DE10057754A1 - Neue Sulfonamid-substituierte Pyrazolopyridinderivate - Google Patents
Neue Sulfonamid-substituierte PyrazolopyridinderivateInfo
- Publication number
- DE10057754A1 DE10057754A1 DE10057754A DE10057754A DE10057754A1 DE 10057754 A1 DE10057754 A1 DE 10057754A1 DE 10057754 A DE10057754 A DE 10057754A DE 10057754 A DE10057754 A DE 10057754A DE 10057754 A1 DE10057754 A1 DE 10057754A1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- general formula
- formula
- compound
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10057754A DE10057754A1 (de) | 2000-11-22 | 2000-11-22 | Neue Sulfonamid-substituierte Pyrazolopyridinderivate |
DE50111292T DE50111292D1 (de) | 2000-11-22 | 2001-11-12 | Neue sulfonamid-substituierte pyrazolopyridinderivate |
JP2002544436A JP4309653B2 (ja) | 2000-11-22 | 2001-11-12 | 新規なスルホンアミド置換ピラゾロピリジン誘導体 |
ES01989460T ES2273910T3 (es) | 2000-11-22 | 2001-11-12 | Nuevos derivados de pirazolopiridinma substituidos con sulfonamida. |
US10/432,572 US7115599B2 (en) | 2000-11-22 | 2001-11-12 | Sulfonamide-substituted pyrazolopyridine compounds |
EP01989460A EP1339714B1 (de) | 2000-11-22 | 2001-11-12 | Neue sulfonamid-substituierte pyrazolopyridinderivate |
AU2002227919A AU2002227919A1 (en) | 2000-11-22 | 2001-11-12 | Novel sulfonamide-substituted pyrazolopyridine derivatives |
CA002429313A CA2429313A1 (en) | 2000-11-22 | 2001-11-12 | Novel sulfonamide-substituted pyrazolopyridine derivatives |
PCT/EP2001/013064 WO2002042302A1 (de) | 2000-11-22 | 2001-11-12 | Neue sulfonamid-substituierte pyrazolopyridinderivate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10057754A DE10057754A1 (de) | 2000-11-22 | 2000-11-22 | Neue Sulfonamid-substituierte Pyrazolopyridinderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10057754A1 true DE10057754A1 (de) | 2002-05-23 |
Family
ID=7664123
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10057754A Withdrawn DE10057754A1 (de) | 2000-11-22 | 2000-11-22 | Neue Sulfonamid-substituierte Pyrazolopyridinderivate |
DE50111292T Expired - Lifetime DE50111292D1 (de) | 2000-11-22 | 2001-11-12 | Neue sulfonamid-substituierte pyrazolopyridinderivate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE50111292T Expired - Lifetime DE50111292D1 (de) | 2000-11-22 | 2001-11-12 | Neue sulfonamid-substituierte pyrazolopyridinderivate |
Country Status (8)
Country | Link |
---|---|
US (1) | US7115599B2 (ja) |
EP (1) | EP1339714B1 (ja) |
JP (1) | JP4309653B2 (ja) |
AU (1) | AU2002227919A1 (ja) |
CA (1) | CA2429313A1 (ja) |
DE (2) | DE10057754A1 (ja) |
ES (1) | ES2273910T3 (ja) |
WO (1) | WO2002042302A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1522314A1 (en) * | 2002-06-26 | 2005-04-13 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10220570A1 (de) * | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
DE10232572A1 (de) * | 2002-07-18 | 2004-02-05 | Bayer Ag | Neue 2,5-disubstituierte Pyrimidinderivate |
DE10244810A1 (de) | 2002-09-26 | 2004-04-08 | Bayer Ag | Neue Morpholin-überbrückte Indazolderivate |
MXPA05011387A (es) * | 2003-04-23 | 2005-12-01 | Pharmacia & Upjohn Co Llc | Pirimidinonas y pirimidinotionas sustituidas. |
DE102006043443A1 (de) * | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
DE102006054757A1 (de) * | 2006-11-21 | 2008-05-29 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
DE102007026392A1 (de) * | 2007-06-06 | 2008-12-11 | Bayer Healthcare Ag | Lösungen für die Perfusion und Konservierung von Organen und Geweben |
EP2373317B1 (en) * | 2008-11-25 | 2016-12-14 | Merck Sharp & Dohme Corp. | 4-amino-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one or 4-amino-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one derivatives as activators of the soluble guanylat cyclase for the treatment of cardiovascular diseases |
DE102008063992A1 (de) | 2008-12-19 | 2010-09-02 | Lerner, Zinoviy, Dipl.-Ing. | Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung |
DE102009004245A1 (de) | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Neue anellierte, Heteroatom-verbrückte Pyrazol- und Imidazol-Derivate und ihre Verwendung |
DK2504334T3 (en) | 2009-11-27 | 2014-12-08 | Bayer Ip Gmbh | PROCEDURE FOR PURIFICATION OF METHYL- {4,6-DIAMINO-2- [1- (2-FLUOROBENZYL) -1H-PYRAZOLO [3,4-B] PYRIDIN-3-YL] PYRIMIDIN-5-YL} METHYL CARBAMATE |
UY33041A (es) | 2009-11-27 | 2011-06-30 | Bayer Schering Pharma Aktienegesellschaft | Procedimiento para la preparaciòn de {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo[3,4-b]piridin-3-il]pirimidin-5-il}carbamato de metilo y su purificaciòn para el uso como principio activo farmacèutico |
