CZ301019B6 - Vitamín E a jeho estery pro použití pri lokální lécbe onemocnení vaginální sliznice - Google Patents
Vitamín E a jeho estery pro použití pri lokální lécbe onemocnení vaginální sliznice Download PDFInfo
- Publication number
- CZ301019B6 CZ301019B6 CZ20010036A CZ200136A CZ301019B6 CZ 301019 B6 CZ301019 B6 CZ 301019B6 CZ 20010036 A CZ20010036 A CZ 20010036A CZ 200136 A CZ200136 A CZ 200136A CZ 301019 B6 CZ301019 B6 CZ 301019B6
- Authority
- CZ
- Czechia
- Prior art keywords
- vitamin
- compound
- esters
- vaginal
- mucous membrane
- Prior art date
Links
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 32
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 14
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 14
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 14
- 239000011709 vitamin E Substances 0.000 title claims abstract description 14
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 14
- 150000002148 esters Chemical class 0.000 title claims abstract description 5
- 208000034493 Mucous membrane disease Diseases 0.000 title abstract 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 21
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 21
- 208000003251 Pruritus Diseases 0.000 claims abstract description 7
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 6
- 208000004746 Atrophic Vaginitis Diseases 0.000 claims abstract description 5
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims abstract description 5
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 9
- 230000000699 topical effect Effects 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 230000007803 itching Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000006216 vaginal suppository Substances 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- -1 carboxylic acid vitamin E ester Chemical class 0.000 claims 1
- 235000020778 linoleic acid Nutrition 0.000 claims 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N linoleic acid group Chemical group C(CCCCCCC\C=C/C\C=C/CCCCC)(=O)O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid group Chemical group C(CCC(=O)O)(=O)O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- 208000002003 vulvitis Diseases 0.000 abstract description 11
- 230000003325 follicular Effects 0.000 abstract description 3
- 210000004400 mucous membrane Anatomy 0.000 abstract description 3
- 230000005855 radiation Effects 0.000 abstract description 3
- 206010048222 Xerosis Diseases 0.000 abstract 1
- 201000003079 ectropion Diseases 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 description 10
- 239000012528 membrane Substances 0.000 description 10
- 210000004877 mucosa Anatomy 0.000 description 10
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 7
- 210000000981 epithelium Anatomy 0.000 description 6
- 230000003078 antioxidant effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 229930003799 tocopherol Natural products 0.000 description 5
- 239000011732 tocopherol Substances 0.000 description 5
- 235000010384 tocopherol Nutrition 0.000 description 5
- 229960001295 tocopherol Drugs 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 206010015150 Erythema Diseases 0.000 description 4
- 210000003679 cervix uteri Anatomy 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 150000003904 phospholipids Chemical class 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000001575 pathological effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 208000004483 Dyspareunia Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 2
