CA2346186C - Injectable intraocular lens - Google Patents
Injectable intraocular lens Download PDFInfo
- Publication number
- CA2346186C CA2346186C CA2346186A CA2346186A CA2346186C CA 2346186 C CA2346186 C CA 2346186C CA 2346186 A CA2346186 A CA 2346186A CA 2346186 A CA2346186 A CA 2346186A CA 2346186 C CA2346186 C CA 2346186C
- Authority
- CA
- Canada
- Prior art keywords
- siloxane
- specific gravity
- cyclotrisiloxane
- lens
- polysiloxanes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000695 crystalline len Anatomy 0.000 claims abstract description 104
- -1 polysiloxanes Polymers 0.000 claims abstract description 93
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 78
- 239000000463 material Substances 0.000 claims abstract description 44
- 230000005484 gravity Effects 0.000 claims abstract description 41
- 238000000034 method Methods 0.000 claims abstract description 23
- 238000002347 injection Methods 0.000 claims abstract description 16
- 239000007924 injection Substances 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- 238000004132 cross linking Methods 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- 239000000178 monomer Substances 0.000 claims description 60
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 34
- 239000003054 catalyst Substances 0.000 claims description 16
- 229920000642 polymer Polymers 0.000 claims description 15
- 239000011541 reaction mixture Substances 0.000 claims description 15
- 229920001897 terpolymer Polymers 0.000 claims description 11
- FGZFESWHQXSPJU-UHFFFAOYSA-N 2-methyl-2-(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane Chemical compound FC(F)(F)CC[Si]1(C)O[SiH2]O[SiH2]O1 FGZFESWHQXSPJU-UHFFFAOYSA-N 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 239000004971 Cross linker Substances 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 239000003431 cross linking reagent Substances 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 5
- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 claims description 5
- 238000011065 in-situ storage Methods 0.000 claims description 5
- VSIKJPJINIDELZ-UHFFFAOYSA-N 2,2,4,4,6,6,8,8-octakis-phenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane Chemical compound O1[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si]1(C=1C=CC=CC=1)C1=CC=CC=C1 VSIKJPJINIDELZ-UHFFFAOYSA-N 0.000 claims description 4
- HAURRGANAANPSQ-UHFFFAOYSA-N cis-2,4,6-Trimethyl-2,4,6-triphenylcyclotrisiloxane Chemical compound O1[Si](C)(C=2C=CC=CC=2)O[Si](C)(C=2C=CC=CC=2)O[Si]1(C)C1=CC=CC=C1 HAURRGANAANPSQ-UHFFFAOYSA-N 0.000 claims description 4
- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 claims description 4
- 239000007943 implant Substances 0.000 claims description 3
- 239000013638 trimer Substances 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- DXXLRWPBGOEOQL-UHFFFAOYSA-N 2-hexyl-2-methyl-1,3,5,2,4,6-trioxatrisilinane Chemical compound C(CCCCC)[Si]1(O[SiH2]O[SiH2]O1)C DXXLRWPBGOEOQL-UHFFFAOYSA-N 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- XYZXJVOKDRDQQZ-UHFFFAOYSA-N 2-hexyl-2-phenyl-1,3,5,2,4,6-trioxatrisilinane Chemical compound CCCCCC[Si]1(O[SiH2]O[SiH2]O1)c1ccccc1 XYZXJVOKDRDQQZ-UHFFFAOYSA-N 0.000 claims 2
- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 210000001508 eye Anatomy 0.000 description 14
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 230000008569 process Effects 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000011521 glass Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 208000002177 Cataract Diseases 0.000 description 7
- 230000002350 accommodative effect Effects 0.000 description 7
- 239000003112 inhibitor Substances 0.000 description 6
- 235000010290 biphenyl Nutrition 0.000 description 5
- 239000004305 biphenyl Substances 0.000 description 5
