DE102005055811A1 - Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen - Google Patents
Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen Download PDFInfo
- Publication number
- DE102005055811A1 DE102005055811A1 DE102005055811A DE102005055811A DE102005055811A1 DE 102005055811 A1 DE102005055811 A1 DE 102005055811A1 DE 102005055811 A DE102005055811 A DE 102005055811A DE 102005055811 A DE102005055811 A DE 102005055811A DE 102005055811 A1 DE102005055811 A1 DE 102005055811A1
- Authority
- DE
- Germany
- Prior art keywords
- use according
- composition
- siloxane
- semifluorinated alkane
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 210000000056 organ Anatomy 0.000 title claims abstract description 35
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 238000004321 preservation Methods 0.000 title claims abstract description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims description 31
- 229910052760 oxygen Inorganic materials 0.000 title claims description 31
- 239000001301 oxygen Substances 0.000 title claims description 31
- 150000001335 aliphatic alkanes Chemical class 0.000 title claims description 19
- -1 alkane compound Chemical class 0.000 claims abstract description 49
- 150000001875 compounds Chemical class 0.000 claims description 13
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 6
- 229940087168 alpha tocopherol Drugs 0.000 claims description 5
- 229960000984 tocofersolan Drugs 0.000 claims description 5
- 239000002076 α-tocopherol Substances 0.000 claims description 5
- 235000004835 α-tocopherol Nutrition 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 3
- 229940108325 retinyl palmitate Drugs 0.000 claims description 3
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 3
- 239000011769 retinyl palmitate Substances 0.000 claims description 3
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 2
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 claims description 2
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 2
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 2
- 229960004308 acetylcysteine Drugs 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 235000021466 carotenoid Nutrition 0.000 claims description 2
- 150000001747 carotenoids Chemical class 0.000 claims description 2
- 231100000433 cytotoxic Toxicity 0.000 claims description 2
- 230000001472 cytotoxic effect Effects 0.000 claims description 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 229960002949 fluorouracil Drugs 0.000 claims description 2
- 229960001680 ibuprofen Drugs 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 150000003431 steroids Chemical class 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 229960002963 ganciclovir Drugs 0.000 claims 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 13
- 229920002545 silicone oil Polymers 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 3
- WRYIIOKOQSICTB-UHFFFAOYSA-N 1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorotetradecane Chemical compound CCCCCCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F WRYIIOKOQSICTB-UHFFFAOYSA-N 0.000 description 2
- DFUYAWQUODQGFF-UHFFFAOYSA-N 1-ethoxy-1,1,2,2,3,3,4,4,4-nonafluorobutane Chemical compound CCOC(F)(F)C(F)(F)C(F)(F)C(F)(F)F DFUYAWQUODQGFF-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 description 2
