CZ322592A3 - 2-aminomethyl-chromans - Google Patents

2-aminomethyl-chromans Download PDF

Info

Publication number
CZ322592A3
CZ322592A3 CS923225A CS322592A CZ322592A3 CZ 322592 A3 CZ322592 A3 CZ 322592A3 CS 923225 A CS923225 A CS 923225A CS 322592 A CS322592 A CS 322592A CZ 322592 A3 CZ322592 A3 CZ 322592A3
Authority
CZ
Czechia
Prior art keywords
group
carbon atoms
straight
formula
branched alkyl
Prior art date
Application number
CS923225A
Other languages
Czech (cs)
English (en)
Inventor
Rudolf Dr Schohe-Loop
Hans-Georg Dr Heine
Bodo Dr Junge
Thomas Dr Glaser
De Vry Jean Marie Dr Viktor
Wolfgang Dr Dompert
Henning Dr Sommermeyer
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CZ322592A3 publication Critical patent/CZ322592A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CS923225A 1991-10-28 1992-10-26 2-aminomethyl-chromans CZ322592A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4135474A DE4135474A1 (de) 1991-10-28 1991-10-28 2-aminomethyl-chromane

Publications (1)

Publication Number Publication Date
CZ322592A3 true CZ322592A3 (en) 1993-05-12

Family

ID=6443566

Family Applications (1)

Application Number Title Priority Date Filing Date
CS923225A CZ322592A3 (en) 1991-10-28 1992-10-26 2-aminomethyl-chromans

Country Status (17)

