CZ20011290A3 - Injikovatelné intraokulární čočky - Google Patents
Injikovatelné intraokulární čočky Download PDFInfo
- Publication number
- CZ20011290A3 CZ20011290A3 CZ20011290A CZ20011290A CZ20011290A3 CZ 20011290 A3 CZ20011290 A3 CZ 20011290A3 CZ 20011290 A CZ20011290 A CZ 20011290A CZ 20011290 A CZ20011290 A CZ 20011290A CZ 20011290 A3 CZ20011290 A3 CZ 20011290A3
- Authority
- CZ
- Czechia
- Prior art keywords
- lens
- polysiloxanes
- specific gravity
- siloxane
- monomers
- Prior art date
Links
- 210000000695 crystalline len Anatomy 0.000 claims abstract description 153
- -1 polysiloxanes Polymers 0.000 claims abstract description 95
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 73
- 239000000463 material Substances 0.000 claims abstract description 34
- 230000005484 gravity Effects 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 29
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 238000002347 injection Methods 0.000 claims abstract description 16
- 239000007924 injection Substances 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000004132 cross linking Methods 0.000 claims abstract description 9
- 239000000178 monomer Substances 0.000 claims description 47
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 36
- 239000000203 mixture Substances 0.000 claims description 31
- 239000002775 capsule Substances 0.000 claims description 20
- 239000003054 catalyst Substances 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 15
- 239000011541 reaction mixture Substances 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229920001897 terpolymer Polymers 0.000 claims description 10
- 239000003431 cross linking reagent Substances 0.000 claims description 9
- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 claims description 8
- FGZFESWHQXSPJU-UHFFFAOYSA-N 2-methyl-2-(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane Chemical compound FC(F)(F)CC[Si]1(C)O[SiH2]O[SiH2]O1 FGZFESWHQXSPJU-UHFFFAOYSA-N 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 5
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 239000013638 trimer Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 210000001508 eye Anatomy 0.000 description 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000008569 process Effects 0.000 description 9
- 208000002177 Cataract Diseases 0.000 description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 8
- 239000000126 substance Substances 0.000 description 7
- 230000004308 accommodation Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000004971 Cross linker Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 229910052697 platinum Inorganic materials 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 5
- 210000001525 retina Anatomy 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 229920005573 silicon-containing polymer Polymers 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 3
- 208000002847 Surgical Wound Diseases 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- HTDJPCNNEPUOOQ-UHFFFAOYSA-N hexamethylcyclotrisiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 HTDJPCNNEPUOOQ-UHFFFAOYSA-N 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000004792 oxidative damage Effects 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- IALUUOKJPBOFJL-UHFFFAOYSA-N potassium oxidosilane Chemical compound [K+].[SiH3][O-] IALUUOKJPBOFJL-UHFFFAOYSA-N 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 125000000725 trifluoropropyl group Chemical group [H]C([H])(*)C([H])([H])C(F)(F)F 0.000 description 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 3
- VSIKJPJINIDELZ-UHFFFAOYSA-N 2,2,4,4,6,6,8,8-octakis-phenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane Chemical compound O1[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si]1(C=1C=CC=CC=1)C1=CC=CC=C1 VSIKJPJINIDELZ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 101000801643 Homo sapiens Retinal-specific phospholipid-transporting ATPase ABCA4 Proteins 0.000 description 2
- 102100033617 Retinal-specific phospholipid-transporting ATPase ABCA4 Human genes 0.000 description 2
- 206010047571 Visual impairment Diseases 0.000 description 2
- 230000002350 accommodative effect Effects 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 235000010290 biphenyl Nutrition 0.000 description 2