- 125000006267 biphenyl group Chemical group 0.000 description 5
- 230000004438 eyesight Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 5
- 229910052697 platinum Inorganic materials 0.000 description 5
- 210000001525 retina Anatomy 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000017 hydrogel Substances 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- IALUUOKJPBOFJL-UHFFFAOYSA-N potassium oxidosilane Chemical compound [K+].[SiH3][O-] IALUUOKJPBOFJL-UHFFFAOYSA-N 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 229920005573 silicon-containing polymer Polymers 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 208000002847 Surgical Wound Diseases 0.000 description 3
- 230000004308 accommodation Effects 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 210000004087 cornea Anatomy 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- BITPLIXHRASDQB-UHFFFAOYSA-N ethenyl-[ethenyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound C=C[Si](C)(C)O[Si](C)(C)C=C BITPLIXHRASDQB-UHFFFAOYSA-N 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- HTDJPCNNEPUOOQ-UHFFFAOYSA-N hexamethylcyclotrisiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 HTDJPCNNEPUOOQ-UHFFFAOYSA-N 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000004792 oxidative damage Effects 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 125000000725 trifluoropropyl group Chemical group [H]C([H])(*)C([H])([H])C(F)(F)F 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229910018557 Si O Inorganic materials 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229920001002 functional polymer Polymers 0.000 description 2
- PQPVPZTVJLXQAS-UHFFFAOYSA-N hydroxy-methyl-phenylsilicon Chemical compound C[Si](O)C1=CC=CC=C1 PQPVPZTVJLXQAS-UHFFFAOYSA-N 0.000 description 2
- 208000029515 lens disease Diseases 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 201000010041 presbyopia Diseases 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 229910052990 silicon hydride Inorganic materials 0.000 description 2
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- VCYDUTCMKSROID-UHFFFAOYSA-N 2,2,4,4,6,6-hexakis-phenyl-1,3,5,2,4,6-trioxatrisilinane Chemical compound O1[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si]1(C=1C=CC=CC=1)C1=CC=CC=C1 VCYDUTCMKSROID-UHFFFAOYSA-N 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010007766 Cataract traumatic Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 101000801643 Homo sapiens Retinal-specific phospholipid-transporting ATPase ABCA4 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229920002319 Poly(methyl acrylate) Polymers 0.000 description 1
- 206010038848 Retinal detachment Diseases 0.000 description 1
- 102100033617 Retinal-specific phospholipid-transporting ATPase ABCA4 Human genes 0.000 description 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 206010044135 Toxic cataract Diseases 0.000 description 1
- 231100000329 Toxic cataract Toxicity 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- FSIJKGMIQTVTNP-UHFFFAOYSA-N bis(ethenyl)-methyl-trimethylsilyloxysilane Chemical compound C[Si](C)(C)O[Si](C)(C=C)C=C FSIJKGMIQTVTNP-UHFFFAOYSA-N 0.000 description 1
- 210000000133 brain stem Anatomy 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- SZPIKCAXBLKNNK-UHFFFAOYSA-N dimethyl-phenoxy-phenylsilane Chemical compound C=1C=CC=CC=1[Si](C)(C)OC1=CC=CC=C1 SZPIKCAXBLKNNK-UHFFFAOYSA-N 0.000 description 1
- UOUILILVWRHZSH-UHFFFAOYSA-N dimethyl-tris[(dimethyl-$l^{3}-silanyl)oxy]silyloxysilicon Chemical compound C[Si](C)O[Si](O[Si](C)C)(O[Si](C)C)O[Si](C)C UOUILILVWRHZSH-UHFFFAOYSA-N 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000871 endothelium corneal Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 230000005865 ionizing radiation Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229920006136 organohydrogenpolysiloxane Polymers 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920000307 polymer substrate Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 201000008525 senile cataract Diseases 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000004489 tear production Effects 0.000 description 1
