DD276687A5 - Verfahren zur herstellung von purinyl- und pyrimidinyl-cyclobutan-derivaten - Google Patents

Verfahren zur herstellung von purinyl- und pyrimidinyl-cyclobutan-derivaten Download PDF

Info

Publication number
DD276687A5
DD276687A5 DD88324295A DD32429588A DD276687A5 DD 276687 A5 DD276687 A5 DD 276687A5 DD 88324295 A DD88324295 A DD 88324295A DD 32429588 A DD32429588 A DD 32429588A DD 276687 A5 DD276687 A5 DD 276687A5
Authority
DD
German Democratic Republic
Prior art keywords
formula
compound
group
atom
bromine
Prior art date
Application number
DD88324295A
Other languages
German (de)
English (en)
Inventor
Robert Zaler
Glenn A Jacobs
Original Assignee
�K@�K@������@�K@����k���Kk��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �K@�K@������@�K@����k���Kk�� filed Critical �K@�K@������@�K@����k���Kk��
Publication of DD276687A5 publication Critical patent/DD276687A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DD88324295A 1987-12-28 1988-12-28 Verfahren zur herstellung von purinyl- und pyrimidinyl-cyclobutan-derivaten DD276687A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/138,737 US4855466A (en) 1987-12-28 1987-12-28 Purinyl cyclobutanes

Publications (1)

Publication Number Publication Date
DD276687A5 true DD276687A5 (de) 1990-03-07

Family

ID=22483400

Family Applications (1)

Application Number Title Priority Date Filing Date
DD88324295A DD276687A5 (de) 1987-12-28 1988-12-28 Verfahren zur herstellung von purinyl- und pyrimidinyl-cyclobutan-derivaten

Country Status (25)