US9284301B2 (en) | 2010-03-25 | 2016-03-15 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
DE102010021637A1 (de) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung |
US9365574B2 (en) | 2010-05-27 | 2016-06-14 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
DE102010040233A1 (de) | 2010-09-03 | 2012-03-08 | Bayer Schering Pharma Aktiengesellschaft | Bicyclische Aza-Heterocyclen und ihre Verwendung |
WO2012058132A1 (en) | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
WO2013076168A1 (de) | 2011-11-25 | 2013-05-30 | Bayer Pharma Aktiengesellschaft | Verfahren zur herstellung von substituierten 5-fluor-1h-pyrazolopyridinen |
JP6386478B2 (ja) | 2013-02-21 | 2018-09-05 | アドヴェリオ・ファーマ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メチル{4,6−ジアミノ−2−[1−(2−フルオロベンジル)−1h−ピラゾロ[3,4−b]ピリジノ−3−イル]ピリミジノ−5−イル}メチルカルバメートの形態 |
EP3062780A1 (en) | 2013-11-01 | 2016-09-07 | Bergen Teknologioverføring AS | Activators or stimulators of soluble guanylate cyclase for use in treating chronic fatigue syndrome |
KR20180002657A (ko) | 2015-05-06 | 2018-01-08 | 바이엘 파마 악티엔게젤샤프트 | 전신 경화증 (SSc)에 수반되는 수족지 궤양 (DU)의 치료를 위한 sGC 자극제, sGC 활성화제 단독 및 PDE5 억제제와의 조합물의 용도 |
CN113750102A (zh) | 2015-07-23 | 2021-12-07 | 拜耳制药股份公司 | 可溶性鸟苷酸环化酶的刺激剂和/或活化剂及其用途 |
CN108463224A (zh) | 2015-12-14 | 2018-08-28 | 铁木医药有限公司 | sGC刺激剂用于胃肠功能障碍治疗的应用 |
WO2018069148A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten |
WO2018069126A1 (de) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend sgc stimulatoren und mineralocorticoid-rezeptor-antagonisten |
US20190381039A1 (en) | 2016-12-13 | 2019-12-19 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS |
EA202092680A1 (ru) | 2018-05-15 | 2021-04-13 | Байер Акциенгезельшафт | 1,3-тиазол-2-ил-замещенные бензамиды для лечения заболеваний, ассоциированных с сенситизацией нервных волокон |
US20210177846A1 (en) | 2018-07-11 | 2021-06-17 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS |
WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19642255A1 (de) | 1996-10-14 | 1998-04-16 | Bayer Ag | Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten |
HUP0001115A3 (en) | 1996-10-14 | 2001-06-28 | Bayer Ag | Heterocyclylmethyl-substituted pyrazol derivatives, process for their preparation and pharmaceuticals containing the same |
DE19649460A1 (de) | 1996-11-26 | 1998-05-28 | Bayer Ag | Neue substituierte Pyrazolderivate |
US6451805B1 (en) | 1997-11-14 | 2002-09-17 | Bayer Aktiengesellschaft | Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases |
DE19834045A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin |
DE19834047A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
DE19834044A1 (de) * | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
DE19846514A1 (de) | 1998-10-09 | 2000-04-20 | Bayer Ag | Neue Heterocyclyl-methyl-substituierte Pyrazole |
-
2000
- 2000-11-22 DE DE10057754A patent/DE10057754A1/de not_active Withdrawn
-
2001
- 2001-11-12 ES ES01989460T patent/ES2273910T3/es not_active Expired - Lifetime
- 2001-11-12 US US10/432,572 patent/US7115599B2/en not_active Expired - Fee Related
- 2001-11-12 DE DE50111292T patent/DE50111292D1/de not_active Expired - Lifetime
- 2001-11-12 JP JP2002544436A patent/JP4309653B2/ja not_active Expired - Fee Related
- 2001-11-12 CA CA002429313A patent/CA2429313A1/en not_active Abandoned
- 2001-11-12 WO PCT/EP2001/013064 patent/WO2002042302A1/de active IP Right Grant
- 2001-11-12 EP EP01989460A patent/EP1339714B1/de not_active Expired - Lifetime
- 2001-11-12 AU AU2002227919A patent/AU2002227919A1/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1522314A1 (en) * | 2002-06-26 | 2005-04-13 | Ono Pharmaceutical Co., Ltd. | Remedies for diseases caused by vascular contraction or dilation |
EP1522314A4 (en) * | 2002-06-26 | 2009-09-16 | Ono Pharmaceutical Co | MEDICINAL PRODUCTS FOR DISEASES CAUSED BY VASCULAR CONTRACTION OR DILATION |
US8765783B2 (en) | 2002-06-26 | 2014-07-01 | Ono Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treatment of disease due to vascular constriction or vasodilation |
Also Published As
Publication number | Publication date |
---|---|
EP1339714B1 (de) | 2006-10-18 |
JP4309653B2 (ja) | 2009-08-05 |
ES2273910T3 (es) | 2007-05-16 |
US7115599B2 (en) | 2006-10-03 |
CA2429313A1 (en) | 2002-05-30 |
EP1339714A1 (de) | 2003-09-03 |
WO2002042302A1 (de) | 2002-05-30 |
DE50111292D1 (de) | 2006-11-30 |
US20040067937A1 (en) | 2004-04-08 |
AU2002227919A1 (en) | 2002-06-03 |
JP2004517828A (ja) | 2004-06-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8139 | Disposal/non-payment of the annual fee |