DE10123952A1 - Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel - Google Patents

Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Info

Publication number
DE10123952A1
DE10123952A1 DE10123952A DE10123952A DE10123952A1 DE 10123952 A1 DE10123952 A1 DE 10123952A1 DE 10123952 A DE10123952 A DE 10123952A DE 10123952 A DE10123952 A DE 10123952A DE 10123952 A1 DE10123952 A1 DE 10123952A1
Authority
DE
Germany
Prior art keywords
alkyl
group
different
optionally
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10123952A
Other languages
German (de)
English (en)
Inventor
Karin Winter
Thomas Weiser
Angelo Ceci
Klaus Klinder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE10123952A priority Critical patent/DE10123952A1/de
Priority to US10/141,208 priority patent/US20030100552A1/en
Priority to NZ530154A priority patent/NZ530154A/en
Priority to CNA028100832A priority patent/CN1533278A/zh
Priority to HU0401273A priority patent/HUP0401273A3/hu
Priority to SK1422-2003A priority patent/SK14222003A3/sk
Priority to PCT/EP2002/005338 priority patent/WO2002100411A1/en
Priority to KR10-2003-7014965A priority patent/KR20040007572A/ko
Priority to CZ20033112A priority patent/CZ20033112A3/cs
Priority to IL15864202A priority patent/IL158642A0/xx
Priority to PL02364053A priority patent/PL364053A1/xx
Priority to JP2003503232A priority patent/JP2004529980A/ja
Priority to MXPA03010373A priority patent/MXPA03010373A/es
Priority to EA200301167A priority patent/EA006608B1/ru
Priority to UY27290A priority patent/UY27290A1/es
Priority to EEP200300566A priority patent/EE200300566A/xx
Priority to BR0209796-6A priority patent/BR0209796A/pt
Priority to YU90403A priority patent/YU90403A/sh
Priority to CA002449189A priority patent/CA2449189A1/en
Priority to EP02750931A priority patent/EP1404340A1/en
Priority to ARP020101827A priority patent/AR036332A1/es
Publication of DE10123952A1 publication Critical patent/DE10123952A1/de
Priority to ZA200308466A priority patent/ZA200308466B/en
Priority to US10/699,374 priority patent/US7026475B2/en
Priority to US10/699,168 priority patent/US20040122003A1/en
Priority to BG108324A priority patent/BG108324A/bg
Priority to HR20030933A priority patent/HRP20030933A2/xx
Priority to NO20035088A priority patent/NO20035088D0/no
Priority to EC2003004852A priority patent/ECSP034852A/es
Priority to CO03105591A priority patent/CO5550460A2/es
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DE10123952A 2001-05-17 2001-05-17 Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel Withdrawn DE10123952A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE10123952A DE10123952A1 (de) 2001-05-17 2001-05-17 Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US10/141,208 US20030100552A1 (en) 2001-05-17 2002-05-08 Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions
EEP200300566A EE200300566A (et) 2001-05-17 2002-05-15 AMPA retseptori allosteerilised positiivsed naftotiasiin-modulaatorid
YU90403A YU90403A (sh) 2001-05-17 2002-05-15 Naftotiazinski pozitivno alosterični modulatori ampa receptora (paarm)
BR0209796-6A BR0209796A (pt) 2001-05-17 2002-05-15 Moduladores de receptor ampa alostérico naftotiazina positivos (paarm)
SK1422-2003A SK14222003A3 (sk) 2001-05-17 2002-05-15 Naftotiazíny, farmaceutický prostriedok s ich obsahom a ich použitie
CNA028100832A CN1533278A (zh) 2001-05-17 2002-05-15 萘并噻嗪正变构的ampa受体调节物(paarm)
KR10-2003-7014965A KR20040007572A (ko) 2001-05-17 2002-05-15 나프토티아진 양성 알로스테릭 ａｍｐａ 수용체변조인자(ｐａａｒｍ)
CZ20033112A CZ20033112A3 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
IL15864202A IL158642A0 (en) 2001-05-17 2002-05-15 Naphthothiazine positive allosteric ampa receptor modulators (paarm)
PL02364053A PL364053A1 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
JP2003503232A JP2004529980A (ja) 2001-05-17 2002-05-15 正のアロステリックａｍｐａレセプターモジュレーター（ｐａａｒｍ）であるナフトチアジン化合物
MXPA03010373A MXPA03010373A (es) 2001-05-17 2002-05-15 Moduladores de receptores ampa alostericos naftotiazina positivos.
CA002449189A CA2449189A1 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
UY27290A UY27290A1 (es) 2001-05-17 2002-05-15 Nuevos moduladores de receptores ampa alostéricos positivos (paarm), procedimientos para su preparación y su empleo como medicamentos
NZ530154A NZ530154A (en) 2001-05-17 2002-05-15 Naphthothiazine positive allosteric AMPA receptor modulators ( PAARM )
HU0401273A HUP0401273A3 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators, their use and pharmaceutical compositions containing them
PCT/EP2002/005338 WO2002100411A1 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
EA200301167A EA006608B1 (ru) 2001-05-17 2002-05-15 Нафтотиазиновые позитивные аллостерические модуляторы амра-рецепторов
EP02750931A EP1404340A1 (en) 2001-05-17 2002-05-15 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
ARP020101827A AR036332A1 (es) 2001-05-17 2002-05-17 Derivados sustituidos de nafto[1,8-de]-[1,3]tiazin-1,1-dioxido, procedimientos para su preparacion, su empleo para la preparacion de un medicamento , y los preparados farmaceuticos que contienen dichos compuestos en calidad de sustancias activas
ZA200308466A ZA200308466B (en) 2001-05-17 2003-10-30 Naphtothiazine positive allosteric ampa receptor modulators (PAARM).
US10/699,374 US7026475B2 (en) 2001-05-17 2003-10-31 Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions
US10/699,168 US20040122003A1 (en) 2001-05-17 2003-10-31 Positive allosteric AMPA receptor modulators (PAARM), processes for preparing them, and their use as pharmaceutical compositions
BG108324A BG108324A (bg) 2001-05-17 2003-11-07 Нафтотиазин положителни алостерични модулатори на амра - рецептор
HR20030933A HRP20030933A2 (en) 2001-05-17 2003-11-14 Naphtothiazine positive allosteric ampa receptor modulators (paarm)
NO20035088A NO20035088D0 (no) 2001-05-17 2003-11-14 Naftotiazin positive allosteriske AMPA reseptor modulatorer (PAARM)
EC2003004852A ECSP034852A (es) 2001-05-17 2003-11-17 Moduladores de receptores ampa alostéricos naftotiazina-positivos (paarm)
CO03105591A CO5550460A2 (es) 2001-05-17 2003-12-01 Moduladores de receptores ampa alostericos naftotiazina positivos (paarm)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10123952A DE10123952A1 (de) 2001-05-17 2001-05-17 Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
DE10123952A1 true DE10123952A1 (de) 2002-11-21