Country Link
US (1) US4855466A (zh)
EP (1) EP0322854B1 (zh)
JP (1) JP2634215B2 (zh)
KR (1) KR970007920B1 (zh)
CN (1) CN1032205C (zh)
AT (1) ATE108452T1 (zh)
AU (2) AU614105B2 (zh)
CA (1) CA1331607C (zh)
DD (1) DD276687A5 (zh)
DE (1) DE3850645T2 (zh)
DK (1) DK170340B1 (zh)
EG (1) EG18639A (zh)
ES (1) ES2056096T3 (zh)
FI (1) FI90422C (zh)
HU (1) HU203236B (zh)
IE (1) IE64591B1 (zh)
IL (1) IL88755A (zh)
MX (1) MX14358A (zh)
NO (1) NO168036C (zh)
NZ (1) NZ227431A (zh)
PH (1) PH25191A (zh)
PL (1) PL159302B1 (zh)
PT (1) PT89349B (zh)
YU (1) YU236288A (zh)
ZA (1) ZA889499B (zh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214048A (en) * 1987-05-19 1993-05-25 Nippon Kayaku Kabushiki Kaisha Oxetanocins
US5597824A (en) * 1987-11-03 1997-01-28 Abbott Laboratories Analogs of oxetanyl purines and pyrimidines
US5723609A (en) * 1988-03-30 1998-03-03 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl purines
US5126345A (en) * 1988-03-30 1992-06-30 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
US5130462A (en) * 1988-03-30 1992-07-14 E. R. Squibb & Sons, Inc. Cyclobutane derivatives
US5185459A (en) * 1988-03-30 1993-02-09 E. R. Squibb & Sons Inc. Bis protected (hydroxymethyl)cyclobutanols
US5369098A (en) * 1988-07-18 1994-11-29 E. R. Squibb & Sons, Inc. Hydroxymethyl cyclobutyl purines
AU622926B2 (en) * 1988-09-09 1992-04-30 Nippon Kayaku Kabushiki Kaisha Pyrimidine or purine cyclobutane derivatives
US5153352A (en) * 1988-10-25 1992-10-06 Bristol-Myers Squibb Company Process for preparation of intermediates of carbocyclic nucleoside analogs
IL92096A0 (en) 1988-10-25 1990-07-12 Abbott Lab Carboxylic nucleoside analogs
US5246931A (en) * 1988-10-25 1993-09-21 Bristol-Myers Squibb Company Carbocyclic nucleoside analogs
US5179084A (en) * 1989-04-10 1993-01-12 Nippon Kayaku Kabushiki Kaisha Antiviral phosphoric acid esters of oxetanocins
US5059690A (en) * 1990-03-01 1991-10-22 E. R. Squibb & Sons, Inc. Purinyl tetrahydrofurans
NZ232993A (en) * 1989-04-24 1992-10-28 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
US5202459A (en) * 1989-11-07 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for producing cyclobutane derivative
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside
US5198583A (en) * 1989-12-18 1993-03-30 E. R. Squibb & Sons, Inc. Optically active cyclobutane nucleoside and intermediates, therefor
US5256806A (en) * 1989-12-18 1993-10-26 E. R. Squibb & Sons, Inc. Intermediates for the preparation of optically active cyclobutane nucleoside
US6001840A (en) * 1990-03-06 1999-12-14 Southern Research Institute Methods of treatment of viral infections using carbocyclic deoxyguanosine analogs
US5235052A (en) * 1990-04-16 1993-08-10 Bristol-Myers Squibb Company Process for preparing substituted cyclobutane purines
US5233076A (en) * 1990-05-24 1993-08-03 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside
US5324730A (en) * 1990-05-24 1994-06-28 Nippon Kayaku Kabushiki Kaisha Phenoxyphosphoryloxymethyl cyclobutyl purines
US5344962A (en) * 1990-05-24 1994-09-06 E. R. Squibb & Sons, Inc. Intermediates in the synthesis of an optically active cyclobutane nucleoside
CA2042931A1 (en) * 1990-05-24 1991-11-25 Robert Zahler Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines
EP0554025A3 (en) * 1992-01-27 1993-11-18 Squibb & Sons Inc Fluorinated cyclobutyl purines and pyrimidines
IL117574A0 (en) * 1995-04-03 1996-07-23 Bristol Myers Squibb Co Processes for the preparation of cyclobutanone derivatives
KR20030025153A (ko) * 2001-09-19 2003-03-28 이보섭 지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
CN101115725A (zh) * 2004-12-10 2008-01-30 埃莫里大学 治疗病毒感染和异常细胞增殖的2’和3’-取代的环丁基核苷类似物
FR3092114B1 (fr) * 2019-01-28 2021-04-30 Univ Grenoble Alpes Nouveaux derives de purine et medicaments les comprenant

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1160226A (en) * 1980-07-15 1984-01-10 Gordon H. Phillipps Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
GB8411291D0 (en) * 1984-05-02 1984-06-06 Nyegaard & Co As Chemical compounds
US4543255A (en) * 1984-05-10 1985-09-24 Southern Research Institute Carbocyclic analogs of purine 2'-deoxyribofuranosides
EP0184473A1 (en) * 1984-10-26 1986-06-11 Merck & Co. Inc. Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
US4743689A (en) * 1984-11-20 1988-05-10 Nippon Kayaku Kabushiki Kaisha Antibiotic derivative of adenine
US4605659A (en) * 1985-04-30 1986-08-12 Syntex (U.S.A.) Inc. Purinyl or pyrimidinyl substituted hydroxycyclopentane compounds useful as antivirals
ES2001094A6 (es) * 1985-08-16 1988-04-16 Glaxo Group Ltd Un procedimiento para la preparacion de un derivado de guanina
EP0219838A3 (en) * 1985-10-22 1988-04-06 Takeda Chemical Industries, Ltd. Carbocyclic purine nucleosides, their production and use
JPH0228161A (ja) * 1987-05-25 1990-01-30 Nippon Kayaku Co Ltd 新規なシクロブタン誘導体
AU4378589A (en) * 1988-10-25 1990-05-03 Bristol-Myers Squibb Company Carbocyclic nucleoside analogs