- 206010069055 Vulvovaginal pain Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000002573 colposcopy Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- 210000003630 histaminocyte Anatomy 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000010606 normalization Methods 0.000 description 2
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- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
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- 230000008961 swelling Effects 0.000 description 2
- 150000003611 tocopherol derivatives Chemical class 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
- 230000001720 vestibular Effects 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 206010006803 Burns third degree Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241001553700 Euphorbia lathyris Species 0.000 description 1
- 206010064503 Excessive skin Diseases 0.000 description 1
- 108010019393 Fibrin Foam Proteins 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241001313288 Labia Species 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 1
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- 206010056651 Vestibulitis Diseases 0.000 description 1
- 208000003728 Vulvodynia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001857 anti-mycotic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 239000002543 antimycotic Substances 0.000 description 1
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- 230000001580 bacterial effect Effects 0.000 description 1
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- 230000033228 biological regulation Effects 0.000 description 1
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- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 206010008323 cervicitis Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
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- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000005061 intracellular organelle Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
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- 230000025053 regulation of cell proliferation Effects 0.000 description 1
- 230000006833 reintegration Effects 0.000 description 1
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- 230000003248 secreting effect Effects 0.000 description 1
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- 239000000344 soap Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT98MI001586A ITMI981586A1 (it) | 1998-07-10 | 1998-07-10 | Vitamina e e suoi esteri per l'uso nel trattamento topico di patologie delle mucose |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ200136A3 CZ200136A3 (cs) | 2001-08-15 |
| CZ301019B6 true CZ301019B6 (cs) | 2009-10-14 |
Family
ID=11380415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20010036A CZ301019B6 (cs) | 1998-07-10 | 1999-07-05 | Vitamín E a jeho estery pro použití pri lokální lécbe onemocnení vaginální sliznice |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1094807B1 (https=) |
| JP (1) | JP2002520281A (https=) |
| CN (1) | CN1135975C (https=) |
| AT (1) | ATE238051T1 (https=) |
| AU (1) | AU762860B2 (https=) |
| BR (1) | BR9911945A (https=) |
| CA (1) | CA2336990A1 (https=) |
| CZ (1) | CZ301019B6 (https=) |
| DE (1) | DE69907193T2 (https=) |
| DK (1) | DK1094807T3 (https=) |
| ES (1) | ES2196813T3 (https=) |
| HU (1) | HU228921B1 (https=) |
| IL (1) | IL140759A0 (https=) |
| IT (1) | ITMI981586A1 (https=) |
| NO (1) | NO20006719L (https=) |
| NZ (1) | NZ509129A (https=) |
| PL (1) | PL345500A1 (https=) |
| PT (1) | PT1094807E (https=) |
| RU (2) | RU2221561C2 (https=) |
| SK (1) | SK284464B6 (https=) |
| TR (2) | TR200100014T2 (https=) |