Family

ID=7685080

Family Applications (1)

Application Number Title Priority Date Filing Date
DE10123952A Withdrawn DE10123952A1 (de) 2001-05-17 2001-05-17 Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Country Status (26)

Country Link
EP (1) EP1404340A1 (zh)
JP (1) JP2004529980A (zh)
KR (1) KR20040007572A (zh)
CN (1) CN1533278A (zh)
AR (1) AR036332A1 (zh)
BG (1) BG108324A (zh)
BR (1) BR0209796A (zh)
CA (1) CA2449189A1 (zh)
CO (1) CO5550460A2 (zh)
CZ (1) CZ20033112A3 (zh)
DE (1) DE10123952A1 (zh)
EA (1) EA006608B1 (zh)
EC (1) ECSP034852A (zh)
EE (1) EE200300566A (zh)
HR (1) HRP20030933A2 (zh)
HU (1) HUP0401273A3 (zh)
IL (1) IL158642A0 (zh)
MX (1) MXPA03010373A (zh)
NO (1) NO20035088D0 (zh)
NZ (1) NZ530154A (zh)
PL (1) PL364053A1 (zh)
SK (1) SK14222003A3 (zh)
UY (1) UY27290A1 (zh)
WO (1) WO2002100411A1 (zh)
YU (1) YU90403A (zh)
ZA (1) ZA200308466B (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010501597A (ja) * 2006-08-31 2010-01-21 ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ 正のアロステリックａｍｐａ受容体モジュレーターを用いて呼吸抑制を阻害する方法
CN111518058B (zh) * 2020-05-29 2021-03-09 四川大学华西医院 一种噁噻嗪类化合物及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4345297A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor
CA2335510A1 (en) * 1998-06-25 1999-12-29 Merck & Co., Inc. Naphtho[1,8-de]thiasin-2-yl methyl carbapenem antibacterials
DE10004572A1 (de) * 2000-02-02 2001-08-09 Boehringer Ingelheim Pharma Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
UY27290A1 (es) 2002-12-31
CZ20033112A3 (en) 2004-03-17
CO5550460A2 (es) 2005-08-31
NO20035088L (no) 2003-11-14
ECSP034852A (es) 2003-12-24
EA006608B1 (ru) 2006-02-24
NO20035088D0 (no) 2003-11-14
JP2004529980A (ja) 2004-09-30
PL364053A1 (en) 2004-12-13
BR0209796A (pt) 2004-06-01
EE200300566A (et) 2004-02-16
IL158642A0 (en) 2004-05-12
EA200301167A1 (ru) 2004-06-24
EP1404340A1 (en) 2004-04-07
HRP20030933A2 (en) 2004-04-30
CA2449189A1 (en) 2002-12-19
ZA200308466B (en) 2004-05-24
HUP0401273A3 (en) 2006-11-28
NZ530154A (en) 2005-09-30
SK14222003A3 (sk) 2004-05-04
BG108324A (bg) 2004-12-30
YU90403A (sh) 2006-05-25
CN1533278A (zh) 2004-09-29
KR20040007572A (ko) 2004-01-24
AR036332A1 (es) 2004-09-01
MXPA03010373A (es) 2004-03-16
WO2002100411A1 (en) 2002-12-19
HUP0401273A2 (hu) 2004-10-28

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG, 55218 IN

8139 Disposal/non-payment of the annual fee