- 229920000950 tetracopolymer Polymers 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 description 1
- 238000009849 vacuum degassing Methods 0.000 description 1
- 208000013021 vision distortion Diseases 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
- G02B1/043—Contact lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
- C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Physics & Mathematics (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Casting Or Compression Moulding Of Plastics Or The Like (AREA)
- Silicon Polymers (AREA)
- Eyeglasses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/170,160 | 1998-10-13 | ||
| GBGB9822244.1A GB9822244D0 (en) | 1998-10-13 | 1998-10-13 | Intraocular lens forming material and lenses formed therefrom |
| US09/170,160 US6066172A (en) | 1998-10-13 | 1998-10-13 | Injectable intraocular lens |
| GB9822244.1 | 1998-10-13 | ||
| PCT/EP1999/007780 WO2000022459A1 (en) | 1998-10-13 | 1999-10-11 | Injectable intraocular lens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2346186A1 CA2346186A1 (en) | 2000-04-20 |
| CA2346186C true CA2346186C (en) | 2011-02-08 |
Family
ID=26314505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2346186A Expired - Lifetime CA2346186C (en) | 1998-10-13 | 1999-10-11 | Injectable intraocular lens |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1141751B1 (enExample) |
| JP (1) | JP4831865B2 (enExample) |
| KR (1) | KR100871500B1 (enExample) |
| CN (1) | CN1173194C (enExample) |
| BR (1) | BR9914431A (enExample) |
| CA (1) | CA2346186C (enExample) |
| CZ (1) | CZ20011290A3 (enExample) |
| EA (1) | EA005114B1 (enExample) |
| HK (1) | HK1040293A1 (enExample) |
| HU (1) | HUP0104197A3 (enExample) |
| ID (1) | ID29522A (enExample) |
| NO (1) | NO20011858L (enExample) |
| NZ (1) | NZ510807A (enExample) |
| PL (1) | PL347252A1 (enExample) |
| SK (1) | SK4892001A3 (enExample) |
| TR (1) | TR200101048T2 (enExample) |
| WO (1) | WO2000022459A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ197899A0 (en) | 1999-08-02 | 1999-08-26 | Commonwealth Scientific And Industrial Research Organisation | Biomedical compositions |
| US6613343B2 (en) | 2000-04-12 | 2003-09-02 | Pharmacia Groningen Bv | Injectable intraocular accommodating lens |
| SE0001352D0 (sv) * | 2000-04-12 | 2000-04-12 | Pharmacia & Upjohn Bv | Injectable intraocular accommodating lens |
| US6598606B2 (en) | 2000-05-24 | 2003-07-29 | Pharmacia Groningen Bv | Methods of implanting an intraocular lens |
| SE0001934D0 (sv) | 2000-05-24 | 2000-05-24 | Pharmacia & Upjohn Bv | Method of implanting an intraocular lens |
| SE0004393D0 (sv) | 2000-11-29 | 2000-11-29 | Pharmacia Groningen Bv | A device for use in eye surgery |
| US6533769B2 (en) | 2001-05-03 | 2003-03-18 | Holmen Joergen | Method for use in cataract surgery |
| SE0102543D0 (sv) * | 2001-07-16 | 2001-07-16 | Pharmacia Groningen Bv | Compositions capable of forming hydrogels in the eye |
| US6864341B2 (en) * | 2001-11-02 | 2005-03-08 | Bausch & Lomb Incorporated | High refractive index aromatic-based prepolymer precursors |
| US7173073B2 (en) | 2002-01-14 | 2007-02-06 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices containing heterocyclic compounds and methods for their production |
| SE0201479D0 (sv) | 2002-05-16 | 2002-05-16 | Pharmacia Groningen Bv | Kit and method in eye surgery |
| SE0201478D0 (sv) | 2002-05-16 | 2002-05-16 | Pharmacia & Upjohn Bv | Method in eye surgery |