| WO (1) | WO2000002554A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040077604A1 (en) | 2001-12-19 | 2004-04-22 | Lenard Lichtenberger | Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity |
| FR2819186A1 (fr) * | 2001-01-10 | 2002-07-12 | L M D | Cystine-voie orale-syndrome de l'oeil sec |
| FR2825088A1 (fr) * | 2001-05-25 | 2002-11-29 | Derma Dev | Nouveaux esters de tocopherol, leurs procedes d'obtention et leurs utilisations |
| US7485666B2 (en) * | 2004-06-17 | 2009-02-03 | Kimberly-Clark Worldwide, Inc. | Vaginal health products |
| US20080038316A1 (en) | 2004-10-01 | 2008-02-14 | Wong Vernon G | Conveniently implantable sustained release drug compositions |
| US8541413B2 (en) * | 2004-10-01 | 2013-09-24 | Ramscor, Inc. | Sustained release eye drop formulations |
| US9993558B2 (en) | 2004-10-01 | 2018-06-12 | Ramscor, Inc. | Sustained release eye drop formulations |
| JP2008531603A (ja) * | 2005-03-03 | 2008-08-14 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 脂質低下特性を有する化合物 |
| CN107468648A (zh) * | 2008-10-09 | 2017-12-15 | 拉姆斯科股份有限公司 | 治疗干眼综合征的组合物和方法 |
| IT1394063B1 (it) * | 2009-05-11 | 2012-05-25 | Giuliani Spa | Composizione per uso oftalmico adatta al trattamento degli stati infiammatori dell'occhio e della sindrome dell'occhio secco |
| US9192594B2 (en) * | 2009-07-27 | 2015-11-24 | Renato Sanseverino | Ophthalmic solution for protecting internal structures of the eyeball against UV-A rays or for the treatment of keratoconus with a trans-epithelial cross-linking technique |
| EP2760433B1 (en) | 2011-09-29 | 2023-05-31 | PLx Opco Inc. | pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME |
| CN104507465A (zh) * | 2012-06-08 | 2015-04-08 | 俄亥俄州立大学 | 使用生育三烯酚治疗灼伤和瘢痕损伤 |
| DE202014106007U1 (de) * | 2014-07-22 | 2015-07-23 | Bio.Lo.Ga. S.R.L. | Zusammensetzung zur Verwendung in der Vorbeugung und Behandlung allergischer Rhinitis |
| CA2965184A1 (en) | 2014-10-22 | 2016-04-28 | Bio.Lo.Ga. S.R.L. | Pharmaceutical composition comprising ester of alpha tocopherol and oily vehicle for use in increasing the trophism of nasal mucosa |
| JP2018507895A (ja) * | 2015-03-18 | 2018-03-22 | バイオヌークス スイス エスエー | ヘルペスを処置するための方法において使用するためのジヒドロケルセチンを含む組成物 |
| JP2017119669A (ja) * | 2015-10-15 | 2017-07-06 | ロート製薬株式会社 | 異物感改善用眼科組成物 |
| WO2020053783A1 (en) * | 2018-09-12 | 2020-03-19 | Neilos S.r.l. | A composition for use in the prevention and/or treatment of epistaxis |
| IT202000003620A1 (it) * | 2020-02-21 | 2021-08-21 | Hulka S R L | Uso di una formulazione per applicazione topica per il mantenimento dell’omeostasi vaginale |
| JP2023518822A (ja) | 2020-03-26 | 2023-05-08 | ピーエルエックス オプコ インコーポレイテッド | ｐＨ依存的再構築が可能な医薬キャリア、その製造方法及び使用方法 |
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| EP0535446A1 (en) * | 1991-09-30 | 1993-04-07 | BONISCONTRO E GAZZONE S.r.l. | Pharmaceutical compositions for topical use containing a chelating agent, a tocopheral and an antimicrobial agent |
| WO1997045098A2 (en) * | 1996-05-31 | 1997-12-04 | Giorgio Panin | Esters of vitamin e as products for topical application |
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| JPS59216812A (ja) * | 1983-05-26 | 1984-12-06 | Dowa Yakushiyou Kk | 頭髪育毛料 |
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| SU1628281A3 (ru) * | 1989-03-30 | 1994-02-28 | Научно-производственная фирма "Флори" | Ранозаживляющее средство |
| JP2811036B2 (ja) * | 1992-05-26 | 1998-10-15 | 参天製薬株式会社 | ビタミンｅ点眼剤 |
| JP3551977B2 (ja) * | 1993-04-08 | 2004-08-11 | ライオン株式会社 | 安定なビタミンａ類及びビタミンｅ類可溶化点眼剤 |
| CN1039087C (zh) * | 1993-12-29 | 1998-07-15 | 昆明宏达实业有限总公司 | 妇科病治疗保健外用药物 |
| RU2125887C1 (ru) * | 1995-08-25 | 1999-02-10 | Владивостокский государственный медицинский университет | Способ приготовления липосомального интерферона |