Country Link
US (3) US5318988A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0540914B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3299321B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930007930A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE180777T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2626492A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2081300A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ322592A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE4135474A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2132105T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI924847L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT62875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL103545A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9205681A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO923975L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW207537B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA928291B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
ATE210657T1 (de) * 1994-10-14 2001-12-15 Merck Patent Gmbh Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
DE19522088A1 (de) * 1995-06-19 1997-01-02 Bayer Ag Benzisothiazolyl-substituierte Aminomethylchromane
US5670667A (en) * 1995-07-25 1997-09-23 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5684039A (en) * 1995-07-25 1997-11-04 American Home Products Corporation Chroman-2-ylmethylamino derivatives
US5663194A (en) * 1995-07-25 1997-09-02 Mewshaw; Richard E. Chroman-2-ylmethylamino derivatives
US5756532A (en) * 1995-11-06 1998-05-26 American Home Products Corporation Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives
AR004523A1 (es) * 1995-11-06 1998-12-16 American Home Prod 2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
PT932609E (pt) * 1996-10-15 2003-09-30 Wyeth Corp Derivados azaheterociclimetilo de 2,3,8,9-tetrahidro-7h-1,4-dioxino¬2,3-e|indol-8-ona
US5869490A (en) * 1996-10-15 1999-02-09 American Home Products Corporation Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
PL338455A1 (en) 1997-07-31 2000-11-06 Du Pont Pharm Co Metho dof obtaining cyclopropyl acetylene
FR2769629B1 (fr) * 1997-10-09 1999-11-12 Synthelabo Derives de 8-azabicyclo[3.2.1]octane-3-methanamine, leur preparation et leur application en therapeutique
UA58476C2 (uk) * 1997-10-09 2003-08-15 Санофі-Сентелябо Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб
DE19751949A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
DE19754573A1 (de) * 1997-12-09 1999-06-10 Bayer Ag Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma
US6235957B1 (en) 1998-06-29 2001-05-22 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
WO2000018706A1 (en) 1998-10-01 2000-04-06 Du Pont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
US6288297B1 (en) 1998-10-01 2001-09-11 Dupont Pharmaceuticals Company Process for the preparation of cyclopropylacetylene
DE19858341A1 (de) * 1998-12-17 2000-06-21 Merck Patent Gmbh Chromanderivate
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
US20030207890A1 (en) 2001-02-23 2003-11-06 Collier Robert J Compounds with 5-ht1a activity useful for treating disorders of the outer retina
US6458802B1 (en) 2001-03-14 2002-10-01 Wyeth Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline
US6803368B2 (en) 2001-04-25 2004-10-12 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene
DE60201590T2 (de) 2001-04-26 2005-02-17 Wyeth Antidepressiv wirksame azaheterocyclymethyl-derivative von oxaheterocycyl-anellierten (1,4)-benzodioxanen
US6927226B2 (en) * 2001-04-26 2005-08-09 Wyeth Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
US6800642B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
US6861434B2 (en) 2001-04-26 2005-03-01 Wyeth Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
US6821981B2 (en) 2001-04-26 2004-11-23 Wyeth Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
ES2247327T3 (es) 2001-04-26 2006-03-01 Wyeth Derivados azaheterociclimetilicos antidepresivos (isrs) de 7,8-dihidro-3h-6,9-dioxa-1,3-diazaciclopenta(a) naftaleno.
DE10120619A1 (de) * 2001-04-26 2002-10-31 Merck Patent Gmbh 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
EP1381612A1 (en) 2001-04-26 2004-01-21 Wyeth Antidepressant aza-heterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
US7008944B2 (en) * 2001-04-26 2006-03-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
US6861427B2 (en) * 2001-04-26 2005-03-01 Wyeth Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
US6627639B2 (en) 2001-04-26 2003-09-30 Wyeth Uses for indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino-[2,3-e]indole
US6800641B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
US6593350B2 (en) 2001-04-26 2003-07-15 Wyeth Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole
ATE334989T1 (de) 2001-04-26 2006-08-15 Wyeth Corp Antidepressive azaheterocyclylmethyl-derivate von 2,3-dihydro-1,4-dioxino 2,3-föchinoxalin
WO2002088145A1 (en) 2001-04-26 2002-11-07 Wyeth AZABICYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZACYCLOPENTA[a]NAPHTHALENE AS 5-HT1A ANTAGONISTS
US6706736B2 (en) 2001-04-26 2004-03-16 Wyeth Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
US6800648B2 (en) 2001-04-26 2004-10-05 Wyeth Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
US6617334B2 (en) 2001-04-30 2003-09-09 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
BR0209407A (pt) 2001-04-30 2004-07-06 Wyeth Corp Antidepressivos de azaheterociclilmetila derivados de 7,8-dihidro-1,6,9-trioxa-3-aza-ciclopenta[a[]naftaleno , método de tratamento usando tais compostos e processo para prepará-los
US6906206B2 (en) * 2001-04-30 2005-06-14 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6555560B2 (en) 2001-04-30 2003-04-29 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
US6815448B2 (en) 2001-05-07 2004-11-09 Wyeth Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
EP1387845A2 (en) * 2001-05-17 2004-02-11 Wyeth PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE
US6541502B1 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6541501B2 (en) 2001-07-20 2003-04-01 Wyeth 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity
US6903110B2 (en) 2001-07-25 2005-06-07 Wyeth Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene
US7872030B2 (en) 2001-07-26 2011-01-18 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
WO2003024960A1 (en) * 2001-09-19 2003-03-27 Merck Patent Gmbh Novel use of substituted aminomethyl chromans
WO2003029239A1 (en) 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
EP1432696A1 (en) * 2001-10-04 2004-06-30 Wyeth Chroman derivatives as 5-hydroxytryptamine-6 ligands
JP2005510480A (ja) 2001-10-05 2005-04-21 ワイス ２−ヒドロキシメチル−クロマンの立体選択的合成方法
BR0213030A (pt) 2001-10-05 2004-10-05 Wyeth Corp Processo estereoespecìfico para a sìntese de derivados de 2-il cromano
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
PA8616201A1 (es) * 2003-10-29 2005-05-24 Wyeth Corp Composiciones farmaceuticas de liberacion sostenida
TW200811182A (en) 2006-05-25 2008-03-01 Wyeth Corp Oxindoledioxans, synthesis thereof, and intermediates thereto
CL2007003043A1 (es) * 2006-10-24 2008-05-30 Wyeth Corp Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros.
CL2007003066A1 (es) * 2006-10-25 2008-01-25 Wyeth Corp Metodo de obtencion de derivados de 8-fenil-cromanos por reduccion de la correspondiente amida.
AU2009242095A1 (en) * 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
RU2010141964A (ru) * 2008-04-29 2012-06-10 НСАБ, Филиаль аф НьюроСерч Свиден АБ, Сверийе (DK) Модуляторы дофаминовой нейротрансмиссии
US20110105462A1 (en) * 2008-04-29 2011-05-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
US8293928B2 (en) * 2009-09-02 2012-10-23 E I Du Pont De Nemours And Company Fluorinated 4-oxo-chroman-7-carboxylates
US20110218319A1 (en) * 2009-09-02 2011-09-08 E. I. Du Pont De Nemours And Company Polyaramid films comprising fluorovinylether functionalized aromatic moieties
EP2473543A2 (en) * 2009-09-02 2012-07-11 E. I. du Pont de Nemours and Company Polyesters comprising fluorovinylether functionalized aromatic moieties
CN102575029B (zh) * 2009-09-02 2014-10-15 纳幕尔杜邦公司 具有改善的拒油性的聚酯膜
CN102597060B (zh) * 2009-09-02 2014-05-07 纳幕尔杜邦公司 包含氟乙烯基醚官能化芳族部分的芳族聚酰胺
BR112012004668A2 (pt) * 2009-09-02 2019-09-24 Du Pont "composição e processo"
CA2839699A1 (en) 2011-06-24 2012-12-27 Amgen Inc. Trpm8 antagonists and their use in treatments
EP2723718A1 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
KR20220101702A (ko) * 2019-11-19 2022-07-19 루핀 리미티드 크로만 화합물의 제조 공정