- 230000000269 nucleophilic effect Effects 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000005840 aryl radicals Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- DIOQZVSQGTUSAI-NJFSPNSNSA-N decane Chemical compound CCCCCCCCC[14CH3] DIOQZVSQGTUSAI-NJFSPNSNSA-N 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- DIOQZVSQGTUSAI-UHFFFAOYSA-N n-butylhexane Natural products CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 1
- ZCYXXKJEDCHMGH-UHFFFAOYSA-N nonane Chemical compound CCCC[CH]CCCC ZCYXXKJEDCHMGH-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- BKIMMITUMNQMOS-UHFFFAOYSA-N normal nonane Natural products CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005055811A DE102005055811A1 (de) | 2005-11-23 | 2005-11-23 | Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen |
| EP06806724A EP1956895B1 (de) | 2005-11-23 | 2006-11-23 | Verwendung einer zusammensetzung zur konservierung von organen und gliedmassen |
| US12/094,951 US8029977B2 (en) | 2005-11-23 | 2006-11-23 | Method for preserving organs or limbs using a composition containing a siloxane and a semifluorinated alkane and/or hydrofluoroether |
| HK09101646.7A HK1126622B (en) | 2005-11-23 | 2006-11-23 | Use of a composition for preserving organs and limbs |
| BRPI0618805-2A BRPI0618805A2 (pt) | 2005-11-23 | 2006-11-23 | uso de uma composição para a preservação de órgãos e de membros |
| JP2008541642A JP5344924B2 (ja) | 2005-11-23 | 2006-11-23 | 臓器／四肢を保存するための組成物の用法 |
| PCT/EP2006/011247 WO2007059968A2 (de) | 2005-11-23 | 2006-11-23 | Verwendung einer zusammensetzung zur konservierung von organen und gliedmassen |
| DK06806724.8T DK1956895T3 (da) | 2005-11-23 | 2006-11-23 | Anvendelse af en sammensætning til konservering af organer og ekstremiteter |
| CA2628085A CA2628085C (en) | 2005-11-23 | 2006-11-23 | Use of a composition for preserving organs and limbs |
| KR1020087013057A KR101058744B1 (ko) | 2005-11-23 | 2006-11-23 | 생체 기관 및 사지 보존용 화합물의 이용 |
| ES06806724T ES2365415T3 (es) | 2005-11-23 | 2006-11-23 | Utilización de una composición para conservar órganos y miembros. |
| AU2006316738A AU2006316738B2 (en) | 2005-11-23 | 2006-11-23 | Use of a composition for preserving organs and limbs |
| CN2006800437943A CN101312647B (zh) | 2005-11-23 | 2006-11-23 | 组合物在保存器官和肢体中的应用 |
| NZ568206A NZ568206A (en) | 2005-11-23 | 2006-11-23 | Use of a composition for preserving organs and limbs |
| AT06806724T ATE509522T1 (de) | 2005-11-23 | 2006-11-23 | Verwendung einer zusammensetzung zur konservierung von organen und gliedmassen |
| ZA200803599A ZA200803599B (en) | 2005-11-23 | 2008-04-23 | Use of a composition for preserving organs and members |
| IL191133A IL191133A0 (en) | 2005-11-23 | 2008-04-29 | Use of a composition for preserving organs and members |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005055811A DE102005055811A1 (de) | 2005-11-23 | 2005-11-23 | Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102005055811A1 true DE102005055811A1 (de) | 2007-05-31 |
Family
ID=37965062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102005055811A Withdrawn DE102005055811A1 (de) | 2005-11-23 | 2005-11-23 | Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8029977B2 (https=) |
| EP (1) | EP1956895B1 (https=) |
| JP (1) | JP5344924B2 (https=) |
| KR (1) | KR101058744B1 (https=) |
| CN (1) | CN101312647B (https=) |
| AT (1) | ATE509522T1 (https=) |
| AU (1) | AU2006316738B2 (https=) |
| BR (1) | BRPI0618805A2 (https=) |
| CA (1) | CA2628085C (https=) |
| DE (1) | DE102005055811A1 (https=) |
| DK (1) | DK1956895T3 (https=) |
| ES (1) | ES2365415T3 (https=) |
