DE102004020856A1 - Biokompatible, biostabile Beschichtung von medizinischen Oberflächen - Google Patents

Biokompatible, biostabile Beschichtung von medizinischen Oberflächen Download PDF

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Publication number
DE102004020856A1
DE102004020856A1 DE102004020856A DE102004020856A DE102004020856A1 DE 102004020856 A1 DE102004020856 A1 DE 102004020856A1 DE 102004020856 A DE102004020856 A DE 102004020856A DE 102004020856 A DE102004020856 A DE 102004020856A DE 102004020856 A1 DE102004020856 A1 DE 102004020856A1
Authority
DE
Germany
Prior art keywords
polysulfone
layer
acid
medical device
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004020856A
Other languages
German (de)
English (en)
Inventor
Roland Horres
Michael Dr. Hoffmann
Volker Dr. Faust
Erika Hoffmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemoteq AG
Original Assignee
Hemoteq AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemoteq AG filed Critical Hemoteq AG
Priority to DE102004020856A priority Critical patent/DE102004020856A1/de
Priority to ES04786896T priority patent/ES2304626T3/es
Priority to AU2004277302A priority patent/AU2004277302B2/en
Priority to EA200600470A priority patent/EA011822B1/ru
Priority to DE112004002385T priority patent/DE112004002385D2/de
Priority to AP2006003570A priority patent/AP2006003570A0/xx
Priority to DE502004005857T priority patent/DE502004005857D1/de
Priority to AT04786896T priority patent/ATE382377T1/de
Priority to PCT/DE2004/002184 priority patent/WO2005032611A2/de
Priority to BRPI0414849A priority patent/BRPI0414849B1/pt
Priority to CNA2004800281495A priority patent/CN101094698A/zh
Priority to EP04786896A priority patent/EP1667743B1/de
Priority to KR1020067005938A priority patent/KR100983440B1/ko
Priority to PL04786896T priority patent/PL1667743T3/pl
Priority to JP2006527276A priority patent/JP4861178B2/ja
Priority to NZ546068A priority patent/NZ546068A/en
Priority to CA2540382A priority patent/CA2540382C/en
Publication of DE102004020856A1 publication Critical patent/DE102004020856A1/de
Priority to ZA2006/02180A priority patent/ZA200602180B/en
Priority to IL174492A priority patent/IL174492A/en
Priority to OA1200600103A priority patent/OA13261A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D181/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur, with or without nitrogen, oxygen, or carbon only; Coating compositions based on polysulfones; Coating compositions based on derivatives of such polymers
    • C09D181/06—Polysulfones; Polyethersulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
DE102004020856A 2003-09-29 2004-04-28 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen Withdrawn DE102004020856A1 (de)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE102004020856A DE102004020856A1 (de) 2003-09-29 2004-04-28 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen
BRPI0414849A BRPI0414849B1 (pt) 2003-09-29 2004-09-29 produto medicinal e método de revestimento biocompatível de produtos medicinais
KR1020067005938A KR100983440B1 (ko) 2003-09-29 2004-09-29 의료품 표면의 생체적합성, 생체안정성 피막
EA200600470A EA011822B1 (ru) 2003-09-29 2004-09-29 Медицинский продукт, покрытый биологически стабильным полисульфоновым слоем, и способ нанесения покрытия
DE112004002385T DE112004002385D2 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen
AP2006003570A AP2006003570A0 (en) 2003-09-29 2004-09-29 Biocompatible, Biostable coating of medical surfaces.
DE502004005857T DE502004005857D1 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile beschichtung von medizinischen oberflächen
AT04786896T ATE382377T1 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile beschichtung von medizinischen oberflächen
PCT/DE2004/002184 WO2005032611A2 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile beschichtung von medizinischen oberflächen
ES04786896T ES2304626T3 (es) 2003-09-29 2004-09-29 Superficies medicas hemocompatibles que tienen un revestimiento biocompatible, bioestable.
CNA2004800281495A CN101094698A (zh) 2003-09-29 2004-09-29 医学表面的生物相容,生物稳定的涂层
EP04786896A EP1667743B1 (de) 2003-09-29 2004-09-29 Biokompatible, biostabile beschichtung von medizinischen oberflächen
AU2004277302A AU2004277302B2 (en) 2003-09-29 2004-09-29 Biocompatible, biostable coating of medical surfaces
PL04786896T PL1667743T3 (pl) 2003-09-29 2004-09-29 Biokompatybilne, biostabilne pokrycie powierzchni medycznych
JP2006527276A JP4861178B2 (ja) 2003-09-29 2004-09-29 生体適合性および生物学的安定性を有する医療用品表面コーティング
NZ546068A NZ546068A (en) 2003-09-29 2004-09-29 Biocompatible, biostable coating of medical surfaces
CA2540382A CA2540382C (en) 2003-09-29 2004-09-29 Biocompatible, biostable coating of medical surfaces
ZA2006/02180A ZA200602180B (en) 2003-09-29 2006-03-15 Biocompatible, biostable coating of medical surfaces
IL174492A IL174492A (en) 2003-09-29 2006-03-22 Biocompatible, biostable coating of medical surfaces
OA1200600103A OA13261A (en) 2003-09-29 2006-09-29 Biocompatible, biostable coating of medical surfaces.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10345132 2003-09-29
DE10345132.3 2003-09-29
DE102004020856A DE102004020856A1 (de) 2003-09-29 2004-04-28 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen

Publications (1)

Publication Number Publication Date
DE102004020856A1 true DE102004020856A1 (de) 2005-04-14

Family

ID=34306136

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004020856A Withdrawn DE102004020856A1 (de) 2003-09-29 2004-04-28 Biokompatible, biostabile Beschichtung von medizinischen Oberflächen

Country Status (3)

Country Link
JP (1) JP4861178B2 (https=)
DE (1) DE102004020856A1 (https=)
OA (1) OA13261A (https=)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008003298A3 (de) * 2006-07-03 2009-07-30 Hemoteq Ag Herstellung, verfahren und verwendung von wirkstofffreisetzenden medizinprodukten zur permanenten offenhaltung von blutgefässen
DE102008043724A1 (de) 2008-11-13 2010-05-20 Biotronik Vi Patent Ag Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein
RU2458710C2 (ru) * 2007-01-21 2012-08-20 Хемотек Аг Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
EP3563811A1 (de) * 2018-05-03 2019-11-06 Biotronik Ag Verminderung der rissbildung in polymerschichten von abbaubaren scaffolds
US11045632B2 (en) 2017-04-24 2021-06-29 Longeviti Neuro Solutions Llc Cerebral spinal fluid shunt plug
US11439798B2 (en) 2017-04-24 2022-09-13 Longeviti Neuro Solutions Llc Cerebral spinal fluid shunt plug
US12569655B2 (en) 2017-04-24 2026-03-10 Longeviti Neuro Solutions, Inc. Cerebral spinal fluid shunt plug

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070160641A1 (en) * 2006-01-12 2007-07-12 Eun-Hyun Jang Coated medical devices and methods of making the same
CN102274550B (zh) * 2010-06-13 2014-11-26 上海微创医疗器械（集团）有限公司 一种介入医疗器械

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432141A2 (en) * 1984-03-30 1991-06-12 Osteonics Biomaterials, Inc. A femoral stem for permanent implantation into the natural femur
DE69112425T2 (de) * 1990-12-21 1996-02-15 Howmedica Hydrogel-zwischenwirbel-discus-pulposus.
WO1996008149A1 (en) * 1994-09-16 1996-03-21 Beatrice Haimovich Thromboresistant surface treatment for biomaterials
DE19539449A1 (de) * 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial
EP0953320A2 (en) * 1998-04-30 1999-11-03 Medtronic, Inc. Medical device
WO2002041931A2 (en) * 2000-11-27 2002-05-30 Medtronic, Inc. Stents and methods for preparing stents
WO2003034944A1 (de) * 2001-10-15 2003-05-01 Hemoteq Gmbh Beschichtung von stents zur verhinderung von restenose

