DE102013215580A1 - 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten - Google Patents

25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten Download PDF

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Publication number
DE102013215580A1
DE102013215580A1 DE102013215580.8A DE102013215580A DE102013215580A1 DE 102013215580 A1 DE102013215580 A1 DE 102013215580A1 DE 102013215580 A DE102013215580 A DE 102013215580A DE 102013215580 A1 DE102013215580 A1 DE 102013215580A1
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Prior art keywords
vitamin
group
compound
formula
tracer
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DE102013215580.8A
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German (de)
English (en)
Inventor
Vukic Soskic
Robert Poppe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orgentec Diagnostika GmbH
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Orgentec Diagnostika GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orgentec Diagnostika GmbH filed Critical Orgentec Diagnostika GmbH
Priority to DE102013215580.8A priority Critical patent/DE102013215580A1/de
Priority to PCT/EP2014/066620 priority patent/WO2015018757A1/de
Priority to MX2016001519A priority patent/MX2016001519A/es
Priority to EP14748179.0A priority patent/EP3030243B1/de
Priority to RU2016108014A priority patent/RU2016108014A/ru
Priority to US14/910,881 priority patent/US10222388B2/en
Priority to AU2014304585A priority patent/AU2014304585A1/en
Priority to CN201480044453.2A priority patent/CN105636595B/zh
Priority to JP2016532339A priority patent/JP6388941B2/ja
Publication of DE102013215580A1 publication Critical patent/DE102013215580A1/de
Priority to IL243856A priority patent/IL243856A0/en
Priority to US16/151,812 priority patent/US11199553B2/en
Withdrawn legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE102013215580.8A 2013-08-07 2013-08-07 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten Withdrawn DE102013215580A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE102013215580.8A DE102013215580A1 (de) 2013-08-07 2013-08-07 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten
US14/910,881 US10222388B2 (en) 2013-08-07 2014-08-01 25-OH vitamin D derivatives for determining vitamin D metabolites
MX2016001519A MX2016001519A (es) 2013-08-07 2014-08-01 Derivados de 25-oh vitamina d para determinacion de metabolitos de vitamina d.
EP14748179.0A EP3030243B1 (de) 2013-08-07 2014-08-01 25-oh vitamin d derivate zur bestimmung von vitamin d metaboliten
RU2016108014A RU2016108014A (ru) 2013-08-07 2014-08-01 Производные 25-он витамина d для определения метаболитов витамина d
PCT/EP2014/066620 WO2015018757A1 (de) 2013-08-07 2014-08-01 25-oh vitamin d derivate zur bestimmung von vitamin d metaboliten
AU2014304585A AU2014304585A1 (en) 2013-08-07 2014-08-01 25-OH Vitamin D derivatives for determination of Vitamin D metabolites
CN201480044453.2A CN105636595B (zh) 2013-08-07 2014-08-01 用于测定维生素d代谢物的25-oh维生素d衍生物
JP2016532339A JP6388941B2 (ja) 2013-08-07 2014-08-01 ビタミンｄ代謝物を測定するための２５−ｏｈビタミンｄ誘導体
IL243856A IL243856A0 (en) 2013-08-07 2016-01-31 History of vitamin d 25–oh for determination of vitamin d metabolites
US16/151,812 US11199553B2 (en) 2013-08-07 2018-10-04 25-OH vitamin D derivatives for determining vitamin D metabolites

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102013215580.8A DE102013215580A1 (de) 2013-08-07 2013-08-07 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten

Publications (1)

Publication Number Publication Date
DE102013215580A1 true DE102013215580A1 (de) 2015-02-12

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Family Applications (1)

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DE102013215580.8A Withdrawn DE102013215580A1 (de) 2013-08-07 2013-08-07 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten

Country Status (10)

