DE10137163A1 - Substituierte Isoindole und ihre Verwendung - Google Patents

Substituierte Isoindole und ihre Verwendung

Info

Publication number
DE10137163A1
DE10137163A1 DE10137163A DE10137163A DE10137163A1 DE 10137163 A1 DE10137163 A1 DE 10137163A1 DE 10137163 A DE10137163 A DE 10137163A DE 10137163 A DE10137163 A DE 10137163A DE 10137163 A1 DE10137163 A1 DE 10137163A1
Authority
DE
Germany
Prior art keywords
compounds
formula
substituted
hydroxy
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10137163A
Other languages
German (de)
English (en)
Inventor
Alexander Straub
Thomas Lampe
Jens Pohlmann
Susanne Roehrig
Elisabeth Perzborn
Karl-Heinz Schlemmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE10137163A priority Critical patent/DE10137163A1/de
Priority to CA002455772A priority patent/CA2455772A1/en
Priority to PCT/EP2002/007957 priority patent/WO2003011858A1/de
Priority to JP2003517050A priority patent/JP2005506970A/ja
Priority to DE50202730T priority patent/DE50202730D1/de
Priority to EP02751145A priority patent/EP1414817B1/de
Priority to ES02751145T priority patent/ES2240775T3/es
Priority to US10/485,412 priority patent/US7189738B2/en
Publication of DE10137163A1 publication Critical patent/DE10137163A1/de
Priority to US11/717,414 priority patent/US7482472B2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
DE10137163A 2001-07-30 2001-07-30 Substituierte Isoindole und ihre Verwendung Withdrawn DE10137163A1 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DE10137163A DE10137163A1 (de) 2001-07-30 2001-07-30 Substituierte Isoindole und ihre Verwendung
CA002455772A CA2455772A1 (en) 2001-07-30 2002-07-17 Substituted isoindoles and their use
PCT/EP2002/007957 WO2003011858A1 (de) 2001-07-30 2002-07-17 Substituierte isoindole und ihre verwendung
JP2003517050A JP2005506970A (ja) 2001-07-30 2002-07-17 置換イソインドール類およびそれらの使用
DE50202730T DE50202730D1 (de) 2001-07-30 2002-07-17 Substituierte isoindole und ihre verwendung
EP02751145A EP1414817B1 (de) 2001-07-30 2002-07-17 Substituierte isoindole und ihre verwendung
ES02751145T ES2240775T3 (es) 2001-07-30 2002-07-17 Isoindoles sustituidos y su uso.
US10/485,412 US7189738B2 (en) 2001-07-30 2002-07-17 Substituted isoindoles and their use thereof
US11/717,414 US7482472B2 (en) 2001-07-30 2007-03-12 Substituted isoindoles and their use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10137163A DE10137163A1 (de) 2001-07-30 2001-07-30 Substituierte Isoindole und ihre Verwendung

Publications (1)

Publication Number Publication Date
DE10137163A1 true DE10137163A1 (de) 2003-02-13

Family

ID=7693643

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10137163A Withdrawn DE10137163A1 (de) 2001-07-30 2001-07-30 Substituierte Isoindole und ihre Verwendung
DE50202730T Expired - Fee Related DE50202730D1 (de) 2001-07-30 2002-07-17 Substituierte isoindole und ihre verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50202730T Expired - Fee Related DE50202730D1 (de) 2001-07-30 2002-07-17 Substituierte isoindole und ihre verwendung

Country Status (7)

Country Link
US (2) US7189738B2 (enExample)
EP (1) EP1414817B1 (enExample)
JP (1) JP2005506970A (enExample)
CA (1) CA2455772A1 (enExample)
DE (2) DE10137163A1 (enExample)
ES (1) ES2240775T3 (enExample)
WO (1) WO2003011858A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10134482A1 (de) * 2001-07-16 2003-01-30 Bayer Ag Substituierte Isoindole und ihre Verwendung
US7361672B2 (en) * 2004-12-23 2008-04-22 Hoffmann-La Roche Inc. Heteroarylacetamide inhibitors of factor Xa
CA2627426A1 (en) * 2005-11-11 2007-05-18 Markus Boehringer Carbocyclic fused cyclic amines as inhibitors of the coagulation factor xa
TW200806625A (en) * 2006-05-26 2008-02-01 Astrazeneca Ab Therapeutic compounds
DE102006025317A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Aktiengesellschaft Isoindolin-1-on-,Isoindolin-3-on und Isoindolin-1,3-dion-Derivate und ihre Verwendung
DE102006025318A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Ag Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
EA030373B1 (ru) * 2014-04-23 2018-07-31 Такеда Фармасьютикал Компани Лимитед Изоиндолин-1-оновые производные в качестве положительных аллостерических модуляторов холинергического мускаринового m1 рецептора для лечения болезни альцгеймера
CN105061404B (zh) * 2015-07-21 2017-07-11 广东炜林纳新材料科技股份有限公司 一种亚酰胺类聚丙烯β晶型成核剂及其制备方法
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
EP3830093A1 (en) 2018-07-27 2021-06-09 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8270898A (en) * 1997-06-26 1999-01-19 Eli Lilly And Company Antithrombotic agents
GB9715894D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic derivatives
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
IL137517A0 (en) 1998-01-27 2001-07-24 Aventis Pharm Prod Inc Substituted oxoazaheterocyclyl factor xa inhibitors
US6534651B2 (en) 2000-04-06 2003-03-18 Inotek Pharmaceuticals Corp. 7-Substituted isoindolinone inhibitors of inflammation and reperfusion injury and methods of use thereof
NZ526003A (en) 2000-10-20 2005-09-30 Biocryst Pharm Inc Biaryl compounds as serine protease inhibitors
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof

Also Published As

Publication number Publication date
US7189738B2 (en) 2007-03-13
JP2005506970A (ja) 2005-03-10
ES2240775T3 (es) 2005-10-16
EP1414817A1 (de) 2004-05-06
DE50202730D1 (de) 2005-05-12
US20080039446A1 (en) 2008-02-14
US20040215019A1 (en) 2004-10-28
WO2003011858A1 (de) 2003-02-13
EP1414817B1 (de) 2005-04-06
CA2455772A1 (en) 2003-02-13
US7482472B2 (en) 2009-01-27

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE

8139 Disposal/non-payment of the annual fee