DE102008006791B4 - Transdermales Therapeutisches System mit Harnstoff-Komponente und Verfahren zu dessen Herstellung - Google Patents
Transdermales Therapeutisches System mit Harnstoff-Komponente und Verfahren zu dessen Herstellung Download PDFInfo
- Publication number
- DE102008006791B4 DE102008006791B4 DE102008006791A DE102008006791A DE102008006791B4 DE 102008006791 B4 DE102008006791 B4 DE 102008006791B4 DE 102008006791 A DE102008006791 A DE 102008006791A DE 102008006791 A DE102008006791 A DE 102008006791A DE 102008006791 B4 DE102008006791 B4 DE 102008006791B4
- Authority
- DE
- Germany
- Prior art keywords
- urea
- layer
- transdermal therapeutic
- therapeutic system
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title claims abstract description 71
- 239000004202 carbamide Substances 0.000 title claims abstract description 71
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims description 3
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- 229940079593 drug Drugs 0.000 claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 24
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- 229920000642 polymer Polymers 0.000 claims description 9
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- 239000003158 myorelaxant agent Substances 0.000 claims description 3
- 239000008177 pharmaceutical agent Substances 0.000 claims description 3
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- 229920002799 BoPET Polymers 0.000 description 8
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- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 5
- 229920001296 polysiloxane Polymers 0.000 description 5
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- PWWDCRQZITYKDV-UHFFFAOYSA-N 1-benzyl-2-piperazin-1-ylbenzimidazole Chemical compound C1CNCCN1C1=NC2=CC=CC=C2N1CC1=CC=CC=C1 PWWDCRQZITYKDV-UHFFFAOYSA-N 0.000 description 3
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 3
- WPNJAUFVNXKLIM-UHFFFAOYSA-N Moxonidine Chemical compound COC1=NC(C)=NC(Cl)=C1NC1=NCCN1 WPNJAUFVNXKLIM-UHFFFAOYSA-N 0.000 description 3
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- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 3
- 229960000488 tizanidine Drugs 0.000 description 3
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
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- 229960003711 glyceryl trinitrate Drugs 0.000 description 2
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- 229960002715 nicotine Drugs 0.000 description 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 2
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- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 description 1
- ISHXLNHNDMZNMC-VTKCIJPMSA-N (3e,8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol Chemical compound O/N=C/1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C\1 ISHXLNHNDMZNMC-VTKCIJPMSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- YREYLAVBNPACJM-UHFFFAOYSA-N 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol Chemical compound CC(C)(C)NCC(O)C1=CC=CC=C1Cl YREYLAVBNPACJM-UHFFFAOYSA-N 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
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- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
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- 229960003204 amorolfine Drugs 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
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- 239000000839 emulsion Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
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- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229960002667 norelgestromin Drugs 0.000 description 1
- 229960001652 norethindrone acetate Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
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- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000859 tulobuterol Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008006791A DE102008006791B4 (de) | 2008-01-30 | 2008-01-30 | Transdermales Therapeutisches System mit Harnstoff-Komponente und Verfahren zu dessen Herstellung |