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US (2) US10222388B2 (enExample)
EP (1) EP3030243B1 (enExample)
JP (1) JP6388941B2 (enExample)
CN (1) CN105636595B (enExample)
AU (1) AU2014304585A1 (enExample)
DE (1) DE102013215580A1 (enExample)
IL (1) IL243856A0 (enExample)
MX (1) MX2016001519A (enExample)
RU (1) RU2016108014A (enExample)
WO (1) WO2015018757A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US20160161473A1 (en) 2014-12-08 2016-06-09 Calbiotech, Inc. Biotin conjugates of analytes containing amino, hydroxyl, or thiol functional groups for use in immunodiagnostic assays
CN111518008B (zh) * 2019-02-01 2023-02-28 科美博阳诊断技术(上海)有限公司 用于测定维生素d的含量或存在的化合物、产品和方法
CN111518005B (zh) * 2019-02-01 2023-04-11 科美博阳诊断技术(上海)有限公司 一种中间体化合物及其制备方法和应用
CN112485418B (zh) * 2020-10-26 2023-04-11 北京利德曼生化股份有限公司 一种用于人体维生素b12含量检测的释放剂及其应用
IL319526A (en) 2022-09-30 2025-05-01 Extend Biosciences Inc Long-acting parathyroid hormone
CN119192387B (zh) * 2023-06-25 2025-11-18 东莞市朋志生物科技有限公司 抗25-oh-vd及其抗体复合物的抗体、检测25-oh-vd的试剂和试剂盒

