DE10159748T1 - Antioxidations-Nahrungsergänzungszusammensetzungen - Google Patents

Antioxidations-Nahrungsergänzungszusammensetzungen Download PDF

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DE10159748T1
DE10159748T1 DE10159748T DE10159748T DE10159748T1 DE 10159748 T1 DE10159748 T1 DE 10159748T1 DE 10159748 T DE10159748 T DE 10159748T DE 10159748 T DE10159748 T DE 10159748T DE 10159748 T1 DE10159748 T1 DE 10159748T1
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supplement
antioxidant
lipophobic
lipophilic
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DE10159748A1 (de
DE10159748B4 (de
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Eileen P. Grand Prairie Vennum
Shayne A. Cedar Hill MCANALLEY
Michael C. Houston KOEPKE
Bill H. Grand Prairie McAnalley
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Mannatech Inc
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Abstract

Antioxidative Nahrungsmittelergänzung umfassend:
ein isoliertes und gereinigtes lipophobes Antioxidanz; und
ein isoliertes und gereinigtes lipophiles Antioxidanz, worin die kombinierten lipophoben und lipophilen Antioxidanzien einen aufgelösten Sauerstoffwert von mehr als 6000 μMol Troloxäquivalente (TE)/Gramm haben.

Claims (22)

  1. Antioxidative Nahrungsmittelergänzung umfassend: ein isoliertes und gereinigtes lipophobes Antioxidanz; und ein isoliertes und gereinigtes lipophiles Antioxidanz, worin die kombinierten lipophoben und lipophilen Antioxidanzien einen aufgelösten Sauerstoffwert von mehr als 6000 μMol Troloxäquivalente (TE)/Gramm haben.
  2. Ergänzung gemäß Anspruch 1, worin das lipophobe und das lipophile Antioxidanz zeitverzögert freigesetzt sind.
  3. Ergänzung gemäß Anspruch 1, worin das lipophobe Antioxidanz ausgewählt ist aus der Gruppe bestehend aus einem oder mehreren Vitaminen E, ausgewählt aus der Gruppe bestehend aus Alpha-, Beta-, Delta-, Epsilon-, Gamma-, Zeta-, Eta-, xi1-, xi2- und Sigma-Tocopherole und Alpha-, Beta-, Delta- und Gamma-Tocotrienole, Analoga davon, pharmazeutisch akzeptable Salze davon und Kombinationen davon.
  4. Ergänzung gemäß Anspruch 1, worin das lipophile Antioxidanz ausgewählt ist aus der Gruppe bestehend aus Quercetin, Kaempferol, Myricetin, Apigenin und Derivaten, Analoga, pharmazeutisch akzeptablen Salzen davon und Kombinationen davon.
  5. Ergänzung gemäß Anspruch 1, weiterhin umfassend zwei oder mehrere essentielle Saccharide.
  6. Ergänzung gemäß Anspruch 1, weiterhin umfassend zwei oder mehrere Saccharide, ausgewählt aus Galactose, Galactosamin, Glucosamin, Glucose, Mannose, acetylierter Mannose, N-Acetylneuraminsäure, Fucose, N-Acetylgalactosamin, N-Acetylglucosamin und Xylose.
  7. Ergänzung gemäß Anspruch 1, weiterhin umfassend eine Pflanzenquelle von Vitamin C.
  8. Ergänzung gemäß Anspruch 7, worin die Pflanzenquelle von Vitamin C eine australische Buschpflaume (Terminalia ferdinandiana) umfasst.
  9. Ergänzung gemäß Anspruch 7, worin die Pflanzenquelle von Vitamin C eine wilde australische Buschpflaume (Terminalia ferdinandiana) umfasst.
  10. Ergänzung gemäß Anspruch 7, weiterhin umfassend ein oder mehrere Probiotika.
  11. Ergänzung gemäß Anspruch 7, weiterhin umfassend ein oder mehrere Probiotika ausgewählt aus Lactobacillus sp. und Bifido-bacterium sp.
  12. Ergänzung gemäß Anspruch 1, worin die Ergänzung komprimiert ist, unter Erhalt einer im allgemeinen sauerstoffundurchlässigen Oberfläche.