| IL (1) | IL191133A0 (https=) |
| NZ (1) | NZ568206A (https=) |
| WO (1) | WO2007059968A2 (https=) |
| ZA (1) | ZA200803599B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2335692A1 (en) * | 2009-12-04 | 2011-06-22 | AL.CHI.MI.A. S.r.l. | Silicone liquid and fluorinated liquid for sequential use in the treatment of retinal tears and/or detachments |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100785656B1 (ko) * | 2007-05-14 | 2007-12-17 | 재단법인서울대학교산학협력재단 | 소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체 |
| EP2110126B9 (de) * | 2008-04-18 | 2012-09-19 | Novaliq GmbH | Inhalative und instillative Verwendung von semifluorierten Alkanen als Wirkstoffträger im intrapulmonalen Bereich |
| WO2011113855A2 (en) | 2010-03-17 | 2011-09-22 | Novaliq Gmbh | Pharmaceutical composition for treatment of increased intraocular pressure |
| EP2444063A1 (en) | 2010-10-20 | 2012-04-25 | Novaliq GmbH | Liquid pharmaceutical compositions for the delivery of active ingredients |
| EP2462921A1 (en) | 2010-11-11 | 2012-06-13 | Novaliq GmbH | Liquid pharmaceutical compositions for the treatment of a posterior eye disease |
| CN107397718A (zh) | 2011-05-25 | 2017-11-28 | 诺瓦利克有限责任公司 | 基于半氟化烷烃类的外用药物组合物 |
| KR101989648B1 (ko) | 2012-01-23 | 2019-06-14 | 노바리크 게엠베하 | 부분불소화 알칸에 기초한 안정화된 단백질 조성물 |
| DK3181119T3 (da) | 2012-09-12 | 2019-09-16 | Novaliq Gmbh | Semifluorerede alkansammensætninger til anvendelse ved behandling af keratoconjunctivitis sicca |
| CN113679697A (zh) | 2012-09-12 | 2021-11-23 | 诺瓦利克有限责任公司 | 包含半氟化烷烃的混合物的组合物 |
| KR101284530B1 (ko) * | 2012-11-13 | 2013-07-16 | 공주대학교 산학협력단 | 생물학적 영구표본 제작용 치환제 및 이의 용도 |
| BR112016001522B1 (pt) | 2013-07-23 | 2019-10-01 | Novaliq Gmbh | Composições de anticorpo estabilizado |
| CN108348777B (zh) | 2015-09-30 | 2020-04-28 | 诺瓦利克有限责任公司 | 半氟化化合物和其组合物 |
| MX2018003781A (es) * | 2015-09-30 | 2018-09-12 | Novaliq Gmbh | Compuestos semifluorados para administracion oftalmica. |
| CN105248412A (zh) * | 2015-10-30 | 2016-01-20 | 暨南大学 | 一种乳化氟碳液在制备肺器官保存液中的应用 |
| USRE50060E1 (en) | 2016-06-23 | 2024-07-30 | Novaliq Gmbh | Topical administration method |
| ES2969758T3 (es) | 2016-09-22 | 2024-05-22 | Novaliq Gmbh | Composiciones farmacéuticas para usar en la terapia de la blefaritis |
| US10813976B2 (en) | 2016-09-23 | 2020-10-27 | Novaliq Gmbh | Ophthalmic compositions comprising ciclosporin |
| PT3399962T (pt) | 2016-12-23 | 2020-09-03 | Novaliq Gmbh | Composição oftálmica para o tratamento da doença do olho seco |
| CA3058097C (en) | 2017-04-21 | 2024-01-02 | Novaliq Gmbh | Iodine compositions |
| US11278503B2 (en) | 2017-05-12 | 2022-03-22 | Novaliq Gmbh | Pharmaceutical compositions comprising semifluorinated alkanes for the treatment of contact lense-related conditions |
| KR20200059272A (ko) | 2017-09-27 | 2020-05-28 | 노바리크 게엠베하 | 안구 질환의 치료에서의 사용을 위한 라타노프로스트를 포함하는 안과적 조성물 |
| CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
| EP3758676A1 (en) | 2018-03-02 | 2021-01-06 | Novaliq GmbH | Pharmaceutical compositions comprising nebivolol |
| KR102882058B1 (ko) | 2018-03-28 | 2025-11-07 | 노바리크 게엠베하 | 티몰롤을 포함하는 약제학적 조성물 |
| JP2021522219A (ja) | 2018-04-27 | 2021-08-30 | ノバリック ゲーエムベーハー | 緑内障の治療のためのタフルプロストを含む眼科用組成物 |
| WO2020064556A1 (en) | 2018-09-27 | 2020-04-02 | Novaliq Gmbh | Topical sunscreen formulation |
| WO2020064549A1 (en) | 2018-09-27 | 2020-04-02 | Novaliq Gmbh | Lipid barrier repair |