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116573A (en) 1988-09-14 1992-05-26 Kureha Kagaku Kogyo Kabushiki Kaisha Labelled vitamin d3 derivative and production process thereof
CH681891A5 (enExample) * 1992-10-09 1993-06-15 Marigen Sa
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters
US5478816A (en) * 1993-07-02 1995-12-26 Bristol-Myers Squibb Company Liquid vitamin formulations containing vitamin D esters
WO1997024127A1 (en) * 1995-12-29 1997-07-10 A And D Assay, Incorporated Labeled vitamin d compounds and the use thereof
DE69713138T2 (de) 1996-11-13 2003-01-16 Immunodiagnostic Systems Ltd., Boldon Immuntestsystem zur bestimmung von vitamin d
US6787660B1 (en) 1998-06-25 2004-09-07 Immundiagnostik Ag Functional vitamin D derivatives and a method for determining 25-hydroxy-vitamin D and 1α, dihydroxy-vitamin D
WO2007079394A2 (en) * 2005-12-30 2007-07-12 Revance Therapeutics, Inc. Arginine heteromers for topical administration
US20080317764A1 (en) 2005-09-29 2008-12-25 Eramus Huber Antibodies against 25-hydroxyvitamin d
US8003400B2 (en) 2006-06-06 2011-08-23 Roche Diagnostics Operations, Inc. Measurement of vitamin D
DE102013205055A1 (de) 2013-03-21 2014-09-25 Orgentec Diagnostika Gmbh Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4119647A (en) * 1977-04-11 1978-10-10 Hoffmann-La Roche Inc. 25-Hydroxycholecalciferol-23,24-3 H and process for the preparation thereof
US6017908A (en) 1997-05-16 2000-01-25 Women And Infants Hospital 3-EPI vitamin D2 compounds and uses thereof
WO2007136932A2 (en) 2006-05-16 2007-11-29 Freescale Semiconductor Inc. Integrated circuit having pads and input/output (i/o) cells
JP2010053118A (ja) 2008-07-28 2010-03-11 Fujifilm Corp ビオチン化チロキシン
CN102628872A (zh) 2012-03-31 2012-08-08 广州菲康生物技术有限公司 25羟基维生素d检测试剂盒及其制备方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116573A (en) 1988-09-14 1992-05-26 Kureha Kagaku Kogyo Kabushiki Kaisha Labelled vitamin d3 derivative and production process thereof
CH681891A5 (enExample) * 1992-10-09 1993-06-15 Marigen Sa
EP0603726A2 (en) * 1992-12-21 1994-06-29 Bristol-Myers Squibb Company Nutritional compositions containing vitamin d esters
US5478816A (en) * 1993-07-02 1995-12-26 Bristol-Myers Squibb Company Liquid vitamin formulations containing vitamin D esters
WO1997024127A1 (en) * 1995-12-29 1997-07-10 A And D Assay, Incorporated Labeled vitamin d compounds and the use thereof
US6291693B1 (en) 1995-12-29 2001-09-18 A & D Bioscience, Inc. Kits comprising labeled vitamin D compounds
DE69713138T2 (de) 1996-11-13 2003-01-16 Immunodiagnostic Systems Ltd., Boldon Immuntestsystem zur bestimmung von vitamin d
US6787660B1 (en) 1998-06-25 2004-09-07 Immundiagnostik Ag Functional vitamin D derivatives and a method for determining 25-hydroxy-vitamin D and 1α, dihydroxy-vitamin D
US20080317764A1 (en) 2005-09-29 2008-12-25 Eramus Huber Antibodies against 25-hydroxyvitamin d
WO2007079394A2 (en) * 2005-12-30 2007-07-12 Revance Therapeutics, Inc. Arginine heteromers for topical administration
US8003400B2 (en) 2006-06-06 2011-08-23 Roche Diagnostics Operations, Inc. Measurement of vitamin D
DE102013205055A1 (de) 2013-03-21 2014-09-25 Orgentec Diagnostika Gmbh Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
HIGASHI, Tatsuya : Enzyme-linked immunosorbent assay for plasma 24,25-dihydroxyvitamin D3. In : Analytica Chimica Acta, 1998, 365, S. 151-158. *
KOBAYASHI, Norihiro : Production and specificity of antisera raised against 25-hydroxyvitamin D3-[C-3]-bovine serum albumin conjugates. In : Steroids, 1992, 57 (10), S. 488-493. *
KOBAYASHI, Norihiro : Specificity of Polyclonal Antibodies Raised against a Novel 24,25-Dihydroxyvitamin D3-Bovine Serum Albumin Conjugant Linked through the C-11alpha or C-3 Position. In : J. Steroid Biochem Molec. Biol., 1997, 62(1), S. 79-87. *
KOBAYASHI, Norihiro : Specificity of Polyclonal Antibodies Raised against a Novel 24,25-Dihydroxyvitamin D3-Bovine Serum Albumin Conjugant Linked through the C-11α or C-3 Position. In : J. Steroid Biochem Molec. Biol., 1997, 62(1), S. 79-87.
PATIL, Sumersing : Synthesis, characterization and in vitro evaluation of novel vitamin D3 nanoparticles as a versatile platform for drug delivery in cancer therapy. In : Journal of Materials Chemistry B, 2013, 1, 5742-5750. *
Roy, A. und Ray, R., Steroids. 1995, 60: 530-533
WASNER, Marita : Synthesis and Characterization of Cordycepin-Trimer-Vitamin and -Lipid Conjugates Potential Inhibitors of HIV-1 Replication. In : Helvetica Chimica Acta, 1996, 79, S. 619. *
WASNER, Marita : Synthesis and Characterization of Monomeric Cordycepin-Vitamin and Cordycepin-Lipid Conjugates Model Substances for Biodegradable Ester and Carbonate Linkages in Conjugates and Potential Inhibitors of HIV-1 Replication. In : Helvetica Chimica Acta, 1996, 79, S. 609. *

Also Published As

Publication number Publication date
WO2015018757A1 (de) 2015-02-12
RU2016108014A (ru) 2017-09-08
US20190101548A1 (en) 2019-04-04
EP3030243A1 (de) 2016-06-15
CN105636595B (zh) 2019-08-27
US11199553B2 (en) 2021-12-14
IL243856A0 (en) 2016-04-21
US10222388B2 (en) 2019-03-05
US20170115313A9 (en) 2017-04-27
EP3030243B1 (de) 2017-07-26
JP2016532695A (ja) 2016-10-20
MX2016001519A (es) 2016-06-23
AU2014304585A1 (en) 2016-02-18
CN105636595A (zh) 2016-06-01
US20160195556A1 (en) 2016-07-07
JP6388941B2 (ja) 2018-09-12

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