  13. Ergänzung gemäß Anspruch 1, worin die Ergänzung ein walzenkomprimiertes Teilchen, eine Kapsel, Tablette, Minitablette, Dragee, schäumende Tablette oder Kombination davon ist.
  14. Ergänzung gemäß Anspruch 1, worin das isolierte und gereinigte lipophile Antioxidanz, das lipophobe und das lipophile Antioxidanz einen Antioxidanz ORAC(fl-lipo)-Wert von mehr als 7000 μMol Troloxäquivalenten (TE)/Gramm haben.
  15. Ergänzung gemäß Anspruch 1, worin das isolierte und gereinigte lipophile Antioxidanz, das lipophobe und das liphophile Antioxidanz bei Verabreichung an einen Patienten eine Erhöhung von mehr als 13%, gemessen durch ORAC(β-PE) von dem Antioxdianz-Grundlinienniveau des Patienten, ergeben.
  16. Nahrungsergänzung, umfassend: eine nahrungsmäßig wirksame Menge von zwei oder mehreren essentiellen Sacchariden, ein isoliertes und gereinigtes lipophobes Sauerstoffradikal-Abfangmittel, und ein isoliertes und gereinigtes lipophiles Sauerstoffradikal-Abfangmittel, worin das lipophobe und das lipophile Sauerstoffradikal-Abfangmittel in kombinierter Form einen Sauerstoffradikal-Abfangwert von mehr als 6000 μMol Troloxäquivalent (TE)/Gramm haben.
  17. Ergänzung gemäß Anspruch 16, worin das lipophobe und das lipophile Sauerstoffradikal-Abfangmittel bei Verabreichung an einen Patienten eine Erhöhung von mehr als 13%, gemessen durch ORAC(β-PE) von dem Grundlinienantioxidanzniveau des Patienten, ergeben.
  18. Ergänzung gemäß Anspruch 16, worin das lipophobe und das lipophile Sauerstoffradikal-Abfangmittel für die verzögerte Freisetzung abgepackt sind.
  19. Ergänzung gemäß Anspruch 16, worin das lipophobe Sauerstoffradikal-Abfangmittel aus der Gruppe ausgewählt ist, bestehend aus einem oder mehreren Vitaminen E, ausgewählt aus der Gruppe, bestehend aus Alpha-, Beta-, Delta-, Epsilon-, Gamma-, Zeta-, Eta-, xi1-, xi2- und Sigma-Tocopherolen und Alpha-, Beta-, Delta- und Gamma-Tocotrienolen, Analoga davon, pharmazeutisch akzeptablen Salzen davon und Kombinationen davon.
  20. Ergänzung gemäß Anspruch 16, worin das lipophile Sauerstoffradikal-Abfangmittel aus der Gruppe ausgewählt ist, bestehend aus Flavonolen, Quercetin, Kaempferol, Myricetin, Apigenin und Derivaten, Analoga, pharmazeutisch akzeptablen Salzen davon und Kombinationen davon.
  21. Ergänzung gemäß Anspruch 16, weiterhin umfassend zwei oder mehrere Saccharide, ausgewählt aus der Gruppe bestehend aus Galactose, Glucose, Mannose, N-Acetylneuraminsäure, Fucose, N-Acetylgalactosamin, N-Acetylglucosamin und Xylose, Derivaten, Analoga, pharmazeutisch akzeptablen Salzen davon und Kombinationen davon.
  22. Ergänzung gemäß Anspruch 16, weiterhin umfassend sechs oder mehr Saccharide, ausgewählt aus der Gruppe bestehend aus Galactose, Glucose, Mannose, N-Acetylneuraminsäure, Fucose, N-Acetylgalactosamin, N-Acetylglucosamin und Xylose, Derivaten, Analoga, pharmazeutisch akzeptablen Salzen davon und Kombinationen davon.