| SG11202102820VA (en) | 2018-10-12 | 2021-04-29 | Novaliq Gmbh | Ophthalmic composition for treatment of dry eye disease |
| CN113710228A (zh) | 2019-02-13 | 2021-11-26 | 诺瓦利克有限责任公司 | 用于治疗眼部新生血管形成的组合物和方法 |
| US12419933B2 (en) | 2019-09-06 | 2025-09-23 | Novaliq Gmbh | Ophthalmic composition for the treatment of uveitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993001798A1 (en) * | 1991-07-17 | 1993-02-04 | S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees | Preparations comprising a fluorocarbon and a lipophilic/fluorophilic organic compound, and their uses |
| US6274303B1 (en) * | 1996-11-07 | 2001-08-14 | Brian G. Wowk | Method for rapid cooling and warming of biological materials |
| US20030022148A1 (en) * | 2001-03-06 | 2003-01-30 | Biobank Co., Ltd. | Method for preserving mammalian organs |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0440925A1 (en) | 1989-12-13 | 1991-08-14 | The Green Cross Corporation | Internal organ-preserving liquid and method for preserving internal organs |
| DE4205341A1 (de) | 1992-02-21 | 1993-08-26 | Pharmpur Gmbh | Verfahren zur reinigung von perfluorcarbonen und verwendung der gereinigten perfluorcarbone |
| FR2716678B1 (fr) * | 1994-02-25 | 1996-05-15 | Opsia | Nouveaux composés organiques fluorés, applications en particulier ophtalmologiques et procédé de fabrication. |
| DE19536504C2 (de) * | 1995-09-29 | 1999-09-23 | H Meinert | Verwendung fluorierter Alkane |
| JPH09157251A (ja) | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法 |
-
2005
- 2005-11-23 DE DE102005055811A patent/DE102005055811A1/de not_active Withdrawn
-
2006
- 2006-11-23 CA CA2628085A patent/CA2628085C/en not_active Expired - Fee Related
- 2006-11-23 JP JP2008541642A patent/JP5344924B2/ja not_active Expired - Fee Related
- 2006-11-23 US US12/094,951 patent/US8029977B2/en not_active Expired - Fee Related
- 2006-11-23 KR KR1020087013057A patent/KR101058744B1/ko not_active Expired - Fee Related
- 2006-11-23 EP EP06806724A patent/EP1956895B1/de not_active Not-in-force
- 2006-11-23 AU AU2006316738A patent/AU2006316738B2/en not_active Ceased
- 2006-11-23 DK DK06806724.8T patent/DK1956895T3/da active
- 2006-11-23 WO PCT/EP2006/011247 patent/WO2007059968A2/de not_active Ceased
- 2006-11-23 BR BRPI0618805-2A patent/BRPI0618805A2/pt not_active Application Discontinuation
- 2006-11-23 NZ NZ568206A patent/NZ568206A/en not_active IP Right Cessation
- 2006-11-23 ES ES06806724T patent/ES2365415T3/es active Active
- 2006-11-23 AT AT06806724T patent/ATE509522T1/de active
- 2006-11-23 CN CN2006800437943A patent/CN101312647B/zh not_active Expired - Fee Related
-
2008
- 2008-04-23 ZA ZA200803599A patent/ZA200803599B/xx unknown
- 2008-04-29 IL IL191133A patent/IL191133A0/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993001798A1 (en) * | 1991-07-17 | 1993-02-04 | S.A. A.T.T.A. Applications Et Transferts De Technologies Avancees | Preparations comprising a fluorocarbon and a lipophilic/fluorophilic organic compound, and their uses |
| US6274303B1 (en) * | 1996-11-07 | 2001-08-14 | Brian G. Wowk | Method for rapid cooling and warming of biological materials |
| US20030022148A1 (en) * | 2001-03-06 | 2003-01-30 | Biobank Co., Ltd. | Method for preserving mammalian organs |
Non-Patent Citations (2)
| Title |
|---|
| Eintrag "Octamethyl-trisiloxan". In: Beilstein, 1963, 4. Aufl. 3. Erg. S. 1879 * |