| US12/865,465 US9066887B2 (en) | 2008-01-30 | 2008-12-09 | Transdermal therapeutic system having urea components |
| KR1020107017007A KR20100105866A (ko) | 2008-01-30 | 2008-12-09 | 우레아 성분을 가진 경피 치료 시스템 |
| BRPI0821975A BRPI0821975B8 (pt) | 2008-01-30 | 2008-12-09 | Sistema terapêutico transdérmico (tts) para liberação de substâncias ativas farmacêuticas através da pele, processo para preparação de um sistema terapêutico transdérmico e uso de uma camada polimérica contendo substância ativa |
| CN200880124963.5A CN101909607B (zh) | 2008-01-30 | 2008-12-09 | 具有尿素成分的透皮治疗系统 |
| PCT/EP2008/010426 WO2009095057A2 (de) | 2008-01-30 | 2008-12-09 | Transdermales therapeutisches system mit harnstoff-komponente |
| HK11105747.2A HK1151716B (en) | 2008-01-30 | 2008-12-09 | Transdermal therapeutic system having urea components |
| ES08871775.6T ES2548295T3 (es) | 2008-01-30 | 2008-12-09 | Sistema terapéutico transdérmico con componentes de urea |
| PL08871775T PL2234605T3 (pl) | 2008-01-30 | 2008-12-09 | Transdermalny system terapeutyczny zawierający mocznik |
| EP08871775.6A EP2234605B1 (de) | 2008-01-30 | 2008-12-09 | Transdermales therapeutisches system mit harnstoff-komponente |
| JP2010544590A JP5389824B2 (ja) | 2008-01-30 | 2008-12-09 | 尿素成分を有する経皮治療システム |
| AU2008349007A AU2008349007B2 (en) | 2008-01-30 | 2008-12-09 | Transdermal therapeutic system having urea components |
| MX2010008334A MX2010008334A (es) | 2008-01-30 | 2008-12-09 | Sistema terapeutico transdermico que tiene componentes de urea. |
| CA2710640A CA2710640C (en) | 2008-01-30 | 2008-12-09 | Transdermal therapeutic system having urea components |
| ZA2010/04012A ZA201004012B (en) | 2008-01-30 | 2010-06-04 | Transdermal therapeutic system having urea components |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008006791A DE102008006791B4 (de) | 2008-01-30 | 2008-01-30 | Transdermales Therapeutisches System mit Harnstoff-Komponente und Verfahren zu dessen Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE102008006791A1 DE102008006791A1 (de) | 2009-08-06 |
| DE102008006791B4 true DE102008006791B4 (de) | 2011-11-24 |
Family
ID=40386379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102008006791A Active DE102008006791B4 (de) | 2008-01-30 | 2008-01-30 | Transdermales Therapeutisches System mit Harnstoff-Komponente und Verfahren zu dessen Herstellung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9066887B2 (enExample) |
| EP (1) | EP2234605B1 (enExample) |
| JP (1) | JP5389824B2 (enExample) |
| KR (1) | KR20100105866A (enExample) |
| CN (1) | CN101909607B (enExample) |
| AU (1) | AU2008349007B2 (enExample) |
| BR (1) | BRPI0821975B8 (enExample) |
| CA (1) | CA2710640C (enExample) |
| DE (1) | DE102008006791B4 (enExample) |
| ES (1) | ES2548295T3 (enExample) |
| MX (1) | MX2010008334A (enExample) |
| PL (1) | PL2234605T3 (enExample) |
| WO (1) | WO2009095057A2 (enExample) |
| ZA (1) | ZA201004012B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106333939A (zh) * | 2016-10-09 | 2017-01-18 | 常州亚环环保科技有限公司 | 一种药用透皮材料的制备方法 |
| CN109549929A (zh) * | 2017-09-27 | 2019-04-02 | 天津金耀集团有限公司 | 一种有机固体溶液降低皮质激素药物粒径的方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4210165A1 (de) * | 1991-07-30 | 1993-02-04 | Schering Ag | Transdermale therapeutische systeme |
| EP0617972A2 (de) * | 1993-03-27 | 1994-10-05 | Röhm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)-acrylat-Mischung |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| DE102004028284A1 (de) * | 2004-06-11 | 2006-01-05 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System auf Basis eines Schmelzklebstoffs zur Anwendung von Norelgestromin |
| US20070104772A1 (en) * | 2004-03-29 | 2007-05-10 | Leslie Zanutto | Amorolfine patch for the treatment of onychomycosis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1404583A (en) * | 1971-10-08 | 1975-09-03 | Vymatt Sa | Urea compositions and methods of preparation thereof |