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| JPH10231243A (ja) * | 1997-02-20 | 1998-09-02 | Sekisui Chem Co Ltd | 粘膜炎症外用薬 |
-
1998
- 1998-07-10 IT IT98MI001586A patent/ITMI981586A1/it unknown
-
1999
- 1999-07-05 DK DK99926687T patent/DK1094807T3/da active
- 1999-07-05 RU RU2001101122/15A patent/RU2221561C2/ru active
- 1999-07-05 ES ES99926687T patent/ES2196813T3/es not_active Expired - Lifetime
- 1999-07-05 DE DE69907193T patent/DE69907193T2/de not_active Expired - Lifetime
- 1999-07-05 TR TR2001/00014T patent/TR200100014T2/xx unknown
- 1999-07-05 TR TR2001/03710T patent/TR200103710T2/xx unknown
- 1999-07-05 CA CA002336990A patent/CA2336990A1/en not_active Abandoned
- 1999-07-05 AT AT99926687T patent/ATE238051T1/de active
- 1999-07-05 JP JP2000558814A patent/JP2002520281A/ja active Pending
- 1999-07-05 NZ NZ509129A patent/NZ509129A/en not_active IP Right Cessation
- 1999-07-05 SK SK35-2001A patent/SK284464B6/sk unknown
- 1999-07-05 HU HU0102781A patent/HU228921B1/hu unknown
- 1999-07-05 CN CNB998084328A patent/CN1135975C/zh not_active Expired - Lifetime
- 1999-07-05 CZ CZ20010036A patent/CZ301019B6/cs unknown
- 1999-07-05 AU AU43858/99A patent/AU762860B2/en not_active Expired
- 1999-07-05 WO PCT/IB1999/001238 patent/WO2000002554A1/en not_active Ceased
- 1999-07-05 PT PT99926687T patent/PT1094807E/pt unknown
- 1999-07-05 IL IL14075999A patent/IL140759A0/xx unknown
- 1999-07-05 EP EP99926687A patent/EP1094807B1/en not_active Expired - Lifetime
- 1999-07-05 BR BR9911945-5A patent/BR9911945A/pt not_active Application Discontinuation
- 1999-07-05 PL PL99345500A patent/PL345500A1/xx not_active Application Discontinuation
-
2000
- 2000-12-29 NO NO20006719A patent/NO20006719L/no not_active Application Discontinuation
-
2003
- 2003-09-11 RU RU2003128023/15A patent/RU2003128023A/ru not_active Application Discontinuation
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0380367A1 (en) * | 1989-01-27 | 1990-08-01 | Stafford-Miller Ltd. | Compositions and method for the treatment of disease |
| EP0535446A1 (en) * | 1991-09-30 | 1993-04-07 | BONISCONTRO E GAZZONE S.r.l. | Pharmaceutical compositions for topical use containing a chelating agent, a tocopheral and an antimicrobial agent |
| WO1997045098A2 (en) * | 1996-05-31 | 1997-12-04 | Giorgio Panin | Esters of vitamin e as products for topical application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1135975C (zh) | 2004-01-28 |
| ES2196813T3 (es) | 2003-12-16 |
| HUP0102781A2 (hu) | 2001-12-28 |
| CZ200136A3 (cs) | 2001-08-15 |
| NO20006719L (no) | 2001-02-16 |
| ATE238051T1 (de) | 2003-05-15 |
| SK284464B6 (sk) | 2005-04-01 |
| WO2000002554A1 (en) | 2000-01-20 |
| NZ509129A (en) | 2003-10-31 |
| HUP0102781A3 (en) | 2002-04-29 |
| RU2003128023A (ru) | 2005-04-10 |
| HU228921B1 (en) | 2013-06-28 |
| AU762860B2 (en) | 2003-07-10 |
| IL140759A0 (en) | 2002-02-10 |
| DE69907193T2 (de) | 2004-04-08 |
| NO20006719D0 (no) | 2000-12-29 |
| CA2336990A1 (en) | 2000-01-20 |
| EP1094807A1 (en) | 2001-05-02 |
| ITMI981586A1 (it) | 2000-01-10 |
| TR200100014T2 (tr) | 2001-06-21 |
| ITMI981586A0 (it) | 1998-07-10 |
| JP2002520281A (ja) | 2002-07-09 |
| DE69907193D1 (de) | 2003-05-28 |
| TR200103710T2 (tr) | 2002-06-21 |
| SK352001A3 (en) | 2001-06-11 |
| EP1094807B1 (en) | 2003-04-23 |
| CN1308531A (zh) | 2001-08-15 |
| AU4385899A (en) | 2000-02-01 |
| PT1094807E (pt) | 2003-08-29 |
| PL345500A1 (en) | 2001-12-17 |
| BR9911945A (pt) | 2001-03-27 |
| DK1094807T3 (da) | 2003-08-11 |
| RU2221561C2 (ru) | 2004-01-20 |
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