DE10159748T 2003-08-26 2004-08-25 Antioxidations-Nahrungsergänzungszusammensetzungen Granted DE10159748T1 (de)

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Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7999003B2 (en) * 2003-08-26 2011-08-16 Mannatech, Incorporated Antioxidant compositions and methods thereto
US20050214413A1 (en) * 2003-08-26 2005-09-29 Mannatech, Inc. Methods and compositions for modified release of nutritional supplements
US7175862B2 (en) * 2004-01-28 2007-02-13 Access Business Group International Llc Method of preparing kakadu plum powder
JP4568578B2 (ja) * 2004-02-19 2010-10-27 ニュースキン インターナショナル インコーポレイテッド バイオフォトニック・フィードバック制御装置及び方法
EP1928268A1 (de) * 2005-09-30 2008-06-11 DSMIP Assets B.V. Neue polyphenolhaltige zusammensetzungen
BRPI0706661A2 (pt) 2006-01-19 2011-04-05 Mary Kay Inc composições compreendendo extrato da ameixa kakadu ou extrato da polpa do açaì
EP2117356B1 (de) * 2007-01-17 2012-07-04 Fytexia Antioxidans-nahrungsmittelzusammensetzung, die früchte und gemüse enthält, verfahren zu ihrer herstellung und verwendung der zusammensetzung
US20080234553A1 (en) * 2007-03-20 2008-09-25 Urman David A Non-invasive human-health-measurement system and method
CN103083642B (zh) * 2007-05-11 2015-11-18 芦荟研究实验室公司 用于皮肤增强的芦荟制剂
CN101632458A (zh) * 2008-07-21 2010-01-27 应维潮 生产高orac值的葡萄提取物的方法以及所生产的葡萄提取物
KR100996450B1 (ko) * 2008-08-21 2010-11-25 한국과학기술연구원 표면 플라즈몬 공명의 원리를 이용한 산소센서와 표면 플라즈몬 공명의 원리를 이용한 산소센서가 포함된 산소투과도 측정장치
US9301536B2 (en) * 2008-09-19 2016-04-05 Epax Norway As Antioxidant composition for marine oils comprising tocopherol, rosemary extract, ascorbic acid and green tea extract
US7833829B2 (en) * 2008-10-28 2010-11-16 Honeywell International Inc. MEMS devices and methods of assembling micro electromechanical systems (MEMS)
FR2937866B1 (fr) 2008-10-30 2010-11-26 Natura Cosmeticos Sa Complexe antioxydant, compositions cosmetiques et pharmaceutiques contenant ledit complexe et utilisation dudit complexe
EP2377875B1 (de) * 2008-11-19 2020-09-02 Morinaga Milk Industry Co., Ltd. Antioxidationsmittel
US7897183B2 (en) * 2008-12-23 2011-03-01 The Dial Corporation Synergistic antioxidant combinations of herb extracts and methods relating thereto
US8986748B2 (en) * 2008-12-23 2015-03-24 The Dial Corporation Combinations of herb extracts having synergistic antioxidant effect, and methods relating thereto
US8198091B2 (en) * 2008-12-24 2012-06-12 Brunswick Laboratories, Llc Method for assaying the antioxidant capacity of a skin care product
MX2012002424A (es) 2009-08-28 2012-06-27 Mary Kay Inc Formulaciones para el cuidado de la piel.
JP2013508724A (ja) * 2009-10-20 2013-03-07 ブリガム・ヤング・ユニバーシティ 食品中にみられるフェノール化合物の相乗的相互作用
US8551419B2 (en) * 2010-03-12 2013-10-08 Amcor Limited Container having an oxygen scavenging indication system
US8496885B2 (en) * 2010-03-12 2013-07-30 Amcor Limited Container having oxygen scavenging system
US8524157B2 (en) * 2010-03-12 2013-09-03 Amcor Limited Container having an oxygen scavenging activation system
MX362176B (es) 2010-06-25 2019-01-07 Amcor Rigid Plastics Usa Llc Sistema de depuracion de oxigeno para un recipiente.