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2580423B2 (ja) * 1991-02-27 1997-02-12 三井東圧化学株式会社 外科用フィラメントの製造方法
JP2002504842A (ja) * 1997-06-24 2002-02-12 シェリング アクチェンゲゼルシャフト フルオロアルキル基でコートされたステント、その製造法、及び再狭窄防止への利用
WO1999019381A1 (en) * 1997-10-09 1999-04-22 Teijin Limited Medical material containing fluorinated polysulfone having excellent antithrombotic activity
US6500549B1 (en) * 1998-10-13 2002-12-31 Gambro Ab Biocompatible polymer film
CA2355873A1 (en) * 1998-12-31 2000-07-13 Angiotech Pharmaceuticals, Inc. Stent grafts with bioactive coatings
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
JP2004131566A (ja) * 2002-10-09 2004-04-30 Asahi Kasei Corp 分岐ポリエチレンオキシド−合成高分子ブロック共重合体
US7279174B2 (en) * 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432141A2 (en) * 1984-03-30 1991-06-12 Osteonics Biomaterials, Inc. A femoral stem for permanent implantation into the natural femur
DE69112425T2 (de) * 1990-12-21 1996-02-15 Howmedica Hydrogel-zwischenwirbel-discus-pulposus.
WO1996008149A1 (en) * 1994-09-16 1996-03-21 Beatrice Haimovich Thromboresistant surface treatment for biomaterials
DE19539449A1 (de) * 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial
EP0953320A2 (en) * 1998-04-30 1999-11-03 Medtronic, Inc. Medical device
WO2002041931A2 (en) * 2000-11-27 2002-05-30 Medtronic, Inc. Stents and methods for preparing stents
WO2003034944A1 (de) * 2001-10-15 2003-05-01 Hemoteq Gmbh Beschichtung von stents zur verhinderung von restenose

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007271554B2 (en) * 2006-07-03 2011-02-10 Hemoteq Ag Manufacture, method, and use of active substance-releasing medical products for permanently keeping blood vessels open
RU2432183C2 (ru) * 2006-07-03 2011-10-27 Хемотек Аг Стент (варианты) и катетерный баллон
RU2432183C9 (ru) * 2006-07-03 2012-03-10 Хемотек Аг Стент
WO2008003298A3 (de) * 2006-07-03 2009-07-30 Hemoteq Ag Herstellung, verfahren und verwendung von wirkstofffreisetzenden medizinprodukten zur permanenten offenhaltung von blutgefässen
RU2458710C2 (ru) * 2007-01-21 2012-08-20 Хемотек Аг Медицинский продукт для лечения обтураций просветов организма и для предупреждения угрожающих повторных обтураций
US8597720B2 (en) 2007-01-21 2013-12-03 Hemoteq Ag Medical product for treating stenosis of body passages and for preventing threatening restenosis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
DE102008043724A1 (de) 2008-11-13 2010-05-20 Biotronik Vi Patent Ag Erhöhung der Effizienz pharmazeutische Wirkstoffe-freisetzender Medizinprodukte durch Kombination mit einem Inhibitor des Transportproteins P-Glycoprotein
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US11278648B2 (en) 2009-07-10 2022-03-22 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US11045632B2 (en) 2017-04-24 2021-06-29 Longeviti Neuro Solutions Llc Cerebral spinal fluid shunt plug
US11439798B2 (en) 2017-04-24 2022-09-13 Longeviti Neuro Solutions Llc Cerebral spinal fluid shunt plug
US12569655B2 (en) 2017-04-24 2026-03-10 Longeviti Neuro Solutions, Inc. Cerebral spinal fluid shunt plug
EP3563811A1 (de) * 2018-05-03 2019-11-06 Biotronik Ag Verminderung der rissbildung in polymerschichten von abbaubaren scaffolds
DE102018110582A1 (de) * 2018-05-03 2019-11-07 Biotronik Ag Verminderung der Rissbildung in Polymerschichten von abbaubaren Scaffolds

Also Published As

Publication number Publication date
OA13261A (en) 2007-01-31
JP2007508039A (ja) 2007-04-05
JP4861178B2 (ja) 2012-01-25

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Legal Events

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OM8 Search report available as to paragraph 43 lit. 1 sentence 1 patent law
8143 Lapsed due to claiming internal priority
8127 New person/name/address of the applicant

Owner name: HEMOTEQ AG, 52146 WUERSELEN, DE