CZ283257B6 - Inhibitory proteolytických enzymů na bázi sacharinových derivátů - Google Patents
Inhibitory proteolytických enzymů na bázi sacharinových derivátů Download PDFInfo
- Publication number
- CZ283257B6 CZ283257B6 CS923746A CS374692A CZ283257B6 CZ 283257 B6 CZ283257 B6 CZ 283257B6 CS 923746 A CS923746 A CS 923746A CS 374692 A CS374692 A CS 374692A CZ 283257 B6 CZ283257 B6 CZ 283257B6
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- CZ
- Czechia
- Prior art keywords
- group
- alkyl
- formula
- hydrogen
- phenyl
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- 238000000034 method Methods 0.000 title claims abstract description 21
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- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 1
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- GCFHZZWXZLABBL-UHFFFAOYSA-N ethanol;hexane Chemical compound CCO.CCCCCC GCFHZZWXZLABBL-UHFFFAOYSA-N 0.000 description 1
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- 239000002024 ethyl acetate extract Substances 0.000 description 1
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- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 1
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- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
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- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- NBNBICNWNFQDDD-UHFFFAOYSA-N sulfuryl dibromide Chemical compound BrS(Br)(=O)=O NBNBICNWNFQDDD-UHFFFAOYSA-N 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- 150000003475 thallium Chemical class 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Cosmetics (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Beans For Foods Or Fodder (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
- Medicinal Preparation (AREA)
- Fertilizers (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81026591A | 1991-12-19 | 1991-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ374692A3 CZ374692A3 (en) | 1993-08-11 |
| CZ283257B6 true CZ283257B6 (cs) | 1998-02-18 |
Family
ID=25203432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS923746A CZ283257B6 (cs) | 1991-12-19 | 1992-12-18 | Inhibitory proteolytických enzymů na bázi sacharinových derivátů |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0547708B1 (enExample) |
| JP (1) | JP3179600B2 (enExample) |
| KR (2) | KR100292995B1 (enExample) |
| AT (1) | ATE233250T1 (enExample) |
| AU (1) | AU668694B2 (enExample) |
| CA (1) | CA2084857A1 (enExample) |
| CZ (1) | CZ283257B6 (enExample) |
| DE (1) | DE69232929D1 (enExample) |
| FI (1) | FI925787A7 (enExample) |
| HU (1) | HU219950B (enExample) |
| IL (1) | IL104154A (enExample) |
| MX (1) | MX9207449A (enExample) |
| MY (1) | MY110104A (enExample) |
| NO (1) | NO300770B1 (enExample) |
| NZ (1) | NZ245518A (enExample) |
| RU (1) | RU2107685C1 (enExample) |
| SG (1) | SG52659A1 (enExample) |
| SK (1) | SK374692A3 (enExample) |
| TW (1) | TW225532B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378720A (en) * | 1991-12-19 | 1995-01-03 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
| US5512576A (en) * | 1994-12-02 | 1996-04-30 | Sterling Winthrop Inc. | 2-substituted 1,2,5,-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof |
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| US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
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| DE3617976A1 (de) * | 1986-05-28 | 1988-01-14 | Alter Sa | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
| NZ233521A (en) * | 1989-05-04 | 1992-05-26 | Sterling Drug Inc | 2-substituted saccharin derivatives, preparation and pharmaceutical compositions thereof |
| AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| TW282463B (enExample) * | 1991-11-15 | 1996-08-01 | Sterling Winthrop Inc |
-
1992
- 1992-11-12 AU AU28292/92A patent/AU668694B2/en not_active Ceased
- 1992-11-18 TW TW081109245A patent/TW225532B/zh active
- 1992-12-08 CA CA002084857A patent/CA2084857A1/en not_active Abandoned
- 1992-12-11 MY MYPI92002285A patent/MY110104A/en unknown
- 1992-12-15 AT AT92203917T patent/ATE233250T1/de not_active IP Right Cessation
- 1992-12-15 DE DE69232929T patent/DE69232929D1/de not_active Expired - Lifetime
- 1992-12-15 SG SG1996007465A patent/SG52659A1/en unknown
- 1992-12-15 EP EP92203917A patent/EP0547708B1/en not_active Expired - Lifetime
- 1992-12-17 JP JP33703492A patent/JP3179600B2/ja not_active Expired - Fee Related
- 1992-12-17 KR KR1019920024707A patent/KR100292995B1/ko not_active Expired - Fee Related
- 1992-12-18 HU HU9204029A patent/HU219950B/hu not_active IP Right Cessation
- 1992-12-18 SK SK3746-92A patent/SK374692A3/sk unknown
- 1992-12-18 NO NO924915A patent/NO300770B1/no unknown
- 1992-12-18 NZ NZ245518A patent/NZ245518A/en unknown
- 1992-12-18 MX MX9207449A patent/MX9207449A/es not_active IP Right Cessation
- 1992-12-18 RU RU92016244A patent/RU2107685C1/ru not_active IP Right Cessation
- 1992-12-18 FI FI925787A patent/FI925787A7/fi unknown
- 1992-12-18 CZ CS923746A patent/CZ283257B6/cs not_active IP Right Cessation
- 1992-12-18 IL IL10415492A patent/IL104154A/en not_active IP Right Cessation
-
2000
- 2000-10-20 KR KR1020000061842A patent/KR100378968B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE233250T1 (de) | 2003-03-15 |
| EP0547708B1 (en) | 2003-02-26 |
| CZ374692A3 (en) | 1993-08-11 |
| RU2107685C1 (ru) | 1998-03-27 |
| MY110104A (en) | 1998-01-27 |
| NZ245518A (en) | 1995-06-27 |
| FI925787L (fi) | 1993-06-20 |
| EP0547708A1 (en) | 1993-06-23 |
| MX9207449A (es) | 1994-03-31 |
| KR100378968B1 (ko) | 2003-04-08 |
| NO300770B1 (no) | 1997-07-21 |
| AU2829292A (en) | 1993-07-08 |
| DE69232929D1 (de) | 2003-04-03 |
| AU668694B2 (en) | 1996-05-16 |
| HU9204029D0 (en) | 1993-04-28 |
| IL104154A (en) | 1996-09-12 |
| NO924915D0 (no) | 1992-12-18 |
| JPH05345771A (ja) | 1993-12-27 |
| IL104154A0 (en) | 1993-05-13 |
| FI925787A7 (fi) | 1993-06-20 |
| CA2084857A1 (en) | 1993-06-20 |
| HU219950B (hu) | 2001-09-28 |
| HUT67039A (en) | 1995-01-30 |
| KR100292995B1 (ko) | 2001-09-17 |
| TW225532B (enExample) | 1994-06-21 |
| JP3179600B2 (ja) | 2001-06-25 |
| SK278390B6 (en) | 1997-02-05 |
| SG52659A1 (en) | 1998-09-28 |
| SK374692A3 (en) | 1997-02-05 |
| FI925787A0 (fi) | 1992-12-18 |
| NO924915L (no) | 1993-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20031218 |