US20130203171A1 (en) * 2010-10-14 2013-08-08 Sportsman Consulting Llc Analytical method and titration device
EP2670415A4 (de) * 2011-02-02 2014-11-26 Justbio Inc Funktionelle nahrungsmittel und getränke mit synergistischen eigenschaften zur förderung von homöostase
KR101274604B1 (ko) 2011-07-13 2013-06-13 매일유업주식회사 Ｎ―아세틸뉴라민산을 포함하는 글리코마크로펩티드 뉴라미니다아제 분해물을 유효성분으로 하는 천연 항균제 조성물
CN102507522B (zh) * 2011-11-07 2014-01-29 上海智城分析仪器制造有限公司 一种氧自由基吸收能力测定分析仪中数据采集方法及加热系统
RU2486499C1 (ru) * 2012-04-10 2013-06-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Уральский государственный экономический университет" (ФГБОУ ВПО "УрГЭУ") Способ определения оксидантной/антиоксидантной активности веществ и устройство для его осуществления
US10434131B2 (en) 2015-03-16 2019-10-08 Nature's Sunshine Products, Inc. Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations
RU2612132C2 (ru) * 2015-07-16 2017-03-02 Федеральное государственное автономное образовательное учреждение высшего образования "Уральский федеральный университет имени первого Президента России Б.Н. Ельцина" Способ потенциометрического определения скорости генерирования пероксильных радикалов
KR20230163571A (ko) * 2017-12-01 2023-11-30 엠케이에스 인스트루먼츠 인코포레이티드 라디칼 가스 및 단기 분자를 위한 다중 센서 가스 샘플링 검출 시스템 및 사용 방법
JP2019113375A (ja) * 2017-12-22 2019-07-11 サッポロホールディングス株式会社 腸内環境評価方法、大腸炎罹患リスク評価方法、及び腸内環境改善物質のスクリーニング方法
GB201804837D0 (en) * 2018-03-26 2018-05-09 Pepsis Ltd Diagnostic methods in treatments in equine dieases
CN108613952A (zh) * 2018-04-14 2018-10-02 河北工业职业技术学院 一种杨梅素的分析测定方法
KR102631708B1 (ko) 2018-06-19 2024-01-31 삼성전자주식회사 항산화 지수 측정 장치 및 방법
KR102544670B1 (ko) 2018-07-27 2023-06-16 삼성전자주식회사 항산화 센서, 항산화 신호 측정 방법 및 항산화 레벨 판단 방법
KR102022338B1 (ko) * 2018-08-06 2019-09-18 이건무 당과 아미노산을 함유하는 안정한 수액제 조성물
CN110146454B (zh) * 2019-05-16 2021-07-09 江南大学 通过构建可分离再生体系验证抗氧化剂间再生作用的方法
EP4202435A4 (de) * 2020-08-20 2024-09-11 Shimadzu Corp Inspektionsvorrichtung und inspektionsverfahren
EP4289417A1 (de) * 2022-06-08 2023-12-13 Tradichem Industrial Services, S.L. Verfahren zur herstellung von quercetin hoher dichte
CN115651761A (zh) * 2022-10-12 2023-01-31 中国林业科学研究院林产化学工业研究所 基于协同效应延长橄榄油货架期的内源性多酚的添加方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2726689A (en) * 1953-03-30 1955-12-13 Robert L Busby Motor attachment device for power tools
US3585719A (en) * 1967-10-19 1971-06-22 Stanley Edward Kivela Power tools
US4317282A (en) * 1980-06-30 1982-03-02 Pace Paul D Wood sanding, grass and wood cutting electric drill attachment device
US4851224A (en) * 1986-06-05 1989-07-25 Carrington Laboratories, Inc. Process for preparation of aloe products
US4457918A (en) * 1982-05-12 1984-07-03 The General Hospital Corporation Glycosides of vitamins A, E and K
US4521410A (en) * 1984-05-03 1985-06-04 The General Hospital Corporation Vitamin D glycosyl orthoesters
JPS6131095A (ja) 1984-07-24 1986-02-13 Kazutaka Shinohara 粘質多糖及びその製造方法
SE452776B (sv) 1986-04-02 1987-12-14 Johansson Hanna Maria E Forfarande for framstellning av oligosackarider
FR2601021B2 (fr) * 1986-07-07 1988-11-18 Pasteur Institut Fraction immunogene active a l'egard des bilharzioses, sa preparation, compositions immunisantes la contenant
US5128143A (en) * 1988-09-19 1992-07-07 Edward Mendell Co., Inc. Sustained release excipient and tablet formulation
US4972589A (en) * 1989-08-31 1990-11-27 Povleski Robert W Cutting and sanding attachments for a hand drill
US5202122A (en) * 1989-10-30 1993-04-13 Humanetics Corporation Process for enhancing the hypocholesterolemic effect of edible pulp and the product obtained thereby