| US7160324B2 (en) | 2002-05-17 | 2007-01-09 | Amo Groningen, B.V. | Method in eye surgery |
| AU2002950469A0 (en) | 2002-07-30 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Improved biomedical compositions |
| US20040150788A1 (en) | 2002-11-22 | 2004-08-05 | Ann-Margret Andersson | Antimicrobial lenses, processes to prepare them and methods of their use |
| US7416737B2 (en) | 2003-11-18 | 2008-08-26 | Johnson & Johnson Vision Care, Inc. | Antimicrobial lenses, processes to prepare them and methods of their use |
| SE0403091D0 (sv) | 2004-12-20 | 2004-12-20 | Amo Groningen Bv | New composition for injectable ophtalmic lenses |
| US9052438B2 (en) | 2005-04-08 | 2015-06-09 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices comprising photochromic materials with reactive substituents |
| US8158037B2 (en) | 2005-04-08 | 2012-04-17 | Johnson & Johnson Vision Care, Inc. | Photochromic materials having extended pi-conjugated systems and compositions and articles including the same |
| CN1810301B (zh) * | 2006-01-24 | 2012-07-04 | 广州卫视博生物科技有限公司 | 人工玻璃体囊袋及其制作工艺 |
| US8002828B2 (en) | 2006-04-28 | 2011-08-23 | Leonard Pinchuk | Method of implantation using polymer adhesive for an intraocular lens that minimizes posterior capsule opacification |
| US7559949B2 (en) | 2006-04-28 | 2009-07-14 | Leonard Pinchuk | Injectable intraocular lens that minimizes posterior capsule opacification and methods and materials for realizing same |
| US8439974B2 (en) | 2006-05-03 | 2013-05-14 | Vision Crc Limited | Adjusted index of refraction of ocular replacement material |
| US20080102095A1 (en) | 2006-10-31 | 2008-05-01 | Kent Young | Acidic processes to prepare antimicrobial contact lenses |
| US7968650B2 (en) | 2006-10-31 | 2011-06-28 | Johnson & Johnson Vision Care, Inc. | Polymeric compositions comprising at least one volume excluding polymer |
| GB0711313D0 (en) * | 2007-06-11 | 2007-07-25 | Dow Corning | A method for making phenylalkylsiloxanes |
| US8697770B2 (en) | 2010-04-13 | 2014-04-15 | Johnson & Johnson Vision Care, Inc. | Pupil-only photochromic contact lenses displaying desirable optics and comfort |
| US9690115B2 (en) | 2010-04-13 | 2017-06-27 | Johnson & Johnson Vision Care, Inc. | Contact lenses displaying reduced indoor glare |
| US8877103B2 (en) | 2010-04-13 | 2014-11-04 | Johnson & Johnson Vision Care, Inc. | Process for manufacture of a thermochromic contact lens material |
| US10278810B2 (en) | 2010-04-29 | 2019-05-07 | Ojo, Llc | Injectable physiologically adaptive intraocular lenses (IOL's) |
| US10383839B2 (en) | 2011-06-30 | 2019-08-20 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| US20130083287A1 (en) | 2011-09-30 | 2013-04-04 | Johnson & Johnson Vision Care, Inc. | Method of creating a visible mark on lens using a leuco dye |
| US20130083286A1 (en) | 2011-09-30 | 2013-04-04 | Johnson & Johnson Vision Care, Inc. | Method of creating a visible mark on lens using a leuco dye |
| CN104004191B (zh) * | 2014-06-18 | 2017-01-04 | 山东大学 | 一种氟硅共聚物及其制备方法 |
| US11724471B2 (en) | 2019-03-28 | 2023-08-15 | Johnson & Johnson Vision Care, Inc. | Methods for the manufacture of photoabsorbing contact lenses and photoabsorbing contact lenses produced thereby |
| AU2020378001A1 (en) * | 2019-11-07 | 2022-05-19 | Lensgen, Inc. | Silicone oil terpolymer for use in intraocular lens devices |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996187A (en) * | 1975-04-29 | 1976-12-07 | American Optical Corporation | Optically clear filled silicone elastomers |
| JPS6043869B2 (ja) * | 1977-12-28 | 1985-09-30 | 東芝シリコ−ン株式会社 | 常温硬化性ポリオルガノシロキサン組成物 |
| EP0094153A2 (en) | 1982-05-10 | 1983-11-16 | Dow Corning Corporation | Inherently wettable silicone resin optical devices |
| JPS63216574A (ja) * | 1987-03-06 | 1988-09-08 | キヤノン株式会社 | 眼内レンズ用組成物 |