- 239000004305 biphenyl Substances 0.000 description 2
- 125000006267 biphenyl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- BITPLIXHRASDQB-UHFFFAOYSA-N ethenyl-[ethenyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound C=C[Si](C)(C)O[Si](C)(C)C=C BITPLIXHRASDQB-UHFFFAOYSA-N 0.000 description 2
- 229920001002 functional polymer Polymers 0.000 description 2
- PQPVPZTVJLXQAS-UHFFFAOYSA-N hydroxy-methyl-phenylsilicon Chemical class C[Si](O)C1=CC=CC=C1 PQPVPZTVJLXQAS-UHFFFAOYSA-N 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 201000010041 presbyopia Diseases 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 125000004950 trifluoroalkyl group Chemical group 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 208000004434 Calcinosis Diseases 0.000 description 1
- 206010007766 Cataract traumatic Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229920002319 Poly(methyl acrylate) Polymers 0.000 description 1
- 206010038848 Retinal detachment Diseases 0.000 description 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 206010044135 Toxic cataract Diseases 0.000 description 1
- 231100000329 Toxic cataract Toxicity 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- FSIJKGMIQTVTNP-UHFFFAOYSA-N bis(ethenyl)-methyl-trimethylsilyloxysilane Chemical compound C[Si](C)(C)O[Si](C)(C=C)C=C FSIJKGMIQTVTNP-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- HAURRGANAANPSQ-UHFFFAOYSA-N cis-2,4,6-Trimethyl-2,4,6-triphenylcyclotrisiloxane Chemical compound O1[Si](C)(C=2C=CC=CC=2)O[Si](C)(C=2C=CC=CC=2)O[Si]1(C)C1=CC=CC=C1 HAURRGANAANPSQ-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- UOUILILVWRHZSH-UHFFFAOYSA-N dimethyl-tris[(dimethyl-$l^{3}-silanyl)oxy]silyloxysilicon Chemical compound C[Si](C)O[Si](O[Si](C)C)(O[Si](C)C)O[Si](C)C UOUILILVWRHZSH-UHFFFAOYSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 210000000871 endothelium corneal Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 208000029515 lens disease Diseases 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229920006136 organohydrogenpolysiloxane Polymers 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- OOUHCAOKCRDABZ-UHFFFAOYSA-N potassium oxido(oxo)silane Chemical compound [K+].[O-][SiH]=O OOUHCAOKCRDABZ-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004264 retinal detachment Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 201000008525 senile cataract Diseases 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000004489 tear production Effects 0.000 description 1
- 229920000950 tetracopolymer Polymers 0.000 description 1
- GTWPLTBXXGOHNT-UHFFFAOYSA-N tetrakis(dimethylsilyl) silicate Chemical compound C[SiH](C)O[Si](O[SiH](C)C)(O[SiH](C)C)O[SiH](C)C GTWPLTBXXGOHNT-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
- C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Physics & Mathematics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Silicon Polymers (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9822244.1A GB9822244D0 (en) | 1998-10-13 | 1998-10-13 | Intraocular lens forming material and lenses formed therefrom |
| US09/170,160 US6066172A (en) | 1998-10-13 | 1998-10-13 | Injectable intraocular lens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20011290A3 true CZ20011290A3 (cs) | 2001-11-14 |
Family
ID=26314505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20011290A CZ20011290A3 (cs) | 1998-10-13 | 1999-10-11 | Injikovatelné intraokulární čočky |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1141751B1 (enExample) |
| JP (1) | JP4831865B2 (enExample) |
| KR (1) | KR100871500B1 (enExample) |
| CN (1) | CN1173194C (enExample) |
| BR (1) | BR9914431A (enExample) |
| CA (1) | CA2346186C (enExample) |
| CZ (1) | CZ20011290A3 (enExample) |
| EA (1) | EA005114B1 (enExample) |
| HK (1) | HK1040293A1 (enExample) |
| HU (1) | HUP0104197A3 (enExample) |
| ID (1) | ID29522A (enExample) |
| NO (1) | NO20011858L (enExample) |
| NZ (1) | NZ510807A (enExample) |
| PL (1) | PL347252A1 (enExample) |
| SK (1) | SK4892001A3 (enExample) |
| TR (1) | TR200101048T2 (enExample) |
| WO (1) | WO2000022459A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ197899A0 (en) | 1999-08-02 | 1999-08-26 | Commonwealth Scientific And Industrial Research Organisation | Biomedical compositions |
