin IX
DE102018114695B9 (de) * 2018-06-19 2020-05-28 Carl Zeiss Meditec Ag Filtersatz, System und Verfahren zur gleichzeitigen Anregung und Beobachtung von Protoporphyrin IX und Fluorescein
EP3805838B1 (en) 2019-10-10 2023-12-06 Leica Instruments (Singapore) Pte. Ltd. Microscope and related apparatuses, methods and computer programs
DE102020131374B4 (de) 2020-11-26 2024-02-08 Dionex Softron Gmbh Fluoreszenzdetektion
DE102022125852A1 (de) * 2022-10-06 2024-04-11 Karl Storz Se & Co. Kg Medizinische Bildgebungsvorrichtung und Verfahren zur medizinischen Bildgebung

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US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
JP3621704B2 (ja) 1995-09-26 2005-02-16 カール．ストルツ．ゲゼルシャフト．ミット．ベシュレンクテル．ハフツング．ウント．カンパニー 光力学的診断用装置
DE19548913A1 (de) 1995-12-31 1997-07-03 Storz Karl Gmbh & Co Vorrichtung zur photodynamischen Diagnose
US20010046673A1 (en) * 1999-03-16 2001-11-29 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6899675B2 (en) * 2002-01-15 2005-05-31 Xillix Technologies Corp. Fluorescence endoscopy video systems with no moving parts in the camera
US7580185B2 (en) 2002-08-28 2009-08-25 Carl Zeiss Surgical Gmbh Microscopy system, microscopy method and a method of treating an aneurysm
JP2006509573A (ja) 2002-12-13 2006-03-23 イエトメド リミテッド 手術中に腫瘍と正常組織とを実時間で区別するのに特に有用な光学的検査方法および装置
DE102005005253B4 (de) * 2004-02-11 2018-06-28 Carl Zeiss Ag Fluoreszenzbeobachtungssystem und Fluoreszenzbeobachtungsverfahren
DE102005008925A1 (de) * 2005-02-24 2006-09-07 Leica Microsystems Cms Gmbh Laser-Mikrodissektionsgerät
DE102005048006A1 (de) * 2005-10-06 2007-04-12 Carl Zeiss Surgical Gmbh Mikroskopiesystem und Aufnahmeverfahren zur Sichtbarmachung einer Fluoreszenz
DE102006015272A1 (de) * 2006-04-01 2007-10-04 Carl Zeiss Microimaging Gmbh Spektralfilter-Set für LED-basierte Mikroskopbeleuchtungen
JP2009122203A (ja) * 2007-11-12 2009-06-04 Shimadzu Corp 光学フィルタ、蛍光分析用フィルタセット及びその光学フィルタを用いた蛍光測定装置
DE102008034008B4 (de) * 2008-07-21 2010-07-01 Carl Zeiss Surgical Gmbh Filtersatz zur Beobachtung von Fluoreszenzstrahlung in biologischem Gewebe
DE102009058663B4 (de) 2009-12-16 2024-07-25 Karl Storz Se & Co. Kg Verfahren zum Prüfen einer optischen Vorrichtung
DE102010033825B9 (de) * 2010-08-09 2024-04-18 Carl Zeiss Meditec Ag Fluoreszenzbeobachtungssystem und Filtersatz
DE102010044503B4 (de) * 2010-09-06 2017-11-02 Leica Microsystems (Schweiz) Ag Fluoreszenz-Operations-Stereomikroskop
DE102011002990B4 (de) * 2011-01-21 2014-02-27 Carl Zeiss Meditec Ag Visualisieren von Gewebe in einem Operationsbereich
JP2014036759A (ja) * 2012-08-17 2014-02-27 Hoya Corp 電子内視鏡システムおよび内視鏡用光源装置
CN103529506A (zh) * 2013-09-27 2014-01-22 华侨大学 一种紫外荧光滤光片及其制备方法
CN103735249B (zh) * 2013-12-27 2015-04-22 中国科学院苏州生物医学工程技术研究所 荧光检测仪

Also Published As

Publication number Publication date
EP2950129A1 (en) 2015-12-02
CN105136753A (zh) 2015-12-09
EP2950129B1 (en) 2020-10-28
US20150346098A1 (en) 2015-12-03
ES2836899T3 (es) 2021-06-28
JP2015225344A (ja) 2015-12-14
DE102014008243A1 (de) 2015-12-03
US9958392B2 (en) 2018-05-01
CN105136753B (zh) 2019-04-12

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