| US4810764A (en) * | 1988-02-09 | 1989-03-07 | Bausch & Lomb Incorporated | Polymeric materials with high oxygen permeability and low protein substantivity |
| JP2618426B2 (ja) * | 1988-03-04 | 1997-06-11 | 株式会社メニコン | 眼内レンズ形成体 |
| JP2604831B2 (ja) * | 1988-10-19 | 1997-04-30 | 株式会社メニコン | バルーン型眼内レンズ用注入材料 |
| JP2604849B2 (ja) * | 1989-03-29 | 1997-04-30 | 株式会社メニコン | 眼内レンズ形成用組成物 |
| JPH03257421A (ja) * | 1990-03-08 | 1991-11-15 | Asahi Chem Ind Co Ltd | ソフトコンタクトレンズ材料 |
| US5444106A (en) * | 1992-04-21 | 1995-08-22 | Kabi Pharmacia Ophthalmics, Inc. | High refractive index silicone compositions |
| ES2113955T3 (es) * | 1992-04-21 | 1998-05-16 | Kabi Pharmacia Ophthalmics Inc | Composiciones de silicona con indice de refraccion elevado. |
| US5278258A (en) | 1992-05-18 | 1994-01-11 | Allergan, Inc. | Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses |
| JP3335216B2 (ja) | 1992-06-29 | 2002-10-15 | 株式会社メニコン | 眼用レンズ材料 |
| JPH06175083A (ja) * | 1992-12-10 | 1994-06-24 | Menicon Co Ltd | 眼用レンズ材料 |
| US5391590A (en) * | 1993-01-12 | 1995-02-21 | Allergan, Inc. | Injectable intraocular lens compositions and precursors thereof |
| GB2278846B (en) * | 1993-06-10 | 1997-04-16 | Gen Electric | Fluorosilicone terpolymeric fluid |
| JPH08245734A (ja) * | 1995-03-10 | 1996-09-24 | Asahi Chem Ind Co Ltd | ３次元架橋性ポリマーの製造方法及びこれを用いた眼科医療用ソフト材料 |
| JP3441024B2 (ja) * | 1995-03-10 | 2003-08-25 | 旭化成アイミー株式会社 | 親水性含フッ素シロキサンモノマー及びその樹脂からなる眼科用レンズ材料 |
| CN1084335C (zh) * | 1995-12-07 | 2002-05-08 | 博士伦公司 | 用于降低硅氧烷水凝胶的模量的单体单元 |
| US5928282A (en) * | 1997-06-13 | 1999-07-27 | Bausch & Lomb Surgical, Inc. | Intraocular lens |
-
1999
- 1999-10-11 HK HK02102016.4A patent/HK1040293A1/zh unknown
- 1999-10-11 TR TR2001/01048T patent/TR200101048T2/xx unknown
- 1999-10-11 HU HU0104197A patent/HUP0104197A3/hu unknown
- 1999-10-11 PL PL99347252A patent/PL347252A1/xx not_active Application Discontinuation
- 1999-10-11 KR KR1020017004623A patent/KR100871500B1/ko not_active Expired - Fee Related
- 1999-10-11 WO PCT/EP1999/007780 patent/WO2000022459A1/en not_active Ceased
- 1999-10-11 BR BR9914431-0A patent/BR9914431A/pt not_active Application Discontinuation
- 1999-10-11 EP EP99953839A patent/EP1141751B1/en not_active Expired - Lifetime
- 1999-10-11 SK SK489-2001A patent/SK4892001A3/sk not_active Application Discontinuation
- 1999-10-11 CA CA2346186A patent/CA2346186C/en not_active Expired - Lifetime
- 1999-10-11 CN CNB998121258A patent/CN1173194C/zh not_active Expired - Lifetime
- 1999-10-11 NZ NZ510807A patent/NZ510807A/en not_active IP Right Cessation
- 1999-10-11 CZ CZ20011290A patent/CZ20011290A3/cs unknown
- 1999-10-11 JP JP2000576302A patent/JP4831865B2/ja not_active Expired - Fee Related
- 1999-10-11 EA EA200100432A patent/EA005114B1/ru not_active IP Right Cessation
- 1999-11-11 ID IDW00200101013A patent/ID29522A/id unknown
-
2001
- 2001-04-11 NO NO20011858A patent/NO20011858L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2346186A1 (en) | 2000-04-20 |
| ID29522A (id) | 2001-09-06 |
| BR9914431A (pt) | 2001-07-03 |
| JP4831865B2 (ja) | 2011-12-07 |
| KR100871500B1 (ko) | 2008-12-05 |
| EP1141751A1 (en) | 2001-10-10 |
| CZ20011290A3 (cs) | 2001-11-14 |
| CN1173194C (zh) | 2004-10-27 |
| SK4892001A3 (en) | 2001-12-03 |
| EA200100432A1 (ru) | 2001-10-22 |
| HK1040293A1 (zh) | 2002-05-31 |
| EP1141751B1 (en) | 2012-11-14 |
| NZ510807A (en) | 2003-10-31 |
| JP2002527170A (ja) | 2002-08-27 |
| PL347252A1 (en) | 2002-03-25 |
| NO20011858D0 (no) | 2001-04-11 |
| EA005114B1 (ru) | 2004-10-28 |
| WO2000022459A1 (en) | 2000-04-20 |
| TR200101048T2 (tr) | 2001-07-23 |
| CN1323400A (zh) | 2001-11-21 |
| HUP0104197A3 (en) | 2003-03-28 |
| KR20010088868A (ko) | 2001-09-28 |
| NO20011858L (no) | 2001-05-10 |
| HUP0104197A2 (hu) | 2002-04-29 |
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