| Mathy-Hartert, M. (u.a.) in: Art. Cells, Blood Subs, and Immob. Biotech., 1997, Vol. 25, S. 563-575 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2335692A1 (en) * | 2009-12-04 | 2011-06-22 | AL.CHI.MI.A. S.r.l. | Silicone liquid and fluorinated liquid for sequential use in the treatment of retinal tears and/or detachments |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007059968A2 (de) | 2007-05-31 |
| CA2628085C (en) | 2013-06-04 |
| DK1956895T3 (da) | 2011-07-25 |
| EP1956895B1 (de) | 2011-05-18 |
| NZ568206A (en) | 2011-05-27 |
| ES2365415T3 (es) | 2011-10-04 |
| EP1956895A2 (de) | 2008-08-20 |
| ZA200803599B (en) | 2009-02-25 |
| AU2006316738A1 (en) | 2007-05-31 |
| US20090226875A1 (en) | 2009-09-10 |
| US8029977B2 (en) | 2011-10-04 |
| HK1126622A1 (en) | 2009-09-11 |
| CA2628085A1 (en) | 2007-05-31 |
| BRPI0618805A2 (pt) | 2011-09-13 |
| WO2007059968A3 (de) | 2008-07-10 |
| CN101312647B (zh) | 2012-06-27 |
| IL191133A0 (en) | 2008-12-29 |
| KR101058744B1 (ko) | 2011-08-24 |
| KR20080064998A (ko) | 2008-07-10 |
| AU2006316738B2 (en) | 2011-10-13 |
| CN101312647A (zh) | 2008-11-26 |
| JP5344924B2 (ja) | 2013-11-20 |
| ATE509522T1 (de) | 2011-06-15 |
| JP2009516717A (ja) | 2009-04-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE102005055811A1 (de) | Verwendung einer Zusammensetzung zur Konservierung von Organen und Gliedmaßen | |
| DE4127442C2 (de) | Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung | |
| DE2712574A1 (de) | Festes, stabiles desinfektions- und/oder sterilisationsmittel | |
| DE2409598A1 (de) | Gastransportwirkstoff fuer tiere | |
| DE19536504A1 (de) | Fluorierte Alkane und ihre Verwendung | |
| EP0965338A1 (de) | Sauerstoffarme Perfluoroalkane für die Ophthalmologie | |
| DE2926850C2 (de) | Verfahren zur Herstellung einer sterilen injizierbaren physiologisch annehmbaren Lösung eines nicht ionischen m-Carboxamido-o-jodo-N-(β-hydroxyalkyl)-anilin-Röntgenkontrastmittels und Lösungen des Röntgenkontrastmittels und eines Puffers | |
| DE69414947T2 (de) | Dialyselösung zur extrakorporalen Hemodialyse | |
| US3758409A (en) | Cleaning and bleaching liquid composition | |
| DE69725900T2 (de) | KEIMTÖTENDE, NIEDER-pH IODZUSAMMENSETZUNGEN MIT ERHÖHTER STABILITÄT | |
| DE69818823T2 (de) | Dipohosphonsäuresalze für die behandlung von osteoporose | |
| DE102009049504A1 (de) | Wund- und Schleimhautantiseptikum auf der Basis von Bispyridiniumalkanen | |
| DE69625254T2 (de) | Zusammensetzungen und verfahren zum konservieren von lebenden geweben | |
| ES2539639T3 (es) | Procedimiento de tratamiento de cucarachas | |
| JP6051480B1 (ja) | ポビドンヨードを主成分とする水溶液殺菌剤組成物 | |
| DE1207048B (de) | Roentgenkontrastmittel und Verfahren zu deren Herstellung | |
| DE3820840C1 (en) | Aqueous reperfusion solution for reducing the reperfusion damage after acute peripheral vascular occlusion | |
| ATE331507T1 (de) | Stabile pharmazeutische zusammensetzung mit safingol und verfahren zu dessen verwendung | |
| DE112012001386T5 (de) | Optimierte Präparate von sehr anpassungsfähigen Aggregaten | |
| JP2513614B2 (ja) | 組織薄膜の透過率を改善した薬物 | |
| DE19519922C2 (de) | Calcium-Quelle für Korallen-Aquarien | |
| KR19990064105A (ko) | 아파판트를 활성 성분으로 함유한 점안 수용액 | |
| DE19811683C2 (de) | Behandlungsmittel für die Ophthalmologie | |
| EP1624896B1 (de) | Verfahren zur herstellung einer stabilen injizierbaren formulierung von paclitaxel | |
| HK1126622B (en) | Use of a composition for preserving organs and limbs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| R120 | Application withdrawn or ip right abandoned |
Effective date: 20120606 |