US5543514A (en) * 1989-12-21 1996-08-06 Board Of Regents, The University Of Texas System Water-soluble sapphyrins
WO1991016449A1 (en) 1990-04-16 1991-10-31 The Trustees Of The University Of Pennsylvania Saccharide compositions, methods and apparatus for their synthesis
SE9003614L (sv) 1990-11-13 1992-05-14 Kurt G I Nilsson Kosmetisk produkt
GB9027131D0 (en) 1990-12-14 1991-02-06 Rice Evans Catherine Diagnostic test
DE4201172C1 (en) * 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh, 6900 Heidelberg, De Pellets contg. Aloe vera extract - useful, e.g. as antiinflammatory of antibiotic agents, or for treating gastric ulcers
US5578307A (en) * 1992-01-17 1996-11-26 Alfatec-Pharma Gmbh Shaped articles containing plant extract(s), in particular pellets, and their pharmaceutical or cosmetic use
KR950001449B1 (ko) * 1992-07-03 1995-02-24 풀무원식품주식회사 알로에를 주원료로 한 건강보조식품의 제조방법
EP0601417A3 (de) * 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung
US5928668A (en) * 1993-12-21 1999-07-27 Applied Analytical Industries, Inc. Method for dry blend compression of medicaments
US5648377A (en) * 1993-12-21 1997-07-15 Indena S.P.A. Formulations containing carotenoids an procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals
IT1265312B1 (it) * 1993-12-21 1996-10-31 Indena Spa Formulazioni contenenti carotenoidi e procarotenoidi associati a polifenoli nella prevenzione dei danni da abnorme produzione di
IL109539A0 (en) * 1994-05-03 1994-08-26 Yissum Res Dev Co Substained-release pharmaceutical system for the delivery of antioxidants
US5518590A (en) 1994-06-21 1996-05-21 Pennzoil Products Company Electrochemical sensors for motor oils and other lubricants
DE69530892T2 (de) * 1994-07-26 2004-02-26 Black & Decker Inc., Newark Kraftwerkzeug mit modularem Antriebssystem und Verfahren zur Montage des modularen Antriebssystems
JPH0840923A (ja) * 1994-07-28 1996-02-13 Masatoshi Nakano 栄養補助剤
US5569458A (en) * 1994-09-14 1996-10-29 Greenberg; Mike Nutritional formula
DE4444238A1 (de) * 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
FR2729857B1 (fr) * 1995-01-27 1997-04-04 Rhone Poulenc Chimie Compositions pharmaceutiques sous forme de comprimes a liberation prolongee a base de granules en polysaccharides de haut poids moleculaire
US5849709A (en) * 1995-05-10 1998-12-15 Glycomed Incorporated Saccharopeptides and derivatives thereof
CA2224269C (en) 1995-06-22 2008-06-17 Akzo Nobel N.V. Compressed dry-granulation desogestrel tablets
JP3510717B2 (ja) * 1995-09-29 2004-03-29 三栄源エフ・エフ・アイ株式会社 活性酸素・フリーラジカル消去活性を有する飲食品
US6638415B1 (en) 1995-11-16 2003-10-28 Lifescan, Inc. Antioxidant sensor
US6929807B1 (en) * 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
CA2262972C (en) * 1996-08-09 2009-07-14 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6642277B1 (en) * 1996-09-20 2003-11-04 The Howard Foundation Food supplements containing polyphenols
US6086910A (en) 1997-09-19 2000-07-11 The Howard Foundation Food supplements
US6632349B1 (en) * 1996-11-15 2003-10-14 Lifescan, Inc. Hemoglobin sensor
US6177260B1 (en) 1997-07-11 2001-01-23 The Hong Kong Polytechnic University Measurement of antioxidant (reducing) power and/or antioxidant concentration
ATE209911T1 (de) * 1997-10-03 2001-12-15 Warner Lambert Co Gepresste nitroglycerintablette und verfahren zu ihrer herstellung
US6114177A (en) 1997-11-12 2000-09-05 Phytochem Technologies, Inc. Fluorometric assay for measurement of antioxidant activity