| CS164542B1 (enExample) * | 1973-02-15 | 1975-11-07 | ||
| JPS557272A (en) * | 1978-06-16 | 1980-01-19 | Rech Pharma Sa | Drug composition containing urea |
| US4687481A (en) * | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| US4699777A (en) * | 1985-08-21 | 1987-10-13 | Schering Corporation | Compositions and method for enhancement of the transdermal flux of albuterol with a combination of 1-dodecyl-azacyclopheptan-2-one and urea |
| US5230896A (en) * | 1989-10-12 | 1993-07-27 | Warner-Lambert Company | Transdermal nicotine delivery system |
| WO1997039740A1 (en) | 1996-04-22 | 1997-10-30 | Toyama Chemical Co., Ltd. | Patch containing 1,2-ethanediol derivatives or salts thereof |
| FR2761889B1 (fr) | 1997-04-11 | 1999-12-31 | Oreal | Patch pharmaceutique, cosmetique ou dermo-pharmaceutique pour la delivrance de plusieurs composes actifs de nature differente |
| US20040018241A1 (en) * | 1997-09-26 | 2004-01-29 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
| GB9826656D0 (en) * | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| EP1331929A1 (en) * | 2000-11-06 | 2003-08-06 | Samyang Corporation | Transdermal drug delivery system with improved water absorbability and adhesion properties |
| DK1341515T3 (da) * | 2000-12-15 | 2007-01-29 | Intendis Gmbh | Vandfri hudplejeformuleringer, der omfatter mikroniseret urinstof, og fremgangsmåde til fremstilling af samme |
| US20050020658A1 (en) | 2002-11-21 | 2005-01-27 | Katsuyuki Inoo | Selective cyclooxygenase-2 inhibitor patch |
-
2008
- 2008-01-30 DE DE102008006791A patent/DE102008006791B4/de active Active
- 2008-12-09 MX MX2010008334A patent/MX2010008334A/es active IP Right Grant
- 2008-12-09 AU AU2008349007A patent/AU2008349007B2/en not_active Expired - Fee Related
- 2008-12-09 CN CN200880124963.5A patent/CN101909607B/zh not_active Expired - Fee Related
- 2008-12-09 PL PL08871775T patent/PL2234605T3/pl unknown
- 2008-12-09 US US12/865,465 patent/US9066887B2/en active Active
- 2008-12-09 BR BRPI0821975A patent/BRPI0821975B8/pt not_active IP Right Cessation
- 2008-12-09 WO PCT/EP2008/010426 patent/WO2009095057A2/de not_active Ceased
- 2008-12-09 EP EP08871775.6A patent/EP2234605B1/de active Active
- 2008-12-09 CA CA2710640A patent/CA2710640C/en active Active
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4210165A1 (de) * | 1991-07-30 | 1993-02-04 | Schering Ag | Transdermale therapeutische systeme |
| WO1993002669A1 (de) * | 1991-07-30 | 1993-02-18 | Schering Aktiengesellschaft Berlin Und Bergkamen | Transdermale therapeutische systeme |
| EP0617972A2 (de) * | 1993-03-27 | 1994-10-05 | Röhm Gmbh | Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)-acrylat-Mischung |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| US20070104772A1 (en) * | 2004-03-29 | 2007-05-10 | Leslie Zanutto | Amorolfine patch for the treatment of onychomycosis |
| DE102004028284A1 (de) * | 2004-06-11 | 2006-01-05 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System auf Basis eines Schmelzklebstoffs zur Anwendung von Norelgestromin |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1151716A1 (en) | 2012-02-10 |
| WO2009095057A2 (de) | 2009-08-06 |
| EP2234605B1 (de) | 2015-08-05 |
| BRPI0821975B1 (pt) | 2019-10-08 |
| CN101909607A (zh) | 2010-12-08 |
| WO2009095057A3 (de) | 2010-03-04 |
| AU2008349007B2 (en) | 2014-10-02 |
| EP2234605A2 (de) | 2010-10-06 |
| US9066887B2 (en) | 2015-06-30 |
| MX2010008334A (es) | 2010-08-23 |
| CN101909607B (zh) | 2014-05-14 |
| ZA201004012B (en) | 2011-02-23 |
| US20100310634A1 (en) | 2010-12-09 |
| ES2548295T3 (es) | 2015-10-15 |
| DE102008006791A1 (de) | 2009-08-06 |
| JP5389824B2 (ja) | 2014-01-15 |
| JP2011510936A (ja) | 2011-04-07 |
| PL2234605T3 (pl) | 2016-01-29 |
| CA2710640A1 (en) | 2009-08-06 |
| AU2008349007A1 (en) | 2009-08-06 |
| BRPI0821975A2 (pt) | 2015-06-23 |
| CA2710640C (en) | 2015-12-08 |
| KR20100105866A (ko) | 2010-09-30 |
| BRPI0821975B8 (pt) | 2023-02-07 |
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