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321270A (en) * 1981-01-29 1982-03-23 E. R. Squibb & Sons, Inc. Substituted chromans
JP2673024B2 (ja) * 1988-01-15 1997-11-05 アボツト・ラボラトリーズ アミノメチル‐クロマン及び‐チオクロマン化合物
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
CA2002649C (en) * 1988-11-14 2000-06-06 Margaret Petty Cardioprotective tocopherol analogs
US5229398A (en) * 1990-02-27 1993-07-20 Adir Et Compagnie Aminomethylpiperidine compounds
US5126367A (en) * 1991-06-21 1992-06-30 American Home Products Corporation Psychotropic benzodioxan derivatives
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane

Also Published As

Publication number Publication date
DE59209704D1 (de) 1999-07-08
JP3299321B2 (ja) 2002-07-08
MX9205681A (es) 1993-04-01
JPH05194473A (ja) 1993-08-03
ES2132105T3 (es) 1999-08-16
KR930007930A (ko) 1993-05-20
US5468882A (en) 1995-11-21
AU2626492A (en) 1993-04-29
IL103545A0 (en) 1993-03-15
US5962513A (en) 1999-10-05
FI924847A7 (fi) 1993-04-29
HU9203383D0 (en) 1993-01-28
DE4135474A1 (de) 1993-04-29
FI924847L (fi) 1993-04-29
HUT62875A (en) 1993-06-28
NO923975D0 (no) 1992-10-13
NO923975L (no) 1993-04-29
ATE180777T1 (de) 1999-06-15
ZA928291B (en) 1993-05-06
CA2081300A1 (en) 1993-04-29
EP0540914A1 (de) 1993-05-12
US5318988A (en) 1994-06-07
EP0540914B1 (de) 1999-06-02
TW207537B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-11
FI924847A0 (fi) 1992-10-26

Similar Documents

Publication Publication Date Title
CZ322592A3 (en) 2-aminomethyl-chromans
EP0679642B1 (en) Condensed heterocyclic compounds, their production and use
SK361392A3 (en) Azaheterocyclylmethyl-chromans, method for producing them, their use and pharmaceutical composition containing same
US6774132B1 (en) Spirooxindole derivatives that act as analgesics
US8420811B2 (en) Tetrahydroisoquinolines and intermediates therefor
KR20040068286A (ko) Ｃｂ１ 길항물질로서의 5,6-디아릴-피라진-2-아미드 유도체
WO2007129111A1 (en) Diazepine derivatives as 5-ht2a antagonists
US5942529A (en) Benzisothiazolyl-substituted aminomethylchromans
HUT54151A (en) Process fopr producing new (r)-(-)-3-quinuclidinone derivatives and pharmaceutical compositions comprising such compounds
CZ281714B6 (cs) Piperidylmethylsubstituované deriváty chromanu
CZ322492A3 (en) Triazaspirodecanone-methyl chromans
EP0362941B1 (en) 4-Methyl and 4-ethyl substituted pyrrolidin-2-ones
US5171752A (en) Benzhydryl derivatives having calmodulin inhibitor properties
US20010056109A1 (en) Imidazole derivatives
WO1994006791A1 (en) Novel condensed thiazole derivative, process for producing the same, and pharmaceutical composition containing the same
EP0375536B1 (en) Derivatives of 1,7'-(imidazo-(1,2-a)pyridine) 5'-(6'H) ones and process for their preparation
EP3560927B1 (en) Azepine derivatives acting as 5-ht7 receptor modulators
Mbere-Nguyen et al. Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities
CZ118893A3 (en) Novel nitriles of 1-aryl-4-piperazinylcyckohexanecarboxylic acids, their preparation and use