| US6613343B2 (en) | 2000-04-12 | 2003-09-02 | Pharmacia Groningen Bv | Injectable intraocular accommodating lens |
| SE0001352D0 (sv) * | 2000-04-12 | 2000-04-12 | Pharmacia & Upjohn Bv | Injectable intraocular accommodating lens |
| US6598606B2 (en) | 2000-05-24 | 2003-07-29 | Pharmacia Groningen Bv | Methods of implanting an intraocular lens |
| SE0001934D0 (sv) | 2000-05-24 | 2000-05-24 | Pharmacia & Upjohn Bv | Method of implanting an intraocular lens |
| SE0004393D0 (sv) | 2000-11-29 | 2000-11-29 | Pharmacia Groningen Bv | A device for use in eye surgery |
| US6533769B2 (en) | 2001-05-03 | 2003-03-18 | Holmen Joergen | Method for use in cataract surgery |
| SE0102543D0 (sv) * | 2001-07-16 | 2001-07-16 | Pharmacia Groningen Bv | Compositions capable of forming hydrogels in the eye |
| US6864341B2 (en) * | 2001-11-02 | 2005-03-08 | Bausch & Lomb Incorporated | High refractive index aromatic-based prepolymer precursors |
| US7173073B2 (en) | 2002-01-14 | 2007-02-06 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing heterocyclic compounds and methods for their production |
| SE0201479D0 (sv) | 2002-05-16 | 2002-05-16 | Pharmacia Groningen Bv | Kit and method in eye surgery |
| SE0201478D0 (sv) | 2002-05-16 | 2002-05-16 | Pharmacia & Upjohn Bv | Method in eye surgery |
| US7160324B2 (en) | 2002-05-17 | 2007-01-09 | Amo Groningen, B.V. | Method in eye surgery |
| AU2002950469A0 (en) | 2002-07-30 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Improved biomedical compositions |
| US20040150788A1 (en) | 2002-11-22 | 2004-08-05 | Ann-Margret Andersson | Antimicrobial lenses, processes to prepare them and methods of their use |
| US7416737B2 (en) | 2003-11-18 | 2008-08-26 | Johnson & Johnson Vision Care, Inc. | Antimicrobial lenses, processes to prepare them and methods of their use |
| SE0403091D0 (sv) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New composition for injectable ophtalmic lenses |
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-
1999
- 1999-10-11 HK HK02102016.4A patent/HK1040293A1/zh unknown
- 1999-10-11 TR TR2001/01048T patent/TR200101048T2/xx unknown
- 1999-10-11 HU HU0104197A patent/HUP0104197A3/hu unknown
- 1999-10-11 PL PL99347252A patent/PL347252A1/xx not_active Application Discontinuation
- 1999-10-11 KR KR1020017004623A patent/KR100871500B1/ko not_active Expired - Fee Related
- 1999-10-11 WO PCT/EP1999/007780 patent/WO2000022459A1/en not_active Ceased
- 1999-10-11 BR BR9914431-0A patent/BR9914431A/pt not_active Application Discontinuation
- 1999-10-11 EP EP99953839A patent/EP1141751B1/en not_active Expired - Lifetime
- 1999-10-11 SK SK489-2001A patent/SK4892001A3/sk not_active Application Discontinuation
- 1999-10-11 CA CA2346186A patent/CA2346186C/en not_active Expired - Lifetime
- 1999-10-11 CN CNB998121258A patent/CN1173194C/zh not_active Expired - Lifetime
- 1999-10-11 NZ NZ510807A patent/NZ510807A/en not_active IP Right Cessation
- 1999-10-11 CZ CZ20011290A patent/CZ20011290A3/cs unknown
- 1999-10-11 JP JP2000576302A patent/JP4831865B2/ja not_active Expired - Fee Related
- 1999-10-11 EA EA200100432A patent/EA005114B1/ru not_active IP Right Cessation
- 1999-11-11 ID IDW00200101013A patent/ID29522A/id unknown
-
2001
- 2001-04-11 NO NO20011858A patent/NO20011858L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2346186A1 (en) | 2000-04-20 |
| ID29522A (id) | 2001-09-06 |
| BR9914431A (pt) | 2001-07-03 |
| JP4831865B2 (ja) | 2011-12-07 |
| CA2346186C (en) | 2011-02-08 |
| KR100871500B1 (ko) | 2008-12-05 |
| EP1141751A1 (en) | 2001-10-10 |
| CN1173194C (zh) | 2004-10-27 |
| SK4892001A3 (en) | 2001-12-03 |
| EA200100432A1 (ru) | 2001-10-22 |
| HK1040293A1 (zh) | 2002-05-31 |
| EP1141751B1 (en) | 2012-11-14 |
| NZ510807A (en) | 2003-10-31 |
| JP2002527170A (ja) | 2002-08-27 |
| PL347252A1 (en) | 2002-03-25 |
| NO20011858D0 (no) | 2001-04-11 |
| EA005114B1 (ru) | 2004-10-28 |
| WO2000022459A1 (en) | 2000-04-20 |
| TR200101048T2 (tr) | 2001-07-23 |
| CN1323400A (zh) | 2001-11-21 |
| HUP0104197A3 (en) | 2003-03-28 |
| KR20010088868A (ko) | 2001-09-28 |
| NO20011858L (no) | 2001-05-10 |
| HUP0104197A2 (hu) | 2002-04-29 |
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