CZ290883B6 - Triazolopyridazinové deriváty, způsob jejich výroby a farmaceutický prostředek je obsahující - Google Patents
Triazolopyridazinové deriváty, způsob jejich výroby a farmaceutický prostředek je obsahující Download PDFInfo
- Publication number
- CZ290883B6 CZ290883B6 CZ20002691A CZ20002691A CZ290883B6 CZ 290883 B6 CZ290883 B6 CZ 290883B6 CZ 20002691 A CZ20002691 A CZ 20002691A CZ 20002691 A CZ20002691 A CZ 20002691A CZ 290883 B6 CZ290883 B6 CZ 290883B6
- Authority
- CZ
- Czechia
- Prior art keywords
- methyl
- pyridazine
- ylmethoxy
- triazol
- triazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9801233.9A GB9801233D0 (en) | 1998-01-21 | 1998-01-21 | Therapeutic agents |
| GBGB9821517.1A GB9821517D0 (en) | 1998-10-02 | 1998-10-02 | Therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ20002691A3 CZ20002691A3 (cs) | 2000-12-13 |
| CZ290883B6 true CZ290883B6 (cs) | 2002-11-13 |
Family
ID=26312988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20002691A CZ290883B6 (cs) | 1998-01-21 | 1999-01-13 | Triazolopyridazinové deriváty, způsob jejich výroby a farmaceutický prostředek je obsahující |
Country Status (24)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2315763A1 (en) * | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9929685D0 (en) | 1999-12-15 | 2000-02-09 | Merck Sharp & Dohme | Therapeutic agents |
| GB0017543D0 (en) | 2000-07-17 | 2000-09-06 | Merck Sharp & Dohme | Therapeutic agents |
| WO2005058860A1 (ja) * | 2003-12-19 | 2005-06-30 | Ube Industries, Ltd. | ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法 |
| WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| MY159523A (en) * | 2005-12-21 | 2017-01-13 | Janssen Pharmaceutica Nv | Triazolopyridazines as tyrosine kinase modulators |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2123619A1 (de) | 2008-05-20 | 2009-11-25 | Bayer Schering Pharma AG | Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung |
| CN102176826B (zh) * | 2008-08-29 | 2014-08-20 | 康瑟特制药公司 | 取代的三唑并哒嗪衍生物 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8501738B2 (en) * | 2009-06-23 | 2013-08-06 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
| CA2774715C (en) * | 2009-07-27 | 2018-04-03 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| WO2012050907A2 (en) | 2010-09-28 | 2012-04-19 | The Regents Of The University Of California | Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| TWI549944B (zh) | 2011-07-01 | 2016-09-21 | 吉李德科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| NO3175985T3 (US06828322-20041207-C00005.png) | 2011-07-01 | 2018-04-28 | ||
| GB201321745D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic agents |
| WO2017151617A1 (en) | 2016-02-29 | 2017-09-08 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
| US11325955B2 (en) | 2017-07-19 | 2022-05-10 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230705A (en) | 1976-09-22 | 1980-10-28 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety |
| CA1080712A (en) * | 1976-09-22 | 1980-07-01 | Jay D. Albright | Hypotensive agents |
| US4112095A (en) | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
| PH12424A (en) * | 1976-10-26 | 1979-02-15 | American Cyanamid Co | Method of treating anxiety in mammals |
| US4260755A (en) * | 1979-10-31 | 1981-04-07 | American Cyanamid Company | Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines |
| US4260756A (en) * | 1979-11-15 | 1981-04-07 | American Cyanamid Company | 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines |
| FI81350C (fi) * | 1982-01-18 | 1990-10-10 | Lepetit Spa | Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. |
| IT1194310B (it) | 1983-07-12 | 1988-09-14 | Lepetit Spa | Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti |
| US4654343A (en) | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
| AU723098B2 (en) * | 1996-07-25 | 2000-08-17 | Merck Sharp & Dohme Limited | Substituted triazolo-pyridazine derivatives as ligands for GABA receptors |
| CA2315763A1 (en) * | 1998-01-21 | 1999-07-29 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
-
1999
- 1999-01-13 CA CA002315763A patent/CA2315763A1/en not_active Abandoned
- 1999-01-13 PL PL99341652A patent/PL341652A1/xx not_active Application Discontinuation
- 1999-01-13 CN CN99802249A patent/CN1110498C/zh not_active Expired - Fee Related
- 1999-01-13 AU AU20657/99A patent/AU748737B2/en not_active Ceased
- 1999-01-13 EE EEP200000430A patent/EE200000430A/xx unknown
- 1999-01-13 US US09/582,589 patent/US6579875B1/en not_active Expired - Fee Related
- 1999-01-13 YU YU43800A patent/YU43800A/sh unknown
- 1999-01-13 GE GEAP19995511A patent/GEP20032868B/en unknown
- 1999-01-13 KR KR1020007007937A patent/KR20010034257A/ko not_active Application Discontinuation
- 1999-01-13 MX MXPA00007135A patent/MXPA00007135A/es unknown
- 1999-01-13 CZ CZ20002691A patent/CZ290883B6/cs not_active IP Right Cessation
- 1999-01-13 EA EA200000783A patent/EA002755B1/ru not_active IP Right Cessation
- 1999-01-13 JP JP2000528565A patent/JP2002501066A/ja not_active Withdrawn
- 1999-01-13 HU HU0100575A patent/HUP0100575A3/hu unknown
- 1999-01-13 EP EP99901025A patent/EP1049696A1/en not_active Withdrawn
- 1999-01-13 IL IL13644299A patent/IL136442A0/xx unknown
- 1999-01-13 NZ NZ504870A patent/NZ504870A/xx unknown
- 1999-01-13 WO PCT/GB1999/000103 patent/WO1999037644A1/en not_active Application Discontinuation
- 1999-01-13 SK SK1092-2000A patent/SK10922000A3/sk unknown
- 1999-01-13 BR BR9906905-9A patent/BR9906905A/pt not_active IP Right Cessation
-
2000
- 2000-06-16 IS IS5540A patent/IS5540A/is unknown
- 2000-07-20 NO NO20003730A patent/NO315516B1/no not_active IP Right Cessation
- 2000-07-21 HR HR20000492A patent/HRP20000492A2/hr not_active Application Discontinuation
- 2000-08-07 BG BG104671A patent/BG104671A/xx unknown
-
2003
- 2003-06-17 US US10/463,075 patent/US6828322B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003730D0 (no) | 2000-07-20 |
| CN1288465A (zh) | 2001-03-21 |
| US6828322B2 (en) | 2004-12-07 |
| US20040063714A1 (en) | 2004-04-01 |
| GEP20032868B (en) | 2003-01-27 |
| CA2315763A1 (en) | 1999-07-29 |
| EA002755B1 (ru) | 2002-08-29 |
| EP1049696A1 (en) | 2000-11-08 |
| NZ504870A (en) | 2002-11-26 |
| PL341652A1 (en) | 2001-04-23 |
| BG104671A (en) | 2001-05-31 |
| NO315516B1 (no) | 2003-09-15 |
| KR20010034257A (ko) | 2001-04-25 |
| NO20003730L (no) | 2000-09-20 |
| MXPA00007135A (es) | 2002-11-07 |
| EA200000783A1 (ru) | 2000-12-25 |
| CZ20002691A3 (cs) | 2000-12-13 |
| EE200000430A (et) | 2001-12-17 |
| IL136442A0 (en) | 2001-06-14 |
| JP2002501066A (ja) | 2002-01-15 |
| CN1110498C (zh) | 2003-06-04 |
| WO1999037644A1 (en) | 1999-07-29 |
| US6579875B1 (en) | 2003-06-17 |
| HUP0100575A3 (en) | 2003-03-28 |
| BR9906905A (pt) | 2000-10-10 |
| AU748737B2 (en) | 2002-06-13 |
| HUP0100575A2 (hu) | 2001-09-28 |
| AU2065799A (en) | 1999-08-09 |
| HRP20000492A2 (en) | 2000-12-31 |
| SK10922000A3 (sk) | 2001-03-12 |
| YU43800A (sh) | 2002-12-10 |
| IS5540A (is) | 2000-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20040113 |