US6429021B1 (en) 1998-03-19 2002-08-06 Amway Corporation Antioxidant activity profile assay
FR2780647B1 (fr) 1998-07-03 2002-03-08 Lanatech Composition cosmetique exploitant des effets antiradicalaires synergiques
IT1302307B1 (it) 1998-09-01 2000-09-05 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed atta a migliorarel'utilizzazione metabolica del glucosio, comprendente acetil
US6036403A (en) * 1998-09-03 2000-03-14 Raytheon Company Cable burial system
DE19846148C2 (de) 1998-10-01 2002-10-10 Igor Popov Verfahren zur Beurteilung der oxidativen Modifikation proteinhaltiger Stoffe mittels Messung ihrer antiradikalen Aktivität
US6258846B1 (en) * 1999-06-01 2001-07-10 Drugtech Corporation Nutritional supplements
US6048260A (en) * 1999-07-01 2000-04-11 Roto-Zip Tool Corporation Angle attachment for power tool
US6805880B1 (en) 1999-08-20 2004-10-19 Ferrosan A/S Pharmaceutical delivery system for vitamin C and vitamin E and use of a combination of vitamin C and E for preventing or treating conditions involving oxidative stress
US6562869B1 (en) 1999-09-23 2003-05-13 Juvenon, Inc. Nutritional supplement for increased energy and stamina
CN1409637A (zh) * 1999-10-14 2003-04-09 日清制油株式会社 皮肤美化剂、皮肤用抗老化剂、皮肤用增白剂和外用制剂
US6291533B1 (en) * 1999-12-22 2001-09-18 Vitamerica, Inc. Dietary supplements for each specific blood type
US6680070B1 (en) * 2000-01-18 2004-01-20 Albemarle Corporation Particulate blends and compacted products formed therefrom, and the preparation thereof
US7115297B2 (en) * 2000-02-22 2006-10-03 Suzanne Jaffe Stillman Nutritionally fortified liquid composition with added value delivery systems/elements/additives
US7416749B2 (en) * 2000-06-12 2008-08-26 Access Business Group International Llc Dietary supplement and related method
WO2002003999A1 (en) * 2000-07-10 2002-01-17 The University Of Missisippi High molecular weight polysaccharide fraction from aloe vera with immunostimulatory activity
JP3589623B2 (ja) * 2000-07-13 2004-11-17 独立行政法人 科学技術振興機構 飲食品の抗酸化成分の分離方法
JP4948737B2 (ja) * 2000-07-14 2012-06-06 ライフスキャン・インコーポレイテッド 化学反応速度を測定する電気化学的方法
US6444115B1 (en) * 2000-07-14 2002-09-03 Lifescan, Inc. Electrochemical method for measuring chemical reaction rates
AU2002221934A1 (en) * 2000-12-16 2002-06-24 Aventis Pharma Deutschland Gmbh Health promoting compositions
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US20040220118A1 (en) * 2001-02-02 2004-11-04 Bland Jeffrey S. Medical composition for balancing bodily processes
US20020192314A1 (en) * 2001-03-06 2002-12-19 Cho Suk H. Dietary supplement compositions
US20020182736A1 (en) 2001-04-02 2002-12-05 Trustees Of Tufts College Methods to measure lipid antioxidant activity
CA2401452A1 (en) * 2001-09-04 2003-03-04 Uri Saragovi Combination of antioxidant substances for the treatment of alzheimer's disease
AU2003217848A1 (en) * 2002-03-01 2003-09-16 John M. Cassady Compositions of and derived from strawberry and raspberry and therapeutic uses therefor
US7067150B2 (en) * 2002-04-16 2006-06-27 Scepter Holdings, Inc. Delivery systems for functional ingredients
US20090011048A1 (en) * 2002-04-16 2009-01-08 Coleman Henry D Dietary Supplement For Promoting Removal Of Heavy Metals From The Body
JP2004251870A (ja) * 2003-02-20 2004-09-09 Miriona Keshohin:Kk 化学発光法による抗酸化能の総合的評価法
US20040258674A1 (en) * 2003-04-10 2004-12-23 Thunder Jalili Quercetin supplementation to treat hypertenstion
US7999003B2 (en) * 2003-08-26 2011-08-16 Mannatech, Incorporated Antioxidant compositions and methods thereto

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