Also Published As

Publication number Publication date
DK724088D0 (da) 1988-12-27
NO885768L (no) 1989-06-29
NO885768D0 (no) 1988-12-27
AU633437B2 (en) 1993-01-28
ATE108452T1 (de) 1994-07-15
YU236288A (en) 1990-04-30
FI90422C (fi) 1994-02-10
PT89349A (pt) 1989-12-29
DE3850645T2 (de) 1994-10-27
CN1032205C (zh) 1996-07-03
KR970007920B1 (ko) 1997-05-17
NO168036B (no) 1991-09-30
PL276787A1 (en) 1989-07-10
MX14358A (es) 1993-11-01
US4855466A (en) 1989-08-08
AU2747088A (en) 1989-06-29
CA1331607C (en) 1994-08-23
EP0322854A1 (en) 1989-07-05
AU614105B2 (en) 1991-08-22
IL88755A0 (en) 1989-07-31
FI90422B (fi) 1993-10-29
HUT48886A (en) 1989-07-28
IL88755A (en) 1993-01-31
JP2634215B2 (ja) 1997-07-23
AU7810791A (en) 1991-08-22
IE64591B1 (en) 1995-08-23
FI885980A (fi) 1989-06-29
HU203236B (en) 1991-06-28
DE3850645D1 (de) 1994-08-18
JPH02780A (ja) 1990-01-05
PH25191A (en) 1991-03-27
EG18639A (en) 1993-10-30
NO168036C (no) 1992-01-08
EP0322854B1 (en) 1994-07-13
CN1036574A (zh) 1989-10-25
KR890009929A (ko) 1989-08-04
ZA889499B (en) 1989-09-27
IE883827L (en) 1989-06-28
DK724088A (da) 1989-06-29
PL159302B1 (pl) 1992-12-31
NZ227431A (en) 1991-05-28
DK170340B1 (da) 1995-08-07
PT89349B (pt) 1993-09-30
ES2056096T3 (es) 1994-10-01

Similar Documents

Publication Publication Date Title
DD276687A5 (de) Verfahren zur herstellung von purinyl- und pyrimidinyl-cyclobutan-derivaten
DE68928353T2 (de) Bis-(hydroxymethyl)cyclobutyl-Purine und Pyrimidine
DE68929277T2 (de) Verfahren zur Herstellung von Purinderivaten
DE69127336T2 (de) Hydroxymethyl(methylencyclopentyl)Purinen und Pyrimidinen
US4918075A (en) Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents
US5059690A (en) Purinyl tetrahydrofurans
US5126345A (en) Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
DE69419328T2 (de) Antivirale Tetrahydropyrane
Reese Synthesis of 1-[cis-3-(hydroxymethyl) cyclobutyl]-uracil,-thymine and-cytosine
DE60204859T2 (de) Verfahren zur Herstellung von 2'-Halo-beta-L-arabino-furanosylnucleosiden
DE68920648T2 (de) Verfahren zur Herstellung von O2,2'-anhydro-1-(beta-D-arabinofuranosyl)Thymin.
EP0452680B1 (de) Substituierte Purine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
EP0521463A2 (de) Cyclisch substituierte Cycloalkyltriole, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung als antivirale und antiparasitäre Mittel
DE69122437T2 (de) Purinyl und Pyrimidinyltetrahydrofurane
EP0394893B1 (en) Purinyl and pyrimidinyl tetrahydrofurans
DE3889248T2 (de) Verfahren zu Herstellung von Purinverbindungen.
US5130462A (en) Cyclobutane derivatives
EP0542681A1 (de) Verfahren zur Herstellung von carbacyclischen Nukleosiden und Zwischenprodukte
DE60007848T2 (de) Herstellung von 2'-substitutierter rns
EP0066303B1 (de) 2-Azidomethyl-1,4-benzodiazepine und deren Salze sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP0464511A2 (de) Verfahren zur Herstellung von substituierten acyclischen Nukleosiden und dabei auftretende Zwischenprodukte
EP0464642A1 (de) Pyrimidin-Derivate, deren Herstellung und Verwendung sowie diese enthaltende Arzneimittel
DE602004010916T2 (de) Verfahren zur hersellung von 2',3'-didehydro-2',3'-dideoxynucleoside und 2',3'-dideoxynucleoside
DE3905725A1 (de) Seco-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung als antivirale mittel

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee